KEGG   Galeopterus variegatus (Sunda flying lemur): 103591505
Entry
103591505         CDS       T08727                                 
Symbol
JAK1
Name
(RefSeq) tyrosine-protein kinase JAK1
  KO
K11217  Janus kinase 1 [EC:2.7.10.2]
Organism
gvr  Galeopterus variegatus (Sunda flying lemur)
Pathway
gvr01521  EGFR tyrosine kinase inhibitor resistance
gvr04151  PI3K-Akt signaling pathway
gvr04217  Necroptosis
gvr04380  Osteoclast differentiation
gvr04550  Signaling pathways regulating pluripotency of stem cells
gvr04620  Toll-like receptor signaling pathway
gvr04621  NOD-like receptor signaling pathway
gvr04630  JAK-STAT signaling pathway
gvr04658  Th1 and Th2 cell differentiation
gvr04659  Th17 cell differentiation
gvr05140  Leishmaniasis
gvr05145  Toxoplasmosis
gvr05152  Tuberculosis
gvr05160  Hepatitis C
gvr05161  Hepatitis B
gvr05162  Measles
gvr05163  Human cytomegalovirus infection
gvr05164  Influenza A
gvr05165  Human papillomavirus infection
gvr05166  Human T-cell leukemia virus 1 infection
gvr05167  Kaposi sarcoma-associated herpesvirus infection
gvr05168  Herpes simplex virus 1 infection
gvr05169  Epstein-Barr virus infection
gvr05171  Coronavirus disease - COVID-19
gvr05200  Pathways in cancer
gvr05203  Viral carcinogenesis
gvr05212  Pancreatic cancer
gvr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:gvr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    103591505 (JAK1)
   04151 PI3K-Akt signaling pathway
    103591505 (JAK1)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    103591505 (JAK1)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    103591505 (JAK1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    103591505 (JAK1)
   04621 NOD-like receptor signaling pathway
    103591505 (JAK1)
   04658 Th1 and Th2 cell differentiation
    103591505 (JAK1)
   04659 Th17 cell differentiation
    103591505 (JAK1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    103591505 (JAK1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103591505 (JAK1)
   05203 Viral carcinogenesis
    103591505 (JAK1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103591505 (JAK1)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    103591505 (JAK1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103591505 (JAK1)
   05161 Hepatitis B
    103591505 (JAK1)
   05160 Hepatitis C
    103591505 (JAK1)
   05171 Coronavirus disease - COVID-19
    103591505 (JAK1)
   05164 Influenza A
    103591505 (JAK1)
   05162 Measles
    103591505 (JAK1)
   05168 Herpes simplex virus 1 infection
    103591505 (JAK1)
   05163 Human cytomegalovirus infection
    103591505 (JAK1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103591505 (JAK1)
   05169 Epstein-Barr virus infection
    103591505 (JAK1)
   05165 Human papillomavirus infection
    103591505 (JAK1)
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    103591505 (JAK1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    103591505 (JAK1)
   05140 Leishmaniasis
    103591505 (JAK1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103591505 (JAK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:gvr01001]
    103591505 (JAK1)
Enzymes [BR:gvr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     103591505 (JAK1)
Protein kinases [BR:gvr01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   103591505 (JAK1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 SH2_1 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1
Other DBs
NCBI-GeneID: 103591505
NCBI-ProteinID: XP_008572204
LinkDB
Position
Unknown
AA seq 1153 aa
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEEL
CIRAAQECHISPLCHNLFALYDENTKLWYAPNRTITIDDKMSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMRKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHSNDSGNVLYYEVMVTGNLGIQWRQKPNVVPVEKEKNKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEVLGGQKQFKNFQIEVQKGHYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLK
RCCQPKPREISNLLVATKKAQEWQPVYPVSQLSFDRILKKDIVQGEHLGRGTRTHIYSGT
LMDYKEDEGTAEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV
ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGYVCTKNLL
LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT
TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI
MRDINKLEEQNPDIVSERKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT
GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS
GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD
FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD
SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYHLMRKCWEFQPFSRTT
FQNLIEGFEALLK
NT seq 3462 nt   +upstreamnt  +downstreamnt
atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg
agctccaagaagaccgaggtgaatctggaggcccctgagccaggagtggaagtgatcttc
tatctgtcagacagggagcccctccgattgggcagtggagagtacacagcagaagaactg
tgcatcagggctgcgcaggaatgccatatctctcctctgtgtcacaacctgtttgccctg
tatgatgagaacaccaagctctggtacgctccgaatcgcaccatcaccattgatgacaaa
atgtcgctccggctccactaccggatgaggttctatttcaccaactggcacgggaccaat
gacaatgagcagtcagtgtggcgacattctccaaagaagcagaaaaatggctatgagaaa
aaaaaggttccagatgcaaccccgctccttgacgctagttcgctggaatatctatttgct
cagggacagtatgacttggtcaaatgcctggctcccattcgagaccccaagactgagcag
gatgggcatgatatcgagaacgagtgtctggggatggctgtcctggccatttcccactat
gccatgatgaggaagatgcagttgccagagcttcccaaggacatcagctacaaacgatat
attccggaaacattgaataagtctatcagacagaggaaccttctcaccaggatgcggata
aataatgttttcaaggatttcctaaaggaatttaacaacaaaaccatttgtgacagcagt
gtgtccacacacgacctgaaggtgaaatacctggctaccttggaaactttgacaaaacat
tatggtgctgaaatatttgagacgtccatgctactgatttcatcagaaaatgagatgaat
tggtttcattcaaatgacagcggaaatgttctctactatgaagtgatggtgactggaaat
cttggaattcagtggaggcaaaaaccaaatgttgttcctgttgaaaaggaaaaaaataaa
ctgaagaggaaaaaactggaaaataaacacaagaaagatgaggagaaaaacaaaatccgg
gaagaatggaacaatttttcttacttccctgaaatcactcacattgtaataaaggagtct
gtggtcagcattaacaagcaggacaacaaaaaaatggaactgaagctctcttcacatgag
gaggccttgtcctttgtgtccctggtagatggctacttccggctcacagcagatgcccat
cattacctctgcactgatgtggctccccccttgatcgtccacaacatacagaacggctgt
catggtccaatctgcacagaatatgccatcaataaattgcggcaagaaggaagcgaggaa
gggatgtacgtgctgaggtggagctgcaccgactttgacaacatcctcatgactgtcacc
tgctttgaaaagtctgaggtactgggtggccagaagcagttcaagaactttcagatcgag
gtgcagaagggccactatagcctgcatggctcggaccgcagcttccctagcctgggagac
ctcatgagccacctcaagaagcaaatcctgcgcacagacaacattagcttcgtgcttaaa
cgctgctgccagcccaagccccgagaaatctccaatttgctggtggctactaaaaaagcc
caggagtggcagcctgtctatccagtgagtcagctgagcttcgatcggatcctcaagaaa
gatattgtacaaggagagcacctcgggagaggcacaagaacacacatctactctgggacc
ctgatggattacaaggaggatgaaggaactgctgaggagaagagaataaaagtgattctc
aaagtcttagacccgagccacagagacatttctctggccttcttcgaggcagccagcatg
atgagacaggtctcccacaaacacatcgtgtacctgtatggtgtctgtgtccgtgatgtg
gagaatatcatggtagaagagtttgtggaggggggacccctggatctcttcatgcaccgg
aaaagcgatgttctcactacaccctggaagttcaaagttgccaaacagctggccagcgcc
ctgagttacttggaggataaagacctggtccatggatacgtgtgtactaagaacctcctc
ctggcccgtgagggcatcgacagcgagtgcggcccattcatcaagctaagtgatcctggc
atccccattaccgtgctgtccaggcaagagtgcatagaacgaatcccatggattgctcct
gagtgtgttgaagactccaagaacctgagtgtggctgctgacaagtggagctttggaacc
acactctgggaaatctgctacaatggcgagatccccctgaaagacaagacactgatagag
aaagagagattctatgaaagccggtgcaggccagtgacaccatcttgcaaggaactggcc
gaccttatgacccgctgcatgaactatgaccccaatcagagacccttcttccgagccatc
atgagagacattaataagcttgaagagcagaatccagacattgtttcagaaagaaagcct
gcaactgaggtggatcccacgcattttgaaaagcgcttcctaaagaggatccgtgacttg
ggagagggccattttgggaaggttgagctctgcagatatgaccccgagggggacaataca
ggggagcaggtggctgtcaaatccctgaagcctgagagtggaggtaaccacatagctgat
ctgaagaaggaaatagaaatcttaaggaacctctatcatgagaacattgtgaagtacaaa
ggaatctgcacagaagatggaggaaacggtattaagctcatcatggaatttctgccttcg
ggaagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcagcta
aaatatgccgttcagatttgtaaggggatggactatttgggttctcggcaatatgttcac
cgggacttggcagcaagaaatgtccttgttgagagtgaacaccaagtgaaaattggagac
tttggtttaaccaaagcaattgaaactgataaggagtactacacagtcaaggacgaccgg
gacagccctgtgttttggtatgctccagaatgtctaattcagtgtaaattctatattgcc
tctgatgtctggtcttttggagtgactctgcatgagctgcttacttactgtgattcagat
tctagtcctatggcattgttcctgaaaatgataggcccaactcatggccagatgacagta
acaagacttgtgaatacattaaaagaaggaaaacgtttgccgtgtccacctaactgtcca
gatgaggtttatcaccttatgagaaaatgctgggaattccaacccttcagtcggacaacc
tttcagaaccttattgaaggatttgaagcacttttaaaataa

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