KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101137723
Entry
101137723         CDS       T02442                                 
Symbol
AKT2
Name
(RefSeq) RAC-beta serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
ggo01521  EGFR tyrosine kinase inhibitor resistance
ggo01522  Endocrine resistance
ggo01524  Platinum drug resistance
ggo04010  MAPK signaling pathway
ggo04012  ErbB signaling pathway
ggo04014  Ras signaling pathway
ggo04015  Rap1 signaling pathway
ggo04022  cGMP-PKG signaling pathway
ggo04024  cAMP signaling pathway
ggo04062  Chemokine signaling pathway
ggo04066  HIF-1 signaling pathway
ggo04068  FoxO signaling pathway
ggo04071  Sphingolipid signaling pathway
ggo04072  Phospholipase D signaling pathway
ggo04140  Autophagy - animal
ggo04150  mTOR signaling pathway
ggo04151  PI3K-Akt signaling pathway
ggo04152  AMPK signaling pathway
ggo04210  Apoptosis
ggo04211  Longevity regulating pathway
ggo04213  Longevity regulating pathway - multiple species
ggo04218  Cellular senescence
ggo04261  Adrenergic signaling in cardiomyocytes
ggo04370  VEGF signaling pathway
ggo04371  Apelin signaling pathway
ggo04380  Osteoclast differentiation
ggo04510  Focal adhesion
ggo04550  Signaling pathways regulating pluripotency of stem cells
ggo04611  Platelet activation
ggo04613  Neutrophil extracellular trap formation
ggo04620  Toll-like receptor signaling pathway
ggo04625  C-type lectin receptor signaling pathway
ggo04630  JAK-STAT signaling pathway
ggo04660  T cell receptor signaling pathway
ggo04662  B cell receptor signaling pathway
ggo04664  Fc epsilon RI signaling pathway
ggo04666  Fc gamma R-mediated phagocytosis
ggo04668  TNF signaling pathway
ggo04722  Neurotrophin signaling pathway
ggo04725  Cholinergic synapse
ggo04728  Dopaminergic synapse
ggo04810  Regulation of actin cytoskeleton
ggo04910  Insulin signaling pathway
ggo04914  Progesterone-mediated oocyte maturation
ggo04915  Estrogen signaling pathway
ggo04917  Prolactin signaling pathway
ggo04919  Thyroid hormone signaling pathway
ggo04920  Adipocytokine signaling pathway
ggo04922  Glucagon signaling pathway
ggo04923  Regulation of lipolysis in adipocytes
ggo04926  Relaxin signaling pathway
ggo04929  GnRH secretion
ggo04931  Insulin resistance
ggo04932  Non-alcoholic fatty liver disease
ggo04933  AGE-RAGE signaling pathway in diabetic complications
ggo04935  Growth hormone synthesis, secretion and action
ggo04936  Alcoholic liver disease
ggo04973  Carbohydrate digestion and absorption
ggo05010  Alzheimer disease
ggo05017  Spinocerebellar ataxia
ggo05132  Salmonella infection
ggo05135  Yersinia infection
ggo05142  Chagas disease
ggo05145  Toxoplasmosis
ggo05152  Tuberculosis
ggo05160  Hepatitis C
ggo05161  Hepatitis B
ggo05162  Measles
ggo05163  Human cytomegalovirus infection
ggo05164  Influenza A
ggo05165  Human papillomavirus infection
ggo05166  Human T-cell leukemia virus 1 infection
ggo05167  Kaposi sarcoma-associated herpesvirus infection
ggo05168  Herpes simplex virus 1 infection
ggo05169  Epstein-Barr virus infection
ggo05170  Human immunodeficiency virus 1 infection
ggo05200  Pathways in cancer
ggo05205  Proteoglycans in cancer
ggo05207  Chemical carcinogenesis - receptor activation
ggo05208  Chemical carcinogenesis - reactive oxygen species
ggo05210  Colorectal cancer
ggo05211  Renal cell carcinoma
ggo05212  Pancreatic cancer
ggo05213  Endometrial cancer
ggo05214  Glioma
ggo05215  Prostate cancer
ggo05218  Melanoma
ggo05220  Chronic myeloid leukemia
ggo05221  Acute myeloid leukemia
ggo05222  Small cell lung cancer
ggo05223  Non-small cell lung cancer
ggo05224  Breast cancer
ggo05225  Hepatocellular carcinoma
ggo05226  Gastric cancer
ggo05230  Central carbon metabolism in cancer
ggo05231  Choline metabolism in cancer
ggo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ggo05415  Diabetic cardiomyopathy
ggo05417  Lipid and atherosclerosis
ggo05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ggo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101137723 (AKT2)
   04012 ErbB signaling pathway
    101137723 (AKT2)
   04014 Ras signaling pathway
    101137723 (AKT2)
   04015 Rap1 signaling pathway
    101137723 (AKT2)
   04370 VEGF signaling pathway
    101137723 (AKT2)
   04371 Apelin signaling pathway
    101137723 (AKT2)
   04630 JAK-STAT signaling pathway
    101137723 (AKT2)
   04668 TNF signaling pathway
    101137723 (AKT2)
   04066 HIF-1 signaling pathway
    101137723 (AKT2)
   04068 FoxO signaling pathway
    101137723 (AKT2)
   04072 Phospholipase D signaling pathway
    101137723 (AKT2)
   04071 Sphingolipid signaling pathway
    101137723 (AKT2)
   04024 cAMP signaling pathway
    101137723 (AKT2)
   04022 cGMP-PKG signaling pathway
    101137723 (AKT2)
   04151 PI3K-Akt signaling pathway
    101137723 (AKT2)
   04152 AMPK signaling pathway
    101137723 (AKT2)
   04150 mTOR signaling pathway
    101137723 (AKT2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    101137723 (AKT2)
  09143 Cell growth and death
   04210 Apoptosis
    101137723 (AKT2)
   04218 Cellular senescence
    101137723 (AKT2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101137723 (AKT2)
   04550 Signaling pathways regulating pluripotency of stem cells
    101137723 (AKT2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101137723 (AKT2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101137723 (AKT2)
   04613 Neutrophil extracellular trap formation
    101137723 (AKT2)
   04620 Toll-like receptor signaling pathway
    101137723 (AKT2)
   04625 C-type lectin receptor signaling pathway
    101137723 (AKT2)
   04660 T cell receptor signaling pathway
    101137723 (AKT2)
   04662 B cell receptor signaling pathway
    101137723 (AKT2)
   04664 Fc epsilon RI signaling pathway
    101137723 (AKT2)
   04666 Fc gamma R-mediated phagocytosis
    101137723 (AKT2)
   04062 Chemokine signaling pathway
    101137723 (AKT2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101137723 (AKT2)
   04922 Glucagon signaling pathway
    101137723 (AKT2)
   04923 Regulation of lipolysis in adipocytes
    101137723 (AKT2)
   04920 Adipocytokine signaling pathway
    101137723 (AKT2)
   04929 GnRH secretion
    101137723 (AKT2)
   04915 Estrogen signaling pathway
    101137723 (AKT2)
   04914 Progesterone-mediated oocyte maturation
    101137723 (AKT2)
   04917 Prolactin signaling pathway
    101137723 (AKT2)
   04926 Relaxin signaling pathway
    101137723 (AKT2)
   04935 Growth hormone synthesis, secretion and action
    101137723 (AKT2)
   04919 Thyroid hormone signaling pathway
    101137723 (AKT2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101137723 (AKT2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    101137723 (AKT2)
  09156 Nervous system
   04725 Cholinergic synapse
    101137723 (AKT2)
   04728 Dopaminergic synapse
    101137723 (AKT2)
   04722 Neurotrophin signaling pathway
    101137723 (AKT2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101137723 (AKT2)
  09149 Aging
   04211 Longevity regulating pathway
    101137723 (AKT2)
   04213 Longevity regulating pathway - multiple species
    101137723 (AKT2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101137723 (AKT2)
   05205 Proteoglycans in cancer
    101137723 (AKT2)
   05207 Chemical carcinogenesis - receptor activation
    101137723 (AKT2)
   05208 Chemical carcinogenesis - reactive oxygen species
    101137723 (AKT2)
   05230 Central carbon metabolism in cancer
    101137723 (AKT2)
   05231 Choline metabolism in cancer
    101137723 (AKT2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101137723 (AKT2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101137723 (AKT2)
   05212 Pancreatic cancer
    101137723 (AKT2)
   05225 Hepatocellular carcinoma
    101137723 (AKT2)
   05226 Gastric cancer
    101137723 (AKT2)
   05214 Glioma
    101137723 (AKT2)
   05221 Acute myeloid leukemia
    101137723 (AKT2)
   05220 Chronic myeloid leukemia
    101137723 (AKT2)
   05218 Melanoma
    101137723 (AKT2)
   05211 Renal cell carcinoma
    101137723 (AKT2)
   05215 Prostate cancer
    101137723 (AKT2)
   05213 Endometrial cancer
    101137723 (AKT2)
   05224 Breast cancer
    101137723 (AKT2)
   05222 Small cell lung cancer
    101137723 (AKT2)
   05223 Non-small cell lung cancer
    101137723 (AKT2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101137723 (AKT2)
   05170 Human immunodeficiency virus 1 infection
    101137723 (AKT2)
   05161 Hepatitis B
    101137723 (AKT2)
   05160 Hepatitis C
    101137723 (AKT2)
   05164 Influenza A
    101137723 (AKT2)
   05162 Measles
    101137723 (AKT2)
   05168 Herpes simplex virus 1 infection
    101137723 (AKT2)
   05163 Human cytomegalovirus infection
    101137723 (AKT2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101137723 (AKT2)
   05169 Epstein-Barr virus infection
    101137723 (AKT2)
   05165 Human papillomavirus infection
    101137723 (AKT2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101137723 (AKT2)
   05135 Yersinia infection
    101137723 (AKT2)
   05152 Tuberculosis
    101137723 (AKT2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101137723 (AKT2)
   05142 Chagas disease
    101137723 (AKT2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101137723 (AKT2)
   05017 Spinocerebellar ataxia
    101137723 (AKT2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101137723 (AKT2)
   05418 Fluid shear stress and atherosclerosis
    101137723 (AKT2)
   05415 Diabetic cardiomyopathy
    101137723 (AKT2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    101137723 (AKT2)
   04932 Non-alcoholic fatty liver disease
    101137723 (AKT2)
   04931 Insulin resistance
    101137723 (AKT2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101137723 (AKT2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101137723 (AKT2)
   01524 Platinum drug resistance
    101137723 (AKT2)
   01522 Endocrine resistance
    101137723 (AKT2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ggo01001]
    101137723 (AKT2)
Enzymes [BR:ggo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     101137723 (AKT2)
Protein kinases [BR:ggo01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   101137723 (AKT2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 PH_11 ABC1 Seadorna_VP7
Other DBs
NCBI-GeneID: 101137723
NCBI-ProteinID: XP_004060786
Ensembl: ENSGGOG00000001397
UniProt: A0A2I2YDQ0
LinkDB
Position
20:complement(join(51985788..51985867,51986960..51987062,51987178..51987265,51987805..51988019,51988172..51988300,51989804..51989926,51990741..51990809,51991881..51991946,51993800..51993931,51994396..51994549,52006816..52006927,52008582..52008710,52017970..52018015))
AA seq 481 aa
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSTAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
NT seq 1446 nt   +upstreamnt  +downstreamnt
atgaacgaggtgtctgtcatcaaagaaggctggctccacaagcgtggtgaatacatcaag
acctggaggccacgatacttcctgctgaagagcgacggctccttcattgggtacaaggag
aggcccgaggcccctgatcagactctaccccccttaaacaacttctccgtagcagaatgc
cagctgatgaagaccgagaggccgcgacccaacacctttgtcatacgttgcctgcagtgg
accacagtcatcgagaggaccttccacgtggattctccagacgagagggaggagtggatg
cgggccatccagatggtcgccaacagcctcaagcagcgggccccaggcgaggaccccatg
gactacaagtgtggctcccccagtgactcctccacggctgaggagatggaagtggcggtc
agcaaggcacgggctaaagtgaccatgaatgacttcgactatctcaaactccttggcaag
ggaacctttggcaaagtcatcctggtgcgggagaaggccactggccgctactacgccatg
aagatcctgcggaaggaagtcatcattgccaaggatgaagtcgctcacacagtcaccgag
agccgggtcctccagaacaccaggcacccgttcctcactgcgctgaagtacgccttccag
acccacgaccgcctgtgcttcgtgatggagtatgccaacgggggtgagctgttcttccac
ctgtcccgggagcgtgtcttcacagaggagcgggcccggttttatggtgcagagattgtc
tcggctcttgagtacttgcactcgcgggacgtggtataccgcgacatcaagctggaaaac
ctcatgctggacaaagatggccacatcaagatcactgactttggcctctgcaaagagggc
atcagtgacggggccaccatgaaaaccttctgtgggaccccggagtacctggcgcctgag
gtgctggaggacaatgactatggccgggccgtggactggtgggggctgggtgtggtcatg
tacgagatgatgtgcggccgcctgcccttctacaaccaggaccacgagcgcctcttcgag
ctcatcctcatggaagagatccgcttcccgcgcacgctcagccctgaggccaagtccctg
cttgctgggctgcttaagaaggaccccaagcagaggcttggtggggggcccagcgatgcc
aaggaggtcatggagcacaggttcttcctcagcatcaactggcaggacgtggtccagaag
aagctcctgccacccttcaaacctcaggtcacatctgaggtcgacacaaggtacttcgat
gatgaatttaccgcccagtccatcacaatcacaccccctgaccgctatgacagcctgggc
ttactggagctggaccagcggacccacttcccccagttctcctactcggccagcatccgc
gagtga

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