KEGG   Hipposideros armiger (great roundleaf bat): 109372681
Entry
109372681         CDS       T04661                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
hai  Hipposideros armiger (great roundleaf bat)
Pathway
hai00562  Inositol phosphate metabolism
hai01100  Metabolic pathways
hai01521  EGFR tyrosine kinase inhibitor resistance
hai01522  Endocrine resistance
hai01524  Platinum drug resistance
hai04012  ErbB signaling pathway
hai04014  Ras signaling pathway
hai04015  Rap1 signaling pathway
hai04024  cAMP signaling pathway
hai04062  Chemokine signaling pathway
hai04066  HIF-1 signaling pathway
hai04068  FoxO signaling pathway
hai04070  Phosphatidylinositol signaling system
hai04071  Sphingolipid signaling pathway
hai04072  Phospholipase D signaling pathway
hai04081  Hormone signaling
hai04140  Autophagy - animal
hai04150  mTOR signaling pathway
hai04151  PI3K-Akt signaling pathway
hai04152  AMPK signaling pathway
hai04210  Apoptosis
hai04211  Longevity regulating pathway
hai04213  Longevity regulating pathway - multiple species
hai04218  Cellular senescence
hai04360  Axon guidance
hai04370  VEGF signaling pathway
hai04380  Osteoclast differentiation
hai04510  Focal adhesion
hai04550  Signaling pathways regulating pluripotency of stem cells
hai04611  Platelet activation
hai04613  Neutrophil extracellular trap formation
hai04620  Toll-like receptor signaling pathway
hai04625  C-type lectin receptor signaling pathway
hai04630  JAK-STAT signaling pathway
hai04650  Natural killer cell mediated cytotoxicity
hai04660  T cell receptor signaling pathway
hai04662  B cell receptor signaling pathway
hai04664  Fc epsilon RI signaling pathway
hai04666  Fc gamma R-mediated phagocytosis
hai04668  TNF signaling pathway
hai04670  Leukocyte transendothelial migration
hai04722  Neurotrophin signaling pathway
hai04725  Cholinergic synapse
hai04750  Inflammatory mediator regulation of TRP channels
hai04810  Regulation of actin cytoskeleton
hai04910  Insulin signaling pathway
hai04914  Progesterone-mediated oocyte maturation
hai04915  Estrogen signaling pathway
hai04917  Prolactin signaling pathway
hai04919  Thyroid hormone signaling pathway
hai04923  Regulation of lipolysis in adipocytes
hai04926  Relaxin signaling pathway
hai04929  GnRH secretion
hai04930  Type II diabetes mellitus
hai04931  Insulin resistance
hai04932  Non-alcoholic fatty liver disease
hai04933  AGE-RAGE signaling pathway in diabetic complications
hai04935  Growth hormone synthesis, secretion and action
hai04960  Aldosterone-regulated sodium reabsorption
hai04973  Carbohydrate digestion and absorption
hai05010  Alzheimer disease
hai05017  Spinocerebellar ataxia
hai05020  Prion disease
hai05100  Bacterial invasion of epithelial cells
hai05132  Salmonella infection
hai05135  Yersinia infection
hai05142  Chagas disease
hai05146  Amoebiasis
hai05160  Hepatitis C
hai05161  Hepatitis B
hai05162  Measles
hai05163  Human cytomegalovirus infection
hai05164  Influenza A
hai05165  Human papillomavirus infection
hai05166  Human T-cell leukemia virus 1 infection
hai05167  Kaposi sarcoma-associated herpesvirus infection
hai05168  Herpes simplex virus 1 infection
hai05169  Epstein-Barr virus infection
hai05170  Human immunodeficiency virus 1 infection
hai05171  Coronavirus disease - COVID-19
hai05200  Pathways in cancer
hai05203  Viral carcinogenesis
hai05205  Proteoglycans in cancer
hai05206  MicroRNAs in cancer
hai05207  Chemical carcinogenesis - receptor activation
hai05208  Chemical carcinogenesis - reactive oxygen species
hai05210  Colorectal cancer
hai05211  Renal cell carcinoma
hai05212  Pancreatic cancer
hai05213  Endometrial cancer
hai05214  Glioma
hai05215  Prostate cancer
hai05218  Melanoma
hai05220  Chronic myeloid leukemia
hai05221  Acute myeloid leukemia
hai05222  Small cell lung cancer
hai05223  Non-small cell lung cancer
hai05224  Breast cancer
hai05225  Hepatocellular carcinoma
hai05226  Gastric cancer
hai05230  Central carbon metabolism in cancer
hai05231  Choline metabolism in cancer
hai05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hai05415  Diabetic cardiomyopathy
hai05417  Lipid and atherosclerosis
hai05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hai00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    109372681 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    109372681 (PIK3CA)
   04014 Ras signaling pathway
    109372681 (PIK3CA)
   04015 Rap1 signaling pathway
    109372681 (PIK3CA)
   04370 VEGF signaling pathway
    109372681 (PIK3CA)
   04630 JAK-STAT signaling pathway
    109372681 (PIK3CA)
   04668 TNF signaling pathway
    109372681 (PIK3CA)
   04066 HIF-1 signaling pathway
    109372681 (PIK3CA)
   04068 FoxO signaling pathway
    109372681 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    109372681 (PIK3CA)
   04072 Phospholipase D signaling pathway
    109372681 (PIK3CA)
   04071 Sphingolipid signaling pathway
    109372681 (PIK3CA)
   04024 cAMP signaling pathway
    109372681 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    109372681 (PIK3CA)
   04152 AMPK signaling pathway
    109372681 (PIK3CA)
   04150 mTOR signaling pathway
    109372681 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    109372681 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    109372681 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    109372681 (PIK3CA)
   04218 Cellular senescence
    109372681 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    109372681 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    109372681 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    109372681 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    109372681 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    109372681 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    109372681 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    109372681 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    109372681 (PIK3CA)
   04660 T cell receptor signaling pathway
    109372681 (PIK3CA)
   04662 B cell receptor signaling pathway
    109372681 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    109372681 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    109372681 (PIK3CA)
   04670 Leukocyte transendothelial migration
    109372681 (PIK3CA)
   04062 Chemokine signaling pathway
    109372681 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    109372681 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    109372681 (PIK3CA)
   04929 GnRH secretion
    109372681 (PIK3CA)
   04915 Estrogen signaling pathway
    109372681 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    109372681 (PIK3CA)
   04917 Prolactin signaling pathway
    109372681 (PIK3CA)
   04926 Relaxin signaling pathway
    109372681 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    109372681 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    109372681 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    109372681 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    109372681 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    109372681 (PIK3CA)
   04722 Neurotrophin signaling pathway
    109372681 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    109372681 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    109372681 (PIK3CA)
   04380 Osteoclast differentiation
    109372681 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    109372681 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    109372681 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109372681 (PIK3CA)
   05206 MicroRNAs in cancer
    109372681 (PIK3CA)
   05205 Proteoglycans in cancer
    109372681 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    109372681 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    109372681 (PIK3CA)
   05203 Viral carcinogenesis
    109372681 (PIK3CA)
   05230 Central carbon metabolism in cancer
    109372681 (PIK3CA)
   05231 Choline metabolism in cancer
    109372681 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    109372681 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    109372681 (PIK3CA)
   05212 Pancreatic cancer
    109372681 (PIK3CA)
   05225 Hepatocellular carcinoma
    109372681 (PIK3CA)
   05226 Gastric cancer
    109372681 (PIK3CA)
   05214 Glioma
    109372681 (PIK3CA)
   05221 Acute myeloid leukemia
    109372681 (PIK3CA)
   05220 Chronic myeloid leukemia
    109372681 (PIK3CA)
   05218 Melanoma
    109372681 (PIK3CA)
   05211 Renal cell carcinoma
    109372681 (PIK3CA)
   05215 Prostate cancer
    109372681 (PIK3CA)
   05213 Endometrial cancer
    109372681 (PIK3CA)
   05224 Breast cancer
    109372681 (PIK3CA)
   05222 Small cell lung cancer
    109372681 (PIK3CA)
   05223 Non-small cell lung cancer
    109372681 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    109372681 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    109372681 (PIK3CA)
   05161 Hepatitis B
    109372681 (PIK3CA)
   05160 Hepatitis C
    109372681 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    109372681 (PIK3CA)
   05164 Influenza A
    109372681 (PIK3CA)
   05162 Measles
    109372681 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    109372681 (PIK3CA)
   05163 Human cytomegalovirus infection
    109372681 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    109372681 (PIK3CA)
   05169 Epstein-Barr virus infection
    109372681 (PIK3CA)
   05165 Human papillomavirus infection
    109372681 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    109372681 (PIK3CA)
   05135 Yersinia infection
    109372681 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    109372681 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    109372681 (PIK3CA)
   05142 Chagas disease
    109372681 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109372681 (PIK3CA)
   05017 Spinocerebellar ataxia
    109372681 (PIK3CA)
   05020 Prion disease
    109372681 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109372681 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    109372681 (PIK3CA)
   05415 Diabetic cardiomyopathy
    109372681 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    109372681 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    109372681 (PIK3CA)
   04931 Insulin resistance
    109372681 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    109372681 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    109372681 (PIK3CA)
   01524 Platinum drug resistance
    109372681 (PIK3CA)
   01522 Endocrine resistance
    109372681 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hai04131]
    109372681 (PIK3CA)
Enzymes [BR:hai01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     109372681 (PIK3CA)
Membrane trafficking [BR:hai04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    109372681 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 109372681
NCBI-ProteinID: XP_019481619
UniProt: A0A8B7PYS0
LinkDB
Position
Unknown
AA seq 1087 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRLPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYCHAGLSNRLARDNELRENDKEQLRSICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRTGRRKVSI
REMVKRAGRPEMLPYGCLSIGDCVGLIEVVRSSHTIMQIQCKGGLKGALQFNSHTLHQWL
KDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHK
KKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINL
FSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHT
IKQHALN
NT seq 3264 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acgttaataacgataaagcatgaactatttaaagaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttactcaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgacctgcggctctttcaaccttttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggctttgct
atcggcatgccagtgtgtgaatttgatatggttaaagacccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaatcatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctgtcatctgaacaactaaaa
ctttgtgttttagaatatcagggcaagtatattttaaaagtatgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggttgcccaatttgatgctgatggctaaagaaagcctttactcgcaactaccaatggac
tgtttcacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctatgtgaatgtaaatattcgagacattgacaagatctatgttagaacaggtatc
taccatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttctaat
cccaggtggaatgaatggctgaattacgacatatacattcctgatcttcctcgtgccgct
cgactttgcctttccatttgttctgtcaaaggccgaaagggtgctaaggaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaattggtctgtg
tcccgagaagcaggatttagttattgccatgcaggactgagtaacagactagctagagac
aacgaattaagggaaaatgataaagaacagctccgatcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactactgtgtaact
atccctgaaattctacccaaattgcttctgtccgttaaatggaattctagagatgaagta
gctcagatgtactgcttggtaaaagattggcctccaatcaaacctgaacaggctatggaa
cttctggactgcaactacccagatcctatggttcgaggttttgctgttcgatgcttggaa
aaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatccgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcctattgtcgtgcatgcgggatgtatttgaag
cacctgaatagacaagttgaagcaatggaaaagctcattaacttaactgacattctcaag
caagagaagaaggatgagacacaaaaggtacagatgaaatttttagtagagcaaatgcgg
cgaccagatttcatggatgctctacagggctttctgtctcctctaaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcggattatgtcctctgcaaaaaggccactgtgg
ctgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaacaggtagaagaaaagtttccata
agagaaatggtcaaaagggcaggaagaccagaaatgttaccttatggttgtctgtcaatt
ggtgactgtgtgggacttatagaggtggtgagaagttctcacactattatgcaaattcag
tgcaaaggtggcctgaaaggtgcactgcagttcaatagtcacacactacaccagtggctc
aaagacaagaacaaaggagaaatatacgatgcagccattgatctgtttacacgttcctgt
gctggatattgtgtcgctaccttcattttgggaattggagatcgtcacaatagtaacatc
atggttaaagatgacggacaactgtttcatatagattttggacactttttggatcacaag
aagaaaaaatttggctataaaagagaacgtgtaccatttgttttgacacaagatttctta
atagtgatcagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggtttcag
gagatgtgttacaaagcttatctagctattcggcagcatgccaacctcttcataaatctt
ttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgcatac
attcgaaagaccctagctttagataaaactgagcaagaggctttggaatatttcatgaaa
caaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccacaca
attaagcagcatgctttgaactga

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