Hemitrygon akajei (red stingray): 140730324 Help Entry 140730324         CDS       T11019                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism haka  Hemitrygon akajei (red stingray) Pathway haka04020   Calcium signaling pathway haka04260   Cardiac muscle contraction haka04261   Adrenergic signaling in cardiomyocytes haka04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:haka00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     140730324 (ryr2a)    04020 Calcium signaling pathway     140730324 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     140730324 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     140730324 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:haka04040]     140730324 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:haka04990]     140730324 (ryr2a) Ion channels [BR:haka04040]  Voltage-gated cation channels   Ryanodine receptor    140730324 (ryr2a) Domain-containing proteins not elsewhere classified [BR:haka04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    140730324 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 Motif Other DBs NCBI-GeneID:  140730324 NCBI-ProteinID:  XP_072906675 LinkDB All DBs Position 7:28576432..29303853 Genome browser AA seq 4952 aa AA seqDB search MAEVGEGEDEIQFLRTNDEVVLQCSATLHKEQLKFCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANNEEKAEGATQGGGHRTLLYGHAVLLRHSYSGMYLSC LSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSISSERYL HLSYGYSTLHVDAAFQQTLWSVAPICSGSEVAQGYLKGGDVLRLPHGHMDECLTVPSGEH GEEQRRTVHYEGGAVSIHARSLWRLETLRVAWSGSHIRWGQPFRLRHVTTGNYLSLIDDK GLLLMGKEKADIKSTAFCFRSSKEKLDAGIRKEVEGMGSPEIKYGDSVCFIQHVDTGLWL TYQSVDAKSARMGTAQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFNRFISG LDALNKQGKSTAVDLPIESVSLSLQDLIGYFQPPDEHLEHEEKQNRLRALKNRQNLFQEE GMINLVLECIDRLNMYSSAAHFTDVAGKEAGESWRAILNSLYELLAALIRGNRKNCAQFS GSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLD VLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTQLINHVSSMRPNIFLGISDGAAQYKK WYFELIVDHVDPFVTTEATHLRVGWASTDGYSPCPGGGEGWGGNGVGDDLYSYGFDGLHL WSGCIARTVNSPNQHLLRDDDVVSCCLDLSAPSISFRINGQPVQGMFENFNTDGLFFPVV SFSTGVKVRFLLGGRHGEFKFLPPPGYAPCFEALLPKEKMRVEHTYEYKQDHNGVRDLLG PTISLTQAAFTPMPVDTTQIVLPPHLDRVREKLAENIHELWVMNKIELGWTYGPIRDDNK RQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGIADDQAEEKVKKLKLPRNYQL PSGYKPAPMDLSHIKLTSTQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRL VPYTLLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARSAQSNNAAQRFRIFRAEK TYAVRSGKWYFEFEAVTAGDMRIGWTRPGCRSDQELGTDDQSFVFDGFKAQRWHQGNEHF GRSWQAGDVVGCLADMNENTMTFTLNGEVLLDDLGSELAFKDFEASDGFIPVCSLGLSQV GRMNFGNDVATLKYFTICGLQEGYEPFAVNMNRDITIWFSKRQPQFISVPANHEHIEVMR IDGTVDSSPCLKVIQRSFGSQNSSTDIVFYRLSMPIECAEVFSKMPIGGLANTNILPQKN EIEDYDADSDFEVLMKTAHGHLASTTSEKEKESAKAEFNNHKDYNQEKPSRLKQRFMLKR TKPDYNLTHSSTRLTEEVLADDRDDYDFLMQTTTYYYSVRIFPGQEPTNVWVGWITSDFH QYDTAYELEKVRTVTVTLGDEKGKVHESIKRSNCYMVWAGECTSPGQGRNNNGLEIGCLV DTASGLLTFTANGKELNTYYQVEASTKLFAAVFAQATSPNVFQFELGRVKNVMPLSAGLF KSECRNPIPQCPPRLHVQYLTPVLWSRVPNEFLKVDVSRVSDRHGWQVQCTEPLRFMSLH IPEENRALDILELTEREDLLKFHYHTLRLYSAVCALGNNRVAHALCSHLDESQLLYAIEN KYVPGLLRTGYYDLLIDTYLNTYATARLMMNNEFIVPMTDETKSITLFPDDNRNHTVPGV GLSTSLRPRMQFSSASFVTVTGECLQYSPEFPLDILKAKTIEMLTEAVQEGSLHVRDPVG GSTEFLFVPLIKLFYTLLIMGIFCSEDLKHVLQLIEPNVFSEETEAIEERSEKDVTKDEQ KTEGGDEEFRNEHVPKEGLLQMKLPEPVKLQMCHLLQYLCDCQLRHRIEAIVAFSDDFVF KLQENQRFRYNEVMQALNMSAALTAKKTKEFRSPPQEQINMLLSFKNDRRECPCPGEVRE DLLDFHEDLMAHCGIELEEEEANNDDSDSTIRGRLMNLVEKVTYLKKKQKENPMEQEVKK STTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGELVRALPKTYTINKVSVE DTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEV MVNVLGGGESKEIIFPKMVANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPSM RGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCAMLVAKGYPDIGWNPVE GERYLDFLRFAVFCNGESVEENANEVVRLLIRRPECFGPALRGEGGDGLLSAMEEAIKIS EDPARDGLSPIDESRRSLEIEEEEDDTIHMGNAIMTFYSALIDLLGRCAPEIHLINAGKG EAIRIKSILRSLIPLEDLEGVISIPFQMPTVAKDGTVVEPDMSAGFCPDHKAAMVLFLER VYGIEEQDFLLHLLEVGFLPDLRAAASLDTVVLSATDMALALNRYLCTAVLPLLTKCAPL FAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDAIEECLLAICGQLRPSVMQHLLRRLVF DVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQ KRYEPELFKLALPCLSAVAGALPPDYMESNYVAMMEKQSSVDTEGNFNPQPVDTSSVTLP EKLDYFINKYAEHSHDKWTMDKFTNGWVYGEVNNEVTKVHPLLKPFKLLSEKDKEVYRWP IKESLKTMVAWSWTIERTREGESMALHHRTRRISQSSQVSIDSAHGYSPRPIDMSNVSLS RDLHAMAELLAENYHNIWAKKKKIELEVKGGGNHPLLVPYDTLTAKEKAKDREKAQEILK FLQINGYAVSRGLKDMELDTPSIEKRFAYSFLQQLIKYVDQAHEYILQFDLCCTSRGEKF VHEQEIKFFAKVVLPLIDQYFKNHRLYFLSTASSPLSSGGHASNKEKEMVTSLFCKLGVL VRNRISLFGSDATSIVNCLHILGQTLDARTLMKTGLESVKLALRTFFESAAEDLEKTIEN LKLGQFTHTRTQPKGVTQIINYTTVALLPVLSSLFEHIGQHQFGEDLILDDVQVSGYRIL NSLYALGTGKSIYVERQRPALGECLAAFAGAFPVAFLETDLNKHNPFSSYNTKTPKDLAA LNLPAKVEDMYPNIPSLECLLEEIMELAESGLRYTQMPHVMEVILPMLCSYMSHWWEHGP ENNPEKAELCCTALTSEHMNTLLGNILKIISNNLGIDEGAWMKRLAVFSLPIISKVKPQL LKTHFLPLMEKLKKKVATVVLEEEHLKAEGRGDMSEAELLILDEFTVLARDLYAFYPLLI RFVDYNRAKWLKEPNSDAEELFRMVAEVFIYWAKSHNFKREEQNFVIQNEINNMSFLITD TKSKMSKGSVSDQERKKSKRKGDRYSLQTSLIVAALKRLLPIGLNICVPGDQELISLAKN RFSMKDTEDEVREIIRNNLHLQGKLEDPAIRWQMALYKDLPNRNEDTSDPEKTVVRVLDI ANVVFHLEQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEK SWIETEEHYFEDKLIEDIAKPGGEKPVEEEEGTKQLDPLHQLILLFSRTALTEKCNLEED FLYMAYADIMAKSCHVEEDEDGEEEVKTFEEKEMEKQKLLYQQARLHDRGAAEMVLQMIS ASKGEMGPMVASTLKLGIAILNGGNSTVQQKMLDCLKEKKDVGFFQSLAGLMQSCSVLDL NAFERQNKAEGLGMVTEEGSVITHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLR TQTGNNTTVNIIISTVDYLLRVQESISDFYWFYSAKDIIDEQGQRNFSKAINVAKQVFNT LTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMV VMLLSMLEGNVVNGTIGKQMVDMLVESSSNVEMILKFFDMFLKLKNLTSSDAFKEYDPDS KGLISKRDFQKAMESHKHYTQSETEFLLSCAETDENEMLDYEEFVERFHEPAKDIGFNVA VLLTNLSEHMPHDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQ WEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDSNERLVCKG ETLKDKIEEEDPRMGFFSITTIRSALMALRYNVMILMKLLTTKSLKKQLKKMKKMTMKDM AMALLSFYWSLLIGFSHFVFSVFRGFFRIMYSTFLGGSLVEGAKKIKVTELLANMPDPTH DEVRGEIGEREGKVRQPTLPTEDLTDLRAITEESDFLSDIFGLDLRREGGHYKLIPHNPN ARMNDLIGPPSPTLSLPELQIGYQTEETKEDETEENEEYKVEPEKADGEDGEKVEKVAEQ KPRRRRRQRHAEKVDEPEVQESAFWKKITAYQQKLLNYFARNFYNMRMLALFVAFAINFI LLFYKVSTSPSIEEKETILGVYSQEGGGSRWSGMGNGHRVTVHYVLQESSGYMEPTLRIL AILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVI NTQSFPYNYWDKFVKRKVMDKYGEFYGRDRISELLGMEKAALDFSDAQEKKKPKKENSFC TVLNSIDIKYQIWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRT ILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMF HMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRD QQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTG QESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14859 nt NT seq  +upstreamnt  +downstreamnt atggctgaggtgggagaaggagaggacgaaatccagttcttgcgaactaacgatgaagtt gtgctgcagtgcagtgccactctccacaaagagcagctcaaattctgtctcgctgctgag ggtttcggcaatcgactctgttttttggagtctacgtcaaattctaagaatgttcctccg gatctctctatctgcacctttgtgttggagcagtccctctctgtccgagctcttcaagag atgttggcaaacaatgaagagaaagcagaaggggcaacgcagggcggcggtcatcggaca ctcctgtatggacatgcagtattgctcaggcactcgtacagtggaatgtatctttcttgt ttgtccacatctcgatcttcaacagacaaattggcctttgatgtcggattgcaggaagac acaactggggaggcctgctggtggaccatacatccagcctctaaacaacgctcagaagga gaaaaagtgcgtgttggagatgaccttattttagtcagcatttcctcagagcggtacctg catttgtcatatggctatagcacattacatgttgatgccgcatttcagcaaaccctctgg agtgttgctccaatttgctctggaagtgaagtggcgcaaggatatttaaagggaggggat gtgctgaggttaccacatggacacatggatgaatgtcttacggttccatcaggagagcat ggagaagaacagcgcaggacagtccattatgaaggaggagcagtgtctattcatgctcga tctctgtggagactggagacactgagggttgcatggagtggaagccatatcagatggggc cagccgttcagactgagacatgttacaactggaaactacttaagtctcattgatgacaaa ggccttcttctgatgggcaaagagaaagctgatataaaaagcacagctttttgtttcaga tcatccaaggaaaaactggatgcaggaatacgaaaagaagtggaaggcatgggatctcca gagataaaatatggtgattctgtgtgctttatccagcatgtagacactggactatggctc acctatcagtctgtagatgccaagtcagctcggatgggaacggctcaacgtaaagccata atgcatcatgaaggtcatatggatgatggattgactctctcccgctctcagcatgaggaa tcgaggactgcgcgtgtgatacgcagcactgtctttctcttcaacagatttattagtggc ctcgatgctctcaacaaacaaggaaagtccacagctgttgatttacccattgaatcagtc agcctgagtctgcaggatctgattggctactttcagccacctgatgaacatctggaacat gaagagaaacagaacagattgagagcattgaagaacagacaaaatctcttccaggaagag ggaatgattaaccttgttcttgagtgcattgatcgtctcaacatgtatagtagtgcggcc catttcactgatgtcgctggaaaggaagcaggagagtcttggagagcaattctaaactca ctctatgaactattagctgccctgatcagaggaaatcgcaaaaactgtgcccagttttct ggttctttggactggctgattagcagactggagagattagaagcctcatccggaattctg gaagttttgcactgtgttcttgtggaaagtcctgaagctctgaacattatcaaagagggg catattaagtccattatttctttgctagataaacatggaagaaatcacaaggttttggat gtattatgctctctgtgtgtgtgccacggagttgctgtgcgatctaaccagcatctaatt tgtgacaacttgctacctggaagagacttactgctgcaaacacagctcatcaaccatgtc agcagcatgcggcccaatatcttcctcggaatcagcgatggtgctgcccagtacaagaag tggtactttgaacttatcgtggaccacgttgacccctttgtaaccacagaagccacacat cttcgggttggttgggcttcaacagatggctactcgccctgccctggagggggtgaagga tggggaggaaatggtgtaggtgatgacctctactcctacggatttgatggattgcacttg tggtcaggctgcattgcccggacagtaaattcaccaaaccagcacttactgagggacgac gatgttgtcagctgctgtctggatttaagcgctccaagtatttcctttcgaattaatgga cagccagttcagggaatgtttgaaaatttcaacaccgatgggctcttctttccagtggtc agcttctctacaggagtaaaagttcggttcttgcttggcggtcgccatggggagtttaag ttccttccccctcctgggtatgctccgtgctttgaagccttactgccaaaagaaaagatg agggtggagcacacgtatgaatataagcaggaccacaatggcgtgcgtgacctcctgggg cctaccatctcactcacgcaagccgcctttacaccgatgcccgtggataccactcagatc gtacttccacctcacctagacagagtacgagaaaagcttgcagaaaacatccatgagctc tgggttatgaacaaaatcgagttggggtggacttatggaccgatccgggatgacaacaaa cgacagcacccttgcctggtagaattctccaagttgccagaacaggaacggaattacaat ttgcagatgtcacttgaaaccctcaaaaccctactggctttaggctgccatgttggtatt gctgatgaccaggcagaagagaaggtgaaaaagttaaagcttcccagaaactaccagctg cccagtggctacaagccagctcctatggatttgagccacatcaaattaacctcaacccag gaggccatggtggataagctggcagagaatgcgcacaatgtttgggccagagaccgcatc aggcagggttggacgtatggtattcagcaggatgtcaaaaacagaagaaacccccgcctg gttccctataccctgttggatgagcgcacgaaaaagtctaacaaagatagcctgcgtgaa gcagtacgcacacttcttgggtacggatataatctggaggcaccagaccaagatcatgct gcacgatccgctcagtcaaacaacgcggctcaacgatttcgtatatttcgtgcggagaaa acctacgctgtgagaagtgggaagtggtactttgagtttgaagcggtgactgcaggcgac atgcgcattggctggacccgacctggctgccgctcagatcaggagcttgggaccgatgac caatccttcgtgttcgatggtttcaaggcccagcggtggcaccagggtaacgaacacttc ggccgctcctggcaggcaggagatgtcgtcggctgcctggctgacatgaacgagaacacc atgacgttcactctgaatggggaggtcctgctggatgacttggggtctgagcttgcgttc aaggattttgaagccagtgatgggtttattccagtgtgcagcttagggctttctcaagtt ggcagaatgaactttggcaatgacgtcgctacgcttaagtatttcaccatctgtggtctg caggaaggatatgagcccttcgcagtgaacatgaacagggacatcacgatatggtttagc aagaggcagccccagttcatttctgtgcctgcaaaccacgaacacatcgaggtgatgaga atagatggcacagtcgatagctcaccctgcttgaaagtcatacaaaggtcttttggctct cagaacagcagcacagacattgtattctaccgactgagtatgcccattgaatgtgcagag gtgttctccaaaatgcccatcggtggtctggcaaacaccaacatactacctcagaaaaat gaaatcgaggactatgacgcagactctgattttgaggttctgatgaagacggcacatggg catctggcctcaaccacatcagagaaagagaaagaaagtgccaaggcagaattcaataac cataaggactacaatcaggaaaaaccttcccgcctaaagcagagatttatgttgaagaga acaaaacctgattataacttaacacactcttcaacacgactcacagaggaggtgttagct gatgatagggacgattatgacttcctcatgcagacaacaacatattattattctgtgaga atatttcctggtcaggaaccaaccaatgtttgggttggttggattacatcagattttcat cagtacgacactgcctatgagctggagaaagttcgtaccgtgactgtcactctgggagat gagaaagggaaagttcatgaaagcattaagcgaagtaactgctacatggtgtgggcagga gaatgcacaagccctgggcaaggacgcaataacaatgggctcgaaataggctgcctggtg gatactgctagtggcttactgacattcacagccaatggcaaggaattaaatacctattat caggtggaagcaagcacaaaactatttgcagcagtatttgcacaagccaccagtcctaat gttttccagtttgaactgggaagggttaagaacgtaatgccactgtcggccgggttgttc aagagcgagtgccggaatccgataccgcagtgccctccccgacttcacgtccagtacctg accccagtgctgtggagcagagtgcctaatgaattcctgaaggtggacgtcagtcgcgtt agtgaccgccatggctggcaggtgcaatgtacggaacccttaagattcatgtccttacat attcccgaagagaacagggctttggatatcttggagctcacagagcgtgaggacctgctg aaatttcactaccataccttgcgtttgtattccgcagtttgtgctctgggcaataaccga gtggcccatgccctttgcagccacctggatgagtcacaattgctgtacgcaatagaaaac aaatatgtccctggcttgctgcggacaggttactatgatctactcattgacacttacctc aatacctatgccacggccaggctgatgatgaacaatgaatttatcgtccccatgacagat gaaaccaagagtattactttgtttcctgatgataaccgcaatcacacggtccctggagtg ggcctcagcacctcactcagaccccggatgcagttttcctcagccagttttgtcactgtg accggggagtgcctccaatacagcccagagtttccactggacatcctgaaggccaagacg attgaaatgttgacagaagccgtgcaggaaggcagtctccacgtgcgggaccctgtcggt ggcagcactgagttcctctttgtacccctcatcaaactcttctacacactcctcattatg ggtatcttctgcagcgaggacttgaagcatgtgctgcagctgatcgagcccaatgtgttc tccgaggagaccgaggccattgaagagaggagtgagaaggatgtgaccaaagacgagcag aaaacagaaggaggcgatgaggagttcaggaatgaacatgttcccaaggaagggttgctg cagatgaagcttcctgagcccgtcaagcttcagatgtgccaccttctgcagtatttgtgt gactgtcagctccgccatcggattgaagccattgtcgccttttccgatgactttgtcttc aagctccaagagaaccaaaggttccgatacaatgaagtgatgcaggcattaaatatgtct gcagcattgactgccaagaaaaccaaagaattccgatcacctccacaggagcagattaac atgttgctaagctttaaaaatgacagacgtgaatgtccttgcccaggagaagtacgtgaa gacctgctggatttccatgaagatctcatggcacattgtgggattgagttggaagaagaa gaagcaaacaatgatgacagtgactccacgatcaggggccgtctaatgaatctggtagaa aaagtgacttacctgaagaaaaagcagaaagagaatccaatggaacaagaagtgaagaag tccaccactcttcagcagttgatctctgagacaatggtacggtgggcccaagagtcagtg attgaagacccagagcttgttcgagccatgttcgtcttgctgcatcggcaatatgatggc attggcgagcttgttcgtgctttacccaagacctacacaataaataaagtgtctgtggag gatacaataaacttgcttgcttcactgggccagatcagatctcttctcagcgttagaatg ggtaaagaagaggaaaagctgatgatccgtgggcttggggatataatgaataataaagtg ttttaccagcatcccaatctaatgagagccctggggatgcacgagacagtgatggaagtg atggtgaatgtgctcggaggtggagagtctaaggaaataatcttcccaaagatggtggcc aactgttgccgtttcctgtgctacttctgccgaatcagtcgacaaaatcagaaagcaatg tttgaccacttgagctacctgttagaaaacagcagtgttggattagcctctccttccatg cgaggttctactcctttggatgttgctgcagcatctgtgatggacaacaatgaacttgcc ctggcattgcgagagcctgatttagaaaaagttgttcagtatttggctggatgtggcttg cagagctgtgccatgctggttgccaagggttacccagatattgggtggaatcccgtcgaa ggggaacgatatttggattttctccgttttgctgtattttgtaatggtgagagtgtggaa gaaaatgccaatgaggttgtgagactgttgattcggcgccctgaatgctttggcccagct ttgcgaggagaaggtggggatggactcctgtctgccatggaggaagccataaagatctct gaagacccagcgagagatggcctttcaccaattgatgaatctcggagaagtctagaaatt gaagaagaggaagatgataccattcatatggggaatgctattatgaccttctattcagct ttaattgatttattgggtcggtgtgcaccagagatccatctcataaatgctggtaaaggt gaggcaatacggattaaatccattctccggtccttgattcctctggaagacctggaagga gttatcagcattcccttccagatgccaactgttgctaaggatgggacagttgtggagcca gacatgtcagctggattctgccctgaccacaaggcagcgatggttttgttcctagaaagg gtgtatgggatcgaagagcaggatttccttttacatctgctggaggttggctttctgcca gatctccgtgctgctgcctcactagacacggttgttttgagtgcgacggatatggcattg gcattgaatcgatacctgtgcactgccgttttgcccctgttaacgaagtgtgcccctctc tttgctggcactgagcaccatgcgtccctcatagattccttgctgcacactgtctacagg ctttctaagggttgctccctcactaaagcccagagggacgccattgaggaatgcttactt gcaatctgtggacaattacggccgtccgtgatgcagcacttgctgaggagattggtgttc gatgttcctctgctgaatgaacacgcaaagatgcctctaaaactcttgaccaatcattat gaacggtgctggaagtattactgtctccctggaggttgggggaacttcggcgctgcttct gaggaagaacttcatttgtcgaggaagttattctggggaattttcgatgccctctcccag aagagatacgaaccggaattatttaagctggctttgccttgcctgagtgctgttgctggg gccctgcctccagactacatggaatccaactacgtggcgatgatggagaagcagtcgtca gtggatacagaaggaaacttcaatccccagcctgtagatacatcaagtgtaacacttcca gaaaagttggattacttcatcaataaatatgcagaacacagtcacgacaaatggacaatg gacaagtttacaaatggatgggtgtatggtgaagtaaacaatgaggtcaccaaggttcat cctttgctaaagccattcaagcttctgtctgaaaaggacaaagaagtgtatcgttggcca atcaaggagtccctgaagacaatggttgcctggagttggacaattgaacgaactcgtgaa ggagagtccatggcattacatcatagaacacgacggatatctcaatcaagtcaggtttct atagattccgcacatggttacagtcctcggcctatcgatatgagtaatgtttccctttcc agggacctacatgcgatggcagaactgctggctgaaaactaccacaatatctgggcaaag aaaaagaagattgaattggaggttaaaggaggaggaaaccacccattgttggtgccatat gacacactgactgccaaagagaaagccaaagatcgggagaaagcacaggagattctcaaa tttctgcagatcaatggctatgcagtctcaaggggtttaaaagacatggaactggacaca ccttctatcgaaaagaggtttgcctacagcttccttcagcaactgatcaaatatgttgac caggctcatgagtacatcctgcagtttgatctttgttgcacaagtagaggggaaaaattt gtgcatgagcaggaaatcaagttctttgctaaggtcgttcttcctttaattgaccaatat tttaagaaccatcgtctgtacttcctgtctactgcaagtagtcctcttagcagtgggggg catgcatccaacaaagaaaaggaaatggtaacaagcctcttctgcaaacttggagtgctt gtcagaaacaggatatcactgtttgggagtgatgccacctcaattgtaaactgtcttcac atactgggccaaactttggatgccaggacgctgatgaagaccggcctggagtctgtcaag ctggctctgcggacgttttttgaaagtgcagcagaagatctggaaaaaaccatagaaaat ctcaaactgggtcagttcactcacacgaggacgcagccgaaaggagtgacgcagatcatc aattacaccacggtggcactgctgcctgtcctgtcatcgctgtttgaacacatcgggcaa caccagttcggcgaagatctcatcctggatgacgtccaagtttctggttaccgaatatta aacagtttatatgcgctgggcacaggaaaaagcatatatgttgaaaggcagcgtccagcc cttggagaatgtctggcagcatttgcgggggcatttcctgttgcctttctggaaactgac ttgaataagcacaatccattctcaagctacaacaccaaaacaccaaaagatctagcagca ctgaatttgccagccaaagtagaagatatgtatcccaatattccttccctggaatgcctg ttggaggagataatggagctggcggaatctggtctacgttacacacagatgccccacgtg atggaagtcattttgcccatgctgtgcagctacatgtcccactggtgggaacatggacca gagaacaaccccgagaaagcagagctgtgttgcactgccctcacctctgagcacatgaat accctcttgggcaacattctgaagattatatcgaacaacttgggcatcgacgaaggagca tggatgaaacgactagcagtattctcactgccgattatcagcaaagtgaaaccgcagctc ctgaaaactcacttccttcccttgatggaaaagctgaagaagaaggtggccacagtggtt ttggaagaggaacacctaaaggctgagggcagaggagatatgtctgaagctgagttgcta attctggatgagtttactgtgctggctcgagatctttatgctttctacccactgctgatc agatttgtggattataaccgtgcaaaatggctgaaagaaccaaattctgatgcagaagag cttttccgtatggtggctgaagttttcatttactgggcaaaatctcacaatttcaaaagg gaagagcagaactttgtgattcagaatgaaatcaacaacatgtctttcctcatcactgac acaaaatccaagatgtccaagggaagtgtgtctgatcaagagaggaagaaatcaaagagg aaaggagaccgctattctctgcaaacatccctcatagttgcagcactgaagaggctactg cctattgggttaaacatttgcgtgcctggtgaccaggaactaatctcattggccaaaaat aggtttagcatgaaagacacggaggatgaagttagagaaataatccgcaataatctacac cttcagggaaaactggaagatcctgccattagatggcagatggccctttacaaagatcta cccaaccggaatgaagatacctccgacccagagaaaacagtggtgcgtgtgctggacatt gccaacgtggtcttccacttggaacaggttgagcacccacagagatctaaaaaagctgtc tggcacaagctgttgtccaagcaacgtaaacgggcagtagtggcctgcttcaggatggca ccgctttataacttacctcggcatcgagctgtcaatctcttcctccaaggctatgagaaa tcgtggattgaaaccgaggaacattattttgaagataagctaatagaagatatagctaaa ccagggggagagaagccagtggaggaagaggaggggaccaaacaacttgaccctcttcac caactcattctgttgtttagtcgaacggctttgacagaaaaatgcaaccttgaagaagat tttctctacatggcttatgctgacattatggcaaagagttgtcatgtagaagaagatgag gatggtgaggaagaagttaaaacctttgaagagaaggaaatggagaaacagaagcttctg tatcaacaggcgagacttcatgatcgaggtgctgctgagatggtgctgcagatgataagt gccagcaaaggtgaaatgggaccaatggttgcatccacactgaagctaggcattgctatt ctgaatggtgggaattccacagttcagcagaaaatgcttgattgtctcaaagaaaagaaa gatgtgggtttctttcagagcctggcaggtctcatgcagtcttgcagtgtacttgatcta aatgcatttgaacggcagaacaaagcagaaggacttggcatggtgacagaagagggatca gtcatcactcatgagcgcggtgagaaggtgatgcaggatgatgaatttacgtgcgatctc tttcgattcctccagctgctttgtgaaggtcacaactcagatttccagaattacctgcgc actcagacaggcaataacacaacagtcaatatcatcatttcaacggtggactatctctta agagttcaggaatcaattagtgacttctattggttttattctgcaaaagacatcattgat gaacaaggacagcgcaatttctcaaaggcaattaatgtggcgaagcaggtgttcaacaca ctgacagaatacattcagggcccatgtactggtaatcagcagagcctggcacacagcagg ctgtgggatgcagtagttggctttcttcacgtctttgctcacatgcaaatgaagttgtcc caggattccagccagattgaactactgaaggagctaatggatcttcaaaaagatatggtg gtgatgctgctttcaatgttagaaggcaatgttgtcaatgggacaattggaaaacagatg gtggacatgttggttgaatcttcgagcaatgtggaaatgattctcaaattctttgacatg ttccttaagctaaagaacctaacctcatctgatgcattcaaagaatacgatcctgatagc aaagggcttatctctaagagggattttcagaaggccatggagagtcacaagcactataca cagtcagaaaccgaattcttgctctcttgtgcggagacggatgagaatgagatgctggat tatgaggagtttgttgaacggtttcacgaacctgcaaaggacattggcttcaatgttgcc gtactgcttactaacctttctgagcacatgccccatgatactcggctacagaccttcctg gagttggcagagagtgttctcaactacttccagccatttctaggccgtatagagattatg ggaagtgctaagcggattgagagggtctactttgagatcagtgaatctagtcggactcag tgggagaagcctcaggtaaaggagtccaagaggcaattcatcttcgatgttgtaaatgaa ggaggagagaaagaaaagatggaactctttgtcaatttctgtgaagacaccatctttgaa atgcaattggctgcacagatctcagagtcagattctaatgagcggttagtgtgtaaagga gaaactttaaaagacaaaatagaggaagaggaccccagaatgggctttttctccattaca acaattagatctgccttaatggctctcaggtacaatgtgatgatcctcatgaagctgctg acaaccaaaagcctcaaaaaacagttgaagaaaatgaaaaagatgacaatgaaagatatg gccatggccctgttatccttttattggagtttattgatcgggttttcccattttgtcttc agtgttttccgtgggtttttccgcatcatgtacagcactttcttgggtgggagtcttgtt gagggggcgaagaaaattaaagtgacagaacttttagcgaacatgcccgatccgacacat gatgaggtacggggtgaaattggagagagggaggggaaagttcgtcagccgaccctgccc actgaagacctgactgatctgagagctatcaccgaggagagtgatttcttatccgatatt tttggtttggacttgcggcgcgagggaggacattacaaactaattccacataacccaaat gcccgcatgaacgatctgattgggccaccttctcctactctttcactaccagaacttcag attggctaccagactgaagaaacaaaggaagatgagacagaagagaatgaagaatataaa gttgaaccagagaaagctgatggagaggatggcgagaaggtggaaaaagttgcagaacag aagcctcggcgaagaaggagacagcgacatgctgagaaagtcgatgaacccgaagtacaa gagtctgctttctggaagaagattacagcttaccagcagaagctgcttaattactttgca cgcaacttctacaatatgaggatgctggcgttgtttgtagcctttgcaattaacttcatt ctccttttctataaggtatcaacatctccatccatagaagagaaggaaaccatacttggt gtttacagtcaagaaggtggaggctctcgatggagcggcatgggaaatggacatagagtc acagttcattacgttctacaagaaagcagtggctatatggagcccactctgagaattctg gccatcttacacactgtcatctcctttttctgcatcattggttattattgtttaaaagtt cctctggttattttcaaacgagagaaggaggttgccaggaagttggagtttgatggatta tacatcacagagcaaccttcagaggatgacatcaagggacagtgggatagattggttata aacacgcaatctttcccatacaattactgggacaagtttgtgaagagaaaggtcatggat aagtatggagaattctatggtagggataggatcagcgaactgctaggaatggaaaaagct gctttagatttcagcgatgcacaagaaaagaaaaagcccaagaaagagaactccttctgt acagtacttaactctattgatatcaagtatcagatctggaagttgggagtggtgtttaca gacaattccttcttgtaccttgcctggtacatgaccatgtcagttctgggacattacaac aactttttctttgctgctcatctgctggatattgcgatgggatttaaaactttgcgtacc atcctttcttcagtgacgcataatggaaaacagctggttttaaccgtgggcttgctagct gtagtggtgtacctgtacaccgtggttgcttttaatttcttccggaaattctacaacaaa agtgaagatggagacacaccagatatgaagtgtgatgatatgctgacctgttatatgttc cacatgtatgtgggtgtccgtgctggtggaggcatcggcgatgagattgaagatcctgct ggggatgaatatgaaatctatcgaatcatttttgacatcaccttcttcttctttgtaatt gtcatcttgctggccatcattcaaggtctaattatagatgccttcggtgaactaagggac cagcaggagcaagtgaaagaagacatggagactaagtgcttcatctgtggaattggcaat gactacttcgacacggtgccccatggctttgagactcacacactgcaggagcacaatttg gcaaattacctatttttcttgatgtaccttattaataaagatgaaactgagcacaccgga caggaatcctacgtgtggaaaatgtatcaagaacgatgctgggaattctttccagctgga gattgcttccgcaagcagtacgaagaccagctcaactaa

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