Garra rufa (doctor fish): 141325528
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Entry
141325528 CDS
T11039
Symbol
gclc
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit
KO
K11204
glutamate---cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
grf Garra rufa (doctor fish)
Pathway
grf00270
Cysteine and methionine metabolism
grf00480
Glutathione metabolism
grf01100
Metabolic pathways
grf01240
Biosynthesis of cofactors
grf04216
Ferroptosis
Module
grf_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
grf00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
141325528 (gclc)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
141325528 (gclc)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
141325528 (gclc)
Enzymes [BR:
grf01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
141325528 (gclc)
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Paralog
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Motif
Pfam:
GCS
GCS2
mRNA_triPase
Motif
Other DBs
NCBI-GeneID:
141325528
NCBI-ProteinID:
XP_073690372
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All DBs
Position
2:complement(45192125..45215433)
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AA seq
631 aa
AA seq
DB search
MGLLSQGSPLNWEETKKHADHVRKHGILQFLNIYNKVKDRQKDVLKWGDEVEYMLVEMDD
KNEKVRLVLKGKDVLETLQERGENINPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMGKRRREAASVLNMNETLLTVTSFPRLGCPGFTQPEYKPTPVEKGVSKSLFFPDEAI
NRHPRFSTLTRNIRHRRGEKVVINVPIFPDKNTPSPFVEAFPEDDGEAARGALPDHIYMD
AMGFGMGNCCLQVTFQACSISEARYLYDQLATFCPIVMALSAASPFYRGYVSDIDCRWGV
ISASVDDRTREERGLEPLKNNKFRIHKSRYDSIDSYLSCCGDKYNDIELTIDEDINKQLL
DAGIDKLLAQHIAHLFIRDPLSLFQEKIHLDDENESDHFENIQSTNWQTMRFKPPPPNSE
IGWRVEFRPMEVQLTDFENSAYVVFIVLLTRVILSYKLDFLIPLSKVDENMKVAQKRNAV
QEGMFYFRKDVFKGCNPVLDPPSTAQNGVESEANDGEEFTLMSIDTIINGKEGVFHGLIP
MLNCYLENMEVDVDTRCTILNYLKLIKKRASGELMTMAKWMREFVAKHPQYKQDSIITDK
INYDLLHKCDRIAKGEEKCPELIGDPVNRGK
NT seq
1896 nt
NT seq
+upstream
nt +downstream
nt
atgggcttactgtcacaagggtcaccgcttaactgggaagagaccaagaaacatgctgac
cacgttagaaagcacggcatccttcagttcctcaacatctacaataaggtcaaagatcga
cagaaggatgtgctcaaatggggagacgaggtggagtacatgttggtggaaatggatgac
aaaaatgagaaggtccgcctagttctgaagggaaaggatgttttggaaacccttcaggaa
aggggtgaaaacatcaaccccaaccaccccacgctgtggaggccggagtacggcagctac
atgatcgaaggaacccctgggcagccgtacggagggactatgtcagagtttaacacggta
gaagacaacatgggaaagcggaggagagaagccgcatctgtgcttaacatgaatgagact
ctcctcacagttacatcatttcccaggttaggctgcccaggcttcactcagccagagtac
aaacccacacctgttgaaaaaggggtgtccaaatcgcttttcttccctgatgaggccatc
aacagacaccctagattcagcactctgaccagaaacatacgccaccggaggggagaaaag
gtagtgataaatgtaccaatttttccagataaaaacaccccatctccttttgtggaggca
ttcccagaggatgatggagaagctgcccggggagctctgcctgatcacatctacatggat
gccatgggctttggcatgggaaactgttgcctgcaggtgaccttccaggcttgcagcatc
agtgaggcgcgctacctttacgaccaactggccactttctgtcccatagtgatggctctc
agcgctgcctcaccgttctatcgggggtacgtatcggacattgattgccgttggggtgtg
atctctgcatctgtggatgacagaacccgagaggagaggggtctggagccattgaagaac
aacaaattcaggatccataaatcacggtacgattcgattgacagctacctctcctgctgt
ggtgacaaatacaatgacattgagctgaccatagatgaagatatcaacaaacagctccta
gatgcaggcattgacaaactgctggcacagcacatcgcacatctcttcatccgcgacccg
ctgtcgctcttccaggagaagattcatttggatgatgagaacgaatcggaccactttgag
aacattcagtcaaccaactggcagacaatgaggttcaagccccctcctccaaactctgaa
atcggatggagagtcgagttccgtccaatggaggttcaactgacagattttgaaaactca
gcttacgtcgtatttatcgttctcctcacccgtgtcatcttgtcctataagttggatttc
ctcattccattgtcaaaggttgatgaaaacatgaaagtagcccagaagcgaaatgcagtg
caggaaggaatgttttattttcggaaggacgtctttaaaggctgcaacccagtgttagat
ccgccctccacagctcagaacggagtggagagtgaagctaatgacggtgaagagttcaca
ctgatgagtattgacaccatcatcaatgggaaggaaggggtatttcacggcttaatacca
atgttgaactgctatcttgagaacatggaggtggatgtcgacacgcggtgcactattctc
aactacctgaaactcattaagaagcgtgcttctggtgagctgatgaccatggcaaagtgg
atgagggagtttgttgccaaacatcctcagtacaagcaggacagcatcattacagacaaa
ataaactacgacctgctgcacaagtgcgacagaatcgcaaagggggaagagaaatgtcca
gaacttatcggagacccggttaacagaggaaaataa
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