KEGG   Galeopterus variegatus (Sunda flying lemur): 103596129
Entry
103596129         CDS       T08727                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
gvr  Galeopterus variegatus (Sunda flying lemur)
Pathway
gvr01521  EGFR tyrosine kinase inhibitor resistance
gvr01522  Endocrine resistance
gvr04010  MAPK signaling pathway
gvr04012  ErbB signaling pathway
gvr04014  Ras signaling pathway
gvr04015  Rap1 signaling pathway
gvr04022  cGMP-PKG signaling pathway
gvr04024  cAMP signaling pathway
gvr04062  Chemokine signaling pathway
gvr04066  HIF-1 signaling pathway
gvr04068  FoxO signaling pathway
gvr04071  Sphingolipid signaling pathway
gvr04072  Phospholipase D signaling pathway
gvr04114  Oocyte meiosis
gvr04140  Autophagy - animal
gvr04148  Efferocytosis
gvr04150  mTOR signaling pathway
gvr04151  PI3K-Akt signaling pathway
gvr04210  Apoptosis
gvr04218  Cellular senescence
gvr04270  Vascular smooth muscle contraction
gvr04370  VEGF signaling pathway
gvr04371  Apelin signaling pathway
gvr04380  Osteoclast differentiation
gvr04510  Focal adhesion
gvr04540  Gap junction
gvr04550  Signaling pathways regulating pluripotency of stem cells
gvr04613  Neutrophil extracellular trap formation
gvr04620  Toll-like receptor signaling pathway
gvr04650  Natural killer cell mediated cytotoxicity
gvr04660  T cell receptor signaling pathway
gvr04662  B cell receptor signaling pathway
gvr04664  Fc epsilon RI signaling pathway
gvr04666  Fc gamma R-mediated phagocytosis
gvr04668  TNF signaling pathway
gvr04720  Long-term potentiation
gvr04722  Neurotrophin signaling pathway
gvr04725  Cholinergic synapse
gvr04726  Serotonergic synapse
gvr04730  Long-term depression
gvr04810  Regulation of actin cytoskeleton
gvr04910  Insulin signaling pathway
gvr04912  GnRH signaling pathway
gvr04914  Progesterone-mediated oocyte maturation
gvr04915  Estrogen signaling pathway
gvr04916  Melanogenesis
gvr04917  Prolactin signaling pathway
gvr04919  Thyroid hormone signaling pathway
gvr04921  Oxytocin signaling pathway
gvr04926  Relaxin signaling pathway
gvr04928  Parathyroid hormone synthesis, secretion and action
gvr04929  GnRH secretion
gvr04934  Cushing syndrome
gvr04935  Growth hormone synthesis, secretion and action
gvr05010  Alzheimer disease
gvr05022  Pathways of neurodegeneration - multiple diseases
gvr05034  Alcoholism
gvr05132  Salmonella infection
gvr05135  Yersinia infection
gvr05160  Hepatitis C
gvr05161  Hepatitis B
gvr05163  Human cytomegalovirus infection
gvr05164  Influenza A
gvr05165  Human papillomavirus infection
gvr05166  Human T-cell leukemia virus 1 infection
gvr05167  Kaposi sarcoma-associated herpesvirus infection
gvr05170  Human immunodeficiency virus 1 infection
gvr05200  Pathways in cancer
gvr05205  Proteoglycans in cancer
gvr05206  MicroRNAs in cancer
gvr05207  Chemical carcinogenesis - receptor activation
gvr05208  Chemical carcinogenesis - reactive oxygen species
gvr05210  Colorectal cancer
gvr05211  Renal cell carcinoma
gvr05212  Pancreatic cancer
gvr05213  Endometrial cancer
gvr05214  Glioma
gvr05215  Prostate cancer
gvr05216  Thyroid cancer
gvr05218  Melanoma
gvr05219  Bladder cancer
gvr05220  Chronic myeloid leukemia
gvr05221  Acute myeloid leukemia
gvr05223  Non-small cell lung cancer
gvr05224  Breast cancer
gvr05225  Hepatocellular carcinoma
gvr05226  Gastric cancer
gvr05230  Central carbon metabolism in cancer
gvr05231  Choline metabolism in cancer
gvr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:gvr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103596129 (MAP2K1)
   04012 ErbB signaling pathway
    103596129 (MAP2K1)
   04014 Ras signaling pathway
    103596129 (MAP2K1)
   04015 Rap1 signaling pathway
    103596129 (MAP2K1)
   04370 VEGF signaling pathway
    103596129 (MAP2K1)
   04371 Apelin signaling pathway
    103596129 (MAP2K1)
   04668 TNF signaling pathway
    103596129 (MAP2K1)
   04066 HIF-1 signaling pathway
    103596129 (MAP2K1)
   04068 FoxO signaling pathway
    103596129 (MAP2K1)
   04072 Phospholipase D signaling pathway
    103596129 (MAP2K1)
   04071 Sphingolipid signaling pathway
    103596129 (MAP2K1)
   04024 cAMP signaling pathway
    103596129 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    103596129 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    103596129 (MAP2K1)
   04150 mTOR signaling pathway
    103596129 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103596129 (MAP2K1)
   04148 Efferocytosis
    103596129 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    103596129 (MAP2K1)
   04210 Apoptosis
    103596129 (MAP2K1)
   04218 Cellular senescence
    103596129 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103596129 (MAP2K1)
   04540 Gap junction
    103596129 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    103596129 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103596129 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    103596129 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    103596129 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    103596129 (MAP2K1)
   04660 T cell receptor signaling pathway
    103596129 (MAP2K1)
   04662 B cell receptor signaling pathway
    103596129 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    103596129 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    103596129 (MAP2K1)
   04062 Chemokine signaling pathway
    103596129 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103596129 (MAP2K1)
   04929 GnRH secretion
    103596129 (MAP2K1)
   04912 GnRH signaling pathway
    103596129 (MAP2K1)
   04915 Estrogen signaling pathway
    103596129 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    103596129 (MAP2K1)
   04917 Prolactin signaling pathway
    103596129 (MAP2K1)
   04921 Oxytocin signaling pathway
    103596129 (MAP2K1)
   04926 Relaxin signaling pathway
    103596129 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    103596129 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    103596129 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    103596129 (MAP2K1)
   04916 Melanogenesis
    103596129 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    103596129 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    103596129 (MAP2K1)
   04726 Serotonergic synapse
    103596129 (MAP2K1)
   04720 Long-term potentiation
    103596129 (MAP2K1)
   04730 Long-term depression
    103596129 (MAP2K1)
   04722 Neurotrophin signaling pathway
    103596129 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    103596129 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103596129 (MAP2K1)
   05206 MicroRNAs in cancer
    103596129 (MAP2K1)
   05205 Proteoglycans in cancer
    103596129 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    103596129 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    103596129 (MAP2K1)
   05230 Central carbon metabolism in cancer
    103596129 (MAP2K1)
   05231 Choline metabolism in cancer
    103596129 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103596129 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103596129 (MAP2K1)
   05212 Pancreatic cancer
    103596129 (MAP2K1)
   05225 Hepatocellular carcinoma
    103596129 (MAP2K1)
   05226 Gastric cancer
    103596129 (MAP2K1)
   05214 Glioma
    103596129 (MAP2K1)
   05216 Thyroid cancer
    103596129 (MAP2K1)
   05221 Acute myeloid leukemia
    103596129 (MAP2K1)
   05220 Chronic myeloid leukemia
    103596129 (MAP2K1)
   05218 Melanoma
    103596129 (MAP2K1)
   05211 Renal cell carcinoma
    103596129 (MAP2K1)
   05219 Bladder cancer
    103596129 (MAP2K1)
   05215 Prostate cancer
    103596129 (MAP2K1)
   05213 Endometrial cancer
    103596129 (MAP2K1)
   05224 Breast cancer
    103596129 (MAP2K1)
   05223 Non-small cell lung cancer
    103596129 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    103596129 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    103596129 (MAP2K1)
   05161 Hepatitis B
    103596129 (MAP2K1)
   05160 Hepatitis C
    103596129 (MAP2K1)
   05164 Influenza A
    103596129 (MAP2K1)
   05163 Human cytomegalovirus infection
    103596129 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    103596129 (MAP2K1)
   05165 Human papillomavirus infection
    103596129 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    103596129 (MAP2K1)
   05135 Yersinia infection
    103596129 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103596129 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    103596129 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    103596129 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    103596129 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103596129 (MAP2K1)
   01522 Endocrine resistance
    103596129 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:gvr01001]
    103596129 (MAP2K1)
Enzymes [BR:gvr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     103596129 (MAP2K1)
Protein kinases [BR:gvr01001]
 Serine/threonine kinases: STE group
  STE7 family
   103596129 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 103596129
NCBI-ProteinID: XP_008577925
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSAY
GMDSRPPMAIFELLDYIVNEPPPKLPNGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGI
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccctgacggctccgcggtt
aacgggaccagttcggcggagaccaacctggaggccttgcagaagaagctggaggagctg
gagcttgatgaacagcagcggaagcgccttgaggcctttcttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggtgctggcaatggtggt
gtggtgttcaaggtctcccacaaaccatctggcctggtaatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcataagggagctgcaggttctacatgag
tgtaactccccatatattgtgggcttctatggtgcattctacagtgatggagagatcagc
atctgcatggagcacatggatgggggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatttg
agggagaagcacaagattatgcacagagatgttaagccctccaacatcctagtcaactcc
cgtggggagatcaagctctgtgactttggtgtcagtggacagctcatcgactccatggcc
aactcctttgtgggaacaaggtcctacatgtcgccagaaagactccaggggactcattac
tctgtgcagtcggacatctggagcatggggctctctctggtggagatggcggttgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggaa
ggagatgcggctgagacaccacccaggccaaggacccccgggaggccccttagtgcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatcgtcaatgag
cctcctccaaaactgcccaatggagtattcagtctagaatttcaagattttgtgaataaa
tgcttaataaaaaaccctgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcctagcacaccaacccacgcagctggcatctaa

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