KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101145420
Entry
101145420         CDS       T02442                                 
Symbol
MAP2K3
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 3 isoform X1
  KO
K04432  mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
ggo04010  MAPK signaling pathway
ggo04015  Rap1 signaling pathway
ggo04218  Cellular senescence
ggo04620  Toll-like receptor signaling pathway
ggo04664  Fc epsilon RI signaling pathway
ggo04668  TNF signaling pathway
ggo04714  Thermogenesis
ggo04750  Inflammatory mediator regulation of TRP channels
ggo04912  GnRH signaling pathway
ggo04935  Growth hormone synthesis, secretion and action
ggo04936  Alcoholic liver disease
ggo05014  Amyotrophic lateral sclerosis
ggo05022  Pathways of neurodegeneration - multiple diseases
ggo05132  Salmonella infection
ggo05135  Yersinia infection
ggo05145  Toxoplasmosis
ggo05161  Hepatitis B
ggo05169  Epstein-Barr virus infection
ggo05170  Human immunodeficiency virus 1 infection
ggo05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ggo05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ggo00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101145420 (MAP2K3)
   04015 Rap1 signaling pathway
    101145420 (MAP2K3)
   04668 TNF signaling pathway
    101145420 (MAP2K3)
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    101145420 (MAP2K3)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    101145420 (MAP2K3)
   04664 Fc epsilon RI signaling pathway
    101145420 (MAP2K3)
  09152 Endocrine system
   04912 GnRH signaling pathway
    101145420 (MAP2K3)
   04935 Growth hormone synthesis, secretion and action
    101145420 (MAP2K3)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101145420 (MAP2K3)
  09159 Environmental adaptation
   04714 Thermogenesis
    101145420 (MAP2K3)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101145420 (MAP2K3)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    101145420 (MAP2K3)
   05161 Hepatitis B
    101145420 (MAP2K3)
   05169 Epstein-Barr virus infection
    101145420 (MAP2K3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101145420 (MAP2K3)
   05135 Yersinia infection
    101145420 (MAP2K3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101145420 (MAP2K3)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    101145420 (MAP2K3)
   05022 Pathways of neurodegeneration - multiple diseases
    101145420 (MAP2K3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101145420 (MAP2K3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    101145420 (MAP2K3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:ggo01001]
    101145420 (MAP2K3)
Enzymes [BR:ggo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     101145420 (MAP2K3)
Protein kinases [BR:ggo01001]
 Serine/threonine kinases: STE group
  STE7 family
   101145420 (MAP2K3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1 Haspin_kinase Pkinase_fungal Seadorna_VP7 Choline_kinase APH RIO1 DUF4344
Other DBs
NCBI-GeneID: 101145420
NCBI-ProteinID: XP_004042142
Ensembl: ENSGGOG00000000670
UniProt: G3QEG5
LinkDB
Position
4:complement(join(79205235..79205318,79205928..79205973,79207194..79207333,79214337..79214414,79214913..79215040,79216232..79216283,79217216..79217332,79218476..79218595,79218811..79218924,79220515..79220563,79220962..79221028,79234496..79234544))
AA seq 347 aa
MESPASSQPASMPQSKGKSKRKKDLRISCMSKPPAPNPTPPRNLDSRTFITIGDRNFEVE
ADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDC
FYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDKNMTIPEDILGEIAVSIVRALEHL
HSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPEL
NQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADRFSPEFVD
FTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
NT seq 1044 nt   +upstreamnt  +downstreamnt
atggagtcgcccgcctcgagccagcccgccagcatgccccagtccaaaggaaaatccaag
aggaagaaggatctacggatatcctgcatgtccaagccacccgcacccaaccccacaccc
ccccggaacctggactcccggaccttcatcaccattggagacagaaactttgaggtggag
gctgatgacttggtgaccatctcagaactgggccgtggagcctatggggtggtagagaag
gtgcggcacgcccagagcggcaccatcatggccgtgaagcggatccgggccaccgtgaac
tcacaggagcagaagcggctgctcatggacctggacatcaacatgcgcacggtcgactgc
ttctacactgtcaccttctacggggcactatttagagagggagacgtctggatctgcatg
gagctcatggacacatccttggacaagttctaccggaaggtgctggataaaaacatgaca
attccagaggacatccttggggagattgctgtgtctatcgtgcgggccctggagcatctg
cacagcaagctgtcggtgatccacagagatgtgaagccctccaatgtccttatcaacaag
gagggccatgtgaagatgtgtgactttggcatcagtggctacttggtggactctgtggcc
aagacgatggatgccggctgcaagccctacatggcccctgagaggatcaacccagagctg
aaccagaagggctacaatgtcaagtccgatgtctggagcctgggcatcaccatgattgag
atggccatcctgcggttcccttacgagtcctgggggaccccgttccagcagctgaagcag
gtggtggaggagccgtccccccagctcccagccgaccgtttctcccccgagtttgtggac
ttcactgctcagtgcctgaggaagaaccccgcagagcgtatgagctacctggagctgatg
gagcaccccttcttcaccttgcacaaaaccaagaagacggacattgctgccttcgtgaag
gagatcctgggagaagactcatag

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