KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101140885
Entry
101140885         CDS       T02442                                 
Symbol
ERBB2
Name
(RefSeq) receptor tyrosine-protein kinase ErbB-2 isoform X1
  KO
K05083  receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
ggo01521  EGFR tyrosine kinase inhibitor resistance
ggo01522  Endocrine resistance
ggo01524  Platinum drug resistance
ggo04010  MAPK signaling pathway
ggo04012  ErbB signaling pathway
ggo04020  Calcium signaling pathway
ggo04066  HIF-1 signaling pathway
ggo04151  PI3K-Akt signaling pathway
ggo04510  Focal adhesion
ggo04518  Integrin signaling
ggo04520  Adherens junction
ggo04530  Tight junction
ggo05200  Pathways in cancer
ggo05205  Proteoglycans in cancer
ggo05206  MicroRNAs in cancer
ggo05212  Pancreatic cancer
ggo05213  Endometrial cancer
ggo05215  Prostate cancer
ggo05219  Bladder cancer
ggo05223  Non-small cell lung cancer
ggo05224  Breast cancer
ggo05226  Gastric cancer
ggo05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ggo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101140885 (ERBB2)
   04012 ErbB signaling pathway
    101140885 (ERBB2)
   04066 HIF-1 signaling pathway
    101140885 (ERBB2)
   04020 Calcium signaling pathway
    101140885 (ERBB2)
   04151 PI3K-Akt signaling pathway
    101140885 (ERBB2)
  09133 Signaling molecules and interaction
   04518 Integrin signaling
    101140885 (ERBB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101140885 (ERBB2)
   04520 Adherens junction
    101140885 (ERBB2)
   04530 Tight junction
    101140885 (ERBB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101140885 (ERBB2)
   05206 MicroRNAs in cancer
    101140885 (ERBB2)
   05205 Proteoglycans in cancer
    101140885 (ERBB2)
   05230 Central carbon metabolism in cancer
    101140885 (ERBB2)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    101140885 (ERBB2)
   05226 Gastric cancer
    101140885 (ERBB2)
   05219 Bladder cancer
    101140885 (ERBB2)
   05215 Prostate cancer
    101140885 (ERBB2)
   05213 Endometrial cancer
    101140885 (ERBB2)
   05224 Breast cancer
    101140885 (ERBB2)
   05223 Non-small cell lung cancer
    101140885 (ERBB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101140885 (ERBB2)
   01524 Platinum drug resistance
    101140885 (ERBB2)
   01522 Endocrine resistance
    101140885 (ERBB2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ggo01001]
    101140885 (ERBB2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:ggo04147]
    101140885 (ERBB2)
   04090 CD molecules [BR:ggo04090]
    101140885 (ERBB2)
Enzymes [BR:ggo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     101140885 (ERBB2)
Protein kinases [BR:ggo01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   101140885 (ERBB2)
Exosome [BR:ggo04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   101140885 (ERBB2)
CD molecules [BR:ggo04090]
 Proteins
  101140885 (ERBB2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 Haspin_kinase ABC1 Kinase-like
Other DBs
NCBI-GeneID: 101140885
NCBI-ProteinID: XP_004041868
Ensembl: ENSGGOG00000004509
UniProt: G3QPD2
LinkDB
Position
4:complement(join(52750271..52750626,52750769..52751021,52751311..52751499,52751674..52751771,52752481..52752627,52752932..52753007,52753112..52753267,52753405..52753590,52754323..52754421,52754676..52754798,52754879..52755017,52758492..52758539,52760851..52761011,52761725..52761815,52761898..52762030,52762391..52762590,52762794..52762884,52762971..52763044,52765898..52766024,52766299..52766418,52767864..52768005,52768144..52768259,52768464..52768532,52768893..52769027,52769811..52770024,52771206..52771357,52778044..52778407))
AA seq 1352 aa
MQLEGASWERACSQSQEEEEVEEEGCLRKYKNEVVKLRFPSIGTGETRGAPRAAARPFPR
GPLLRRAPGPHPSQHPAPRALPAGSSRSHGAGAAVSTMELAALCRWGLLLALLPPGAAST
QVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGY
VLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASSGGLRELQLR
SLTEILKGGVLIQRNPELCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPVCKGSR
CWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGI
CELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVT
AEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDG
DPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSIFQNLQVIRGRILHNGAYSL
TLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDE
CVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLLC
HPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGAC
QPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIR
KYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDG
ENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPY
GCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITD
FGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPY
DGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDP
QRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMV
HHRHRSSSTRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPT
HDPSPLQRYSEDPTVPLPSETDGYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPA
GATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQGGAAPQPHPPPAFSPAFDNLYYW
DQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
NT seq 4059 nt   +upstreamnt  +downstreamnt
atgcagttggagggggcgagctgggagcgcgcttgctcccaatcacaggaggaggaggag
gtggaggaggagggctgcttgaggaagtataagaatgaagttgtgaagctgagattcccc
tccattgggaccggagaaaccaggggagccccccgggcagccgcgcgccccttcccacgg
ggccctttactgcgccgcgcgcccggcccccacccctcgcagcaccccgcgccccgcgcc
ctcccagccgggtccagccggagccatggggccggagccgcagtgagcaccatggagctg
gcggccttgtgccgctgggggctcctcctcgccctcttgccccccggagccgcgagcacc
caagtgtgcaccggcacagacatgaagctgcggctccctgccagtcccgagacccatctg
gacatgctccgccacctctaccagggctgccaggtggtgcagggaaacctggaactcacc
tacctgcccaccaatgccagcctgtccttcctgcaggatatccaggaggtgcagggctac
gtgctcatcgctcacaaccaagtgaggcaggtcccactacagaggctgcggattgtgcga
ggcacccagctctttgaggacaactatgccctggccgtgctagacaatggagacccgctg
aacaataccacccctgtcacaggggcctcctcaggaggcctgcgggagctgcagcttcga
agcctcacagagatcttgaaaggaggggtcttgatccagcggaaccccgagctctgctac
caggacacgattttgtggaaggacatcttccacaagaacaatcagctggctctcacactg
atagacaccaaccgctctcgggcctgccacccctgttctccggtgtgtaagggctcccgc
tgctggggagagagttctgaggattgtcagagcctgacacgcactgtctgtgccggtggc
tgtgcccgctgcaaggggccactgcccactgactgctgccatgagcagtgtgctgccggc
tgcacgggccccaagcactctgactgcctggcctgcctccacttcaaccacagtggcatc
tgtgagctgcactgcccagccctggtcacctacaacacagacacgtttgagtccatgccc
aatcccgagggccggtatacattcggcgccagctgtgtgactgcctgtccctacaactac
ctttctacggacgtgggatcctgcaccctcgtctgccccctgcacaaccaagaggtgaca
gcagaggatggaacacagcggtgtgagaagtgcagcaagccctgtgcccgagtgtgctat
ggtctgggcatggagcacttgcgagaggtgagggcagttaccagtgccaatatccaggag
tttgctggctgcaagaagatctttgggagcctggcatttctgccggagagctttgatggg
gacccagcctccaacaccgccccgctccagccagagcagctccaagtgtttgagactctg
gaagagatcacaggttacctatacatctcagcatggccagacagcctgcctgacctcagc
atcttccagaacctgcaagtaatccggggacgaattctgcacaatggcgcctactcgctg
accctgcaagggctgggcatcagctggctggggctgcgctcgctgagggaactgggcagt
ggactggccctcatccaccataacacccacctctgcttcgtgcacacggtgccctgggac
cagctctttcggaacccgcaccaagctctgctccacactgccaaccggccagaggacgag
tgtgtgggcgagggcctggcctgccaccagctgtgcgcccgagggcactgctggggtcca
gggcccacccagtgtgtcaactgcagccagttccttcggggccaggagtgcgtggaggaa
tgccgagtactgcaggggctccccagggagtatgtgaatgccaggcactgtttgctgtgc
caccctgagtgtcagccccagaatggctcagtgacctgttttggaccggaggctgaccag
tgtgtggcctgtgcccactataaggatcctcccttctgcgtggcccgctgccccagcggt
gtgaaacctgacctctcctacatgcccatctggaagtttccagatgaggagggcgcatgc
cagccttgccccatcaactgcacccactcctgtgtggacctggatgacaagggctgcccc
gccgagcagagagccagccctctgacgtccatcatctctgcggtggttggcattctgctg
gtcgtggtcttgggggtggtctttgggatcctcatcaagcgacggcagcagaagatccgg
aagtacacgatgcggagactgctgcaggaaacggagctggtggagccgctgacacctagc
ggagcgatgcccaaccaggcgcagatgcggatcctgaaagagacggagctgaggaaggtg
aaggtgcttggatctggcgcttttggcacagtctacaagggcatctggatccctgatggg
gagaatgtgaaaattccagtggccatcaaagtgttgagggaaaacacatcccccaaagcc
aataaagaaatcttagacgaagcatacgtgatggctggtgtgggctccccatatgtctcc
cgccttctgggcatctgcctgacatccacggtgcagctggtgacacagcttatgccctat
ggctgcctcttagaccatgtccgggaaaaccgcggacgcctgggctcccaggacctgctg
aactggtgtatgcagattgccaaggggatgagctacctggaggatgtgcggcttgtacac
agggacttggctgctcggaacgtgctggtcaagagtcccaaccatgtcaaaattacagac
ttcgggctggctcggctgctggacattgacgagacagagtaccatgcagatgggggcaag
gtgcccatcaagtggatggcgctggagtccattctccgccggcggttcacccaccagagt
gatgtgtggagttatggtgtgactgtgtgggagctgatgacttttggggccaaaccttac
gatgggatcccagcccgggagatccctgacctgctggaaaagggggagcggctgccccag
ccccccatctgcaccattgatgtctacatgatcatggtcaaatgttggatgattgactct
gaatgtcggccgagattccgggagttggtgtctgaattctcccgcatggccagggacccc
cagcgctttgtggtcatccagaatgaggacttgggcccagccagtcccttggacagcacc
ttctaccgctcactgctggaggacgatgacatgggggacctggtggatgctgaggagtat
ctggtaccccagcagggcttcttctgtccagaccctgccccgggcgctgggggcatggtc
caccacaggcaccgcagctcatctaccaggagtggcggtggggacctgacactagggctg
gagccctctgaagaggaggcccccaggtctccactggcaccctccgaaggggctggctcc
gatgtatttgatggtgacctgggaatgggggcagccaaggggctgcaaagcctccccaca
catgaccccagccctctacagcggtacagtgaggaccccacagtacccctgccctctgag
actgatggctacgttgcccccctgacctgcagcccccagcccgaatatgtgaaccagcca
gatgttcggccccagcccccttcgccccgagagggccctctgcctgctgcccgacctgct
ggtgccactctggaaaggcccaagactctctccccagggaagaatggggtcgtcaaagac
gtttttgcctttgggggtgccgtggagaaccccgagtacttgacaccccagggaggagct
gcccctcagccccaccctcctcctgccttcagcccagccttcgacaacctctattactgg
gaccaggacccaccagagcggggggctccacccagcaccttcaaagggacacctacggca
gagaacccagagtacctgggtctggacgtgccagtgtga

DBGET integrated database retrieval system