Gadus morhua (Atlantic cod): 115531306 Help Entry 115531306         CDS       T10832                                  Symbol ryr2 Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism gmh  Gadus morhua (Atlantic cod) Pathway gmh04020   Calcium signaling pathway gmh04260   Cardiac muscle contraction gmh04261   Adrenergic signaling in cardiomyocytes gmh04371   Apelin signaling pathway Brite Ion channels [BR:gmh04040]  Voltage-gated cation channels   Ryanodine receptor    115531306 (ryr2) Domain-containing proteins not elsewhere classified [BR:gmh04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    115531306 (ryr2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 EF-hand_5 Motif Other DBs NCBI-GeneID:  115531306 NCBI-ProteinID:  XP_030196346 Ensembl:  ENSGMOG00000012679 LinkDB All DBs Position 18:complement(21198339..21366929) Genome browser AA seq 4976 aa AA seqDB search MAEGAEAEDEIQFLRTDDEVVLQCSATLHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICAFVLEQSLSVRALQEMLANTEEKAEGHVDVEKWKFMMKTAQGSGHRTLLYGHAVL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSHGYEHLHVDAAFQQTLWSVVPICSGSEVAQGYLIGGDVLRLLHGH MDECLTVASGDHGEEQRRTVNYEGGAVSIHARSLWRLEMLRVVWSGSHTRWGQPFRLRHV TTGKYLSLLDDRSLLLTDKDKADVKSTAFCFKSSKEKLDSGMKKEIDGMGVADIKYGDSV CYVQHMDTSLWLTYQAMDTKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIR STVFLFNRFIRGLDVLSKKGNTSALDLPIESVSLSLRDLIGYFQPPDEHLEHEEKQNRLR HLKNRQNLFQEEGMTSLLLECIDRLHVYSSAAHFAEVAGKEAGEAWRSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNLIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQNLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYRKWYYELIVDQVQPFVTAEATHVRVGWASTDGYAPYPGGGEGWGCNGAGD DLYSYSFDGLHLWSGCIARTVSSPNQHMLTVEDVVSCCLDLNSPSISFRINGQPVQGMFE NFNCDGLFFPVVSFSAGIKVRFLFGGRHGEFKFLPPPGYAPCYEAVLPREKLRVEHSQEY KQDLAGTRDLLGPTLTLSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIQL GWTYGVVRDDNKRQHPCLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGLADEHAIEK VHSLKLSPSYELTSSYKPAPLDLSHVKLASAQEAMVDKLAENAHNVWARDRIGQGWTYGI QQDVKNRRNPRLVPYALLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHARADLDNVS AERFRVFRAEKTYSVSAGKWYFELEIHTAGEIRVGWARPGCLPDQELGSDEQAFAFDGFK AQRWHQGNEHFGRSWQPADVVGCMVDLGERTMMFTLNGEVLLDDSGSELAFKDFEVYEGF IPVCSLGVCQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDITMWLGKRLAQFIPV PHNHEHVEVSRIDGTMESYPCLKVTQKSFGSQNSSTDITFYRLSMPIECAETFSASLGGG APAYVFPPKKECEDFETVADFEVLVKSSHGHMGVPSEKDEFNNHKDHNQEKPSKFKQRLM LKRAKPDNSSSSARLSEEVTVAGDMDDCEFPMQTSTYFFSVRVFPGQEPGSVWVGWVTSD FHQYDPSFELHKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGECTSPGQGRSNNNGLEIG CLVDTASGLLTFTANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGHIKNVMPVSA GLFKSEKMNPAPQCPPRLHVQFLTSVLWSRLPNHFPKVSASRVNDRHGWLVQCNEPLQFM ALHIPEENRSMDIQELSEHAELLKFHYHTLRLYSAVCALGNNRVAHALCSHVDEAQLLQA IENKYMPGLLRTGYYDLLMDIHLSSYATARLMMNNEYIVPMTEETKTITLFPDHTKKHAL PGIGLSTSLRPRMHFSSPSFVRRAGSRGGSNAPALSWDCFQHSPEFPLETLKTKTIGMLT EAVREGSMHVRDPVGGSSEFLFVPLIKLFYTLLIMGVFHNGDLKNVLQLIEPNVFSEGAG APEERTPQASAPEVADGADGAGGGGGGGGGGRGLLQMKLPEPVKLQMCRLLQYLCDCQVR HRIEAVVAFSDDFVACLQANQKFRYNEVMQALNMSAALTAKKTKEFRSPPQEQINMLLNF KDEKHECPCPEGIREQLMAFHEDLMIHCGIEIDEDKGNDCDGDCTFRGRLMSLVEKVANL KRKTDELPKKKKDKKPSTLQQLISDTMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQV RALPKTYTINAVSVEDTIKLLAALGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHP NLMRALGMHETVMEVMVNVLSGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLS YLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCAM LVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEG GNGLLAAMEEAIHISANACRDRPSSPASESTKSLSEDEEDDTIHMGNAVMTFYAALIDLL GRCAPEMHLIHAGKGEAVRIRAILRSLIPIQDLEGVISIPFSMPTLATDGSVVEPDMSAG FCPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTAVLSATDMALALNRY LCAAVLPLLTKCAPLFAGTEPYASLIDSLLHTVYRLSKGCCLTKAQRDAIEDCLLAVCGK LRPSMMQHLLRRLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLAVGWGGFGVASDEELH LSRKLFWGIFDALSRKRYDQELFKLALPCLSAVAGALPPDYMESNYVAMIEKQSSMDSEG NFNPQPADTSNVSVPEKLDYFINRYAEHLHEKWSMDKFSEGWLYGEQLCEATKSQPLLKP YKGLSEKDKESYRWPIKESIGTMVSWGWVVERIREGDPSSLQKSRRISQVSQLSFEGAPG FSPRPIDMSNVTLSRDLHSMAELLAENFHNTWAKKKKMEMEAKGGGSHPLLVPYDTLTAK EKSRDREKAQEIFKFLQINGYTVSRCVREQDLDTPAIEKRFAYTFLQQLIEYVDKAHQHM MDADAGTRAKGEECPQEQQTKFFGKVLLPLVDQYFKNHRLYFLSTAIRPISSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKAALRAF FENAAEDLEKTQDNLKLGQFTHERTQPRDVTQVINYTTFALLPVLSSLFEHIGQNLFGQD LILDNVQVSCYRILNSLYSLGTSKSIYVERHRPAIGECLAAFSAAFPVAFLEPYLDMFNG FSIYNSKGAKERGALGLPAPVLEACPLIPSLEKTLEEIMTLAESGIRYTQMPHIMEVVLP MLCSYMSHWWEYGPENNPESTDRCCTSLRWEHMNALLGNILKIIYNNLGIDEGTWMKRLA VFSQPIISKANAQLLKTHFLPLMEKLKKKAAVVLMDEEQTKAEGRGDMSEAELLVLDEFT ILVRDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIFWAKSHNFKREEQNFV VQNEINNMSFLITDTKSKMSKGAISDQERKKLKRKGDRYTMQTSLIVATLKRMLPVGLNI CAPGDQELIALAKNRFTQKDTEDEVREIIKSNLHLQGKLEDPAIRWQMALYRDLPNRNEE TSDPEKTVERVLDIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLP RHRAVNLFLQGYEKSWIEAEDHYFEDKLIEDLAKSGEDEPAEEEDSLKHIDPLHQLIQLF SRTALTEKCKLDEDNLYMAYADIMAKSCHDEVEEDGDEVKSFEEKEMEKQKLLYQQARLH DRGAAEMVLQTISASKGEMGPMVASTLKLGIAVLNGGNSTVQQKMLDYLRDKKDVGFFQG LAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSAITSERGEKVMQDDEFTCDLFRFLQLL CEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKEVIDEQGQRNF SKAINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIE LLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDL TSSDAFKEYDLDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENELLDYEEFVER FHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLALAESVLDYFQPYLGRIEIMGSAKRIE RVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQM SDAGERSAVKEESEQERPEEAGPETGFFSVATLRTALLALRYNVVIVMKVLSMKSVKKQV KRLKKMTVRDLVTTLASFYWSTLLRVLYVVFSVARGFCRITYKSLMGGSLLNGGSAMKVS ELLGSLPDLSQDEGVRGEGAEPEKKSSDRAFHPEDELADLAINTGETEVLSDIFGLDLRR EGGQYKLTPHDPNASLTHLLISPPPAAIPSPELRQRHQIKSSGLEDSEGTAETSHESKKT GPENEDKDKVKKEAMAKQKIRQNYIFKSEEPDLQESVFWKKIIAYQRKLLNYFARNFYNM RMLALFVAFAINFILLFYKVSTSSAVVEQKELLYPSSQSRVEWATLEEMEGRAAEEGREA PRPVTVHFVLEESSGYMEPTLRILAIMHTVISFFCIIGYYCLKVPLVIFKREKEVARKLE FDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLG MDRAALDFSDSHEKRKPKKDNSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMTMSIL GHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRK FYNKGEDGESPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFF FFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQ EHNLANYLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14931 nt NT seq  +upstreamnt  +downstreamnt atggctgaaggggcagaagccgaggatgagatccaattcctacggacagacgacgaggtg gtgctgcagtgctctgccactctccataaagagcagcagaagctttgtctggctgctgaa ggctttggaaacagactgtgcttcctagagtccacgtccaactccaagaatgtgcctcca gacctgtccatctgcgcctttgttctggagcagtctctgtcggtccgggcgctgcaggag atgctggccaacaccgaggagaaggctgaagggcatgtagatgtggaaaaatggaaattc atgatgaagacagcccagggaagcggacatcgcactttactttacggacatgctgttctc ttacgacactcctacagtgggatgtacttgtgctgtctgtccacctcccgctcgtcaaca gataaactggcctttgatgtgggactgcaagaagacactacaggcgaggcttgctggtgg accatccacccagcctccaaacagcggtcggagggagagaaggtcagagttggtgatgac ctcatcctagtcagcgtctcctcagaacgatacctgcacttgtcccatggttatgaacac ctccacgtggacgcagccttccagcagaccctctggagtgtggtccccatctgctcaggc agtgaggtggcccaaggctacctgatcgggggagacgtgctgcggctgctccatggacac atggacgagtgcttgaccgtggcctccggggaccacggggaggagcagaggagaacggtg aactacgagggcggagcggtgtccatccacgcccggtccctgtggaggctggaaatgctc cgggtggtgtggagcggcagccacacccgctggggccagccgttcagactacgacacgtg accacagggaagtacctgagtctgctggacgaccgctccctcctcctgacggacaaagac aaggcggacgtcaagtccaccgccttctgcttcaagtcatccaaggaaaagttggattcc gggatgaaaaaggaaatagatggaatgggagtggctgatataaagtacggcgactctgtg tgttacgtccagcacatggacaccagtttgtggctcacctaccaggccatggataccaag tgtgcccgcatgggcggagtgcaacggaaggccatcatgcaccacgagggccacatggac gatggcctcactctgtctcggtcacagcatgaggagagtcgtacggcgcgagtcattcgg agtactgtattcttgttcaaccgcttcatcaggggcctggacgtgctctctaaaaaaggg aacacctctgctctcgatctgccaatcgaatcggtcagcctcagtttgcgggatctgata ggctacttccagcccccggacgagcacttggagcacgaggagaagcagaaccggctacga catctgaagaaccggcagaatctgttccaggaggaggggatgaccagcctgctcctggag tgcatcgaccggctccacgtctacagcagcgccgcccattttgccgaggttgcagggaaa gaggcgggggaggcgtggaggtccatccttaactcgttatacgagctccttgctgcactc ataaggggcaaccggaagaattgtgctcagttctctggctctctggattggctgataagc agactggaaagactggaagcttcatctggtatactggaggttctacactgtgtactggtg gaaagtcctgaggccctcaatctcatcaaagagggacacatcaagtccattatttctctg ctggacaaacatggacgcaaccataaggttctagacgtgctgtgctccctgtgtgtgtgt catggcgtggcggtgcgctctaaccagaacctgatctgtgacaaccttctgccgggcaga gacctgctgctgcagaccaggctggtcaaccacgtcagcagcatgcggcccaacatcttc ctgggcgtgagcgagggctcggcgcagtacaggaagtggtactacgagctgatcgtggac caggtgcagcccttcgtcacggcggaggccacccacgtccgcgttggctgggccagcacc gatggctacgccccctacccaggggggggcgagggctggggctgcaacggggcgggggac gacctctactcctacagcttcgacggactccacctgtggtcagggtgtatcgcacggaca gtgagctctcccaaccaacacatgctgacggtggaggatgtggtcagctgttgtctggat ctcaactcgcccagcatttccttcaggatcaacggtcagccggtgcagggcatgttcgag aacttcaactgtgacggactgtttttccctgtcgtcagcttctctgctgggattaaggtg cgtttcctgtttggaggacgtcacggagagtttaagttccttccgccgccgggctacgcc ccgtgctacgaggccgtgctgcccagggagaagctcagggtggaacacagccaggagtac aagcaggatctggctgggacccgagacctcctgggacccactctcacgctctctcaggct gccttcactcccacacctgtggacaccagccagattgtcctaccaccccatctggagagg atcagggagaagctggcagagaacatccatgaactttgggtcatgaacaagatccaactg ggctggacctacggagtggtgcgggatgataacaagcggcagcacccgtgcctagtggag ttctccaagctgcccgagcaggagcgcagctacaacctgcagatgtctctggagacccta aaaaccctcctggccctaggctgtcacgttggcctggccgatgaacacgccatagagaag gtccacagcctgaagctttcccctagctatgagttgaccagcagctataagccggctccc ctggacttgagccacgttaaactggcatctgcccaggaggccatggtggacaaactggca gagaacgcacacaacgtctgggcccgagatcgcataggccaaggctggacttatggcatt caacaggacgtgaagaaccgccgtaaccctcgcctggtgccctacgccctgctggacgag aggaccaagaagtccaacaaggacagcctgagagaggcggttcgcaccctgctgggatac gggtacaacctggaggccccggatcaggaccacgcccgggcggacctcgacaacgtttca gccgagcgctttcgtgtcttccgagcagaaaagacttacagtgtcagcgccggcaaatgg tactttgagcttgagatccacactgcgggtgagatcagggtgggatgggcccggccaggc tgtctgccggaccaggagctcggatcagatgaacaggcctttgcatttgatggctttaag gcgcagcgttggcaccaagggaacgaacactttggccgctcctggcagccggccgacgtg gtgggctgcatggtggacctcggggaacgcaccatgatgttcacccttaacggagaggtt ctgctggatgactctggctcagagctggccttcaaggattttgaagtctacgaagggttc atcccggtatgcagtctgggcgtttgtcaggtgggcaggatgaattttggcaaggacgta agcaccctgaagtacttcaccatctgtggcctgcaggagggctacgagcccttcgccgtc aacatgaaccgagacatcaccatgtggctgggcaagaggctggcccagttcatccctgtc ccgcacaaccacgagcacgtcgaggtgagcaggatcgacgggacgatggagtcgtacccg tgtctgaaggtcacccagaagtcctttggctctcagaacagcagcactgacatcaccttc taccgcctcagcatgcccatcgagtgtgctgagaccttctccgcctctctgggcggcggc gcgccagcctacgtcttcccacccaagaaggagtgcgaggactttgagacggtagctgac tttgaggttctggtcaagtcttctcacggtcacatgggggtccccagtgagaaggacgag ttcaacaaccacaaagaccacaaccaggagaaaccctccaagttcaaacagcggttgatg ctgaagagggccaagccagacaacagctccagctctgctcggctctcagaggaggtgacc gtggccggtgatatggacgattgtgagtttccgatgcaaacctctacgtacttcttctcg gtgcgcgtcttcccagggcaggagcccgggagcgtgtgggtgggatgggtcacctctgac ttccatcagtacgacccttcctttgagctgcacaaggtgcgcacggtcaccgtcaccctt ggagacgagaagggcaaagttcacgagagcataaagcgcagcaactgctacatggtgtgg gctggagagtgcaccagtccaggccagggacgtagcaacaacaacggtttggagatagga tgtctggtggacaccgccagcggactgctcaccttcacggccaacgggaaagagctcagc acttactaccaggtggagcccagcaccaagctgttccctgcagtctttgctcaggccacc agtcccaacgtgttccagtttgaactgggtcacataaagaacgtgatgccggtgtcagcc ggtctgttcaagagtgagaagatgaacccggcgccgcagtgccccccgcggctccatgtg cagttcctcacctcggtgttgtggagtcggctccccaaccacttccctaaggtgtcggcg tccagggtgaacgacagacacggatggctggtccagtgcaacgagccgctgcagttcatg gcgcttcatatccctgaagagaacaggtccatggacatccaggagctgtcagagcacgcc gagctgctgaagttccactaccacaccctgcggctgtactcggccgtgtgcgccctgggg aacaaccgggtggcccacgccctctgctcccacgtggacgaggcccagctgctccaggcc atagagaacaagtacatgccagggttgttgcgtaccggctactatgacctcctcatggac atccacctgagcagctacgccacagcccgcctgatgatgaacaacgagtacatcgtgccc atgaccgaggagaccaagaccatcacgctgttccccgaccacaccaagaagcacgcgctg ccgggcatcggcctcagcacctcgctgcggcccaggatgcacttctcctccccgagcttc gtccgccgagcgggctcgcgagggggcagcaacgcgccggccctgtcgtgggactgcttc cagcacagccccgagttccccttggagacgctgaagaccaagaccatcggcatgctgacc gaggcggtgagggagggcagcatgcacgtgagggaccctgtgggcgggagcagcgagttc ctcttcgtgcccctcatcaagctcttctacacgctgctcatcatgggggtgttccacaac ggagacctgaagaacgtcctgcagcttatcgagcccaacgtgttctcagagggagccggc gcccctgaggagaggactccgcaggcctcggccccggaggtggcggacggggctgacgga gcaggaggaggaggaggaggaggaggaggaggaagaggactgctccagatgaagcttcca gagccagtgaaactccagatgtgccgcctgctgcagtacctgtgtgactgccaggttcgt caccgcatcgaggccgtggtggccttctccgacgacttcgtagcctgcctccaggccaac cagaagttccgctacaacgaggtgatgcaggcgctcaacatgtccgccgcgctcactgcc aagaagacgaaggagttccgctccccaccacaggaacagataaacatgctgctgaacttc aaggatgagaagcacgagtgtccctgtccagagggcatcagggaacagctgatggccttc catgaagacctcatgatccactgcggcatagagattgacgaggacaaaggaaacgactgc gacggtgactgcaccttccgcggccgtctgatgtcgctggtggagaaggtggccaacctc aagaggaagaccgatgagctgcccaagaaaaagaaggacaagaagcccagcaccctccag cagctgatctctgacacaatggtccgctgggctcaggagtcggtcatcgaggaccctgag ctcgtcagagccatgttcgtcctgcttcaccggcagtatgacggcatcggagggcaggta cgagcgctccccaagacctacaccatcaacgctgtgtcggtggaggacaccatcaagctg ctggcggcactgggccagatccgctcgctgctcagtgtccgcatggggaaggaggaggag aagctgatgatcagaggactaggggacatcatgaacaacaaggtcttctaccagcacccc aacctgatgcgggcgctgggcatgcacgagacggtcatggaggtcatggtcaacgtgctg agtgggggagagtccaaggaaatcacgtttcccaagatggtggcaaactgctgccgcttc ctgtgctacttctgccggatcagccgtcaaaaccaaaaggccatgttcgaccacctcagc tacctcctggagaacagcagcgtgggcctagcgtccccatcgatgaggggctccacccct ctggacgtggcagcggcgtcggtcatggacaacaacgagctggccctggctctgagggag cccgacctagagaaggtggtacagtatttggcaggatgtgggctccagagctgtgccatg ctggtctccaagggataccccgatatcggctggaaccctgtcgaaggagaacgctacctg gacttcctgcgctttgctgtcttctgcaatggagagagtgtggaggagaacgccaacgtg gtggtgcggctgctgattcgtcggcctgagtgctttggccccgcccttagaggtgagggt ggtaacgggttgctggcggccatggaggaagccatccacatctcggccaacgcctgcaga gaccgcccctcctcgcccgcatccgagagcaccaagtccctcagcgaggacgaggaggac gacaccatccacatgggcaacgccgtcatgaccttctacgccgcgctcatcgacctgctg ggccgctgcgcgcctgagatgcacttgatccatgctggcaaaggagaggcggtccgcatc agagccatcctcaggtctctgatccccatccaggacttggagggagtcatcagtatcccc ttctccatgcccactctagccactgacggatccgtggtggagccagacatgtcggcaggg ttctgcccggaccataaggcggccatggtcctgttcctggaccgggtatacggcatcgag gaccagaacttcctcttacaccttctggaggttggctttctaccagacctccgagccgca gcctcactggacactgcggttctcagtgccacggacatggctctggccctcaacaggtac ctgtgcgcagctgtgctgcccctgctgactaagtgcgcaccgctgtttgccggcacggag ccgtacgcctcgctgatcgactccctgctccacaccgtgtaccggctgtccaagggctgc tgcctcaccaaggcccagagagacgccatcgaggactgcctcttggccgtgtgcgggaag ctgcgtccctccatgatgcagcacctcctcaggaggctggtgtttgacgtcccactcctg aacgagcacaccaagatgccgctcaaattgctgaccaaccactacgagcggtgttggaag tactactgccttgctgttggctggggcggcttcggggtggcctccgacgaggagctgcac ctctccaggaaactcttctggggcatcttcgatgctctgtcacgcaagcggtacgaccag gagctgttcaagctggccctgccctgcctgagtgcggtggccggggctctgcccccggac tatatggagtccaactatgtggccatgattgagaagcagtcctctatggactcggaggga aactttaacccacagcctgcagacaccagcaacgtcagtgttcctgagaagctggactac ttcatcaacagatatgcggagcatttgcatgagaagtggtctatggataagttctctgag ggctggctgtatggagagcagctgtgcgaagccaccaagagccaacctctcctcaagccc tacaaaggtctttctgaaaaggacaaggagtcgtaccgctggccgatcaaggagtccatc gggaccatggtgtcctggggctgggtggtggagcgcatcagagagggagaccccagcagt ctgcagaagtctcgtcggatttcacaagtcagccagctgtcttttgaaggagctcccggt ttcagtccgaggcccatcgacatgagcaacgtcactctgtccagagacctgcactcaatg gctgagcttctggcagaaaattttcataatacttgggctaaaaaaaagaagatggaaatg gaagccaaaggtggaggcagtcatccgttgctggtcccatacgacacactcactgccaaa gagaagtccagagaccgtgagaaagcacaggagatctttaagttcctccagatcaatggc tacaccgtatctaggtgtgtaagggagcaggacctggacacgccggccatagagaagcgt tttgcctacaccttcctgcaacagctcatagaatacgtagacaaggcccatcaacacatg atggacgccgatgcaggaacccgagccaagggagaggaatgtccccaggagcagcaaacc aagttctttggaaaggttctcttgccattggtggaccagtactttaagaaccataggctc tacttcctgtctacagccattcgtccaatcagcagtggcggccatgcctcaaacaaggag aaggagatggtgaccagtcttttctgcaaactgggagttcttgtcagacataggatatcg ctttttggaaacgacgccacttccatcgttaactgccttcacatcctgggacagacgctg gatgcaaggacggtcatgaagacggggctggagtcggtgaaggcggcactgcgggcgttc ttcgagaacgcggcggaggacctggagaagacccaggacaacctgaagctgggccagttc acccacgagcgcacgcagccgcgcgacgtcacccaggtcatcaactacaccaccttcgcc ctgctgcccgtgctctcctccctgttcgagcacatcggacagaacctcttcggccaggac ctcatcttggacaatgttcaggtgtcttgctacaggatcctcaacagtctctactcactc gggaccagcaagagcatctatgtagagaggcatcgtccggccattggagagtgtctggcg gccttctctgcagccttccccgtggccttcttggagccctacctggatatgttcaacggc ttctccatctacaacagcaaaggagccaaggagagaggagctcttgggcttccagccccg gtgcttgaggcctgtcctctcatcccctccctggagaagacccttgaggagatcatgacg ctggcggagtcgggcatcaggtacacccagatgccccacatcatggaggtggtgctgccc atgctgtgcagctacatgtcccactggtgggaatacggtccagagaacaacccggagagc accgaccgctgctgcacctctctgaggtgggagcacatgaacgccctcctgggaaacatc ctgaagatcatctacaacaacctgggcatcgacgagggcacctggatgaagagactggca gtattttctcagccaatcatcagtaaggccaatgctcagcttctcaagacccacttcctg cctctgatggaaaaactcaaaaaaaaagcggctgtggtcctcatggacgaggagcagacc aaagccgagggcagaggggacatgtcggaggcagagctgctggtgttggatgagttcacc atcctggtccgggacctgtatgccttctaccccctcctcattcgcttcgtcgattacaac agggcgaagtggctgaaggaaccgaacccagaggcagaggagctgttccgcatggtcgcc gaagtcttcatcttctgggccaagtcgcataacttcaagagggaagagcagaactttgtg gtccaaaatgagatcaacaacatgtccttcctcatcaccgataccaagtctaagatgtcg aagggtgccatttcggaccaggagaggaagaagctgaagaggaaaggggaccgctacacc atgcagaccagcctgatcgtggccacgctgaagcgcatgctcccagtggggctgaacatc tgcgcgccaggagaccaggagctcatagcgttggctaagaaccgcttcactcagaaagac acggaagatgaagttcgggagatcatcaaaagcaatctacatcttcaagggaagttggaa gacccagcgattcgatggcagatggccctgtaccgagaccttcccaaccgcaacgaggag acctctgatccggagaagactgtcgagagggtgctagatatcgctcatgtcctcttccac ttagaccaggtggagcacccccagcgcagtaagaaggctgtgtggcacaagctgctgtcc aagcagaggaagagggccgttgtggcgtgcttcaggatggctcccctgtacaacctgccc agacacagagctgtcaacctgtttcttcaaggctacgagaagtcctggatcgaggcagaa gaccactactttgaagataagctcatagaggacctggctaaatctggcgaggacgagcca gccgaagaggaagacagtctgaagcacattgacccgctgcatcaactcattcagctgttc agccgaaccgctctcactgagaaatgcaaactagatgaagacaatctctacatggcctac gccgacataatggccaagagctgtcacgatgaggtggaggaggacggagacgaagtgaaa agctttgaggagaaggagatggagaaacagaagctgctctaccagcaggctcgtctccac gaccggggagcggctgagatggttctgcagaccatcagcgccagcaaaggtgagatgggc ccgatggtggcgtccactctgaagctggggatagcggtcctcaacggggggaactccacc gtgcagcagaaaatgcttgactatctgagagacaaaaaggacgtgggattcttccagggt ctggccggcctcatgcagtcctgcagtgttctggatctgaatgcgttcgagaggcagaac aaggcagagggactgggcatggtgacagaggaaggatcagccatcacctctgagcgtggt gaaaaggtgatgcaggacgacgagttcacctgtgacctgttccgcttcctgcagctcctc tgtgaaggacacaactctgatttccagaactaccttcgaacccagacagggaacaacacg accgttaacataattatctctactgtggactacctcctcagagtacaggagtccatcagt gacttctactggtactactccgggaaggaggtgatcgacgagcagggacagagaaacttc tccaaggccatcaacgtggccaagcaggtgttcaacacgctgactgagtacatccagggc ccgtgcacagggaaccaacagagtctggcccacagccgcctgtgggacgcggttgtgggc ttcctgcatgtcttcgcccatatgcagatgaaactgtctcaggactccagtcagatagag ttactgaaggagctgatggacctccagaaggacatggtggtcatgctgctctctatgctt gagggtaacgtggtgaacggcaccattggcaagcagatggtggacatgctggtggaatct tccaacaacgtggagatgatcctcaagttcttcgacatgttcctcaaactcaaagacctg acctcctcggacgccttcaaggagtacgatctggatggcaaaggcgtgatctccaagagg gacttccataaagccatggaaagccacaagcactacacccagtcggaaacggagttcctc ctctcctgtgcagagacggacgaaaacgaactgctggactatgaggagtttgtggagcgc ttccacgagccggccaaggacattggcttcaacgtggcagttctgctgaccaacctgtca gagcacatgccccacgacacacggctgcagaccttcctggcgctggcggagagcgtgctg gactacttccagccctacctggggaggatcgagatcatggggagcgccaagcgcattgaa cgggtttacttcgagatcagcgagtccagccggacgcagtgggagaagccccaggtgaag gagtcgaagcgacagttcatctttgacgtggtgaacgagggcggcgagaaggagaagatg gagctgttcgtcaacttctgcgaggacaccatcttcgagatgcagctagccgcgcagatg tcggatgcgggcgagcgctcggcggtgaaggaggaaagcgagcaggagcggcccgaggag gcgggccccgagacgggcttcttctccgtggccaccctgcggacggcgttgctcgcgctg cgctacaacgtggtgatcgtcatgaaggtgctgtcgatgaagagcgtgaagaagcaggtg aagaggttgaagaagatgactgtcagggacctggtgaccacgctggcctctttctactgg tccacgctgctccgggtcctgtacgttgtcttcagcgtggccaggggcttctgcaggatc acatacaagagcctgatgggaggcagccttctgaacggcggcagcgccatgaaggtgtcg gagctgctgggcagcctgcctgacctcagccaggatgagggggtgcgtggggagggggcg gagccagagaagaagtcctcagaccgcgccttccaccccgaggatgagctggcagacctg gccatcaacaccggcgaaaccgaggttctgtcggacatcttcggcctggacctgagaagg gaggggggccagtacaagctcacgccccacgaccccaacgcaagcctgacccacctgctg atctcccctccccccgccgcaatcccctccccggagctcagacagaggcaccagataaag agttcaggcttggaggacagcgaaggaacagcagagaccagccatgagtccaagaaaaca gggcctgagaacgaagacaaagacaaagtgaaaaaagaggcgatggctaaacagaagatc cgacagaattacatcttcaagtctgaggaaccagacctgcaggagtccgtcttctggaag aagattatcgcctaccagaggaaactgttgaactactttgccaggaatttctacaacatg cggatgctggctctgtttgtggcctttgccatcaatttcatcctcctcttctacaaggtg tccacgtcctcggccgtggtggagcagaaggagctgctgtatcccagcagccagtccagg gtggagtgggccacactggaggagatggagggccgggcggccgaggaaggccgggaggcc cccaggccggtcacggtgcacttcgtcctggaggagagcagcggttacatggagcccacc ctacgtatcctggccatcatgcacacggtcatctccttcttctgcatcatcggctactac tgtctgaaggtgccgttggtgatcttcaagcgtgagaaggaggtggcccgcaagctggag tttgatggcctgtatatcacggaacagccgtctgaggacgacatcaagggccagtgggac cgactggtcatcaacacacaatctttcccaaacaattactgggacaaatttgtgaagaga aaggtgatggataagtacggagagttctacggccacgacaggatcagcgagctgctgggg atggaccgggccgcgctggacttcagcgactcacacgagaagaggaaacccaagaaagac aactcattagctgctgtgctgaactccattgatgttaaataccagatctggaaacttggg gtggtgttcactgataattccttcctgtaccttgcctggtacatgaccatgtctattctg ggacactacaacaacttcttcttcgctgcccacctgctggacatcgccatgggcttcaag acgctgcgcaccatcctgtcctcggtcacgcacaacggcaaacagctggttctgacggtg ggcctgctggcggtggtggtgtatctctacaccgtggtggccttcaacttcttcagaaag ttctacaacaagggtgaagacggagagtcgcccgacatgaagtgtgacgacatgttgact tgctacatgttccacatgtacgtgggcgtgcgggcgggcgggggaattggcgaccagatt gaagaccctgccggagacgaatacgaaatctaccgaatcatcttcgacatcaccttcttt ttcttcgtcatcgtcatcctcttagccatcattcagggtctgattatcgatgctttcggg gagctgagagaccagcaggagcaggtgaaagaggacatggagacaaagtgcttcatctgc ggaatagggaacgactactttgacacggtcccgcatggctttgagacgcacacactgcag gagcacaaccttgccaactacctgtttttcgtgatgtatctaatcaacaaggatgaaaca gagcacacaggccaggagtcctatgtgtggaagatgtaccaggagcgttgctgggagttc tttcctgccggcgactgtttccggaagcagtatgaggatcaactcaactga

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