Globicephala melas (long-finned pilot whale): 115846710
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Entry
115846710 CDS
T11080
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X8
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
gmf Globicephala melas (long-finned pilot whale)
Pathway
gmf00310
Lysine degradation
gmf01100
Metabolic pathways
gmf05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
gmf00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
115846710 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
115846710 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
gmf03036
]
115846710 (DOT1L)
Enzymes [BR:
gmf01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
115846710 (DOT1L)
Chromosome and associated proteins [BR:
gmf03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
115846710 (DOT1L)
HMT complexes
Dot1-containing complex
115846710 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
115846710
NCBI-ProteinID:
XP_030701640
LinkDB
All DBs
Position
3:complement(169795357..169850224)
Genome browser
AA seq
1719 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVP
ESKTAMPADTPMDSGAEEEKAGATTVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSTA
NPERKPKKTQSALDLLHAQTVSRAASPSPQGAPYQLPPSTQRRPPEQLLLAPAPPALHRL
LESFKIQYLQFLAYTKTPQYKANLQQLLDQEKEKNARLLGAVQQLFGHCQAQKEEIKRLF
QQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLEKGNRELRSQSLRLLKARCEEL
KLDWSTLSLEGLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDD
ALSLHLRGKGGLGREPEAEPGRPHLELDCARFSLPHLSNMSPELSMNGHAAGYELCGALS
RPSPKQNTPQYLASPLDQEVVPCTPNHSGRPRLEKLSGLALPDYTRLSPAKLVLRRHLSQ
DHTANSRATASELHSRAEHAKENGLPYQSPGIANGIKLSPQDPRPSSPAALQMTGEKGSE
KGLKERTYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKVRSTPSPVPQA
RESSSTLEKQMGAGTHGSGCNAAGSRSLALAPAGFAYAGSVAISGALAGSPAPLVSGAEP
PALDESSSSGSLFATVGSRSSTPQHPPLLAQPRNCGSASPAPQLCASPRLGAQGPLPDTS
KGDLPSEAGFSDPESEAKRRIVFTISAGSSSAKQSPSSKHSPLSSGARGDGGQSHGQDSR
KRGRRKRAAAGTPGFSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAIS
SPESSLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSEDEPSSARIERKI
ATISLESKSPPKTLENGGGLAGRKVPASEPVNSSKWKSTFSPISDLGLAKAADSPLQATS
ALSHNSLFAFRPGLEEPGAGDAKLAAHPRKSFPGALPGAGGLSPSSHPASSFALGGGLAA
DLSLHSFSDGASLSHKAPEAAGLGTPLSFPGPRGKEGGAADPGPFVNKRQLDGLAPKGEG
GPPVCGPADKASATHGKAGKGRDREPDVKNGHNLFMAAAAAAAAAAATPPGGLLSGPGLA
PAASSAGGTAPSAQTHRPFLGAFAPGPQFALGPMSLQANLGPSVLQSLFSSVPAAGLVHV
STAATRLTNSHAMGSFSSGVAGGAVGGAFNHAVPPASAHPFGASFGSGAACRSATLSLTP
LQAVASTPASSFQAPPPAEPRPPPPPPHLGRPPPGPPALHAPPPPNAALPPPPALLPANS
EPVLLQNLASLPANQAFLPASSAASVPPANASLSIKLASLPHKVSRPSFTVHHPPLPGLA
LAQAAPVIPQASSTGPPAVWVSLGMPPPYAARLAGVKPR
NT seq
5160 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggctgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcatgaaatcatcgagacc
atccggtgggtctgtgaagaaatcccagatctcaagctcgctatggagaattatgtttta
atcgactacgacaccaaaagcttcgaaagcatgcagaggctctgtgacaagtacaaccgg
gccatcgacagcatccaccagctgtggaagggcaccacgcagcccatgaagctgaacacg
cggccgtccacggggctcctgcgccacatcctgcagcaggtctacaaccactcggtgacc
gaccccgagaaactcaacaactatgagcccttctccccggaggtgtacggggagacttcc
ttcgacctggtcgcccagatgatcgacgagatcaagatgaccgaagacgacctgtttgtg
gacctgggtagcggagtgggccaggttgtgctgcaggtcgctgcggctaccaactgcaaa
catcactatggtgtcgagaaagctgacatcccggccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggagaga
ggagatttcctctcggaggagtggagagagcggatcgccaacacgagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggttcgcaaacatg
aaggaaggtggcagaatcgtgtcctcgaagccctttgcacctctgaacttcagaataaac
agtagaaacttgagtgacatcggcaccatcatgcgcgtcgtggagctgtcgcctctaaaa
ggctcggtgtcgtggacggggaagccggtgtcttactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaatccaaaactcagggaggaacaagaggca
gctcggcgccggcagcagcgggagaacaagagcaacacgaccacccccaccaaggtgccc
gagagcaagacggccatgcccgccgacacccccatggactctggtgctgaggaagagaaa
gccggggcgaccactgtcaagaagccatctccctccaaggcccggaagaagaagctgaac
aagaagggccggaagatggccggccggaagcgcggacgtcccaagaagatgagcaccgcc
aaccccgagcgcaagcccaagaagacccagagcgcactggacctgctgcacgcccagact
gtgtcgcgggcggcgtcaccctcgccgcagggcgccccctaccagctacctcccagcacg
cagcgacgcccccctgagcagctgctgctggcgcccgccccgcctgccctacaccggctg
ctagaatccttcaagattcagtacctgcagttcctggcgtacacaaagacccctcagtac
aaggccaacctgcagcagctgctggaccaggagaaggagaagaacgcccggttgctgggc
gccgtgcagcagctgttcggccactgccaagctcagaaggaggagatcaagaggcttttc
cagcagaaactggatgagctgggagtgaaggcgctgacctacaacgacctgatccaagcg
cagaaggagatctcagctcacaaccagcagctgagggagcagacggagcagctggagaag
ggcaaccgggagctgaggagccagagcctgcggctgctcaaggcacggtgcgaggagctg
aagctggactggtccacgctgtcccttgagggcctgctgaaggagaagcaggccctgaag
agccagatctcggagaagcagaggcactgcctggagctgcagatcagcattgtggagctg
gagaagagccagcggcagcaggagctcctgcagctgaagtcctgcgtgccgcccgacgac
gccctgtccctgcacctgcgcgggaagggtggcctgggccgagagccggaggccgagccc
ggccggccacacctggagctggactgtgccaggttctccctgccccacttgagcaacatg
agcccggagctgtccatgaacggccacgcggccggctatgagctctgcggcgcgctgagc
cggccctcgcccaagcagaacaccccccagtacctggcctcccccctggaccaggaggtc
gtgccctgcaccccgaaccacagtggccggccgaggctcgagaagttgtccggcctggcc
ctgcccgactacaccaggctctccccggccaagctggtgctgcggcgccacctgagccag
gaccacacagccaacagcagggcgaccgccagcgagctgcactcacgagctgagcatgcc
aaggagaacggcctcccgtaccagagccccggcatcgccaacggcatcaaactgagccca
caggaccctcggccctcgtcccctgcggccttgcagatgacgggagagaagggcagtgag
aagggtttgaaggagcgcacctacgccagcagtggggaggccatcaccagcctgcccgtc
agcatcccgctcagcaccgtgcagcctagcaagctgccagtcagcatccctctggccagc
gtggtgctgcccagccgcgccgagaaggtgagaagcacccccagccccgtgccgcaggcc
cgagagtcctcgtccacactggagaagcagatgggtgctggcacccacggctccgggtgc
aacgctgctgggagcagaagcctcgccctggcccccgcaggctttgcctacgccggctca
gtggccatcagtggggccctggcaggcagcccggcaccactcgtctctggagccgagccc
cccgccctggacgagtcctccagctccggaagcctctttgccactgtggggtcccgcagc
tccacccctcagcacccccccctgctggcgcagccccgcaactgcggctcggcctcgccc
gccccccagctctgcgccagtccccggctcggcgcccagggcccgctccccgacaccagc
aaaggagacctgccctctgaggccggcttctcggatcccgagagtgaagccaagagaagg
atcgtcttcaccatctcggccggctctagcagcgccaagcagtcaccttccagcaagcac
agccctctgtcctcgggcgcccgcggtgacggcggccagagccacgggcaggacagccgc
aagaggggcaggaggaagcgggcagcggcagggacccccggcttcagctcgggcgtgtcc
cccaagcgccgggccctgccgtccgtcgccggcctcttcacccagtcttcagggtccccc
ctgaacctcaactccatggtcagcaacatcaaccagcccttggaaatcacggccatctcg
tcccccgagagctccctgaagagctcgcctgtcccttaccaggacaacgaccagccgccc
gtgctcaagaaggagaagcccctgagccagaccaacggggcccactattccccgctgacc
tcggatgaggagcagggctctgaggacgagcccagcagtgccagaattgagagaaaaatt
gcaaccatctccttagaaagcaaatctcctccgaaaaccttggaaaatgggggcggcctg
gcgggaaggaaggtgccagccagcgagccggtcaacagcagcaagtggaagtccaccttc
tcgcccatctccgacctcggcctggccaaggcagccgacagcccgctgcaggccacctcc
gctctgagccacaactccctgttcgctttccggcccggcctggaggaacctggcgcgggt
gatgccaagctggctgcccaccccaggaagagcttcccaggcgcgctgccgggggcgggc
gggctgagccccagcagccatcccgccagcagcttcgccctgggcgggggcctggcggcc
gacctcagtttacacagcttcagcgatggtgcttctctctcccacaaggcccccgaggcg
gccggcctgggcacccccctgagctttcccggcccgcggggcaaggagggcggcgccgca
gaccccggccccttcgtgaacaagagacagctggacggactggccccgaagggcgagggg
ggcccacctgtgtgtgggcccgcggacaaggcctcagcgacgcacggcaaggcgggcaag
ggccgtgaccgcgagcccgacgtcaagaacggccacaacctcttcatggccgctgctgct
gctgccgccgccgccgctgccaccccccccgggggcctcctcagcggcccgggccttgcc
ccggcggcgtcctcggcagggggcacggccccgtccgcccagacccaccgccccttcctg
ggcgccttcgcccctggcccgcagttcgcactgggccccatgtccctgcaggccaacctg
ggtccgtctgtgctgcagtccctgttcagctccgtgcccgccgccggcctggtgcacgtc
tcaaccgccgccaccagactgaccaactcgcacgccatgggcagcttctcctccggggtg
gccggcggtgcagtcggaggtgcctttaaccacgcggtgcctcccgcctccgctcatccg
tttggagccagtttcggcagtggggctgcatgtcgcagcgccacgctgagcctaaccccg
ctgcaggcggtggccagcaccccggcttcttcctttcaggccccgccccctgcggagccg
aggccgcccccgccccctccgcacctgggccggccccctccggggccgcccgccctccac
gccccgccccctcctaacgccgccttgcctccgccccccgcgctgctcccggctaactct
gagcccgtgctcctgcagaacctcgcgtccctcccagctaaccaagctttcttacctgcc
tcctctgctgcctctgtgccgcctgctaacgcctctctgtccatcaagctcgcctcactt
ccgcacaaggtgtcccgcccctccttcacggtgcaccacccgcccctgcccgggctggcc
ctggcccaggccgcgcccgtgatcccgcaggccagctccacggggccgcccgccgtgtgg
gtttcccttggcatgccacctccgtatgccgcgcgccttgcgggggttaagccgcgataa
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