KEGG   Hipposideros armiger (great roundleaf bat): 109384329
Entry
109384329         CDS       T04661                                 
Symbol
PLCB3
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
hai  Hipposideros armiger (great roundleaf bat)
Pathway
hai00562  Inositol phosphate metabolism
hai01100  Metabolic pathways
hai04015  Rap1 signaling pathway
hai04020  Calcium signaling pathway
hai04022  cGMP-PKG signaling pathway
hai04062  Chemokine signaling pathway
hai04070  Phosphatidylinositol signaling system
hai04071  Sphingolipid signaling pathway
hai04072  Phospholipase D signaling pathway
hai04081  Hormone signaling
hai04082  Neuroactive ligand signaling
hai04261  Adrenergic signaling in cardiomyocytes
hai04270  Vascular smooth muscle contraction
hai04310  Wnt signaling pathway
hai04371  Apelin signaling pathway
hai04540  Gap junction
hai04611  Platelet activation
hai04613  Neutrophil extracellular trap formation
hai04621  NOD-like receptor signaling pathway
hai04713  Circadian entrainment
hai04720  Long-term potentiation
hai04723  Retrograde endocannabinoid signaling
hai04724  Glutamatergic synapse
hai04725  Cholinergic synapse
hai04726  Serotonergic synapse
hai04728  Dopaminergic synapse
hai04730  Long-term depression
hai04742  Taste transduction
hai04750  Inflammatory mediator regulation of TRP channels
hai04911  Insulin secretion
hai04912  GnRH signaling pathway
hai04915  Estrogen signaling pathway
hai04916  Melanogenesis
hai04918  Thyroid hormone synthesis
hai04919  Thyroid hormone signaling pathway
hai04921  Oxytocin signaling pathway
hai04922  Glucagon signaling pathway
hai04924  Renin secretion
hai04925  Aldosterone synthesis and secretion
hai04926  Relaxin signaling pathway
hai04927  Cortisol synthesis and secretion
hai04928  Parathyroid hormone synthesis, secretion and action
hai04929  GnRH secretion
hai04933  AGE-RAGE signaling pathway in diabetic complications
hai04934  Cushing syndrome
hai04935  Growth hormone synthesis, secretion and action
hai04961  Endocrine and other factor-regulated calcium reabsorption
hai04970  Salivary secretion
hai04971  Gastric acid secretion
hai04972  Pancreatic secretion
hai04973  Carbohydrate digestion and absorption
hai05010  Alzheimer disease
hai05016  Huntington disease
hai05017  Spinocerebellar ataxia
hai05022  Pathways of neurodegeneration - multiple diseases
hai05142  Chagas disease
hai05143  African trypanosomiasis
hai05146  Amoebiasis
hai05163  Human cytomegalovirus infection
hai05200  Pathways in cancer
hai05415  Diabetic cardiomyopathy
hai05417  Lipid and atherosclerosis
Module
hai_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:hai00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    109384329 (PLCB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    109384329 (PLCB3)
   04310 Wnt signaling pathway
    109384329 (PLCB3)
   04371 Apelin signaling pathway
    109384329 (PLCB3)
   04020 Calcium signaling pathway
    109384329 (PLCB3)
   04070 Phosphatidylinositol signaling system
    109384329 (PLCB3)
   04072 Phospholipase D signaling pathway
    109384329 (PLCB3)
   04071 Sphingolipid signaling pathway
    109384329 (PLCB3)
   04022 cGMP-PKG signaling pathway
    109384329 (PLCB3)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    109384329 (PLCB3)
   04081 Hormone signaling
    109384329 (PLCB3)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    109384329 (PLCB3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    109384329 (PLCB3)
   04613 Neutrophil extracellular trap formation
    109384329 (PLCB3)
   04621 NOD-like receptor signaling pathway
    109384329 (PLCB3)
   04062 Chemokine signaling pathway
    109384329 (PLCB3)
  09152 Endocrine system
   04911 Insulin secretion
    109384329 (PLCB3)
   04922 Glucagon signaling pathway
    109384329 (PLCB3)
   04929 GnRH secretion
    109384329 (PLCB3)
   04912 GnRH signaling pathway
    109384329 (PLCB3)
   04915 Estrogen signaling pathway
    109384329 (PLCB3)
   04921 Oxytocin signaling pathway
    109384329 (PLCB3)
   04926 Relaxin signaling pathway
    109384329 (PLCB3)
   04935 Growth hormone synthesis, secretion and action
    109384329 (PLCB3)
   04918 Thyroid hormone synthesis
    109384329 (PLCB3)
   04919 Thyroid hormone signaling pathway
    109384329 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    109384329 (PLCB3)
   04916 Melanogenesis
    109384329 (PLCB3)
   04924 Renin secretion
    109384329 (PLCB3)
   04925 Aldosterone synthesis and secretion
    109384329 (PLCB3)
   04927 Cortisol synthesis and secretion
    109384329 (PLCB3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    109384329 (PLCB3)
   04270 Vascular smooth muscle contraction
    109384329 (PLCB3)
  09154 Digestive system
   04970 Salivary secretion
    109384329 (PLCB3)
   04971 Gastric acid secretion
    109384329 (PLCB3)
   04972 Pancreatic secretion
    109384329 (PLCB3)
   04973 Carbohydrate digestion and absorption
    109384329 (PLCB3)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    109384329 (PLCB3)
  09156 Nervous system
   04724 Glutamatergic synapse
    109384329 (PLCB3)
   04725 Cholinergic synapse
    109384329 (PLCB3)
   04728 Dopaminergic synapse
    109384329 (PLCB3)
   04726 Serotonergic synapse
    109384329 (PLCB3)
   04720 Long-term potentiation
    109384329 (PLCB3)
   04730 Long-term depression
    109384329 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    109384329 (PLCB3)
  09157 Sensory system
   04742 Taste transduction
    109384329 (PLCB3)
   04750 Inflammatory mediator regulation of TRP channels
    109384329 (PLCB3)
  09159 Environmental adaptation
   04713 Circadian entrainment
    109384329 (PLCB3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    109384329 (PLCB3)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    109384329 (PLCB3)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    109384329 (PLCB3)
   05142 Chagas disease
    109384329 (PLCB3)
   05143 African trypanosomiasis
    109384329 (PLCB3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    109384329 (PLCB3)
   05016 Huntington disease
    109384329 (PLCB3)
   05017 Spinocerebellar ataxia
    109384329 (PLCB3)
   05022 Pathways of neurodegeneration - multiple diseases
    109384329 (PLCB3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    109384329 (PLCB3)
   05415 Diabetic cardiomyopathy
    109384329 (PLCB3)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    109384329 (PLCB3)
   04934 Cushing syndrome
    109384329 (PLCB3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hai04131]
    109384329 (PLCB3)
Enzymes [BR:hai01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     109384329 (PLCB3)
Membrane trafficking [BR:hai04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    109384329 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    109384329 (PLCB3)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 109384329
NCBI-ProteinID: XP_019501156
UniProt: A0A8B7RJB8
LinkDB
Position
Unknown
AA seq 1227 aa
MAGASPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDTNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVAGPDPVNTTFLNF
MAVQDDTAKVWTEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLKDFINQKQRDPRLNEVLYPPLGPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSTGVPNS
SVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEAGLEKPSLEPQKSLGE
EGLQRGPDLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVK
FKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMP
QLFWNVGCQLVALNFQTLDLAMQLNAGVFEYNGRSGYLLKPEFMWRPDKSFDPFTEVIVD
GIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPF
DFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALLIY
TEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGEREAQANQETCQETQSQQLG
SQPTPNPTPSQMDTSPRRPPGPVTSPASPSLSSPGQRDDLIASILSEVAVAPLDEFRSHK
ALVKLRSRQERDLRELCKKHQRKAVALTRRLLDSLAQAQAESRCRHQPGVLGREEKEEEE
VKRYQEFQKRQVQILLELREAQADAETERRLEHLRQVQQRLKEVVLDAHTTQCKRLKETN
DREKKELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQKQRH
ERLVAAQQQVQQQLVEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLGDGHLVAC
ASNGHAPGSSGHLSGVDSESQEENTKL
NT seq 3684 nt   +upstreamnt  +downstreamnt
atggcgggcgccagtcctggcgtccacgcgttgcagctggagccgcccaccgtggtggag
accctgcggcgcgggagtaagttcatcaaatgggacgaggaggcctccagtcggaacctg
gtgactctgcgcgtggacaccaatggcttcttcctgtactggacaggacccaacatggag
gtggacacattggacatcagttccatcagggacacgcggacaggccgttacgctcgcctg
cccaaagaccccaagatccgtgaggtgttgggttttgggggccctgatgcccggctggag
gaaaagctgatgacagtggtggctgggccagacccggtgaacacaactttcttaaacttc
atggctgtgcaggacgacacagccaaggtctggactgaggagctgttcaagctggctatg
aacatcctggctcagaacgcctccaggaacaccttcctgcgcaaagcatacacaaagtta
aagctgcaggtgaatcaggatggacggatcccagtcaagaacatcctgaagatgttctca
gcagacaagaaacgggtggagactgcactggaatcctgtggcctcaagtttaaccggagt
gagtccatccggcctgatgagttttccttggaaatctttgagcggttcctgaacaagttg
tgtctgcggccagacattgacaagatcctgctggagataggtgccaagggcaagccatac
ctgacactagaacagctcaaggacttcatcaaccagaagcaaagggacccaagactcaat
gaagtactatacccacccctggggccctcccaggcccggctgctcattgagaagtatgag
cccaaccagcagttcctggagcgagaccagatgtccatggagggcttcagccgctaccta
ggaggtgaggagaacggcatcttgcccctagaggccctggatctgagcgcggacatgacc
cagccgctaagcgcatacttcatcaactcctcacacaacacctatctcacggcgggacag
ctggctgggacctcgtccgtggagatgtaccggcaggcattgctgtggggctgccgctgt
gtggaactggacgtgtggaaagggcggccgcccgaggaggagccctttatcacccacggc
tttaccatgaccacggaggtgccactgcgggacgtgctcgaggccatcgccgagaccgcc
ttcaagacttcgccttaccccgtcatcctctccttcgagaaccacgtggactcggcaaag
cagcaggccaagatggctgagtactgccgctccatctttggggatgcgctgctcatcgac
ccactggacaagtacccgctggctccaggcgtccccctgcccagcccccaggacctgatg
ggccgcatcctggtgaagaacaagaagcggcaccggcccagcactggcgtccctaacagc
tctgtgcgcaagcgacccctggaacagagcaactcagccctgagcgagagctccgccgcc
accgagccctcctcaccccagctcgggtcccccagctccgacagctgtccaggcctgagc
aatggggaggaggcaggacttgagaagcccagcctggagcctcagaagtccctgggtgaa
gaggggctgcagcggggccctgatcttggccctgccgaccgtgaggatgaggaagaggat
gaggaagaggaggaacagacagaccccaaaaagccaaccacagatgagggcactgccagc
agtgaggtcaatgccactgaagaaatgtcaacccttgttaactacatcgagcctgtcaag
ttcaagtcctttgaggctgctcgaaagaggaacaagtgcttcgagatgtcatccttcgtg
gagaccaaggccatggagcagctgaccaagagccccatggagtttgtggaatacaacaag
cagcagctcagccgcatctaccccaagggaacccgtgtggactcttccaactacatgcca
cagctcttctggaatgtgggctgccagcttgtggcgctcaacttccagaccctcgatctg
gcgatgcagctcaacgcaggcgtgtttgagtacaacgggcgcagtggctacctgcttaag
cctgagttcatgtggcggccggacaagtcctttgaccccttcactgaggtcatcgtggac
ggcattgtggccaatgccttgcgggtcaaggtgatctccgggcagttcctgtccgacagg
aaggtgggcatctacgtggaggtggatatgtttggcctccctgttgacacgcggcgcaaa
taccgcacgcggacctctcaggggaactcgttcaaccctgtgtgggatgaggagcccttc
gacttccccaaggtggtgctgcccacactggcttcgctgcgcatcgcggcttttgaggag
ggcggcaagtttgtggggcaccggatcctgcccgtctctgccatccgctcagggtaccac
tacatctgcctgcgaaacgaggccaaccaaccgctgtgcctgccagccctgctcatctac
accgaggcctctgactacatccccgacgaccaccaggactatgcagaggccctgatcaac
cccatcaagcacgtcagcctgatggaccagagggccaagcagctggctgccctcattggg
gagagggaggctcaggctaaccaggagacatgtcaggagacccagtctcagcagctgggg
tcccagccgaccccaaaccccacacccagccaaatggacacctccccccgtcggccccca
ggccctgtcacctcccccgccagcccctccctcagcagcccaggtcagcgggatgatctc
attgccagtatcctctcagaggtggccgtggccccactggacgagttccgaagccacaag
gctctggtgaagctccgcagccggcaagagcgagacctgcgggagctgtgcaagaagcat
caacggaaggcagttgccctcactcgccgattgctggacagcctggcccaggcccaggcc
gagagcaggtgcaggcaccagccaggtgtcctaggccgggaggagaaggaggaggaagaa
gtgaagcggtatcaagagttccagaagagacaggtgcagatcctgctggagctgcgtgag
gcccaggcagatgcagagactgagcggaggctggagcacctgagacaggttcagcaacgg
ctcaaggaggttgtcctggatgctcacacaactcagtgcaagaggctgaaggagacgaac
gacagagagaagaaggaactgcagaagatactggacaggaaacgccacaacagtatctca
gaggccaagacaagggagaaacataagaaggaagcggaactgacagagattaaccgtcgg
cacatcaccgagtcggtcaactccatccgccggctggaggaggcccagaagcagcggcat
gaacgccttgtggctgcccagcagcaggtccaacagcagctggtggaagaggagcccaag
ctgctggcccagctggcccaggagtgtcaggagcagcgggcaaggctgccccaggagatc
cgccggagcctgctaggcgagatgccggaggggctgggggacgggcatctggtggcatgt
gccagcaacggtcacgcgcctgggagcagcggacacctgtctggcgttgactcggagagc
caagaggagaatacgaagctctga

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