Gadus morhua (Atlantic cod): 115531306 Help Entry 115531306         CDS       T10832                                  Symbol ryr2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism gmh  Gadus morhua (Atlantic cod) Pathway gmh04020   Calcium signaling pathway gmh04260   Cardiac muscle contraction gmh04261   Adrenergic signaling in cardiomyocytes gmh04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:gmh00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     115531306 (ryr2)    04020 Calcium signaling pathway     115531306 (ryr2)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     115531306 (ryr2)    04261 Adrenergic signaling in cardiomyocytes     115531306 (ryr2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:gmh04040]     115531306 (ryr2)    04990 Domain-containing proteins not elsewhere classified [BR:gmh04990]     115531306 (ryr2) Ion channels [BR:gmh04040]  Voltage-gated cation channels   Ryanodine receptor    115531306 (ryr2) Domain-containing proteins not elsewhere classified [BR:gmh04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    115531306 (ryr2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 EF-hand_5 Motif Other DBs NCBI-GeneID:  115531306 NCBI-ProteinID:  XP_030196346 Ensembl:  ENSGMOG00000012679 LinkDB All DBs Position 18:complement(21198339..21366929) Genome browser AA seq 4976 aa AA seqDB search MAEGAEAEDEIQFLRTDDEVVLQCSATLHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICAFVLEQSLSVRALQEMLANTEEKAEGHVDVEKWKFMMKTAQGSGHRTLLYGHAVL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSHGYEHLHVDAAFQQTLWSVVPICSGSEVAQGYLIGGDVLRLLHGH MDECLTVASGDHGEEQRRTVNYEGGAVSIHARSLWRLEMLRVVWSGSHTRWGQPFRLRHV TTGKYLSLLDDRSLLLTDKDKADVKSTAFCFKSSKEKLDSGMKKEIDGMGVADIKYGDSV CYVQHMDTSLWLTYQAMDTKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIR STVFLFNRFIRGLDVLSKKGNTSALDLPIESVSLSLRDLIGYFQPPDEHLEHEEKQNRLR HLKNRQNLFQEEGMTSLLLECIDRLHVYSSAAHFAEVAGKEAGEAWRSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNLIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQNLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYRKWYYELIVDQVQPFVTAEATHVRVGWASTDGYAPYPGGGEGWGCNGAGD DLYSYSFDGLHLWSGCIARTVSSPNQHMLTVEDVVSCCLDLNSPSISFRINGQPVQGMFE NFNCDGLFFPVVSFSAGIKVRFLFGGRHGEFKFLPPPGYAPCYEAVLPREKLRVEHSQEY KQDLAGTRDLLGPTLTLSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIQL GWTYGVVRDDNKRQHPCLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGLADEHAIEK VHSLKLSPSYELTSSYKPAPLDLSHVKLASAQEAMVDKLAENAHNVWARDRIGQGWTYGI QQDVKNRRNPRLVPYALLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHARADLDNVS AERFRVFRAEKTYSVSAGKWYFELEIHTAGEIRVGWARPGCLPDQELGSDEQAFAFDGFK AQRWHQGNEHFGRSWQPADVVGCMVDLGERTMMFTLNGEVLLDDSGSELAFKDFEVYEGF IPVCSLGVCQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDITMWLGKRLAQFIPV PHNHEHVEVSRIDGTMESYPCLKVTQKSFGSQNSSTDITFYRLSMPIECAETFSASLGGG APAYVFPPKKECEDFETVADFEVLVKSSHGHMGVPSEKDEFNNHKDHNQEKPSKFKQRLM LKRAKPDNSSSSARLSEEVTVAGDMDDCEFPMQTSTYFFSVRVFPGQEPGSVWVGWVTSD FHQYDPSFELHKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGECTSPGQGRSNNNGLEIG CLVDTASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGHIKNVMPVSA GLFKSEKMNPAPQCPPRLHVQFLTSVLWSRLPNHFPKVSASRVNDRHGWLVQCNEPLQFM ALHIPEENRSMDIQELSEHAELLKFHYHTLRLYSAVCALGNNRVAHALCSHVDEAQLLQA IENKYMPGLLRTGYYDLLMDIHLSSYATARLMMNNEYIVPMTEETKTITLFPDHTKKHAL PGIGLSTSLRPRMHFSSPSFVRRAGSRGGSNAPALSWDCFQHSPEFPLETLKTKTIGMLT EAVREGSMHVRDPVGGSSEFLFVPLIKLFYTLLIMGVFHNGDLKNVLQLIEPNVFSEGAG APEERTPQASAPEVADGADGAGGGGGGGGGGRGLLQMKLPEPVKLQMCRLLQYLCDCQVR HRIEAVVAFSDDFVACLQANQKFRYNEVMQALNMSAALTAKKTKEFRSPPQEQINMLLNF KDEKHECPCPEGIREQLMAFHEDLMIHCGIEIDEDKGNDCDGDCTFRGRLMSLVEKVANL KRKTDELPKKKKDKKPSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQV RALPKTYTINAVSVEDTIKLLAALGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHP NLMRALGMHETVMEVMVNVLSGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLS YLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCAM LVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEG GNGLLAAMEEAIHISANACRDRPSSPASESTKSLSEDEEDDTIHMGNAVMTFYAALIDLL GRCAPEMHLIHAGKGEAVRIRAILRSLIPIQDLEGVISIPFSMPTLATDGSVVEPDMSAG FCPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTAVLSATDMALALNRY LCAAVLPLLTKCAPLFAGTEPYASLIDSLLHTVYRLSKGCCLTKAQRDAIEDCLLAVCGK LRPSMMQHLLRRLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLAVGWGGFGVASDEELH LSRKLFWGIFDALSRKRYDQELFKLALPCLSAVAGALPPDYMESNYVAMIEKQSSMDSEG NFNPQPADTSNVSVPEKLDYFINRYAEHLHEKWSMDKFSEGWLYGEQLCEATKSQPLLKP YKGLSEKDKESYRWPIKESIGTMVSWGWVVERIREGDPSSLQKSRRISQVSQLSFEGAPG FSPRPIDMSNVTLSRDLHSMAELLAENFHNTWAKKKKMEMEAKGGGSHPLLVPYDTLTAK EKSRDREKAQEIFKFLQINGYTVSRCVREQDLDTPAIEKRFAYTFLQQLIEYVDKAHQHM MDADAGTRAKGEECPQEQQTKFFGKVLLPLVDQYFKNHRLYFLSTAIRPISSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKAALRAF FENAAEDLEKTQDNLKLGQFTHERTQPRDVTQVINYTTFALLPVLSSLFEHIGQNLFGQD LILDNVQVSCYRILNSLYSLGTSKSIYVERHRPAIGECLAAFSAAFPVAFLEPYLDMFNG FSIYNSKGAKERGALGLPAPVLEACPLIPSLEKTLEEIMTLAESGIRYTQMPHIMEVVLP MLCSYMSHWWEYGPENNPESTDRCCTSLRWEHMNALLGNILKIIYNNLGIDEGTWMKRLA VFSQPIISKANAQLLKTHFLPLMEKLKKKAAVVLMDEEQTKAEGRGDMSEAELLVLDEFT ILVRDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIFWAKSHNFKREEQNFV VQNEINNMSFLITDTKSKMSKGAISDQERKKLKRKGDRYTMQTSLIVATLKRMLPVGLNI CAPGDQELIALAKNRFTQKDTEDEVREIIKSNLHLQGKLEDPAIRWQMALYRDLPNRNEE TSDPEKTVERVLDIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLP RHRAVNLFLQGYEKSWIEAEDHYFEDKLIEDLAKSGEDEPAEEEDSLKHIDPLHQLIQLF SRTALTEKCKLDEDNLYMAYADIMAKSCHDEVEEDGDEVKSFEEKEMEKQKLLYQQARLH DRGAAEMVLQTISASKGEMGPMVASTLKLGIAVLNGGNSTVQQKMLDYLRDKKDVGFFQG LAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSAITSERGEKVMQDDEFTCDLFRFLQLL CEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKEVIDEQGQRNF SKAINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIE LLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDL TSSDAFKEYDLDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENELLDYEEFVER FHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLALAESVLDYFQPYLGRIEIMGSAKRIE RVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQM SDAGERSAVKEESEQERPEEAGPETGFFSVATLRTALLALRYNVVIVMKVLSMKSVKKQV KRLKKMTVRDLVTTLASFYWSTLLRVLYVVFSVARGFCRITYKSLMGGSLLNGGSAMKVS ELLGSLPDLSQDEGVRGEGAEPEKKSSDRAFHPEDELADLAINTGETEVLSDIFGLDLRR EGGQYKLTPHDPNASLTHLLISPPPAAIPSPELRQRHQIKSSGLEDSEGTAETSHESKKT GPENEDKDKVKKEAMAKQKIRQNYIFKSEEPDLQESVFWKKIIAYQRKLLNYFARNFYNM RMLALFVAFAINFILLFYKVSTSSAVVEQKELLYPSSQSRVEWATLEEMEGRAAEEGREA PRPVTVHFVLEESSGYMEPTLRILAIMHTVISFFCIIGYYCLKVPLVIFKREKEVARKLE FDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLG MDRAALDFSDSHEKRKPKKDNSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMTMSIL GHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRK FYNKGEDGESPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFF FFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQ EHNLANYLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14931 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggggcagaagccgaggatgagatccaattcctacggacagacgacgaggtg gtgctgcagtgctctgccactctccataaagagcagcagaagctttgtctggctgctgaa ggctttggaaacagactgtgcttcctagagtccacgtccaactccaagaatgtgcctcca gacctgtccatctgcgcctttgttctggagcagtctctgtcggtccgggcgctgcaggag atgctggccaacaccgaggagaaggctgaagggcatgtagatgtggaaaaatggaaattc atgatgaagacagcccagggaagcggacatcgcactttactttacggacatgctgttctc ttacgacactcctacagtgggatgtacttgtgctgtctgtccacctcccgctcgtcaaca gataaactggcctttgatgtgggactgcaagaagacactacaggcgaggcttgctggtgg accatccacccagcctccaaacagcggtcggagggagagaaggtcagagttggtgatgac ctcatcctagtcagcgtctcctcagaacgatacctgcacttgtcccatggttatgaacac ctccacgtggacgcagccttccagcagaccctctggagtgtggtccccatctgctcaggc agtgaggtggcccaaggctacctgatcgggggagacgtgctgcggctgctccatggacac atggacgagtgcttgaccgtggcctccggggaccacggggaggagcagaggagaacggtg aactacgagggcggagcggtgtccatccacgcccggtccctgtggaggctggaaatgctc cgggtggtgtggagcggcagccacacccgctggggccagccgttcagactacgacacgtg accacagggaagtacctgagtctgctggacgaccgctccctcctcctgacggacaaagac aaggcggacgtcaagtccaccgccttctgcttcaagtcatccaaggaaaagttggattcc gggatgaaaaaggaaatagatggaatgggagtggctgatataaagtacggcgactctgtg tgttacgtccagcacatggacaccagtttgtggctcacctaccaggccatggataccaag tgtgcccgcatgggcggagtgcaacggaaggccatcatgcaccacgagggccacatggac gatggcctcactctgtctcggtcacagcatgaggagagtcgtacggcgcgagtcattcgg agtactgtattcttgttcaaccgcttcatcaggggcctggacgtgctctctaaaaaaggg aacacctctgctctcgatctgccaatcgaatcggtcagcctcagtttgcgggatctgata ggctacttccagcccccggacgagcacttggagcacgaggagaagcagaaccggctacga catctgaagaaccggcagaatctgttccaggaggaggggatgaccagcctgctcctggag tgcatcgaccggctccacgtctacagcagcgccgcccattttgccgaggttgcagggaaa gaggcgggggaggcgtggaggtccatccttaactcgttatacgagctccttgctgcactc ataaggggcaaccggaagaattgtgctcagttctctggctctctggattggctgataagc agactggaaagactggaagcttcatctggtatactggaggttctacactgtgtactggtg gaaagtcctgaggccctcaatctcatcaaagagggacacatcaagtccattatttctctg ctggacaaacatggacgcaaccataaggttctagacgtgctgtgctccctgtgtgtgtgt catggcgtggcggtgcgctctaaccagaacctgatctgtgacaaccttctgccgggcaga gacctgctgctgcagaccaggctggtcaaccacgtcagcagcatgcggcccaacatcttc ctgggcgtgagcgagggctcggcgcagtacaggaagtggtactacgagctgatcgtggac caggtgcagcccttcgtcacggcggaggccacccacgtccgcgttggctgggccagcacc gatggctacgccccctacccaggggggggcgagggctggggctgcaacggggcgggggac gacctctactcctacagcttcgacggactccacctgtggtcagggtgtatcgcacggaca gtgagctctcccaaccaacacatgctgacggtggaggatgtggtcagctgttgtctggat ctcaactcgcccagcatttccttcaggatcaacggtcagccggtgcagggcatgttcgag aacttcaactgtgacggactgtttttccctgtcgtcagcttctctgctgggattaaggtg cgtttcctgtttggaggacgtcacggagagtttaagttccttccgccgccgggctacgcc ccgtgctacgaggccgtgctgcccagggagaagctcagggtggaacacagccaggagtac aagcaggatctggctgggacccgagacctcctgggacccactctcacgctctctcaggct gccttcactcccacacctgtggacaccagccagattgtcctaccaccccatctggagagg atcagggagaagctggcagagaacatccatgaactttgggtcatgaacaagatccaactg ggctggacctacggagtggtgcgggatgataacaagcggcagcacccgtgcctagtggag ttctccaagctgcccgagcaggagcgcagctacaacctgcagatgtctctggagacccta aaaaccctcctggccctaggctgtcacgttggcctggccgatgaacacgccatagagaag gtccacagcctgaagctttcccctagctatgagttgaccagcagctataagccggctccc ctggacttgagccacgttaaactggcatctgcccaggaggccatggtggacaaactggca gagaacgcacacaacgtctgggcccgagatcgcataggccaaggctggacttatggcatt caacaggacgtgaagaaccgccgtaaccctcgcctggtgccctacgccctgctggacgag aggaccaagaagtccaacaaggacagcctgagagaggcggttcgcaccctgctgggatac gggtacaacctggaggccccggatcaggaccacgcccgggcggacctcgacaacgtttca gccgagcgctttcgtgtcttccgagcagaaaagacttacagtgtcagcgccggcaaatgg tactttgagcttgagatccacactgcgggtgagatcagggtgggatgggcccggccaggc tgtctgccggaccaggagctcggatcagatgaacaggcctttgcatttgatggctttaag gcgcagcgttggcaccaagggaacgaacactttggccgctcctggcagccggccgacgtg gtgggctgcatggtggacctcggggaacgcaccatgatgttcacccttaacggagaggtt ctgctggatgactctggctcagagctggccttcaaggattttgaagtctacgaagggttc atcccggtatgcagtctgggcgtttgtcaggtgggcaggatgaattttggcaaggacgta agcaccctgaagtacttcaccatctgtggcctgcaggagggctacgagcccttcgccgtc aacatgaaccgagacatcaccatgtggctgggcaagaggctggcccagttcatccctgtc ccgcacaaccacgagcacgtcgaggtgagcaggatcgacgggacgatggagtcgtacccg tgtctgaaggtcacccagaagtcctttggctctcagaacagcagcactgacatcaccttc taccgcctcagcatgcccatcgagtgtgctgagaccttctccgcctctctgggcggcggc gcgccagcctacgtcttcccacccaagaaggagtgcgaggactttgagacggtagctgac tttgaggttctggtcaagtcttctcacggtcacatgggggtccccagtgagaaggacgag ttcaacaaccacaaagaccacaaccaggagaaaccctccaagttcaaacagcggttgatg ctgaagagggccaagccagacaacagctccagctctgctcggctctcagaggaggtgacc gtggccggtgatatggacgattgtgagtttccgatgcaaacctctacgtacttcttctcg gtgcgcgtcttcccagggcaggagcccgggagcgtgtgggtgggatgggtcacctctgac ttccatcagtacgacccttcctttgagctgcacaaggtgcgcacggtcaccgtcaccctt ggagacgagaagggcaaagttcacgagagcataaagcgcagcaactgctacatggtgtgg gctggagagtgcaccagtccaggccagggacgtagcaacaacaacggtttggagatagga tgtctggtggacaccgccagcggactgctcaccttcacggccaacgggaaagagctcagc acttactaccaggtggagcccagcaccaagctgttccctgcagtctttgctcaggccacc agtcccaacgtgttccagtttgaactgggtcacataaagaacgtgatgccggtgtcagcc ggtctgttcaagagtgagaagatgaacccggcgccgcagtgccccccgcggctccatgtg cagttcctcacctcggtgttgtggagtcggctccccaaccacttccctaaggtgtcggcg tccagggtgaacgacagacacggatggctggtccagtgcaacgagccgctgcagttcatg gcgcttcatatccctgaagagaacaggtccatggacatccaggagctgtcagagcacgcc gagctgctgaagttccactaccacaccctgcggctgtactcggccgtgtgcgccctgggg aacaaccgggtggcccacgccctctgctcccacgtggacgaggcccagctgctccaggcc atagagaacaagtacatgccagggttgttgcgtaccggctactatgacctcctcatggac atccacctgagcagctacgccacagcccgcctgatgatgaacaacgagtacatcgtgccc atgaccgaggagaccaagaccatcacgctgttccccgaccacaccaagaagcacgcgctg ccgggcatcggcctcagcacctcgctgcggcccaggatgcacttctcctccccgagcttc gtccgccgagcgggctcgcgagggggcagcaacgcgccggccctgtcgtgggactgcttc cagcacagccccgagttccccttggagacgctgaagaccaagaccatcggcatgctgacc gaggcggtgagggagggcagcatgcacgtgagggaccctgtgggcgggagcagcgagttc ctcttcgtgcccctcatcaagctcttctacacgctgctcatcatgggggtgttccacaac ggagacctgaagaacgtcctgcagcttatcgagcccaacgtgttctcagagggagccggc gcccctgaggagaggactccgcaggcctcggccccggaggtggcggacggggctgacgga gcaggaggaggaggaggaggaggaggaggaggaagaggactgctccagatgaagcttcca gagccagtgaaactccagatgtgccgcctgctgcagtacctgtgtgactgccaggttcgt caccgcatcgaggccgtggtggccttctccgacgacttcgtagcctgcctccaggccaac cagaagttccgctacaacgaggtgatgcaggcgctcaacatgtccgccgcgctcactgcc aagaagacgaaggagttccgctccccaccacaggaacagataaacatgctgctgaacttc aaggatgagaagcacgagtgtccctgtccagagggcatcagggaacagctgatggccttc catgaagacctcatgatccactgcggcatagagattgacgaggacaaaggaaacgactgc gacggtgactgcaccttccgcggccgtctgatgtcgctggtggagaaggtggccaacctc aagaggaagaccgatgagctgcccaagaaaaagaaggacaagaagcccagcaccctccag cagctgatctctgacacaatggtccgctgggctcaggagtcggtcatcgaggaccctgag ctcgtcagagccatgttcgtcctgcttcaccggcagtatgacggcatcggagggcaggta cgagcgctccccaagacctacaccatcaacgctgtgtcggtggaggacaccatcaagctg ctggcggcactgggccagatccgctcgctgctcagtgtccgcatggggaaggaggaggag aagctgatgatcagaggactaggggacatcatgaacaacaaggtcttctaccagcacccc aacctgatgcgggcgctgggcatgcacgagacggtcatggaggtcatggtcaacgtgctg agtgggggagagtccaaggaaatcacgtttcccaagatggtggcaaactgctgccgcttc ctgtgctacttctgccggatcagccgtcaaaaccaaaaggccatgttcgaccacctcagc tacctcctggagaacagcagcgtgggcctagcgtccccatcgatgaggggctccacccct ctggacgtggcagcggcgtcggtcatggacaacaacgagctggccctggctctgagggag cccgacctagagaaggtggtacagtatttggcaggatgtgggctccagagctgtgccatg ctggtctccaagggataccccgatatcggctggaaccctgtcgaaggagaacgctacctg gacttcctgcgctttgctgtcttctgcaatggagagagtgtggaggagaacgccaacgtg gtggtgcggctgctgattcgtcggcctgagtgctttggccccgcccttagaggtgagggt ggtaacgggttgctggcggccatggaggaagccatccacatctcggccaacgcctgcaga gaccgcccctcctcgcccgcatccgagagcaccaagtccctcagcgaggacgaggaggac gacaccatccacatgggcaacgccgtcatgaccttctacgccgcgctcatcgacctgctg ggccgctgcgcgcctgagatgcacttgatccatgctggcaaaggagaggcggtccgcatc agagccatcctcaggtctctgatccccatccaggacttggagggagtcatcagtatcccc ttctccatgcccactctagccactgacggatccgtggtggagccagacatgtcggcaggg ttctgcccggaccataaggcggccatggtcctgttcctggaccgggtatacggcatcgag gaccagaacttcctcttacaccttctggaggttggctttctaccagacctccgagccgca gcctcactggacactgcggttctcagtgccacggacatggctctggccctcaacaggtac ctgtgcgcagctgtgctgcccctgctgactaagtgcgcaccgctgtttgccggcacggag ccgtacgcctcgctgatcgactccctgctccacaccgtgtaccggctgtccaagggctgc tgcctcaccaaggcccagagagacgccatcgaggactgcctcttggccgtgtgcgggaag ctgcgtccctccatgatgcagcacctcctcaggaggctggtgtttgacgtcccactcctg aacgagcacaccaagatgccgctcaaattgctgaccaaccactacgagcggtgttggaag tactactgccttgctgttggctggggcggcttcggggtggcctccgacgaggagctgcac ctctccaggaaactcttctggggcatcttcgatgctctgtcacgcaagcggtacgaccag gagctgttcaagctggccctgccctgcctgagtgcggtggccggggctctgcccccggac tatatggagtccaactatgtggccatgattgagaagcagtcctctatggactcggaggga aactttaacccacagcctgcagacaccagcaacgtcagtgttcctgagaagctggactac ttcatcaacagatatgcggagcatttgcatgagaagtggtctatggataagttctctgag ggctggctgtatggagagcagctgtgcgaagccaccaagagccaacctctcctcaagccc tacaaaggtctttctgaaaaggacaaggagtcgtaccgctggccgatcaaggagtccatc gggaccatggtgtcctggggctgggtggtggagcgcatcagagagggagaccccagcagt ctgcagaagtctcgtcggatttcacaagtcagccagctgtcttttgaaggagctcccggt ttcagtccgaggcccatcgacatgagcaacgtcactctgtccagagacctgcactcaatg gctgagcttctggcagaaaattttcataatacttgggctaaaaaaaagaagatggaaatg gaagccaaaggtggaggcagtcatccgttgctggtcccatacgacacactcactgccaaa gagaagtccagagaccgtgagaaagcacaggagatctttaagttcctccagatcaatggc tacaccgtatctaggtgtgtaagggagcaggacctggacacgccggccatagagaagcgt tttgcctacaccttcctgcaacagctcatagaatacgtagacaaggcccatcaacacatg atggacgccgatgcaggaacccgagccaagggagaggaatgtccccaggagcagcaaacc aagttctttggaaaggttctcttgccattggtggaccagtactttaagaaccataggctc tacttcctgtctacagccattcgtccaatcagcagtggcggccatgcctcaaacaaggag aaggagatggtgaccagtcttttctgcaaactgggagttcttgtcagacataggatatcg ctttttggaaacgacgccacttccatcgttaactgccttcacatcctgggacagacgctg gatgcaaggacggtcatgaagacggggctggagtcggtgaaggcggcactgcgggcgttc ttcgagaacgcggcggaggacctggagaagacccaggacaacctgaagctgggccagttc acccacgagcgcacgcagccgcgcgacgtcacccaggtcatcaactacaccaccttcgcc ctgctgcccgtgctctcctccctgttcgagcacatcggacagaacctcttcggccaggac ctcatcttggacaatgttcaggtgtcttgctacaggatcctcaacagtctctactcactc gggaccagcaagagcatctatgtagagaggcatcgtccggccattggagagtgtctggcg gccttctctgcagccttccccgtggccttcttggagccctacctggatatgttcaacggc ttctccatctacaacagcaaaggagccaaggagagaggagctcttgggcttccagccccg gtgcttgaggcctgtcctctcatcccctccctggagaagacccttgaggagatcatgacg ctggcggagtcgggcatcaggtacacccagatgccccacatcatggaggtggtgctgccc atgctgtgcagctacatgtcccactggtgggaatacggtccagagaacaacccggagagc accgaccgctgctgcacctctctgaggtgggagcacatgaacgccctcctgggaaacatc ctgaagatcatctacaacaacctgggcatcgacgagggcacctggatgaagagactggca gtattttctcagccaatcatcagtaaggccaatgctcagcttctcaagacccacttcctg cctctgatggaaaaactcaaaaaaaaagcggctgtggtcctcatggacgaggagcagacc aaagccgagggcagaggggacatgtcggaggcagagctgctggtgttggatgagttcacc atcctggtccgggacctgtatgccttctaccccctcctcattcgcttcgtcgattacaac agggcgaagtggctgaaggaaccgaacccagaggcagaggagctgttccgcatggtcgcc gaagtcttcatcttctgggccaagtcgcataacttcaagagggaagagcagaactttgtg gtccaaaatgagatcaacaacatgtccttcctcatcaccgataccaagtctaagatgtcg aagggtgccatttcggaccaggagaggaagaagctgaagaggaaaggggaccgctacacc atgcagaccagcctgatcgtggccacgctgaagcgcatgctcccagtggggctgaacatc tgcgcgccaggagaccaggagctcatagcgttggctaagaaccgcttcactcagaaagac acggaagatgaagttcgggagatcatcaaaagcaatctacatcttcaagggaagttggaa gacccagcgattcgatggcagatggccctgtaccgagaccttcccaaccgcaacgaggag acctctgatccggagaagactgtcgagagggtgctagatatcgctcatgtcctcttccac ttagaccaggtggagcacccccagcgcagtaagaaggctgtgtggcacaagctgctgtcc aagcagaggaagagggccgttgtggcgtgcttcaggatggctcccctgtacaacctgccc agacacagagctgtcaacctgtttcttcaaggctacgagaagtcctggatcgaggcagaa gaccactactttgaagataagctcatagaggacctggctaaatctggcgaggacgagcca gccgaagaggaagacagtctgaagcacattgacccgctgcatcaactcattcagctgttc agccgaaccgctctcactgagaaatgcaaactagatgaagacaatctctacatggcctac gccgacataatggccaagagctgtcacgatgaggtggaggaggacggagacgaagtgaaa agctttgaggagaaggagatggagaaacagaagctgctctaccagcaggctcgtctccac gaccggggagcggctgagatggttctgcagaccatcagcgccagcaaaggtgagatgggc ccgatggtggcgtccactctgaagctggggatagcggtcctcaacggggggaactccacc gtgcagcagaaaatgcttgactatctgagagacaaaaaggacgtgggattcttccagggt ctggccggcctcatgcagtcctgcagtgttctggatctgaatgcgttcgagaggcagaac aaggcagagggactgggcatggtgacagaggaaggatcagccatcacctctgagcgtggt gaaaaggtgatgcaggacgacgagttcacctgtgacctgttccgcttcctgcagctcctc tgtgaaggacacaactctgatttccagaactaccttcgaacccagacagggaacaacacg accgttaacataattatctctactgtggactacctcctcagagtacaggagtccatcagt gacttctactggtactactccgggaaggaggtgatcgacgagcagggacagagaaacttc tccaaggccatcaacgtggccaagcaggtgttcaacacgctgactgagtacatccagggc ccgtgcacagggaaccaacagagtctggcccacagccgcctgtgggacgcggttgtgggc ttcctgcatgtcttcgcccatatgcagatgaaactgtctcaggactccagtcagatagag ttactgaaggagctgatggacctccagaaggacatggtggtcatgctgctctctatgctt gagggtaacgtggtgaacggcaccattggcaagcagatggtggacatgctggtggaatct tccaacaacgtggagatgatcctcaagttcttcgacatgttcctcaaactcaaagacctg acctcctcggacgccttcaaggagtacgatctggatggcaaaggcgtgatctccaagagg gacttccataaagccatggaaagccacaagcactacacccagtcggaaacggagttcctc ctctcctgtgcagagacggacgaaaacgaactgctggactatgaggagtttgtggagcgc ttccacgagccggccaaggacattggcttcaacgtggcagttctgctgaccaacctgtca gagcacatgccccacgacacacggctgcagaccttcctggcgctggcggagagcgtgctg gactacttccagccctacctggggaggatcgagatcatggggagcgccaagcgcattgaa cgggtttacttcgagatcagcgagtccagccggacgcagtgggagaagccccaggtgaag gagtcgaagcgacagttcatctttgacgtggtgaacgagggcggcgagaaggagaagatg gagctgttcgtcaacttctgcgaggacaccatcttcgagatgcagctagccgcgcagatg tcggatgcgggcgagcgctcggcggtgaaggaggaaagcgagcaggagcggcccgaggag gcgggccccgagacgggcttcttctccgtggccaccctgcggacggcgttgctcgcgctg cgctacaacgtggtgatcgtcatgaaggtgctgtcgatgaagagcgtgaagaagcaggtg aagaggttgaagaagatgactgtcagggacctggtgaccacgctggcctctttctactgg tccacgctgctccgggtcctgtacgttgtcttcagcgtggccaggggcttctgcaggatc acatacaagagcctgatgggaggcagccttctgaacggcggcagcgccatgaaggtgtcg gagctgctgggcagcctgcctgacctcagccaggatgagggggtgcgtggggagggggcg gagccagagaagaagtcctcagaccgcgccttccaccccgaggatgagctggcagacctg gccatcaacaccggcgaaaccgaggttctgtcggacatcttcggcctggacctgagaagg gaggggggccagtacaagctcacgccccacgaccccaacgcaagcctgacccacctgctg atctcccctccccccgccgcaatcccctccccggagctcagacagaggcaccagataaag agttcaggcttggaggacagcgaaggaacagcagagaccagccatgagtccaagaaaaca gggcctgagaacgaagacaaagacaaagtgaaaaaagaggcgatggctaaacagaagatc cgacagaattacatcttcaagtctgaggaaccagacctgcaggagtccgtcttctggaag aagattatcgcctaccagaggaaactgttgaactactttgccaggaatttctacaacatg cggatgctggctctgtttgtggcctttgccatcaatttcatcctcctcttctacaaggtg tccacgtcctcggccgtggtggagcagaaggagctgctgtatcccagcagccagtccagg gtggagtgggccacactggaggagatggagggccgggcggccgaggaaggccgggaggcc cccaggccggtcacggtgcacttcgtcctggaggagagcagcggttacatggagcccacc ctacgtatcctggccatcatgcacacggtcatctccttcttctgcatcatcggctactac tgtctgaaggtgccgttggtgatcttcaagcgtgagaaggaggtggcccgcaagctggag tttgatggcctgtatatcacggaacagccgtctgaggacgacatcaagggccagtgggac cgactggtcatcaacacacaatctttcccaaacaattactgggacaaatttgtgaagaga aaggtgatggataagtacggagagttctacggccacgacaggatcagcgagctgctgggg atggaccgggccgcgctggacttcagcgactcacacgagaagaggaaacccaagaaagac aactcattagctgctgtgctgaactccattgatgttaaataccagatctggaaacttggg gtggtgttcactgataattccttcctgtaccttgcctggtacatgaccatgtctattctg ggacactacaacaacttcttcttcgctgcccacctgctggacatcgccatgggcttcaag acgctgcgcaccatcctgtcctcggtcacgcacaacggcaaacagctggttctgacggtg ggcctgctggcggtggtggtgtatctctacaccgtggtggccttcaacttcttcagaaag ttctacaacaagggtgaagacggagagtcgcccgacatgaagtgtgacgacatgttgact tgctacatgttccacatgtacgtgggcgtgcgggcgggcgggggaattggcgaccagatt gaagaccctgccggagacgaatacgaaatctaccgaatcatcttcgacatcaccttcttt ttcttcgtcatcgtcatcctcttagccatcattcagggtctgattatcgatgctttcggg gagctgagagaccagcaggagcaggtgaaagaggacatggagacaaagtgcttcatctgc ggaatagggaacgactactttgacacggtcccgcatggctttgagacgcacacactgcag gagcacaaccttgccaactacctgtttttcgtgatgtatctaatcaacaaggatgaaaca gagcacacaggccaggagtcctatgtgtggaagatgtaccaggagcgttgctgggagttc tttcctgccggcgactgtttccggaagcagtatgaggatcaactcaactga

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