Gavialis gangeticus (Gharial): 109304240 Help Entry 109304240         CDS       T07453                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism ggn  Gavialis gangeticus (Gharial) Pathway ggn04020   Calcium signaling pathway ggn04260   Cardiac muscle contraction ggn04261   Adrenergic signaling in cardiomyocytes ggn04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:ggn00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     109304240 (RYR2)    04020 Calcium signaling pathway     109304240 (RYR2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     109304240 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     109304240 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:ggn04040]     109304240 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:ggn04990]     109304240 (RYR2) Ion channels [BR:ggn04040]  Voltage-gated cation channels   Ryanodine receptor    109304240 (RYR2) Domain-containing proteins not elsewhere classified [BR:ggn04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    109304240 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  109304240 NCBI-ProteinID:  XP_019382265 LinkDB All DBs Position Unknown AA seq 4980 aa AA seqDB search MSENESYAGIYLLLLFMHDFSYDFINASQNPDDEVVLQCTATVHKEQQKLCLAAEGFGNR LCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTEEKAEGLVDVEKWKFMMKTA QGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSMDKLAFDVGLQEDTTGEACWWTIHPA SKQRSEGEKVRVGDDLILVSISSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEVAQ GYLIGGDVLRLLHGHMDECLTVPSGEHGEELRRTVHYEGGAVSIHARSLWRLETLRVAWS GSHSRWGQPFRLRHITTGKYLSLLDDKSLLLTDKEKADVKSTAFCFRSSKEKLDVGIRKE VDGMGAPEIKYGDSVCYIQHVDTGLWLTYQSVDAKSVRMGSVQRKAIMHHEGHMDDGLTL SRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKAKSSTVDLPIESVSLSLQDLIGYFHP PDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGET WKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEA LNIIKEGHIKSIICLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQ TRLVNHVSSMRPNIFLGISEGSAQYRKWYYELMVDHMEPFVTAEATHLRVGWASTEGYSP YPGGGTEWGGNGVGDDLYSYGFDGLHLWSGCVARTVNSPNQHLLKTDDVVSCCLDLSAPS ISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCFEA VLPKEKLKVEQSREYKQDRNGTRDLLGPTISLSQAAFTPIPVDTSQIVLPPHLERIREKL AENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLA LGCHVGIADEHAEEKVKKVKLPKNYQLSSGYKPTPMDLSFIKLTPSQEAMVDKLAENAHN VWARDRIRQGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREAVRTLLGYGYNLE APDQDHATRSDVCSGIIEKFRIFRTEKTYAVKAGKWYFEFEAATAGDMRVGWTRPGCLPD QELGADEQAFVFDGFKAQRWHQGNEHFGRSWLAGDVVGCMVDMNEHTMMFTLNGEILLDD SGSELAFKDFEVGDGFIPVCSLGLSQVGRINFGKDVSTLKYFTICGLQEGYEPFAVNTNR DITMWLSKRLPQFLPVPPNHEHIEVMRIDGTIDSCPCLKVTQKSFGSQNSKTDVMFFRLS MPIECAEVFSKTPAGGLPGSGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVEREKEA AKPEFNNHKDYTQEKPSRLKQRFMLRRTKPDYSTSHSARLTEDVLADDRDDYDYLMQTST YYYSVRIFPGQEPANVWVGWITSDFHQYDTTFDLDRVRTVTVTLGDEKGKVHESIKRSNC YMVCAGESMSPGQGRNNNGLEIGCLVDAASGLVTFTANGKELSTYYQVEPSTKLFPAVFA QATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLTHVLWSRVPNHFLK VDVSRVSERQGWMIQCLDPLQFMALHVPEENRSIDILELTEQEELLKFHYHALRLYSAVC ALGNNRVAHAMCSHVDESQLLYAIEKKYMPGLLRTGYYDLLIDIHLNTYATARLMMNNEF IVPMTDETKSITLFPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSISSECYQFSPEFPLE ILKAKTIEMLTEAVQEGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGVFHNGDLKHILQL IEPSVFKEDTSQEDENEMPEKELTTEELKPEGGEEEARGEQVPKEGLLQMKLPEPVKLQM CHLLQYLCDCQIRHRIEAIVAFSDDFVAKLQENQRFRYNEVMQALNMSAALTARKTKEFR SPPQEQINMLLNFKDDKSDCPCPEEIQDHLLDFHEDLMTHCGIELDEDGALDGNSDLTIR GRLLYLVEKMTYLKKKQTEKPTDNHSKKPSTLQQLISDTMVRWAQESVIEDPELVRAMFV LLHRQYDGIGGLVRTLPKTYTINSVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGL GDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRI SRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVV RYLAGCGLQSCPLLISKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIR RPECFGPALRGEGGNGLLAAMEEAIKISEDPTRDGPSPSNGSCKTLEMEEQEDDTIHMGN AIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLEDLVGVISIPFHMPTIV KDGTVVEPDMSAGFCPDHKAAMVLFLDRVYGIEDQDFLLHLLEVGFLPDLRAAASLDTAA LSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQR DSIEECLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGG WGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYV SMMEKQSSMDSDGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMEKFANGWIYGEM YSESAKVQPLMKQYKLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDTMALYNRTRR ISQTSQVSVDTAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELEAKVGG GNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYVVSRGLKDLELDTPSIEKRFAYSF LQQLIRYVDEAHQYILEFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSA ASRPLSSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTV MKTGLESVKMALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPVL SSLFEHIGQHQFGEDLILEDVQVSCYRILASLYALGTSKSIYVERQRSALGECLAAFAGA FPVAFLETHLNKHNTYSIYNTKCVRDRAALDLPASVDEVCPNIPSLEKLMEEIVELAESG IRYTQMPHIMEVILPMLCSYMSHWWEHGPENNPEKAEMCCTGLTSEHMNTLLGNILKIIY NNLGIDEGAWMKRLAVFSQPIISKAKPQLLKTHFLPLMDKLKKKAAMVISDEEHLRAEGR GDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVADVFIY WSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSTQTSL IVAALKRLLPIGLNICAPGDQELIALAKTRFSMKDTEDEVRDIIRSNLHLQGKLEDPAIR WQMALYKDLPNRTENTSDPEKTVERVLDIANVLFHLEQVEHPQRSKKAVWHKLLSKQRKR AVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLARPGEEPPEEEES IKRVDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEVT GSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVAATLKLGIAILNGG NSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKV MQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFY WYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLH VFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNN VEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGVISKRDFQKAMESHKHYTQSETEFLLSC AEPDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELAESVLNYF QPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELF VNFCEDTIFEMQLAAQISESDLSERSANKEENEKDKLEEQDPRMGFFSLVTVKSALVAFK YNIMTLMKMLSVKSLKKQMKKMKKMTMKDMVMALFSSYWSILMGLLHFTSSVFRGFFRIM YSLLLGGSLVEGAKKIKVAELLANMPDPTQDEVRGEGEEGERKPTETALPAEDLTDLTAL SDDGDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLLSTPSLLPLPEVQEKVQEQKVKED EKDEKEETKSEPEKAEGEDGEKEEKTKDEKGKQKLRQLHTHRYGEPEVQESAFWKKIIAY QQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVTEEKEVHVVHAGENSKLNSL ESGSHRIITVHYVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVA RKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRIS ELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMT MSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFN FFRKFYNKSEDGDMPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFD ITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFET HTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14943 nt NT seq  +upstreamnt  +downstreamnt atgtcggagaatgaaagctatgctggcatttacctgctgttgctctttatgcatgatttc agctatgacttcataaatgcttcccagaatcctgacgatgaagtggttctgcagtgcact gcaactgttcacaaggaacaacagaaactgtgtcttgctgcagaaggatttggcaacaga ctctgttttttggaatccacttcaaattctaagaatgttccaccagatctctccatttgt acttttgtgctggaacagtccttgtcagtgcgggctcttcaagaaatgctggcaaacact gaagagaaagcagaagggctagttgatgttgaaaaatggaaatttatgatgaagactgca caaggtgggggtcatcgaacgctcctatatggacatgcaatattactgcgccattcatac agtggcatgtacctttgttgcctctccacctctcgatcatcaatggataaattggcattt gacgtgggattgcaagaagacacaacaggtgaggcctgctggtggaccatccaccctgcc tccaaacaacgatcagagggagaaaaagtgcgtgttggagatgacctcatcttagtcagc atctcctcagaaagatacttgcatttatcttatggcaatggtagcttacatgttgatgca gccttccagcagacactttggagtgtagcaccaatcagttcaggaagcgaagtggcccaa gggtatctgataggaggtgatgtgctgaggttattgcatggtcatatggatgaatgcttg actgttccatcaggggagcatggagaagaactgcgaagaactgtccactatgaaggtggt gctgtgtcgattcatgctcgttccctctggcgactagagaccctaagagttgcgtggagt ggaagccacagcagatggggacagccattcagactaaggcatataacaacagggaagtat ttgagcctcctggatgacaagagtctccttctcacagacaaagagaaagctgatgtgaaa tctacagcattttgttttcggtcttccaaggaaaaattggatgtagggataagaaaagaa gtggatggaatgggagcacctgaaataaaatatggtgactctgtatgctatatacaacac gtagacacgggcctgtggctcacataccagtctgtggatgcaaagtctgtaaggatggga tcagtgcagcgcaaggctataatgcatcatgaaggccacatggatgatggtttgacattg tccagatctcagcatgaagagtcccgtacagcaagagttatccgtagtacagtcttcctc ttcaacaggtttataaggggccttgatgctctcagcaagaaagcaaagtcttccacggtt gacttgcctattgagtcagtcagcctaagccttcaggacctgattggctactttcaccca cctgatgagcatttagagcatgaagacaaacaaaacaggctaagagcactgaaaaatcga cagaatctcttccaggaagagggtatgatcaaccttgtcctcgaatgtattgatcgctta catgtttacagcagtgcagctcactttgctgatgtagctgggaaggaagcaggagagacc tggaaatctattctaaactctttgtatgagttattagcggctctgattagagggaatcgc aagaactgtgctcaattttctggttctcttgactggctgatcagcagattagaaagacta gaagcctcctctggaattctagaggttttgcactgtgtgttggtggaaagcccagaagct ctaaacattattaaggaaggacatattaaatcaattatatgccttctcgacaaacatgga agaaaccataaggttttagatgtcttgtgctctctctgtgtatgccatggagtagctgtg cggtccaaccaacatttaatctgtgacaacctcctaccaggaagagatcttctcctacag acacgccttgtcaaccatgtgagcagcatgagacccaacatcttccttgggatcagtgaa ggctctgcccagtacagaaaatggtactacgaacttatggttgaccacatggagcctttt gtaacagcagaagcaactcatctacgagtgggctgggcttcaactgagggctattcaccg taccctggaggaggcacagaatggggtggaaatggtgttggcgatgacctctattcttat ggatttgatggtcttcatctgtggtcaggttgtgtagcccggacagtaaattctcccaac cagcatctgctaaaaactgatgatgtagtcagctgctgcttagatctgagtgccccaagc atctcattccggattaatggtcagccagttcaaggaatgtttgagaatttcaacatagat gggctcttctttccagttgtcagcttctctgcaggaataaaggtacgtttcctacttgga ggccgccatggagaattcaaattccttcctccacctgggtatgctccttgctttgaagct gttctgccaaaagagaagctaaaagtagaacagagccgagaatacaaacaagaccgcaat ggcacaagagacctgttgggtccaaccatatctctgtcacaagcagccttcacaccaatt cctgtagatactagtcagattgtattacctcctcacctggaaagaattagagaaaaatta gcggagaacatccatgaactttgggtcatgaataaaattgaacttggatggcagtatggc cctgtgagagatgacaacaaaagacagcacccatgcttagtggaattttcaaagttgcca gagcaggaaagaaattataatttacaaatgtcgcttgagacactgaagacccttttagca ttaggttgtcatgttggaattgcagatgaacatgccgaagaaaaagtgaaaaaagttaaa cttcctaagaattaccagttgtcaagtggatacaagcctactcccatggatctgagcttt atcaagctgaccccctctcaggaagctatggtggataaactagcagagaatgctcataat gtgtgggcgagggaccgtatcaggcagggttggacatacggtatccagcaggatgtgaag aatcgacggaacccccgccttgtcccgtatgctcttttggatgatcgtaccaagaaatca aacaaagatagcctccgggaggcagtacgcacccttcttgggtatggttacaaccttgaa gcccctgatcaagatcacgctacaagatcagatgtgtgcagtgggataatagaaaagttc cggatcttccgcacagagaaaacctatgcagtgaaggctggcaagtggtattttgagttt gaggcagccactgcgggagacatgagggttggctggaccaggccaggctgcctaccagat caagaacttggtgcagatgaacaagcttttgtctttgatggtttcaaggcccagcggtgg caccagggaaatgagcattttggccgctcttggctggcgggggatgtcgtgggatgcatg gttgacatgaatgagcataccatgatgttcaccttgaatggtgaaatcctgcttgatgac tctggatcagagcttgcattcaaggacttcgaggttggtgatggatttatacctgtgtgc agcttgggtttgtctcaagtgggaagaatcaactttggcaaagatgtcagtaccttgaaa tatttcactatctgtggcttacaagaaggttatgaaccctttgcggttaatacaaataga gacattaccatgtggctgagcaagagacttcctcagtttctaccagtgccgccaaatcac gaacacattgaggtgatgagaatagatggcaccatagacagctgcccctgtctgaaggtc acacagaagtcctttggttcacagaacagcaaaacagatgttatgttttttcgcctgagc atgcctatcgaatgtgcagaagtattctccaaaacacctgcaggagggttaccaggctct ggtctttttggcccaaagaatgacttggaagattatgatgctgattctgattttgaagtt ctgatgaagactgctcatggtcacctggtgcctgatcgggtagaaagagaaaaagaagct gcaaaaccagaattcaataaccataaagattacactcaagagaaaccttcacgccttaaa caaaggtttatgcttagaaggacaaagccagactacagtacaagccattctgcacggctc actgaggatgtcttagcagatgatagagatgattatgattacttgatgcagacttctacg tactactattcagtgagaatatttcctgggcaagaacctgcaaatgtctgggtgggctgg attacatctgacttccatcagtatgatacaacctttgacttggacagagttcgcactgtt actgttacactgggggatgaaaagggaaaggttcatgagagcatcaaacgcagcaactgc tatatggtatgcgcaggagagagcatgagccctggacaaggccgcaacaataatggactg gagattggttgcttggttgatgctgccagtggtctggtgaccttcactgctaatggcaaa gaacttagtacctactatcaggttgaaccaagtactaaattatttcctgcagtgtttgca caagctacaagtcctaatgttttccagtttgaattgggaagaataaagaatgtaatgcca ctgtctgctggcttgttcaaaagtgaacacaaaaacccagtgcctcagtgtcccccacgt ctccatgtccagtttctgacccatgtgctgtggagcagagtaccaaatcacttcctcaag gttgatgtctctcgtgtcagtgaacgtcaaggctggatgatacagtgcttggatccattg cagtttatggctcttcatgttccagaagaaaacaggtctatagatattttagagttgaca gaacaagaggaattgctgaaatttcactatcatgctctccgattatattcagctgtttgt gctttagggaacaatcgggtagcacatgctatgtgcagccacgtggatgaatctcagctc ctgtatgccattgagaaaaaatatatgccaggcttgttacgtacaggctattatgactta cttattgatatccacctcaacacctatgccactgccagattaatgatgaataatgaattt attgttccgatgacagatgagaccaagagcattactctgtttcctgatgagaataaaaaa catggcctccctggtatagggctcagcacctctctgcggcctaggatgcagttctcttct cccagctttgtaagcattagcagtgagtgctatcaatttagccctgaattccctctggaa atcttaaaggccaaaactattgagatgctgactgaagctgttcaagagggcagcctccat gttagagatccagtagggggttctacagagtttctttttgtcccgctcatcaagcttttt tacaccctgttaatcatgggagtcttccataatggggatctgaagcacatcttgcagttg attgagcccagtgttttcaaagaagacacaagccaagaggatgaaaatgaaatgccagag aaggagctgactacagaggagctaaagccagaaggaggagaggaagaagccagaggagag caagtgccaaaggaagggcttcttcaaatgaaacttcctgaacctgtaaaattgcagatg tgtcacttattgcaatatctgtgcgattgccaaatacgtcatcggatagaagccattgta gcattttctgatgattttgtagctaagcttcaagaaaatcagcgctttcgttacaatgaa gttatgcaagccttaaacatgtctgctgcactgacagccaggaaaacaaaagaatttcgg tctccacctcaagagcagataaacatgcttctgaactttaaggatgataaaagtgattgt ccttgccctgaggaaattcaagatcatcttcttgattttcatgaagatctaatgacacat tgtggaattgaactagatgaagatggagccctggatggaaatagtgatttaaccatcaga ggtcgtctattatacttagttgaaaaaatgacatacttgaagaagaaacaaactgagaaa cccactgataatcattctaaaaaaccctccactcttcaacaactgatttcagacacaatg gtacgctgggcccaggagtcggtaatagaggatcctgaattagtgagggccatgtttgtt ttgctgcatcgccagtatgatggtattggtggcctggttcgaaccttaccaaagacctac accataaatagtgtatcagtagaagacactatcaacctgctagcatcgctgggccagatc cgttctctgctcagtgtccgaatggggaaagaggaagaaaagctcatgattcgcggatta ggagacatcatgaacaataaagtgttttaccaacatcctaatcttatgagagcgttagga atgcatgagactgttatggaagtgatggtaaatgtacttggaggaggagaatccaaggaa atcacatttcctaagatggtggcaaactgctgtcgttttctatgttatttttgccgcatc agcaggcagaatcaaaaagctatgtttgatcatcttagttatttgctggaaaatagcagt gttggacttgcatccccttctatgcgaggatcaacccctctagatgttgcagcagcatct gtgatggataacaatgaacttgcactagctttaagggaacctgatttggaaaaggtagtt cgctatctggctggatgtggtttgcaaagctgccctttgttgatttctaagggctatcca gacattggatggaatccagttgaaggagaaagatatctggattttcttcggtttgctgtt ttttgcaatggagagagtgttgaagagaatgctaatgttgtggtcaggctgcttattcgt cgccccgagtgctttggtccagcactgagaggtgaaggaggcaatggtttacttgctgcc atggaggaagctataaaaatatcagaagatcctaccagagatggaccctcccctagtaat ggatcttgtaaaacgcttgagatggaagaacaagaagatgacacaatccacatgggaaat gccatcatgacattttatgctgctttgattgacctcttaggacgctgtgcccctgaaatg cacctaatccatgccggcaaaggggaagctattaggatcaggtcaatactgcggtctttg attccattggaagacttggtgggtgtaattagcattcctttccacatgccaacaatagtg aaagatggtactgtggtggaacctgacatgtctgcggggttttgcccagatcacaaggca gccatggttttgttccttgacagggtctatggcattgaggatcaggatttccttctgcat ctgctcgaagttggctttctgccggatctccgtgctgctgcttccttagacacggctgct ctgagtgctaccgacatggctttagctctgaatcgatacctttgcactgcagtgttgcct ttgttgaccagatgtgctcctctttttgctggcacagagcaccatgcttctcttatagat tccttattacatactgtatacagactttcaaagggctgctctcttaccaaagctcagagg gactccattgaagaatgtttactctccatttgtggccagctaaggccttccatgatgcaa cacttactgaggagattagtgtttgatgttcctctactaaatgagcatgcaaagatgcct cttaagttgctgacaaatcattatgaaagatgctggaaatattattgtttgccaggtgga tggggcaactttggtgcagcctctgaagaagaacttcatttatccagaaaattgttttgg ggaatttttgatgctctgtctcaaaagaagtatgaacaagagctatttaaactggccttg ccttgcttgagtgcagttgcaggggctctaccaccagactacatggaatcaaattatgtc agtatgatggaaaaacaatcttcaatggattcagatgggaattttaacccgcaacctgtt gatacatcaaatatcactattcctgagaagctagaatatttcattaataaatatgcagaa cattcacatgataaatggtccatggaaaagttcgcaaatggttggatttatggtgaaatg tattctgagtctgcaaaggtgcaacctttaatgaaacaatacaaattactatcagaaaag gagaaagaaatttatcggtggcccatcaaggagtctttgaaaactatgctagcttgggga tggcgaattgaaagaacaagagaaggagacactatggctctttataaccggacacgtcgc atatctcagacaagtcaagtttctgtggacactgcccatggttacagcccccgagcaatt gacatgagcaatgtaactctctccagagatctgcatgctatggctgagatgatggctgag aactatcataacatatgggcgaagaaaaagaagatggaactggaagcaaaagtaggagga ggcaaccatcctctactagttccctatgatacactgacagccaaagagaaagcaaaggac agagagaaagcacaggatattctgaaatttctgcagatcaatggctacgttgtctccaga ggattaaaggatctggagttagacaccccttccattgagaaacgctttgcctacagtttc cttcagcagctcataagatatgtggatgaagcacatcagtacatactggagtttgatggt ggcagcagaggcaaaggagaacacttcccttatgagcaagaaatcaaattctttgccaaa gttgtactccctttaatcgatcagtatttcaaaaaccatcgcctatatttcctatctgca gcaagcaggcctcttagcagtggtggccatgcctctaacaaggagaaagaaatggtgaca agcctgttctgcaaacttggagttcttgtcaggcataggatttcactgtttggaaatgat gcaacttcaatagtcaactgtcttcacatactgggtcagaccttggatgcaaggacagtg atgaaaactggtctggagtctgttaaaatggcactgagagcatttttggataatgctgca gaggatctggagaaaacaatggaaaatcttaagcaaggccagtttacacacaccagaaac cagccaaagggagtaacacaaatcattaactacaccacagtggctctcctgccagtgctc tcttcattatttgaacacattggacagcatcaatttggggaagatttaatattggaagat gttcaagtatcctgttacagaatattggccagtttatatgctcttggaactagcaagagc atctatgtggagcggcagcggtcagcactaggagaatgcttagctgcttttgctggtgcc ttccctgtggcttttttggaaactcatctaaataaacataatacatattctatctacaac accaaatgtgtaagagaccgagcagcccttgacttgccagctagtgtggatgaagtttgt ccaaatattccttccctggagaagctaatggaagaaattgtggaattggctgagtctggt attcggtacacccaaatgccacatattatggaagtgatactgcctatgctgtgtagctac atgtcacattggtgggagcatgggccagaaaataatcctgaaaaggctgaaatgtgctgc acaggcttgacatctgagcacatgaacactctgttgggcaatatactgaaaatcatatat aacaaccttggtattgatgaaggagcctggatgaagagattagcagtgttttcccagccg attataagcaaagcgaagccccagctcttaaagacccactttctaccactgatggataaa ctgaaaaagaaagcagcaatggttatatcagatgaagaacatctaagagcagaaggcaga ggtgacatgtctgaggctgaactgctcatcctagacgagttcaccactttggcaagggac ctctatgccttctaccctttgttgatcagatttgtggattataacagggcaaaatggctg aaagaaccgaaccctgaagcagaggaactgttccgtatggtggctgatgtatttatttac tggtcaaagtcccataatttcaaaagggaagaacagaactttgtggtacagaatgaaatc aacaatatgtcttttcttattaccgacaccaaatctaagatgtccaaggcagctgtttct gatcaggagagaaagaaaatgaagcgaaagggcgatcgctattctacgcagacttctctc attgtagcagcactgaagagattactgcccattggattaaatatttgtgcacctggagac caggagttaattgcactggctaaaaccagattcagcatgaaagacactgaggatgaagtt cgggatattatccgtagtaatctgcatttgcagggcaagcttgaggatcctgccattagg tggcagatggccctttacaaagatttaccaaacaggacggaaaatacctctgatccagag aagacagtggaaagagttcttgatatagctaatgtactttttcacctggaacaggtggag catcctcagaggtccaaaaaggcagtgtggcacaaattgctgtccaaacagagaaagaga gctgtagtagcctgctttagaatggcaccattatataatctgccaaggcatcgagctgtc aatctttttcttcaaggttatgaaaagtcttggattgaaacagaagagcattactttgaa gataaactgatagaagacttagcaagacctggagaggagccaccagaggaagaggaaagc attaaaagagtcgatcctcttcatcagctcatcctactattcagtcgaacagccttaact gaaaaatgcaaattggaagaagatttcctatatatggcttatgctgatattatggctaag agctgtcatgatgaagaggatgatgatggtgaagaagaagtaaagagttttgaagtcaca ggatcccaacgcagcaaggaaaaggaaatggaaaagcaaaaacttctgtaccagcaagcc agactgcatgatcggggtgctgcggagatggtacttcagactatcagtgccagcaaaggt gagatgggtccaatggttgcagctactctaaagcttggaattgccatcttaaatggagga aactctacagttcagcagaaaatgctggactaccttaaggacaaaaaggatgtgggtttc tttcagagccttgctggtcttatgcagtcttgcagtgttcttgacttaaatgcttttgaa cgtcagaacaaagcagagggcctcggcatggtgacagaagagggatcaggagaaaaggtg atgcaagatgatgaattcacctgtgaccttttccgctttctccaattgctttgtgaagga cacaattcagattttcagaattatttgagaactcagactggcaacaacacaactgtcaat attatcatctctactgtggactacttactgagagttcaggaatcgattagtgatttctac tggtattattctgggaaggatgttattgatgagcaaggacaacgtaatttctccaaagca attcaagttgcaaaacaggtctttaatactctcacagagtatattcagggtccatgcact gggaatcagcagagtctggcgcacagcaggctgtgggatgcagtggttggttttcttcat gtatttgcccacatgcagatgaaattatctcaggactccagtcaaattgaattattgaaa gagttaatggatctgcagaaagatatggtggtcatgctgctgtctatgctggaaggtaat gttgtgaatggaactatcggcaagcaaatggttgacatgttggtagaatcgtccaacaac gtagagatgattctgaagttttttgatatgttcttaaaactgaaagatttaacttcttct gatgcattcaaggaatatgaccctgatggcaaaggtgtaatttcaaagagggactttcaa aaggcaatggaaagccataagcattacacccaatctgaaacagagtttctgctctcttgt gctgagccagatgagaatgagactctggactatgaagaatttgtgaaacggttccacgaa cctgctaaagacattggtttcaatgttgctgttctcttaacaaacctgtcagagcacatg ccccatgacactcgcttgcagactttccttgagctagcagagagtgttctgaattatttt cagccctttcttgggcgcatagaaatcatgggcagtgcaaagcgcattgagcgagtttat tttgaaataagtgagtcaagtcggactcagtgggagaaacctcaggttaaagagtcaaag cgacagtttatatttgatgtagttaatgaaggtggagagaaagaaaagatggagcttttt gttaatttctgtgaggataccatctttgaaatgcagttggctgctcagatctctgaatca gatttgagtgagagatcagcaaataaagaagagaatgagaaagataagctggaggaacag gaccctagaatgggctttttctcccttgtgactgtaaagtcagctttagtagccttcaag tataacataatgactcttatgaaaatgctcagtgtgaagagtctaaagaagcagatgaag aagatgaagaaaatgaccatgaaggatatggttatggctttgttttcttcctactggagt attttgatgggcttactccatttcacatctagtgttttccggggcttctttcgcatcatg tacagtttattacttggtggaagcctagtagaaggggctaagaagatcaaggtggctgaa cttttagctaatatgccagatcccactcaggatgaagtgcgtggggaaggggaagaagga gagaggaaacccacagaaactgcactgcctgcagaagatctgacagatctaacagctttg tcagatgatggtgacctactctcagacatatttggcttggacttgaaaagagaaggaggc cagtataagttgatccctcacaacccaaatgctggtctgagtgatttattgagcactcct tcattgctcccattacctgaggtgcaagaaaaagtccaggagcagaaggtgaaagaagat gaaaaggatgagaaggaagaaactaaatctgaacctgaaaaagcagagggtgaagatgga gaaaaggaagagaaaactaaagatgaaaaagggaaacagaagttgagacagcttcataca cacagatacggagaaccagaagttcaagaatcagccttttggaagaaaatcatagcgtat caacagaaacttcttaactattttgctcgtaatttttataacatgaggatgttggctttg tttgttgcttttgccatcaacttcatcttgctcttctataaggtctccacatcttccgtg acagaagaaaaggaagttcatgtggttcatgctggtgaaaactccaaattaaacagccta gaaagtggctctcataggattatcacggtgcactatgtgcttgaagaaagcagtgggtat atggagcccacgctgcggatcttggctatcctacacactgtcatctcctttttctgcatc attggatactactgtttgaaagttccactggttatttttaagcgagaaaaagaagttgca aggaaattagaattcgatggtttatatattacagaacaaccatcagaagatgatattaaa gggcagtgggatagacttgttatcaatacacagtcatttcctaacaactattgggacaaa tttgttaaaagaaaggttatggataagtatggtgagttttatggccgtgacagaatcagc gagttgctaggaatggacaaagctgctctggattttagtgatgccagagaaaaaaagaaa ccaaagaaagatagctccttatctgctgtgctaaattccattgacgtgaagtatcagatg tggaaattgggagttgttttcactgacaattctttcctttatctagcctggtacatgacc atgtcagtcctaggccattacaacaattttttctttgctgctcatctccttgatattgca atgggattcaagacactacgaactatcctttcatcagtgacccacaatggcaaacagctt gtcttaacagtgggattattggcagtagtagtatacttgtacacagtagtagcattcaat tttttccgtaaattctacaacaagagtgaagatggagatatgccagatatgaaatgtgat gatatgctaacatgctacatgtttcacatgtatgttggagtgcgtgcaggtggaggaatt ggtgatgaaattgaggatccagcaggagatgaatatgaaatctatcggatcatctttgac atcactttcttcttctttgtaattgtcatcttgctagccatcatacaaggtttaataatt gatgcttttggggagttgagagaccaacaagagcaagttaaagaagacatggagaccaaa tgctttatttgtgggataggaaatgactactttgatacagtgccgcatggctttgaaaca cacacgctacaggagcacaacttggccaactatctgttttttctgatgtatctcattaac aaagatgaaacagagcacacgggacaggaatcctatgtatggaaaatgtatcaagaacgg tgctgggagtttttccctgctggcgattgcttccgaaaacagtatgaagatcagctcaac tga

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