KEGG   Galeopterus variegatus (Sunda flying lemur): 103586228
Entry
103586228         CDS       T08727                                 
Symbol
PLCB3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
gvr  Galeopterus variegatus (Sunda flying lemur)
Pathway
gvr00562  Inositol phosphate metabolism
gvr01100  Metabolic pathways
gvr04015  Rap1 signaling pathway
gvr04020  Calcium signaling pathway
gvr04022  cGMP-PKG signaling pathway
gvr04062  Chemokine signaling pathway
gvr04070  Phosphatidylinositol signaling system
gvr04071  Sphingolipid signaling pathway
gvr04072  Phospholipase D signaling pathway
gvr04081  Hormone signaling
gvr04082  Neuroactive ligand signaling
gvr04261  Adrenergic signaling in cardiomyocytes
gvr04270  Vascular smooth muscle contraction
gvr04310  Wnt signaling pathway
gvr04371  Apelin signaling pathway
gvr04540  Gap junction
gvr04611  Platelet activation
gvr04613  Neutrophil extracellular trap formation
gvr04621  NOD-like receptor signaling pathway
gvr04713  Circadian entrainment
gvr04720  Long-term potentiation
gvr04723  Retrograde endocannabinoid signaling
gvr04724  Glutamatergic synapse
gvr04725  Cholinergic synapse
gvr04726  Serotonergic synapse
gvr04728  Dopaminergic synapse
gvr04730  Long-term depression
gvr04742  Taste transduction
gvr04750  Inflammatory mediator regulation of TRP channels
gvr04911  Insulin secretion
gvr04912  GnRH signaling pathway
gvr04915  Estrogen signaling pathway
gvr04916  Melanogenesis
gvr04918  Thyroid hormone synthesis
gvr04919  Thyroid hormone signaling pathway
gvr04921  Oxytocin signaling pathway
gvr04922  Glucagon signaling pathway
gvr04924  Renin secretion
gvr04925  Aldosterone synthesis and secretion
gvr04926  Relaxin signaling pathway
gvr04927  Cortisol synthesis and secretion
gvr04928  Parathyroid hormone synthesis, secretion and action
gvr04929  GnRH secretion
gvr04933  AGE-RAGE signaling pathway in diabetic complications
gvr04934  Cushing syndrome
gvr04935  Growth hormone synthesis, secretion and action
gvr04961  Endocrine and other factor-regulated calcium reabsorption
gvr04970  Salivary secretion
gvr04971  Gastric acid secretion
gvr04972  Pancreatic secretion
gvr04973  Carbohydrate digestion and absorption
gvr05010  Alzheimer disease
gvr05016  Huntington disease
gvr05017  Spinocerebellar ataxia
gvr05022  Pathways of neurodegeneration - multiple diseases
gvr05142  Chagas disease
gvr05143  African trypanosomiasis
gvr05146  Amoebiasis
gvr05163  Human cytomegalovirus infection
gvr05200  Pathways in cancer
gvr05415  Diabetic cardiomyopathy
gvr05417  Lipid and atherosclerosis
Module
gvr_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:gvr00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    103586228 (PLCB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    103586228 (PLCB3)
   04310 Wnt signaling pathway
    103586228 (PLCB3)
   04371 Apelin signaling pathway
    103586228 (PLCB3)
   04020 Calcium signaling pathway
    103586228 (PLCB3)
   04070 Phosphatidylinositol signaling system
    103586228 (PLCB3)
   04072 Phospholipase D signaling pathway
    103586228 (PLCB3)
   04071 Sphingolipid signaling pathway
    103586228 (PLCB3)
   04022 cGMP-PKG signaling pathway
    103586228 (PLCB3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    103586228 (PLCB3)
   04081 Hormone signaling
    103586228 (PLCB3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    103586228 (PLCB3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103586228 (PLCB3)
   04613 Neutrophil extracellular trap formation
    103586228 (PLCB3)
   04621 NOD-like receptor signaling pathway
    103586228 (PLCB3)
   04062 Chemokine signaling pathway
    103586228 (PLCB3)
  09152 Endocrine system
   04911 Insulin secretion
    103586228 (PLCB3)
   04922 Glucagon signaling pathway
    103586228 (PLCB3)
   04929 GnRH secretion
    103586228 (PLCB3)
   04912 GnRH signaling pathway
    103586228 (PLCB3)
   04915 Estrogen signaling pathway
    103586228 (PLCB3)
   04921 Oxytocin signaling pathway
    103586228 (PLCB3)
   04926 Relaxin signaling pathway
    103586228 (PLCB3)
   04935 Growth hormone synthesis, secretion and action
    103586228 (PLCB3)
   04918 Thyroid hormone synthesis
    103586228 (PLCB3)
   04919 Thyroid hormone signaling pathway
    103586228 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    103586228 (PLCB3)
   04916 Melanogenesis
    103586228 (PLCB3)
   04924 Renin secretion
    103586228 (PLCB3)
   04925 Aldosterone synthesis and secretion
    103586228 (PLCB3)
   04927 Cortisol synthesis and secretion
    103586228 (PLCB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    103586228 (PLCB3)
   04270 Vascular smooth muscle contraction
    103586228 (PLCB3)
  09154 Digestive system
   04970 Salivary secretion
    103586228 (PLCB3)
   04971 Gastric acid secretion
    103586228 (PLCB3)
   04972 Pancreatic secretion
    103586228 (PLCB3)
   04973 Carbohydrate digestion and absorption
    103586228 (PLCB3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    103586228 (PLCB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    103586228 (PLCB3)
   04725 Cholinergic synapse
    103586228 (PLCB3)
   04728 Dopaminergic synapse
    103586228 (PLCB3)
   04726 Serotonergic synapse
    103586228 (PLCB3)
   04720 Long-term potentiation
    103586228 (PLCB3)
   04730 Long-term depression
    103586228 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    103586228 (PLCB3)
  09157 Sensory system
   04742 Taste transduction
    103586228 (PLCB3)
   04750 Inflammatory mediator regulation of TRP channels
    103586228 (PLCB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    103586228 (PLCB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103586228 (PLCB3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    103586228 (PLCB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    103586228 (PLCB3)
   05142 Chagas disease
    103586228 (PLCB3)
   05143 African trypanosomiasis
    103586228 (PLCB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103586228 (PLCB3)
   05016 Huntington disease
    103586228 (PLCB3)
   05017 Spinocerebellar ataxia
    103586228 (PLCB3)
   05022 Pathways of neurodegeneration - multiple diseases
    103586228 (PLCB3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103586228 (PLCB3)
   05415 Diabetic cardiomyopathy
    103586228 (PLCB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    103586228 (PLCB3)
   04934 Cushing syndrome
    103586228 (PLCB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:gvr04131]
    103586228 (PLCB3)
Enzymes [BR:gvr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     103586228 (PLCB3)
Membrane trafficking [BR:gvr04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    103586228 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    103586228 (PLCB3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PI-PLC-Y PH_14 PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 103586228
NCBI-ProteinID: XP_008565677
LinkDB
Position
Unknown
AA seq 1375 aa
MWEWKGVGTACGAGIRKGLAGFFRADQHVDRAPGDGGVRKQGRSCPGPQTPYSAGSHAPP
RKKPRTLASPLGNLNGLTPALLKQWPLHPIPPAVPPISPPKPQAPYTHLGPEELSPAESP
SNASHSSRCSGPHLRLRIPVLRPTHVSHRPPLPRAPPSPGPPPGLHELPRCFFPEASSRN
LVTLRVDPNGFFLYWTGPNMEVDTLDISSIRDTRMGRYARLPKDPKIREVLGFGGPDARL
EEKLMTVVAGPDPVNTTFLNFMAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTK
LKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNK
LCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKY
EPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAG
QLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAET
AFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIDPLDKYPLAPGIPLPSPQDL
MGRILVKNKKRHRPSAGVPGSSVRKRPLEQSNSVLSESSAATEPSSPQLGSPSSDSCPGL
SNGEEAGLEKPSLEPRKSLGEEGPNRGPDALGPADREDEEEDEEEEEQTDPKKPTTDEGT
ASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEY
NKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYL
LKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTR
RKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSG
YHYVCLRNEANQPLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAAL
IGESEAQAGPETCQESQSQQLGTQLSLNPTPSPLDTSPRRPPGPATTPTSTSLSSPGQRD
DLIASILSEVAPTPLDELRGHKALVKLRSRQERDLRELCKKHQRKAVTLTRRLLDGLAQA
RAEGRCRHQPGVLGGATDVEDMKEEEEEVKRYQEFQNRQVQSLLELREAQADTEAERRLE
HLKQAQQRLREIVLESQAAQCKRLKEMNEREKKELQKILDRKRHNSISEAKTREKHKKEA
ELTEINRRHITESVNSIRRLEEAQKQRHDRLMAGQQQVLQQLAEEEPKLLAQLVQECQEQ
RARLPQEIRQSLLGEMPEGLGDGPMVACASNGHAPGSSGHLSGADSESQEENTQL
NT seq 4128 nt   +upstreamnt  +downstreamnt
atgtgggagtggaagggagtgggcactgcgtgcggggcggggatccgcaaggggctagcg
ggcttctttcgcgcggaccagcacgtggaccgagctcccggggatggaggagtgagaaag
cagggcaggagctgcccgggtccccagacgccctactcggcggggtcccacgccccccca
cggaagaagccacgtaccctggcctcccctctgggaaacctcaacgggctgaccccggcc
cttcttaagcagtggcctctacatccgatccctccagccgtacccccaattagcccccct
aagccccaagcgccctacacccacctcgggcccgaagaattaagtcctgctgagtccccc
agcaacgcctcccactcgtccagatgttcgggcccccacctgcggctccgcatcccagtc
ctgcgccccacccacgtttcacaccgcccccctctgccccgggcccctccttccccaggg
cctccacccggcctgcacgagcttcctcgctgcttcttcccagaggcctccagtcgtaac
ctggtgaccctgcgagtggaccccaacggcttcttcttgtactggacaggacctaacatg
gaggtggacacacttgacatcagttctatcagggacacacggatgggccgttatgcccgc
ctgcccaaggaccctaagatccgggaagtgctgggttttgggggccccgatgcccggctg
gaggagaagctgatgacggtggtagctgggcccgacccagtgaacacaacatttttgaac
ttcatggcggtgcaggatgacacagccaaggtctggtctgaggagctgttcaagctggct
atgaacatcctggcccagaatgcctcccggaacaccttcctgcgcaaagcatacacgaag
ctgaagctgcaggtgaaccaggatggacggatcccagtcaagaacatcctgaagatgttt
tcagcagacaagaaacgggtggagaccgcgctggagtcctgtggcctcaatttcaaccgg
agtgagtccattcgtcctgatgagttttccttggaaatcttcgagcggttcctgaacaag
ttgtgtctacggccagacattgacaagatcctgctggagataggtgccaagggcaagccg
tacctgacgctagaacagcttatggacttcatcaaccagaagcaacgggacccgagactc
aacgaagtgctgtacccacccctgaggccctcccaggcccggctgctcattgagaagtac
gagcccaaccagcagttcctggagcgagaccagatgtccatggagggcttcagccgctac
ctgggaggggaagagaatggcatcctgcccctggaagccctggacctgagtgcagacatg
acccagccgctgagtgcctacttcatcaactcctcgcacaacacctatctcacggcgggg
cagctggccgggacctcgtcggtggagatgtaccgccaggcgctgctgtggggctgccgc
tgcgtggagctagacgtgtggaaggggcggccgcccgaggaggagcccttcatcacccat
ggcttcaccatgaccaccgaggtgccccttcgtgacgtgctcgaggccattgcagagacc
gccttcaagacctcgccttaccccgtcatcctctccttcgagaaccacgtggactcggca
aagcagcaggccaagatggccgagtactgccgctccatctttggggacgcgctgctcatc
gaccccctggacaagtacccgctggccccaggcatccccctgcccagcccccaggaccta
atgggccgcatcctggtgaagaacaagaagcggcaccggcccagcgcaggcgtccccggc
agctccgtgcgcaagcggccgctggagcagagcaactcggtgctgagcgagagctccgcc
gccaccgagccctcctccccgcagctcgggtcccccagctctgacagctgcccaggcctg
agcaatggggaggaggcggggctggagaagcccagcctggagcctcgcaagtctctgggt
gaggagggcccaaatcggggtcctgatgctctgggacctgctgaccgtgaggatgaggag
gaagacgaggaagaggaggagcagacagaccccaaaaagccaaccacggatgagggcaca
gccagcagtgaggtcaacgccactgaggagatgtcaacgctcgtcaactacattgagcct
gtcaagttcaagtccttcgaagctgctcgaaagaggaacaagtgctttgagatgtcatcc
ttcgtggagaccaaggccatggagcagctgaccaagagccccatggagtttgtggagtac
aacaagcagcagctcagccgcatctaccccaagggcacccgtgtggactcctccaactac
atgccccagctcttctggaacgtaggctgccagcttgtcgcactcaacttccagaccctg
gatgtggcgatgcagcttaatgcaggcgtgtttgagtacaatgggcgcagtgggtacctg
ctcaagcccgagttcatgcggcggccggacaagtcctttgatcccttcactgaagtcatc
gtggatggcatcgtggcgaatgccttgcgggtcaaggtgatttcggggcagttcctgtct
gacaggaaggtgggaatctacgtggaggtggacatgtttggtctccctgttgacacgcgg
cgcaagtatcgcacacggacctcacaggggaactcgttcaaccccgtgtgggatgaggag
ccctttgacttccccaaggtggtgctacccacgctggcttcgcttcgcattgcggccttt
gaggagggcggcaagtttgtagggcaccggatcctgcctgtctcggccattcgctcaggg
taccactatgtctgcctgcggaatgaggccaaccagcccttgtgcctgccggccctgctc
atctacactgaggcctctgactacatccctgatgaccaccaggactacgccgaggccctg
atcaaccccatcaagcacgtcagcctgatggaccagagggccaggcagctggccgccctc
attggggagagcgaggctcaggcaggcccagagacgtgccaggagagccagtctcagcag
ctggggacccagctatccctaaaccccacacccagcccactggacacctccccccgccgg
cctccaggccctgccaccacccccaccagcacctccctcagcagcccagggcagcgggat
gacctcattgccagcatcctctcagaggtggcccccacccccctggacgagctccgaggc
cacaaggctctggtgaagctccggagccggcaggagcgagacctgcgggagctgtgcaag
aagcaccagcgcaaggcggtcaccctcacccgccgcttgctcgatggcctggcccaggcc
cgggccgagggccgctgccggcaccagccaggtgtcctaggcggggccactgatgtggag
gacatgaaagaggaggaggaagaggtgaagcggtatcaagagttccagaacagacaggtg
cagagtctgctagaactgagagaggcccaggcggacacagaggctgagcggaggctggag
cacctgaaacaggctcagcagcggctcagggagatcgtcctggagtcccaggcagctcag
tgcaagaggctgaaggagatgaatgagagggagaagaaggagctgcagaagatcctggac
aggaagcgccacaacagtatctcggaggccaagacaagggagaaacataagaaggaggca
gaactgacagagattaatcgtcggcacatcaccgagtcggtcaactccatccgtcggctg
gaggaggcccagaagcagcggcacgatcgtctcatggctgggcagcagcaggtcctacag
cagctggcagaagaggaacccaagctgctggcccagctggtccaggagtgtcaggagcag
cgggccaggctgccacaggagatccgtcagagtctgctgggagaaatgccagaggggctg
ggggacgggcccatggtggcctgtgccagcaatggtcacgcgcctgggagcagcgggcac
ctgtctggcgctgactcagagagccaagaggagaacacacagctctga

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