KEGG   Globicephala melas (long-finned pilot whale): 115852632
Entry
115852632         CDS       T11080                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
gmf  Globicephala melas (long-finned pilot whale)
Pathway
gmf01522  Endocrine resistance
gmf04010  MAPK signaling pathway
gmf04015  Rap1 signaling pathway
gmf04068  FoxO signaling pathway
gmf04071  Sphingolipid signaling pathway
gmf04114  Oocyte meiosis
gmf04148  Efferocytosis
gmf04218  Cellular senescence
gmf04261  Adrenergic signaling in cardiomyocytes
gmf04370  VEGF signaling pathway
gmf04380  Osteoclast differentiation
gmf04517  IgSF CAM signaling
gmf04550  Signaling pathways regulating pluripotency of stem cells
gmf04611  Platelet activation
gmf04613  Neutrophil extracellular trap formation
gmf04620  Toll-like receptor signaling pathway
gmf04621  NOD-like receptor signaling pathway
gmf04622  RIG-I-like receptor signaling pathway
gmf04625  C-type lectin receptor signaling pathway
gmf04657  IL-17 signaling pathway
gmf04658  Th1 and Th2 cell differentiation
gmf04659  Th17 cell differentiation
gmf04660  T cell receptor signaling pathway
gmf04664  Fc epsilon RI signaling pathway
gmf04668  TNF signaling pathway
gmf04670  Leukocyte transendothelial migration
gmf04714  Thermogenesis
gmf04722  Neurotrophin signaling pathway
gmf04723  Retrograde endocannabinoid signaling
gmf04728  Dopaminergic synapse
gmf04750  Inflammatory mediator regulation of TRP channels
gmf04912  GnRH signaling pathway
gmf04914  Progesterone-mediated oocyte maturation
gmf04917  Prolactin signaling pathway
gmf04926  Relaxin signaling pathway
gmf04932  Non-alcoholic fatty liver disease
gmf04933  AGE-RAGE signaling pathway in diabetic complications
gmf04935  Growth hormone synthesis, secretion and action
gmf04936  Alcoholic liver disease
gmf05014  Amyotrophic lateral sclerosis
gmf05020  Prion disease
gmf05022  Pathways of neurodegeneration - multiple diseases
gmf05132  Salmonella infection
gmf05133  Pertussis
gmf05135  Yersinia infection
gmf05140  Leishmaniasis
gmf05142  Chagas disease
gmf05145  Toxoplasmosis
gmf05152  Tuberculosis
gmf05161  Hepatitis B
gmf05163  Human cytomegalovirus infection
gmf05167  Kaposi sarcoma-associated herpesvirus infection
gmf05169  Epstein-Barr virus infection
gmf05170  Human immunodeficiency virus 1 infection
gmf05171  Coronavirus disease - COVID-19
gmf05205  Proteoglycans in cancer
gmf05208  Chemical carcinogenesis - reactive oxygen species
gmf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
gmf05415  Diabetic cardiomyopathy
gmf05417  Lipid and atherosclerosis
gmf05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:gmf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    115852632 (MAPK12)
   04015 Rap1 signaling pathway
    115852632 (MAPK12)
   04370 VEGF signaling pathway
    115852632 (MAPK12)
   04668 TNF signaling pathway
    115852632 (MAPK12)
   04068 FoxO signaling pathway
    115852632 (MAPK12)
   04071 Sphingolipid signaling pathway
    115852632 (MAPK12)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    115852632 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    115852632 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    115852632 (MAPK12)
   04218 Cellular senescence
    115852632 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    115852632 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    115852632 (MAPK12)
   04613 Neutrophil extracellular trap formation
    115852632 (MAPK12)
   04620 Toll-like receptor signaling pathway
    115852632 (MAPK12)
   04621 NOD-like receptor signaling pathway
    115852632 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    115852632 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    115852632 (MAPK12)
   04660 T cell receptor signaling pathway
    115852632 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    115852632 (MAPK12)
   04659 Th17 cell differentiation
    115852632 (MAPK12)
   04657 IL-17 signaling pathway
    115852632 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    115852632 (MAPK12)
   04670 Leukocyte transendothelial migration
    115852632 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    115852632 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    115852632 (MAPK12)
   04917 Prolactin signaling pathway
    115852632 (MAPK12)
   04926 Relaxin signaling pathway
    115852632 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    115852632 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    115852632 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    115852632 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    115852632 (MAPK12)
   04722 Neurotrophin signaling pathway
    115852632 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    115852632 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    115852632 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    115852632 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    115852632 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    115852632 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    115852632 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    115852632 (MAPK12)
   05161 Hepatitis B
    115852632 (MAPK12)
   05171 Coronavirus disease - COVID-19
    115852632 (MAPK12)
   05163 Human cytomegalovirus infection
    115852632 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    115852632 (MAPK12)
   05169 Epstein-Barr virus infection
    115852632 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    115852632 (MAPK12)
   05135 Yersinia infection
    115852632 (MAPK12)
   05133 Pertussis
    115852632 (MAPK12)
   05152 Tuberculosis
    115852632 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    115852632 (MAPK12)
   05140 Leishmaniasis
    115852632 (MAPK12)
   05142 Chagas disease
    115852632 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    115852632 (MAPK12)
   05020 Prion disease
    115852632 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    115852632 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    115852632 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    115852632 (MAPK12)
   05415 Diabetic cardiomyopathy
    115852632 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    115852632 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    115852632 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    115852632 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    115852632 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:gmf01001]
    115852632 (MAPK12)
Enzymes [BR:gmf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     115852632 (MAPK12)
Protein kinases [BR:gmf01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   115852632 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Haspin_kinase Kinase-like
Other DBs
NCBI-GeneID: 115852632
NCBI-ProteinID: XP_030711408
LinkDB
Position
10:460391..469042
AA seq 367 aa
MSSAPPARKGFYRQEVTKTAWEVRAVYQDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPNETLDDFTDFYLVMPFMGTDLGKLM
KHEKLSEDRIQFLVYQMLKGLKYIHAAGVIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIMAEMITGETLFKGSDHLDQLKEIMK
VTGTPPAEFVQRLQSAEAQNYMNGLPELKKKDFAAILTNASPLAVNLLEKMLVLDAERRV
TAAKALTHPYFESLHDTEDEPKAQKYDESFDDVDRTLEEWKRVTYREVLSFKPPRQLGAK
VSKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctctgcgccgcccgcccgcaagggcttttaccgccaggaggtgaccaagacggcc
tgggaggtgcgcgccgtgtaccaggacctgcagcccgtaggctcgggcgcctatggcgcc
gtgtgctcggcggtggacagtcgcacgggcgccaaggtggccataaagaagctgtaccgg
cccttccagtccgagctgttcgccaagcgcgcctaccgcgagctgcgcctgctcaagcac
atgcgccatgagaacgtaattgggctgctggatgtgttcacacccaatgagaccctggat
gatttcacggacttttacctggtgatgccgttcatgggcaccgacctggggaagctcatg
aagcacgagaagctgagcgaggaccgaatccagttcctcgtctaccagatgctcaagggg
ctgaagtacatccatgctgctggcgtcatccacagggacctgaagcccggcaacctggcc
gtgaacgaggactgtgagctcaagatcctggactttggcctggcccggcaggcagatagc
gagatgactgggtacgtggtgacccggtggtaccgggcgcctgaggtcatcttgaattgg
atgcactacacacagacggtggacatctggtcagtgggctgcatcatggctgagatgatc
acaggggagacgctcttcaaaggcagcgaccacctggaccagctgaaggagatcatgaag
gtgacggggacgcctcccgccgagttcgtgcagaggctgcagagtgccgaggctcagaac
tacatgaacggcctccccgagctaaagaaaaaggattttgccgccatcctgaccaacgca
agccctctggccgtgaacctcctggagaagatgctggtgctggatgcggagcggcgggtg
acggcggccaaggcgctgacccacccctacttcgagtcgctccacgacacggaggacgag
cccaaagcccaaaagtacgatgaatcctttgatgacgtggaccgcacgctggaagagtgg
aagcgtgtcacatacagagaggtgctcagcttcaagcctccccgacagctgggggccaag
gtctccaaggagacggccctgtga

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