KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101147879
Entry
101147879         CDS       T02442                                 
Symbol
SIRT1
Name
(RefSeq) NAD-dependent protein deacetylase sirtuin-1 isoform X3
  KO
K11411  NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
ggo00760  Nicotinate and nicotinamide metabolism
ggo01100  Metabolic pathways
ggo04068  FoxO signaling pathway
ggo04148  Efferocytosis
ggo04152  AMPK signaling pathway
ggo04211  Longevity regulating pathway
ggo04213  Longevity regulating pathway - multiple species
ggo04218  Cellular senescence
ggo04310  Wnt signaling pathway
ggo04922  Glucagon signaling pathway
ggo04936  Alcoholic liver disease
ggo05031  Amphetamine addiction
ggo05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ggo00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    101147879 (SIRT1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    101147879 (SIRT1)
   04068 FoxO signaling pathway
    101147879 (SIRT1)
   04152 AMPK signaling pathway
    101147879 (SIRT1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    101147879 (SIRT1)
  09143 Cell growth and death
   04218 Cellular senescence
    101147879 (SIRT1)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    101147879 (SIRT1)
  09149 Aging
   04211 Longevity regulating pathway
    101147879 (SIRT1)
   04213 Longevity regulating pathway - multiple species
    101147879 (SIRT1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    101147879 (SIRT1)
  09165 Substance dependence
   05031 Amphetamine addiction
    101147879 (SIRT1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    101147879 (SIRT1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:ggo03036]
    101147879 (SIRT1)
   03029 Mitochondrial biogenesis [BR:ggo03029]
    101147879 (SIRT1)
Enzymes [BR:ggo01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.286  protein acetyllysine N-acetyltransferase
     101147879 (SIRT1)
Chromosome and associated proteins [BR:ggo03036]
 Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    SIRTs (sirtuins, class III HDACs)
     101147879 (SIRT1)
Mitochondrial biogenesis [BR:ggo03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    101147879 (SIRT1)
SSDB
Motif
Pfam: SIR2
Other DBs
NCBI-GeneID: 101147879
NCBI-ProteinID: XP_018890590
Ensembl: ENSGGOG00000010187
UniProt: G3SBE0
LinkDB
Position
8:complement(join(47831097..47831425,47834658..47835215,47838282..47838468,47839606..47839685,47840779..47840926,47841431..47841463))
AA seq 444 aa
MCLCSGRKTILEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCH
GSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFH
RAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCD
VIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPER
TSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDLKNV
GSSTGEKNERTSVAGTVRKCWPNRVAKEQISKRLDGNQYLFLPPNRYIFHGAEVYSDSED
DVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTDGDD
QEAINEAISVKQEVTDMNYPSNKS
NT seq 1335 nt   +upstreamnt  +downstreamnt
atgtgcctgtgcagtggaaggaaaacaattttggaaatatatcctggacaattccagcca
tctctctgtcacaaattcatagccttgtcagataaggaaggaaaactacttcgcaactat
acccagaacatagacacgctggaacaggttgcgggaatccaaaggataattcagtgtcat
ggttcctttgcaacagcatcttgcctgatttgtaaatacaaagttgactgtgaagctgta
cgaggagatatttttaatcaggtagttcctcgatgtcctaggtgcccagctgatgaaccg
cttgctatcatgaaaccagagattgtgttttttggtgaaaatttaccagaacagtttcat
agagccatgaagtatgacaaagatgaagttgacctcctcattgttattgggtcttccctc
aaagtaagaccagtagcactaattccaagttccataccccatgaagtgcctcagatatta
attaatagagaacctttgcctcatctgcattttgatgtagagcttcttggagactgtgat
gtcataattaatgaattgtgtcataggttaggtggtgaatatgccaaactttgctgtaac
cctgtaaagctttcagaaattactgaaaaacctccacgaacacaaaaagaattggcttat
ttgtcagagttgccgcccacacctcttcatgtttcagaagactcaagttcaccagaaaga
acttcaccaccagattcttcagtgattgtcacacttttagaccaagcagctaagagtaat
gatgatttagatgtgtctgaatcaaaaggttgtatggaagaaaaaccacaggaagtacaa
acttctaggaatgttgaaagtattgctgaacagatggaaaatccggatttgaagaatgtt
ggttctagtactggggagaaaaatgaaagaacttcagtggctggaacagtgagaaaatgc
tggcctaatagagtggcaaaggagcagattagtaagcggcttgatggtaatcagtatctg
tttttgccaccaaatcgttacattttccatggcgctgaggtatattcagactctgaagat
gacgtcttatcctctagttcttgtggcagtaacagtgatagtgggacatgccagagtcca
agtttagaagaacccatggaggatgaaagtgaaattgaagaattctacaatggcttagaa
gatgagcctgatgttccagagagagctggaggagctggatttgggactgatggagatgat
caagaggcaattaatgaagctatatctgtgaaacaggaagtaacagacatgaactatcca
tcaaacaaatcatag

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