Geobacillus sp. WCH70: GWCH70_0204
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Entry
GWCH70_0204 CDS
T00915
Name
(GenBank) UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate/D-alanyl-D-alanyl ligase
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
gwc
Geobacillus sp. WCH70
Pathway
gwc00300
Lysine biosynthesis
gwc00550
Peptidoglycan biosynthesis
gwc01100
Metabolic pathways
gwc01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
gwc00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
GWCH70_0204
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
GWCH70_0204
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
GWCH70_0204
Enzymes [BR:
gwc01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
GWCH70_0204
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Mur_ligase
DUF2997
Motif
Other DBs
NCBI-ProteinID:
ACS23135
UniProt:
C5D4C7
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Position
222459..223850
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AA seq
463 aa
AA seq
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MKVKEMITRTLRDIQSMVDGRGLANEFFDITVYGVSTDTRTIQQGNLYVPLKGAKFNGHA
FVQDAIDKGASAVLWAETEGTPPKDVPVIIVDDTLRALQRLAHRYRKQLSVKVIGITGSN
GKTTTKDMIAALLATTYKVQKTEGNLNNHIGVPLTLLRLEEDTEMAVVEMGMSNFGEIEL
LSNIAEPDAAVITNIGESHLQELGSREGIAQAKLEILSGLKKNGLFVYHGDEPLLVNRVP
DLPLPEHVLRFGQGSDNDYYPKAVHVQANGTTFTVHQAPNRSFFLPILGKHHVYNALAAI
AVARFFHVSWEKIQEAFSQLQVTRMRMELIETKKGWTIINDAYNANPTSMKAALQLLHEL
TGYEKKIAVLGDMLELGDQEVEFHREIGAMLRPEMVDYVFTYGALARHIALAAQPFFPDG
RVKAYEDKQSLAKDLLAVVSSGDVILLKASRGMKLEELLPDLQ
NT seq
1392 nt
NT seq
+upstream
nt +downstream
nt
atgaaggtgaaagaaatgatcactcgtacattgcgcgatatacagtcgatggtggacggc
cgcgggttggcgaacgagtttttcgacatcacggtttacggggtttcgaccgatacgcga
acgattcaacaaggcaatttgtatgttccattaaaaggagctaagtttaacggccatgcg
tttgttcaagatgcgatcgataaaggggcgagcgctgtgctttgggcggaaacggaagga
accccgccgaaagacgtgccagtgattatcgtggacgacacgttgcgcgcgctccagcgt
cttgcacatcgatatcgcaagcagctttcggtaaaagtcatcggcattacgggaagcaat
ggcaaaacgacgacaaaggatatgatagcagcactattagcaacaacatataaagtacaa
aagacggaaggaaatttgaacaatcatattggcgtaccattgacattgctccgcttggaa
gaagatacagagatggctgtcgtcgaaatgggaatgagcaattttggcgaaatcgaatta
ttatctaacatcgccgagccggatgcggcagttattacaaatattggcgaatcgcatttg
caagaactaggttcacgcgaagggattgctcaagcaaaattagaaattttatcggggtta
aaaaagaacggcctttttgtttatcatggagatgagccgttgctggtgaaccgggttcca
gacttgccgctgcctgagcacgtcttgagatttgggcaaggaagcgacaacgattattat
ccgaaagcggtccatgtacaggccaatggcactacgtttaccgttcatcaggcgccaaat
cgctcctttttccttccgattttagggaagcatcatgtatataacgcgttggctgctatc
gctgtagctcgcttttttcacgtaagctgggagaagattcaagaagcattttcacaattg
caagtgacgcgtatgcgcatggaattaatcgaaacaaagaaaggctggacgattattaat
gacgcgtataacgctaacccaacatcgatgaaagcggcgttgcaattacttcacgaattg
acgggatatgagaaaaagattgctgtgttaggagacatgctggagcttggcgatcaagaa
gtggagtttcatcgggaaatcggcgcaatgctgcggccggaaatggtcgattatgtattt
acgtatggagcgttagcacgtcatattgcgctcgcggcacagccgttttttccagatggg
cgcgtgaaagcatatgaagataagcagtctttggcaaaagacttgcttgcagttgtttcc
tctggcgatgtgattttgctgaaggcttcacgtggaatgaagctagaagagttgcttcct
gatttgcaataa
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