KEGG   Globicephala melas (long-finned pilot whale): 115856081
Entry
115856081         CDS       T11080                                 
Symbol
NF1
Name
(RefSeq) neurofibromin isoform X2
  KO
K08052  neurofibromin 1
Organism
gmf  Globicephala melas (long-finned pilot whale)
Pathway
gmf01521  EGFR tyrosine kinase inhibitor resistance
gmf04010  MAPK signaling pathway
gmf04014  Ras signaling pathway
Brite
KEGG Orthology (KO) [BR:gmf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    115856081 (NF1)
   04014 Ras signaling pathway
    115856081 (NF1)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    115856081 (NF1)
SSDB
Motif
Pfam: PH_NF1 RasGAP CRAL_TRIO_2 CRAL_TRIO MIF4G_like_2
Other DBs
NCBI-GeneID: 115856081
NCBI-ProteinID: XP_030717947
LinkDB
Position
20:complement(3543296..3793711)
AA seq 2841 aa
MAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINISKYKFSLVISGLTT
ILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHF
LHTCREGNQHAAELRNSASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELL
QYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENYPDEFTKLYQIPQT
DMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKKLFL
DSLRKALAGHGGSRQLTESAAIACVKLCKASTYINWEDNSVIFLLVQSMVVDLKNLLFNP
SKPFSRGSQPADVDLMIDCLVSCFRISPHNNQHFKICLAQNSPSTFHYVLVNSLHRIITN
SALDWWPKIDAVYCHSVELRNMFGETLHKAVQGCGAHPAIRMAPSLTFKEKVTSLKFKEK
PTDLETRSYKYLLLSMVKLIHADPKLLLCNPRKQGPETQGSTAELITGLVQLVPQSHMPE
IAQEAMEALLVLHQLDSIDLWNPDAPVETFWEISSQMLFYICKKLTSHQMLSSTEILKWL
REILICRNKFLLKNKQADRSSCHFLFLYGVGCDVPSSGNTSQVSIDHEELLRTCTPGTSL
RKGKGNSSMDSAAGYSGTPPICRQAQTKLEVALYMFLWSPDTEAVLVAMSCFRHLCEEAD
IRCGVDEVSVHNFLPNYNTFMEFASVSNMMSTGRAALQKRVMALLRRIEHPTAGNTEAWE
DTHAKWEQATKLILNYPKAKMEDGQAAESLHKTIVKRRMSHVSGGGSIDLSDTDSLQEWI
NMTGFLCALGGVCLQQRSNSGLATYSPPMGPVSERKGSMISVMSSEGNADTPVSKFMDRL
LSLMVCNHEKVGLQIRTNVKDLVGLELSPALYPMLFNKLKNTISKFFDSQGQVLLTDTNT
QFVEQTIAIMKNLLDNHTEGSSEHLGQASIETMMLNLVRYVRVLGNMVHAIQIKTKLCQL
VEVMMARRDDLSFCQEMKFRNKMVEYLTDWVMGTSNQAADDDVKCLTRDLDQASMEAVVS
LLAGLPLQPEEGDGVELMEAKSQLFLKYFTLFMNLLNDCSEVEDENAQTGGRKRGMSRRL
ASLRHCTVLAMSNLLNANVDSGLMHSIGLGYHKDLQTRATFMEVLTKILQQGTEFDTLAE
TVLADRFERLVELVTMMGDQGELPIAMALANVVPCSQWDELARVLVTLFDSRHLLYQLLW
NMFSKEVELADSMQTLFRGNSLASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVS
FEVDPTRLEQSESLEENQRNLLQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLN
KATVKEKKENKKSVVSQRFPQNSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERG
LKLMSKVLQSIANHVLFTKEEHMRPFNDFVKSNFDAARRFFLDIASDCPTSDAVNHSLSF
ISDGNVLALHRLLWNNQEKIGQYLSSNRDHKAVGRRPFDKMATLLAYLGPPEHKPVADTH
WSSLNLTSSKFEEFMTRHQVHEKEEFKALKTLSIFYQAGTSKAGNPIFYYVARRFKTGQI
NGDLLIYHVLLTLKPYYAKPYEIVVDLTHTGPSNRFKTDFLSKWFVVFPGFAYDNVSAVY
IYNCNSWVREYTKYHERLLTGLKGSKRLIFIDCPGKLAEHIEHEQQKLPAATLALEEDLK
VFHNALKLAHKDTKVSIKVGSTAVQVTSAERTKVLGQSVFLNDIYYASEIEEICLVDENQ
FTLTIANQGTPLTFMHQECEAIVQSIIHIRTRWELSQPDSIPQHTKIRPKDVPGTLLNIA
LLNLGSSDPSLRSAAYNLLCALTCTFNLKIEGQLLETSGLCIPANNTLFIVSISKTLAAN
EPHLTLEFLEECISGFSKSSIELKHLCLEYMTPWLSNLVRFCKHNDDAKRQRVTAILDKL
ITMTINEKQMYPSIQAKIWGSLGQITDLLDVVLDSFIKTSATGGLGSIKAEVMADTAVAL
ASGNVKLVSSKVIGRMCKIIDKTCLSPTPTLEQHLMWDDIAILARYMLMLSFNNSLDVAA
HLPYLFHVVTFLVATGPLSLRASTHGLVINIIHSLCTCSQLHFSEETKQVLRLSLTEFSL
PKFYLLFGISKVKSAAVIAFRSSYRDRSFSPGSYERETFALTSLETVTEALLEIMEACMR
DIPTCKWLDQWTELAQRFAFQYNPSLQPRALVVFGCISKRVSHGQIKQIIRILSKALESC
LKGPDTYNSQVLIEATVIALTKLQPLLNKDSPLHKALFWVAVAVLQLDEVNLYSAGTALL
EQNLHTLDSLRIFNDKSPEEVFMAIRNPLEWHCKQMDHFVGLNFNSNFNFALVGHLLKGY
RHPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHR
KSLLLTDISMENIPMDTYPIHHGDPSYRTLKENQPWSSPKGSEGYLAASYPPAGQTSPRA
RKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYE
METQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRI
LYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQY
QTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTP
TSPYPPAVQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSA
SQVQKQRSAGSFKRNSIKKIV
NT seq 8526 nt   +upstreamnt  +downstreamnt
atggccgcgcacaggccggtggaatgggtccaggccgtggtcagccgcttcgacgagcag
cttccaataaaaacaggacagcagaacacacataccaaagtcagtaccgaacacaacaag
gaatgtcttatcaatatttccaaatacaagttttctttggttataagcggcctcaccact
atcttaaagaatgttaacaatatgagaatatttggagaagctgctgaaaaaaatttatat
ctctctcagttgattatattggatacactggaaaaatgtcttgctgggcaaccaaaggac
acgatgaggttagatgaaacgatgctggtcaaacagttgctgccagaaatctgccatttt
cttcacacttgtcgtgagggaaaccaacatgcagctgaacttcggaattctgcctctggg
gttttattttctctcagctgtaacaacttcaatgcagtctttagtcgaatttctaccagg
ttacaggaattgactgtttgttcagaagacaatgttgatgttcatgatatagaattgtta
cagtatatcaatgtggattgtgcaaaattaaaacgactcctgaaggaaacagcatttaaa
tttaaagccctaaagaaagttgcacaattagcggttataaatagcctggaaaaggcattt
tggaactgggtagaaaattatccagatgaatttacaaagttataccagattccacagact
gatatggctgagtgtgcagaaaaactctttgacctagtggatggttttgctgaaagcacc
aaacgtaaagcagcagtttggccactacaaatcattctccttatcttgtgtccagaaata
atccaggatatatccaaggatgtggttgatgaaaacaacatgaataagaagttgtttctg
gacagtctacgaaaagcacttgccggccacggaggaagcaggcagctgactgaaagcgct
gcaattgcctgtgtcaaactgtgtaaagcaagtacttacatcaattgggaagataactct
gtcatcttcttactagttcagtccatggtggttgatcttaagaacctgctttttaatcca
agtaaaccattctcaagaggcagtcagcctgcagatgtggatctaatgattgactgcctt
gtttcttgctttcgtataagccctcacaacaaccaacactttaagatctgtctggctcag
aattccccttctacatttcactatgtgctggtaaattcactccatcgaatcatcaccaat
tctgcattggattggtggcctaagattgatgccgtatattgtcactcagttgaacttcga
aatatgtttggtgaaacacttcataaagcagtccagggttgtggagcgcacccagcgata
cgaatggcaccgagtcttacatttaaagaaaaagtaacaagccttaaatttaaagaaaaa
cctacagacctggagacaagaagctataagtatctcctcttgtccatggtgaaactaatt
catgcagatccaaagctcttgctttgtaatccgagaaaacaggggcctgaaactcaaggc
agtaccgcagaattaattacagggctcgtccaactggtacctcagtcacacatgccagag
attgctcaggaagcaatggaggctctgttggttcttcatcagttagatagcattgatttg
tggaatcctgatgctcctgtagaaacattttgggaaatcagctcacaaatgcttttttac
atctgcaagaaattaactagccatcaaatgcttagtagcacagaaattctcaaatggttg
cgggaaattttgatctgcaggaataaatttcttcttaaaaataagcaggcagatagaagt
tcctgtcactttctcttcctttatggagtaggatgtgatgttccttcaagtggaaatacc
agtcaggtgtccatagatcatgaagaattactacgtacttgtactcctgggacgtctctc
cgaaagggaaaaggaaattcatccatggatagtgcagcagggtacagcggaaccccgcca
atatgccgacaagcccagaccaaactagaagtggccctgtacatgtttctgtggagccct
gacactgaagctgttctggttgccatgtcctgttttcgtcacctctgtgaggaagcggat
atccggtgtggggtggatgaagtgtcagtgcacaacttcttgcccaactataacacgttc
atggagtttgcctctgtcagcaatatgatgtcaacaggaagagcagcacttcagaaaaga
gtgatggcattactacggcgaattgagcatcccaccgcaggaaacactgaggcttgggaa
gatacacatgcaaagtgggaacaagctacaaaactaatcctcaactacccaaaagccaaa
atggaagatggccaggctgctgaaagccttcacaagaccatcgttaagaggcgaatgtct
catgtgagtggaggaggatccatagatttgtctgacacagactccctacaagaatggatc
aacatgactggcttcctttgtgcccttgggggagtatgcctgcagcagagaagcaattct
ggcctggcaacctatagcccacccatgggcccagtcagtgaacgcaagggttccatgatt
tcagtgatgtcctcagagggaaacgcagatacacctgtcagcaaatttatggatcgattg
ctatccttaatggtctgtaaccatgagaaagtgggacttcagatacggaccaatgttaag
gatctggtgggtctagaattgagtcctgctctttatccaatgctctttaacaaactgaag
aataccatcagcaagttttttgactcccaagggcaggttttattgactgacaccaatact
cagttcgtggagcaaaccatagctataatgaagaacttactagataatcatactgaaggc
agctctgaacatctggggcaagctagcattgaaacaatgatgttaaatctggtcagatat
gttcgtgtgcttgggaatatggtccatgcaattcaaataaaaacgaaactgtgtcagtta
gtggaggtaatgatggcaaggagagacgacctctcattttgtcaagagatgaaatttagg
aataagatggtagaatacctgacagattgggttatgggaacatcaaaccaagcagcagat
gatgatgtcaaatgtcttacaagagatttggaccaggcaagcatggaagcagtagtttca
ctcctggctggtcttccgctgcagcctgaggaaggagatggtgtggaattgatggaagcc
aaatcacagttatttcttaagtatttcacattgtttatgaaccttttgaacgactgtagt
gaagttgaagatgaaaatgcacaaacaggtggcaggaaacgtggcatgtctcggaggctg
gcatcactgaggcactgtacagtcctggcaatgtcaaacttactcaatgctaacgtggac
agtggcctcatgcactccatcggtttaggttatcacaaagatcttcagacaagagctaca
tttatggaagttctgacaaaaatccttcaacaaggcacagaatttgacacacttgcagaa
accgtgttggcagatcgttttgagagactggtggagttggtcacaatgatgggtgatcaa
ggagagctcccaatagctatggctctggccaatgtggtcccttgttctcagtgggatgaa
ctagctcgagttctagtgactctatttgactctcggcatttactctaccaactgctctgg
aacatgttttctaaggaagtagaattggcagactccatgcagactcttttccgaggcaac
agcttggccagtaaaataatgaccttctgtttcaaggtatatggtgctacctacctacag
aaactcctggatcctttattacggattgtgatcacatcctctgattggcagcatgttagc
tttgaagtagatcctaccaggttagaacagtcagagagccttgaggaaaaccagcgaaac
ctccttcagatgaccgaaaagttcttccatgccatcatcagttcctcctccgaatttccc
cctcagctacgaagtgtgtgccactgtttgtaccaggcaacttgccactccctactgaat
aaagctacagtaaaagaaaaaaaggaaaacaaaaaatcagtggttagccagcgtttccct
cagaacagcatcggtgcagtgggaagtgccatgtttctcagatttatcaatcctgccatt
gtctcaccatatgaagcagggattctagataaaaagccgccacctagaatcgaaagaggc
ttgaagttaatgtcaaaggtacttcagagtattgccaatcatgttcttttcacaaaagaa
gagcacatgcggccttttaatgattttgtgaaaagcaactttgatgcagcacgaaggttt
ttccttgatatagcatccgattgtcctacaagtgatgcagtaaatcacagtctttccttc
atcagtgatggcaatgtgcttgctttacatcgtctactctggaacaatcaagagaaaatt
ggccagtatctttccagcaacagggatcacaaagctgttggaagacgaccttttgataag
atggcaacacttcttgcatacctgggtcctccagagcacaaacctgtggcagatacacac
tggtccagccttaaccttaccagttcaaagtttgaggaatttatgactaggcatcaagta
catgaaaaagaagagttcaaagctttgaaaactttgagtattttctaccaagctgggact
tccaaagctgggaatcctatattttattatgttgcacggaggttcaaaactggtcaaatc
aatggcgatttgctgatataccacgtcttacttactttaaagccatattatgcaaagcca
tatgaaattgtagtggaccttacccatactgggcctagcaatcgctttaaaacagacttt
ctctccaagtggtttgttgtttttcctggctttgcttatgataatgtctctgcagtctat
atctataactgtaactcctgggtcagggaatacaccaagtatcacgagcggctgctgact
ggcctcaaaggcagcaaaagactcattttcatagactgtcctgggaaactggccgagcac
attgagcatgaacaacagaaactacctgctgccaccttggctttagaagaggacctgaag
gtattccacaatgctctcaagctagctcacaaagacaccaaggtttctattaaagttggt
tctactgctgttcaagtaacctcagcagagcgaacaaaagtcctggggcagtcagtcttt
ctaaatgatatctattatgcttcggaaattgaagagatctgcctagtggatgagaaccag
ttcaccttaactattgcaaaccagggcacaccactgaccttcatgcaccaagagtgtgaa
gccattgttcagtctatcattcacatccggacacgttgggagctgtcgcagcccgactcc
atcccccagcacaccaagattcgcccaaaagatgtccctgggacactgctcaatatcgcg
ttacttaatttaggcagttcagaccctagtttacggtcagctgcctataatcttctgtgt
gccttaacttgtacctttaatttaaaaatcgagggccagttactagagacatcaggttta
tgtatcccagccaacaacaccctatttattgtctctattagcaagacactggcagccaat
gagccacacctcaccttagaatttttggaagagtgtatttctggatttagcaaatctagt
attgaattgaaacacctttgtttggaatacatgactccgtggctgtcaaatctagtacgt
ttttgtaagcacaatgatgatgccaaaagacaaagagttactgcgattcttgataagctg
ataacaatgactataaacgagaaacagatgtatccatctattcaagcaaaaatatggggg
agccttgggcagattacagacctccttgatgttgtcctagacagtttcatcaaaaccagt
gcaacgggtggcttgggatcaataaaagctgaggtgatggcagatactgctgtagctttg
gcttctggaaatgtgaaattggtttcaagcaaggttattggaaggatgtgcaaaataatt
gacaagacatgcttatctccaactcctactttagagcaacatcttatgtgggacgatatt
gctattctagcccgctacatgctgatgctgtccttcaacaattccctggatgtggcagct
catctcccctacctcttccacgtcgttactttcttagtagccacagggccactctccctt
agagcttccacacatggattggtcattaatatcattcactctctgtgtacttgttctcag
cttcattttagtgaagagaccaagcaagttttgagactcagtttgacagagttctcatta
cccaaattttacctgctgtttggcattagcaaagtcaagtcagctgctgtcattgccttc
cgctccagctaccgggacaggtcattctctcctggctcctatgagagggagacttttgct
ttgacatccttggaaacagtcacagaagctttgttggagatcatggaggcatgtatgaga
gatattccaacatgcaagtggctggaccagtggacagaactagctcaaagatttgcgttc
cagtataatccatccctgcaaccaagagcccttgttgtcttcggctgtatcagcaaacgg
gtgtctcatggacagataaagcagattatccgcatcctcagcaaggcgcttgagagttgc
ttaaaaggacctgatacttacaacagtcaagttctgatagaagctacagtaatagcacta
accaagttacaaccacttcttaataaggactcccctctgcataaagccctcttttgggta
gctgtggccgtgctgcagctcgatgaagtcaacttgtattcagcaggcaccgcacttctg
gaacaaaacctgcacaccttagacagtctccggatattcaatgacaagagtccagaggaa
gtattcatggcgatccggaatcctctggaatggcactgcaaacaaatggatcattttgtt
ggactcaatttcaactctaactttaacttcgcactggttggacacctcttaaaaggatac
aggcatccttcacctgccattgttgcaagaacagtcagaattttgcatacactactaact
ctggttaataaacatagaaattgtgacaaatttgaggtgaatacacagagcgtggcttac
ttggcagctttacttacagtgtctgaggaggttcgaagtcgctgtagcctaaaacataga
aagtctcttcttcttactgatatttcaatggaaaatattcctatggatacatatcccatt
catcacggtgaccctagctataggacactaaaggagaatcagccatggtcctctcccaaa
ggttctgaagggtacctcgcagccagctatccacctgcgggccagaccagtccccgagcc
aggaaatccatgagtttggacatggggcagccttctcaggccaacacgaagaagttgctt
ggaacaaggaaaagttttgatcacttgatatcagacacaaaggctcctaaaaggcaagaa
atggaatcagggatcacaacaccccccaaaatgaggagagtagcagaaactgattatgaa
atggaaactcaaaggatttcctcatcacaacagcacccacatttacgtaaagtttcagtg
tctgaatcaaatgttctcttagatgaggaagtacttactgatccgaagatccaagcactt
cttcttactgttctggctacgctggtgaaatacaccacagatgagtttgatcaacgaatt
ctttatgaatacttagcagaagctagtgttgttttccccaaagtttttcctgttgtgcac
aatttgttggactctaagatcaacaccctgttgtcattgtgccaagatccaaatttgtta
aatccaatccatgggattgtgcaaagtgtggtgtaccatgaagaatccccaccacagtac
caaacatcttacctgcaaagttttggttttaatggcctatggcggtttgcaggacccttt
tcaaagcaaacacaaatcccagactatgctgagcttattgttaagtttcttgatgccttg
attgacacgtatttgcctggaattgatgaagaaaccagtgaggagtccctcctgacaccc
acatctccttatcctcctgcagtgcagagccagcttagtattactgctaaccttaacctt
tctaattccatgacctcacttgcaacttcccagcattccccaggaatcgacaaggagaat
gttgaactctcccctaccactgggcactgtaacagtgggcgaactcgtcatggatccgca
agccaggtgcagaagcaaagaagcgctggcagtttcaaacgtaatagcattaagaagatc
gtgtga

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