Galeopterus variegatus (Sunda flying lemur): 103586022
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Entry
103586022 CDS
T08727
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
gvr
Galeopterus variegatus (Sunda flying lemur)
Pathway
gvr05012
Parkinson disease
gvr05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
gvr00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
103586022 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
103586022 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
gvr01001
]
103586022 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
gvr04131
]
103586022 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
gvr04147
]
103586022 (LRRK2)
Enzymes [BR:
gvr01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
103586022 (LRRK2)
Protein kinases [BR:
gvr01001
]
Serine/threonine kinases: TKL group
LRRK family
103586022 (LRRK2)
Membrane trafficking [BR:
gvr04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
103586022 (LRRK2)
Exosome [BR:
gvr04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
103586022 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
Roc
LRR_8
LRR_4
COR-B
Ras
COR-A
LRR_14
LRR_9
Beta-prop_WDR36-Utp21_1st
Beta-prop_RSE1_2nd
Arf
WD40_CDC20-Fz
nSTAND3
Ank_2
Beta-prop_EML_2
T2SSE
AAA_22
Beta-prop_THOC3
GTP_EFTU
ABC_tran
PduV-EutP
AAA_7
TrwB_AAD_bind
Beta-prop_BBS7
Kdo
MMR_HSR1
G-alpha
AAA_16
NACHT
MobB
TsaE
Septin
WD40_WDHD1_1st
TniB
WD40_Prp19
Beta-prop_WDR3_1st
AAA_29
FtsK_SpoIIIE
cobW
SRPRB
NB-ARC
nSTAND_NTPase5
AAA_23
AAA_14
ResIII
Motif
Other DBs
NCBI-GeneID:
103586022
NCBI-ProteinID:
XP_008565364
UniProt:
A0ABM0QAH3
LinkDB
All DBs
Position
Unknown
AA seq
2525 aa
AA seq
DB search
MASGSCQGCEEDEESLKKLIVRLNNVQEGKQIDTLVQILEDMLVFTYAEHAAKLFQDKNV
HVPLLIVLDSYMRVASVQQVGWSFLCKLIEICPDTMQSLVGPQDIGNDWEILGVHQLILK
MLTVHNASINLSTIGLKALDLLLTSGKITLLILDEESDIFLLIFDAMRTFSANDEVQKLG
CKALHVLFERVSEEQLTEFVENKDYMILLNALKHFKDEEEIVLHVLHCLHSLAIPCNNVE
VLMSGNVRCYNIVVEAMKAFPTNEKIQEVSCCLLHRLTLGNFFNILVLNDIHEFVVKAVQ
QYSQNAALQISALSCLALLTETIFLNQDLEEKNENKENEDEEEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHKKIGDEDGQFPAHREVILSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKQIHSPEVAESGCKMLNHLFEGSNTSLDTM
AAVVPKIITVMKSHDTSLSVQLEALRAILHFLVLGMPEESREDAEFQRKLNMAKKQCFRN
DIHKLVLVALNRFIGNPGIQKCGLKVLSSIAHFPDALEILSPEGAIDSVLHTLQMYPDDQ
EIQCLGLSLIGCLITKKLCIETGHLLAKILVSSLQRFKDVAEVQTEGFQTTLAILELSIS
FSKLLVHYSFDSVIFHQMSSSIMELKDQQFLNLCCKCFAKLAMDNELKNMMLEAACDQNN
SIMVECLLLLGADVNQAKEATSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIRK
GDSQIISLLLRRLALDLANNSICLGGFCIGKIEPSWLGPLFPDKTSNLRKQTNKGSILAR
MVLRYQMKSAVEEGAASGSDGNFSVDVLDKFGEWTFVPDSSVDSVFGQSDDLDSEGSEGS
FLVKKKSNSISVGEFYHDPALQRCSPNLQRHSNSLGPILDHEDLPRRKRKIFFSDDSLRS
SKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQRCCISGHLEHLEKLELHQN
ALTSFPQQLCETLKCLTHLDLHSNKFTSFPSYLLKMNCIANLDVSRNDIGPSVVLDPAVK
CSTLKQFSLSYNQLSSVPENLADVVEKLEQLILEGNKISGTCSPLSLKELKILNLSKNHI
SSLSENFLEACPKVESFSARMNFLAAVPLLPASITCLKLSQNKFTCIPEAILNLPHLRTL
DMSNNNIQYLPAPTHWKSLNLRELLFSYNQISILDLSEKACAWSRVEKLHLSHNKLKEIP
PEIGCLENLTSFDVSHNLELRFFPNEMGKLSKIWDLPLDELHLNFDFKHIGYKAKDIIRF
LQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDIGIQSATVGIDVKDWPIQIR
GKRKKDLILNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKAR
ASSSPVILVGTHLDISDEKARKACVSKITKELLNKRGFPAIRDYHFVNATEESDALAKLR
KTIVNESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKQLLQLVKEHQ
LQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGCLKH
PKGIISRRDVEKFLSKKRRFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIE
LPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRTYWRQGIYLN
WSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDIC
GEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDEPRLTIPISQIAPDLIL
ADLPRNIMLNNDELEFEQSPEFLLGDGSFGSVYRAVYEGEEVAVKIFNKHTSLRLLRQEL
VVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDTASLTRTLQHRIALHVADG
LRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAP
EVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELAIQGKLPDPVKEYGC
TPWPMVEKLIKKCLKENPQERPTSAQVFDILNSADLICLMRHILIPKNVTVECMVATNPN
SKSASIWLGCGHPDKGQLSFLDLNTEAHTSEEVIDSRILCLALVHLPVEKESWIVSGTQS
GALLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGSLAIFEDRTVK
CKGAAPLKILNIGDVSTPLMCLSESMNSTEKNIMWGGCGTKIFSFSSDFTIQKLIETRTN
QLFSYTAFSDSNIIAVVVDAALYIAKKNSPVVEVWDKKTEKLCELIDCVHFLKEVMIKIN
KESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLFDLSTRRVIRIIYNFCDSVRVMMTA
QLGNLKNVMLVLGYNWKSTEGTQHQKEIQSCLSVWDINLPHEVQNLEKHIEVRRELAEKM
RKNIC
NT seq
7578 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagctgtcagggctgcgaggaggacgaggagagtctgaagaagttgata
gtcaggctgaacaatgtccaggaaggaaaacagatagacacgctggtccagatcctggag
gacatgctggtgttcacatacgccgagcacgctgccaagttatttcaagacaaaaacgtt
cacgtgccactgttgatcgtcctggactcgtatatgagagtcgcgagtgtgcagcaggtg
ggttggtcatttctgtgcaaattaatagaaatctgtccagatacaatgcaaagcttagtg
ggaccccaggatattggaaatgattgggaaatccttggtgttcaccaactgattcttaaa
atgctaacagttcataatgccagtataaacctgtcaacaattggactgaaggccttagat
ctcctcctaacttcaggtaaaatcactttgctgatattggatgaagaaagcgatatcttc
ctattaattttcgatgccatgcgcacattttcagccaatgatgaagtccagaaacttgga
tgcaaagctttacatgtgctgtttgagagagtttcagaagagcagctgactgaatttgta
gagaacaaagattatatgatattgctaaatgcattgaaacattttaaagatgaagaggaa
attgtgcttcatgttctgcactgtttacattccctagcaattccttgcaataatgttgaa
gtccttatgagtggcaacgtcaggtgttataatattgtggtggaagccatgaaagcattc
cctaccaatgaaaaaattcaagaagtgagttgctgcttgctccataggcttacattaggt
aacttttttaatatcctggtattaaacgacatacatgagtttgtggtgaaggccgtgcag
caatattcacagaatgcagcattacaaatctcagcactcagctgtttagcgctcctcact
gagaccatatttttaaatcaagacttagaggaaaagaatgagaataaggagaatgaggat
gaggaggaagaagataagttgttttggctggaagcttgttacaaagcattaacttggcat
agaaagaacaagcatgtgcaggaggccgcgtgctgggcattaaataatctccttatgtac
caaaacagtttacacaagaagattggagatgaagatggccagttcccagctcacagggag
gtgattctgtccatgctgatgcattcttcatcaaaagaagtcttccaggcatctgcaaat
gccttgtcaactctcttagaacaaaatgttaatttcagaaaaatcctgttgtcaaaggga
atatacctcaatgttttggagttaatgcagaagcaaatacattctcctgaagtggctgaa
agtggctgtaaaatgctaaatcacctttttgaaggaagtaacacttccctggatacaatg
gcagcagtggtccccaaaataataacagttatgaaaagtcacgacacatcattatcagtg
cagctggaggcacttcgagctattttacattttttggtattaggcatgccagaagaatcc
agggaggatgctgaatttcaacgcaagctaaatatggctaaaaaacaatgtttcaggaat
gatattcacaaattggtcctagtggctttgaacaggtttattggaaatcctgggattcag
aagtgtggattaaaagtactttcttctatagcacattttcctgatgcattagagatatta
tccccggaaggtgctattgactcagtgcttcacacactgcagatgtatccagatgaccaa
gaaattcagtgtctgggtttaagtctcataggatgcttgattacaaagaagttatgcata
gaaactggacatctgctggcaaaaattttggtttccagcttacaacgttttaaagatgtt
gccgaagtacagactgaaggatttcagacaaccttagcaatacttgaattgtccatatct
ttttctaagctgctggtgcattattcatttgactcagtaatattccatcagatgtcttcc
agtatcatggaactaaaggatcaacagtttctaaacctctgttgcaagtgctttgcaaaa
ttagctatggacaatgaattaaaaaacatgatgctagaggcagcttgtgatcagaataat
agtatcatggttgaatgcttgcttctcttgggagctgatgtcaatcaagcaaaggaggca
acttctttaatttgccaggtatgtgagaaagagagcagtcccaaattggtggaactgtta
ctgaatagtgggtcccgtgaacaagatgtacggaaagcactgacaataagcattaggaaa
ggtgacagccaaatcatcagtttactcttaaggagacttgccctggatctggccaataat
agcatttgccttggaggattttgtataggaaaaatcgaaccttcttggcttggcccttta
tttccagataagacatctaatttaaggaaacagacaaataaaggatctatactagcaaga
atggtgctcagatatcagatgaaaagtgctgtggaagaaggagcagcctcaggcagtgat
gggaatttttctgtagatgtacttgataaatttggtgaatggacctttgttcctgactct
tctgtggacagcgtgttcggtcaaagtgatgatctggatagtgaaggaagtgaaggctca
tttcttgtgaaaaagaaatcaaattcaattagtgtaggagaattttaccacgatcctgct
ttgcagcgttgctcaccaaatttgcaaaggcattccaattcattggggcccattttggat
catgaagatttaccgaggaggaaaagaaaaatatttttttcagatgattcactcaggtca
tcaaaacttcaatcccatatgaggcattcagacagcatttcttccctggcttctgagaga
gaatatattacatcattagacctttcagcaaatgaactaagagacattgatgccctaagc
cagagatgctgcataagtggtcatctggagcatcttgaaaagctggagcttcaccagaat
gcactcacgagctttcctcaacagctatgtgaaactctgaagtgtttgacacacttggac
ttgcacagtaataaatttacatcatttccctcctacttgttgaaaatgaactgtattgcc
aatcttgatgtttctcgaaatgacattggaccctcagtagttttagatcctgcagtgaaa
tgttcaaccctgaaacagttcagcctgtcatataaccagctgtcttctgttcctgagaac
ctcgctgatgtggtagagaaattggaacagctcattttagaaggaaataaaatatcaggg
acatgttcccccttgagcctgaaggaactgaagattttaaaccttagtaaaaatcatatt
tcatccctatcagagaactttcttgaggcttgtcctaaagtggagagtttcagtgccaga
atgaattttcttgctgctgtgcctcttttgcctgcttccataacatgcctaaaattatct
cagaacaaatttacatgtattccagaagcaattttaaatctcccacacttgcggacttta
gatatgagcaacaataatattcaatatctgccagctcctacacactggaaatctttgaac
ttaagagaactcttatttagctataatcagatcagtatcttggacttgagtgaaaaagca
tgtgcatggtctagagtagagaaactacacctttctcataataaactgaaggagattcct
cctgagattggctgtcttgaaaatctgacatcttttgatgttagccacaacttggaactg
agattctttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttggatgaa
ctgcatctaaattttgattttaaacatataggatataaagccaaagacatcataaggttt
cttcaacagcggttaaaaaaggccgtgccttataaccgaatgaaacttatgattgtggga
aacactgggagtggtaaaaccaccttattgcagcaattaatgaaaaccaagaaatcagac
attggcatacaaagtgccacagttggcatagatgtgaaagactggcctatccaaataaga
ggcaaaaggaagaaagacctcattctgaatgtgtgggattttgcaggccgtgaggaattc
tatagtactcatccccactttatgacccagcgagcactgtacctggctgtctatgacctc
agcaaaggacaagctgaggttgatgccatgaagccttggctcttcaatataaaggcccgt
gcttcctcttcccctgtgattctcgtcggcacacatttggatatttctgatgagaaggcg
cgcaaagcctgcgtaagtaaaatcaccaaggagctcttgaataagcgagggttccctgca
atacgagattaccactttgtgaatgccacagaggaatccgatgctttggcgaaacttcgg
aaaaccatcgtaaatgagagccttaatttcaagatccgagatcagcctgttgttgggcag
ctgattccagactgctatgtggagcttgagaaaatcattttatcagaacgcaaaaatgtg
ccaattgaatttcctgtcattgaccggaaacagttattgcaactagtgaaagagcatcag
cttcaattagatgaaaatgagctccctcatgcggttcacttcctaaatgaatcaggagtc
cttcttcattttcaagacccagcactacaattgagtgacttatatttcgtggaacccaag
tggctttgcaaagtcatggcacagattttgacagtgaaagtggaaggctgtctgaaacat
cctaagggaattatttcacgtagagatgtggaaaaatttctttcaaagaaaaggagattt
ccaaagaactacatgtcacagtactttaaactcctagaaaaattccagattgccttgcca
ataggagaagaatatttactagttccaagcagtttgtctgaccacaggcctgtgatagag
cttccccattgtgagaattctgaaattatcattcgactatacgaaatgccttattttcca
atgggattttggtcaagattaatcaatcgattacttgaaatttcaccttacatgctttca
ggaagagaacgagcacttcgcccaaacagaacgtattggcgacaaggcatctacttaaat
tggtctcctgaagcttactgtttggttggatctgaagtcctggacaatcacccagagagt
ttcttaaaaattacagttccttcttgtagaaaaggctgtattcttctgggccaagttgtg
gaccacattgattctctcatggaagaatggtttcctgggctgctggagattgatatttgt
ggagaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgaagag
caccaaaaaattttacttgatgacttgatgaagaaagcagaagaaggagaccttctagta
aatccagatgaaccaaggctcaccattccgatatctcagattgcacctgacttgatcttg
gctgacctccctagaaatattatgttgaataatgatgagttggaattcgagcagtctccc
gagtttctcttaggtgatggcagttttgggtcagtttatcgagcagtctatgaaggagaa
gaagtggcggtgaagatttttaataaacatacatcacttaggctgttaagacaagagctg
gtagtgctttgccacctccaccatcccagcttaatatctttgctggcggctgggattcgt
cctcgaatgttagtgatggagttagcctccaagggctctttggatcgcctgcttcagcag
gacacagccagcctcaccagaaccctacagcacaggatcgcactacatgtggctgatggc
ttgagatacctccactcagccatgattatataccgtgacttgaagccccacaatgtactg
ctttttaccctgtatcccaatgctgccatcattgccaagattgctgactacggaattgca
cagtactgctgtagaatggggataaaaacgtcagagggcacaccagggtttcgtgcacct
gaagttgccagaggaaatgttatttataaccaacaggctgatgtttattcatttggttta
ctactctatgacattttgacaactggaggaagaatagtagagggtttgaagtttccaaat
gagtttgatgaattagcaatacaaggaaaattacctgatccagttaaagaatatggttgt
accccatggcccatggttgagaagttaattaaaaagtgtttgaaagaaaatcctcaagaa
aggcctacttctgctcaggtctttgacattttgaattcagctgacttaatctgtctgatg
agacacattttaatacctaaaaacgttactgttgaatgcatggttgctacaaatcctaac
agcaagagtgcaagcatttggctgggctgtggacatcctgacaaaggacagctctcattt
ctcgacttaaatactgaagcacacacttctgaggaagttattgatagtagaatattgtgc
ttagccttggtgcatcttcctgttgaaaaggaaagctggatcgtgtctgggacacagtct
ggtgctctcctggtcatcaatactgaagatgggaaaaagagacatacccttgaaaagatg
accgattctgttacttgtctgtattgcaattccttttccaagcaaagcaagcaaaaaaat
ttccttttggtgggaactgctgatggcagcttagcgatttttgaagacagaactgttaag
tgtaaaggagctgctcctttgaagatactaaatataggagatgtcagcacgccactgatg
tgtttgagtgaatccatgaattcaactgaaaaaaatataatgtggggaggatgtggcacg
aagattttctcattttctagtgatttcaccattcagaaactcattgagacaaggacaaat
cagctgttttcttatacagctttcagcgattccaacatcatagcagtggtggtagacgcg
gctctctatattgctaagaaaaatagtcctgttgtggaagtgtgggataagaaaactgaa
aaactctgcgagctgatagactgtgtgcactttttaaaggaggtaatgataaagataaac
aaggaatcaaaacacaaaatgtcttattctgggagagtgaaaactctctgccttcagaag
aacacggctctctggatagggactggaggaggccatattttactctttgatctttcaact
cgtcgagttatacgtataatttacaacttttgtgattcggttagagtcatgatgacagca
cagttaggcaaccttaaaaatgtgatgctggttttggggtacaactggaaaagtactgaa
ggtacacaacaccaaaaagagatacaatcttgcttatctgtttgggacatcaatcttcca
catgaagtgcaaaatttagaaaaacacattgaagtgagaagagaattagctgaaaaaatg
agaaaaaatatctgttga
DBGET
integrated database retrieval system
