Hyalella azteca: 108677992 Help Entry 108677992         CDS       T07535                                  Name (RefSeq) E3 ubiquitin-protein ligase UBR4   KO K10691   E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27] Organism hazt  Hyalella azteca Brite KEGG Orthology (KO) [BR:hazt00001]  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04121 Ubiquitin system [BR:hazt04121]     108677992 Enzymes [BR:hazt01000]  2. Transferases   2.3  Acyltransferases    2.3.2  Aminoacyltransferases     2.3.2.27  RING-type E3 ubiquitin transferase      108677992 Ubiquitin system [BR:hazt04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    UBR box proteins     108677992 SSDB OrthologParalogGFIT Motif Pfam:  E3_UBR4_N E3_UbLigase_R4 UBR4_TPR UBR4_Ub UBR4 zf-UBR_1 zf-UBR DNA_pol_phi BUD22 Motif Other DBs NCBI-GeneID:  108677992 NCBI-ProteinID:  XP_047736103 UniProt:  A0A979FGP5 LinkDB All DBs Position Unknown AA seq 6010 aa AA seqDB search MAASRGSVDWSQLVKPIISFWPVSDASFNKQDLPELVKAILKCKEDIGQHEDQYEAFYSA FCILAADYLATHAQYLSVGGVVHSVSACKVLLQHLVSRVGSPPLTVTIPAAISHNHSHSH ISTHSVAPTTASSGKHVQGSSAPVISTSVLSPSSINILSSVTPVVAPVADADQSDSDSHS DNVPQIIGSIAVTTPAATSGSGVAPITISTTSSSSGAVNIVTPVNKDDREKVVSITDKQL VLAMKALCRGSGCLSRADQSSLISVIRSAKLPPCVRTHSHDKDASCGAGSGSAGSSSGGI KDGRRNRNDPSAAVLEQLILPLHDFGSDAAGKTRPGGGLSTDKDGAGRLSDVAHLFASRC EAALQSIGGGATLLDVCLKMSSISKYNTKYKELLEGKGFSFPSNQHEVLAFKPGLAQVVS ELSIVSRILQLPVLEPLTAERLQKLASISMAALLAALHVAVASAVTAVTSAPATTASATS SKTPPASARDDELDSLSTSVTEKALLIYSVVLRAVKTSTRAGGHHHQNLQLMGGWLLSSG LHQLMVIVSAVSPAPAAAAAAAGGSGPSPATFTDKNTKEDKGKSPTKKDVVSRINLNKVQ QGVSSVVVALAQLCCELLSLLLEDVAVEGWNANKPTPTPAKMSVLETFSATNRIARIFNA VPLNQLLFYLATVSYRKACSLRRSQRSMHEGDTYSLTDSTIYYEDDFSEGSLGEEDDDSV IIGSWFEEPCTPGAEEGGQRGGSGGPRRGSVGGRPRPAWGVSASTHGGGSSQPQSISESE SCSSGGGAPLNSRSSRVLDASGPPVIPDKSEPHGFLNLATLIFGLMNRHLVECDCAYVQQ YVRTGLADTHMIVLAAIIKDLDRDTAKTDAELGSSGGAVVQKLYEQFSQSLYRFTHNLIA SGALSDALQATLLHQLGVSPWISDGDWPLLLLPRTLTVLAQVLLLRQRRDKDDLKCDCDT ACVVIWQRVVATLVKAVTCPAPHPDHEVDDLNVEHAQLLLFLFHALQLMQKKAVLLSVAS ALITVAPVVKTPMRDSQLLHLSRLLLIFEYLMKNLYEAPQTLIEQVQWNLFSPISRDVVR VDNSGASSNNLNCGPSTAGDSAGNAKMYHVWRDIEDNYQKHHQADETGPSCAPTLKPKFY TLTPVDTNSQDTPKLDGLACSFILATPDTLKYTTLYETLVGLLGVSCQVDPSFRASSSHS SDITRSASSDVIKQCAASDATTTPATARPGTEVLRSVSTDCAAASARVQSNDNNLSYLGH CAVQYTFSFVYRILLTLPPSVAALEALASPDTKLEGPWLLHALIWGPRASHKVFNGWIKD GLVRQSLTTQKADALLKSVTNVTSSLQHDLRVAGLVISSLVAKIHSKTAASGTATSIMNV ASFADLLLVDAVLARLQVTLDDGWQRGDLDLRGAGDTHDLCQTLKITADQLPVTSLLSLI MLLTESARHGVVHSMSSSPATTSSGSSSTSKSAAAEETAASDAGPLIEALSRVLAVSGDQ AGFVQPCLSKDCRNPLLNAALQRWTSNTLDTFPQPQAWKSSQCGGDVLPGESFVSGVVLG HVSCLSDAPNFTVASSPLKHVLRTLITFTTDLAGWYTESEKPHAQLVQTLVSIAADATCD GLSTTLGSALERLLPSPPTAATGVTMGGGSGNESVGSASSSSSSSSSDSTAAGTGDSSSS SGSNTQATVAHHLYGRQLVHVQALLKIAANYHGVVSDRVLSGIGDFLCQLLEDPAGRQSL RSHFQTSPHFCSVLLSPVPPKLTAIKSSSSSKLAKRSVSDKEEDPSSEALTSAETESERN ILPEPILLFLIVLFQQAEKQPKDSDLSGICNHIWSWVDTGALQRWLISANKAHYSVSSRS TETPGSTKIVEVTPQLPPPSRLPGFIRKRKDRKFLAKTILFESPFLDPDLVPLNFLSSAA TSATKGKMNEAMVLDDDDGDTGDDEDDETTKRRGVPASDLVTQEMRLRHCWSLVQAMAKY ACAQDTQLAKSHCTSLLRALETVGNSITDEAIVTGDPEESCRFLKPISTLVPIMRSLAGG AAPQGHVILLRTAIQWLQIYKYVVFPGATMNVHSPGDAGTSSDDRNLSPAVVERLKNQIL VPAHLLFSYLSDVLVALKISGEQTKTCAIEGEPSGDIQSVTDAADSDLLDDRNHDDGLDD EEVLEDSEDESVCNKLCTYTLTQKEFVSQHWYHCHTCQMEDGVGVCSVCAKVCHKGHDVT YAKYGSFFCDCGAKEDGSCQALVKRTPSYSNRGDATESAGAVFSVGALASASGLRKKRAL SPSLSYTDSVREQTNKRRQVLARQIEGVWSSLCSSNTHLSVCLYFLHNLLPRLEDEAHAR AALNSLNANRKALHTLHSAPKNVQMGDHLMFSPLGAQENAFENVRLNYSGDQGQTIRQLV ATHAIRRVAMSIMTSPTSRRQHLAVTHEKGKIVLLQLSSILRQKELGLPSSNFGASKRKL TISRLTSLPLPFLVLSLSANPCNDDYLAVCGLKDCHVLVFSSTCSVMEHLVLHLQLESSG YIIKVVWLPGEQTQLAVVTADFVKIYDLSVDALSPQYYLLLPSGKIRDACFASLPDGSVH MLLMTSSGYIYTQELNEDSSAKHGSFYVTNVLAVDQAAAELKDVSGVVGGGGVSIHYSQG LQLLCFSYSHGRSFMAPLTQLGENAKLDKLFPINVKPSGSNASLSSNGASSSSSLGSSGG SSSSAGSSSKMSPLCQWSEVLGHPGLFTCFMIQGNVPVLIYVKPESIMVQEIKIPSSKNK VCDIVALRHAAGNESRTTLLLLSEDGSLRVFSAFSDSADFWTSSNESRLALPGDNSAPRT SRKKKNVKHGASSSGSVAFPVDFFEHCNPISDVDFGGNDLLQVYNVQQLKNRLNSQSTYV ACSKPGGFQLEVTNKDANVVMCGARVAVGSLHPLKNPTFVKVFGRTIPVNTSRNRWYDIP FTREESLKSDKKLVLTFGPSTDPSQVTIIDAVKIYGETKEEFGWPDDEEYATASVGGNAT STSAPTTATNSHANASRSIGDDTDMTTAKASSNDSVLESLFCSALDALDGCFSTMQNVNS SARKQALEIVTRMINLQLSPRLQSCTRSLLSSLHESRQTYHQQLDGAQLSGVIETLNSLI ATGQKDPSLMECRAFHNIIVLAREVAVSRPHNLVKFTQKARDLNTTLVESSVRVTVDAPE DSVADKTLENDSEEALSEEPKAFVSDQSEVNVPSGAPQEEAADDHFLSLLMEAFWLLLKA RPLNPLLSPVYQPGLTHVEATVQAMLEILHGYSLCSPSSVPLVMRLYCSLLLSPHHQVSF SAKTALVRLLRPRTKKHKRVFLPSPPRCSTPGEGKSSGLAVAGPSGASAAAGEGSSHRSA GGHRAAGNNEASDLVGALAEVARASGELLGAAAPGSGADLLAGMMELGGGGGEDDDDAMM ELAIALSLHDEASAGGQQLAGMERLQHLRGHVLQSLLASGALQAPPSLQNQALNQNDDGD DEDAEDDGENDHDDDDEHEVDEDDDDDDDDDDDDDDDDDDDDDDDDVDHMDVIHVIGGSN LTQDLDDVANDLDNAAGNAAGDLVNVGGEIVNVAGGLDVGEDNQGGQFSDTTASANASDD EDGEVSNAATDGGSNLMRTSPADQGCSGGSESGCSVVESLLGEQSSMATVGSAGAMSATS TAYDATTHDQIPAPDDAHNADGNAPNPEGSGSSNPSSSGSTNNVSVHSLRLALLDALTTR LQRLQQLGGIAAIPTLQVILMLSTDLDPRNSRDRVTLDALLNALVASLDLNSAGRSTDEP SASSSVAATGAVSSSAGDSGGESDAITNTDHEQPPCHERTPAREVQLLIMRLLSVLMSRS KTAASTTSVTRGGVTAPSAGASLMLPQVTANCLVRAGAVTHCLSLLQQMLPYWRSESQDT NTTLLGSVLLKPRPMHPLPDMSPFFLRPLKDSENDVFASFPQLLTELVLRLPYQVHKVCD RGSGCGVLSVSSWSHYLCEYTLLQQPAIVKRQVRKLLLALTGHKDKYRTIRDLHALDHRI KEVKLLCAKGGFSFSSNGSQSPVSLPYDSLIQLIEHLKACVDIAQVRTHNWQKYCLKEET VLSFLIEASCQLDEGVAPTILQLLQAALCPAATDSSAAVVTVGPPVASAAQKALAADSSL SRGSSSSKRASSEDSEAGAGGSSEANKSEPQAHWPQLVAQVHMYLDRSRLSQFIHTFLLV SNSTSVRWQAHSLVLSLYRHSAPKDQDALLSLMWSLWPRLPVYGRLAAQFVDLLGYFSLN TTHEEKIVDYANMAVELLRTQSKHLASHPNASLYNSLASLVHFDGYYLESEPCLVCNNPE VPFTTAKLTSIKADSKYTTTTQLVKLVNNQLISRITLRINELKRTKMVRVLNIYYNNRTV QNIVELKNKPNMWHKAKRVTLASNQTEVKIDFPLPIAACNLMLEYADFYENMQSNTETLQ CPRCSAGVPASPGVCNNCGENVYQCHKCRAINYDEKDPFLCTACGYCKYAKFDYTLQCRM CCAVDPIDNEEDRKKSTMFINLMLDKADSSYKQLQAYKPALEALLLKAAEQGGERGLDDA LAGSNTVAAAPLVGNTYVNKTIQQLAQKYCGECKSAFDALSKLIQRIQACRRELVAYDRS QKEGSKRAVASLSSAQISPDGAPSAAFAAAASTMSICRCYGCASAASHHCITLLRALATK KPLRAALCGHGLIQDLLQHNLRRGNVQVRKEVRELLVLLTQDDIRATTELNDLISERIMS SVTSSAHLSSPDLAVAVRHEVALLAAAAAHKDSCWETRLRCVAKLFLMAGGNNSSPEVME HISLPCLRILQQAMITTQAKHAPEQLPKAAAGKSTGSSKSSGLPPRKPRADRSAAAKESG PSKSTTAAKTLPSPVMTGQYEKGCCVAVDLHSWLIGDPEHSFEAWKKRTRGTKSDRKPVN FSKMTKPQVRQYYLAEKYACRWVSHSIRPKFQLALTGADAAHNSWLRQMLFNPASRLARN VVWQVVYVIARTNPTWNAKLLDLLTEYLPEICVAGESGQEFVDLYKWLMMGPEWKQYLAV RGVLTTLGSLITREIQQLSVLEETCLSTDLLQGYALKTVTKLLQLFLDDAGIKSVYKRQL LPTVLSGYLSLRKLVVQRTKYVDDAQEELLDMLEDMTLGTEEETRRFMAVCIETVQQYPA DDLRTPVFLFERLCSIIHPEDNDVGEFFMLLEKDPQQEDFLQGRMNNNPYSSEDPAMGPR MRDVKNKICQDCELVALLEDDNGMELLVSNKIISLDLAVRDVYKMWLAENPENHDMRIVY RMRGLLGDATEEFVGTLVKKKEDDIDKEQVYRMASVMAECGGLKAMLDCLQRITDLSYAR PLVTVLLKLFQLCVKLRVNRTALMQPSSGAVAVLLHTLKQCLAAEPEVVAGAPGQPTFTE QLLMVLEAILEEACVMPAGEYAELVETCGTLEDIHLLLNYVATSSTTNAQEKQRLMRVLP FLVFCHKEKMELLVGHFRPILDFDRFDVEHTPEDAAKMESFCVFCSGIERSEIGSQLKDM ILRANIVKDAISYIERHIPKNQKIVVVCNNEWKDFLSRPSLKYILRLLTGMACKHPGSQR AVAESCIPAIHRLEQISSDEHVGSLAENLLEALTDDPAIAKQVGEVRRQTRQEKKRLAMK TRSKELNRLGLCANEKEQITSKSSLLQHMSDITDEQGLVCAICLEGYRNAPQKVLAIYTY SKRRAVEDRENKPHKTFGYSTVSHFNVVHVDCHLAAVKASRARDEWESAALHNANTLANG LLPLWGPQVPESAFVSCLARHNTYLQEYTMHRDINYTWTLHDLKLLLLRFARERSFSEDS GGGGPQSNMNLAPYILHMALYVINTTRANIREERRVEIFIESTAKDPARWVDASYEVEGP YFFVTLALAVCSSGKWNSGLRKEMLKRLLATAHVRSVSAVPPMGSKVATKAAKDWTVYKS AAIFWTLIDKLHSIMFTNVSVERNNEWSVALAAYIRHNDTAILDAAGRVLNVYQNELLPC SRNIYRPTQP NT seq 18033 nt NT seq  +upstreamnt  +downstreamnt atggcggcgagcagaggtagcgtcgattggtcgcaattagtgaagccgataatatcattt tggccggtttctgatgcatctttcaacaaacaagatctaccggaacttgttaaagctatt cttaaatgcaaagaggatattggacagcatgaggatcagtatgaagcattctacagcgcc ttctgcatcctggctgctgactaccttgccacacatgcccaatatttgtccgtgggaggt gtggtgcacagcgtcagcgcatgcaaggtgttgctgcagcacctcgtgagccgagtgggc tctcccccactgactgttaccatccctgctgctatcagccacaatcattcccactcgcac atatcaacccattctgttgcacccacaactgcatcatctgggaaacatgttcaaggctct tcagccccagtaatttctactagcgttctatccccatcctccatcaatatcctatcaagt gtgactcctgttgtagctcctgtagctgatgctgaccaaagtgactcggacagtcacagt gacaatgttccccaaatcattggtagcattgcagtcacaacccctgcagctacttcaggg tctggtgttgctcccatcaccatcagcaccacaagcagtagttctggtgctgtcaacatt gttactcctgtcaacaaggatgaccgggagaaggtggtctcgatcacggacaagcagttg gtgctggctatgaaggctctgtgtcgtggcagtggctgcctcagccgtgcagatcagtcc tcgcttatatctgtgatacgctcagctaagctgccgccgtgcgtacgcactcactctcac gacaaggacgcatcgtgtggtgcaggcagtggcagtgctggcagcagcagcggtggcatc aaggatggtcgccgcaaccgcaatgacccaagtgctgctgttcttgaacagctcatcttg cccctgcatgactttggaagtgacgcggcaggaaagacgaggcctggaggaggtctctca actgacaaggatggtgctggtcgtctttcagacgttgcgcatttgtttgcaagtcgctgt gaggcagcactgcagagcattggtggcggtgctacgctgcttgacgtgtgcctcaagatg tccagcatcagcaaatacaacaccaagtacaaggaactgttggagggcaaaggcttctcc ttcccttctaatcaacatgaagtgcttgcattcaaacctggtttggcacaggtagtgtcg gagctgagcatcgtgtcacgcatactgcagctgccagtactagaacctttgacagctgag cgcctgcagaagcttgcctctatcagcatggcagctctgctcgcagctctccacgtcgcg gtcgcgtctgctgtcaccgccgtcacctcagcgcctgccaccactgcatcagcgacttcc agcaagactccacccgcgagcgcacgtgacgatgagcttgattcgctgtccacgagcgtg acggagaaagctttgctcatctactcggtggtgctgcgcgctgtgaagacctccaccagg gctggtggacatcaccaccaaaacctgcaactcatgggcggttggctgctgtcgtctgga ctacaccagcttatggtgatcgtctctgccgtctcgcctgctcctgcagctgctgctgct gctgcaggcggtagtggtccttcaccagccaccttcactgacaagaataccaaagaagac aagggcaaaagtccaacaaagaaagatgttgtttccagaattaacctaaataaagttcag cagggcgtcagttcggtggtggttgccctcgcgcagctgtgctgtgaacttctttctctg ctgctggaggacgtggccgtcgagggctggaatgctaacaaacccactcccacgcctgcc aagatgagcgtcctggagacattctctgccaccaaccgcatcgctaggatcttcaacgcc gtgcctctcaaccagctgctcttctacctcgccactgtgtcgtacaggaaggcttgtagc ttgcggcgcagccagcgcagcatgcacgagggtgacacgtacagtctcaccgacagcacc atctactacgaagacgacttctctgagggcagtcttggagaagaagacgacgattcggtg atcatcgggtcatggttcgaggagccgtgcacgccaggggcagaggaggggggccagcga ggaggcagcggcggcccacgacgcggttctgtgggaggacgacctcgtccagcctggggc gtgagcgcctccacacatggtggtggttccagtcaaccgcagtcgatatcagagagcgag agctgctcgtccggtggcggcgcccccctgaacagcagaagttcccgcgtcctcgacgcc tcaggacctcctgtcatccctgacaagtccgagccccatgggttcctgaacctagcaacg ctcattttcggtctgatgaaccggcacctggtggagtgtgactgcgcgtatgtccagcag tatgtgcgcacaggcctcgccgacacgcacatgattgtgcttgctgccatcatcaaagac ttagaccgcgacactgccaaaactgacgcagagcttggcagcagtggaggagcagtagtg cagaagctgtatgagcaattctcgcagtcactctatcgcttcactcataacctcatcgcc tcgggggcgctcagtgatgctctgcaggccacgctgttgcatcaacttggggtctccccc tggatctctgacggtgactggccgctcttgctgctgcccaggacgctcacagtcctcgct caggttttgctgctacgccaacgtcgtgacaaagacgacctgaagtgcgactgtgacacg gcctgcgtcgtcatctggcagcgcgtcgtcgctacgctcgtcaaggccgtcacctgcccc gcccctcatccagaccatgaagtcgatgacctaaacgtagagcacgcacagctcctgctc ttcctgttccacgcactccagttgatgcagaagaaagctgtgttactgagcgtggccagc gctctcatcacagtcgcccctgtcgtcaagacgcccatgagggactcccagctacttcat ttatccaggctactcctcatctttgagtacctcatgaagaatttgtatgaggcacctcag acgcttatcgaacaggtccaatggaacctcttcagtccaatatctcgcgatgtagtgaga gtggacaacagtggagcttcttcaaacaacttgaattgtggtcccagtacggctggcgac agcgctggcaatgccaagatgtaccacgtgtggcgtgacattgaagataattaccagaag catcaccaggccgacgagaccggcccatcctgcgcccctaccttgaagcccaagttctac actctcactcctgttgacaccaattctcaggacactcccaagctggacggacttgcatgc agtttcattttggctacaccggacaccctgaagtacaccactttgtacgaaacccttgtt ggcctgctgggtgtgagttgccaagtggacccaagcttccgtgcgtcttcatctcactcg agcgatataacgcgctcggcatcttcagacgtcatcaagcagtgtgccgcaagtgacgcc accaccacccccgccactgccaggccgggcactgaagtcctgcggtccgtttcgactgat tgcgccgcggcttctgcacgtgttcagtctaatgacaacaatctaagttacctcggacac tgtgctgtccagtatacgttctccttcgtgtaccgcatactgttgacactgccaccctcg gttgctgcactagaggctcttgcgagtcccgacactaagctcgagggaccttggctcctg catgctcttatttgggggcctagggcttctcataaagttttcaatggctggatcaaggat ggtcttgtacgtcagagtttgacaacccagaaggcagacgctctgcttaagtctgtgacg aatgtcacttcgtcgctgcagcatgacttgcgcgtcgcaggcctcgtcatctcttctcta gtagctaagatccactcgaaaactgcagcatctggcaccgctacgtccattatgaatgta gcaagcttcgccgatttgctgttggttgacgcggtgcttgcgagactgcaggtcacgctg gatgatggatggcagcgaggtgacctggacctacgaggtgccggggacactcatgattta tgccagacgctgaaaatcacggcagatcaattacccgtcacgtcgctcctgtcactgatc atgctactgacggagtcagcacggcacggtgttgtgcacagcatgagctcctctcctgct acgacgagcagcggcagcagcagcacttccaagtcagcggctgctgaagaaactgcggca tctgatgccggtccattaatagaagctctgagtcgcgttctcgccgtatctggagaccag gcaggctttgtacagccatgtctctcaaaggactgtcgtaaccctctgttgaacgcggct ctgcaacgctggacctccaataccctcgacacattccctcagcctcaagcttggaagagc agccagtgcgggggcgacgtgttgcctggcgagagctttgtgtcgggcgtggtgctcggc cacgtgtcttgtctctccgacgcccccaacttcacggtcgccagctcccccctgaagcat gtcctgcgcaccctcattaccttcactactgacctcgccggctggtacaccgagagtgaa aaaccgcacgctcagctggtccaaacgctggtatcgatcgccgccgacgccacctgcgac ggcctgtccaccacgctgggctcggcccttgaacggctcctgccatcgccaccaaccgca gctactggcgttacaatgggcggtggtagcggcaacgagagcgttggtagcgctagcagt agcagcagcagtagcagttctgacagcactgcggcgggcactggtgacagcagtagcagt agtggcagtaacactcaggccacggtagctcatcacctctacggcaggcagctcgtgcac gtgcaggctctgctcaagatagctgccaactaccacggtgtggtgagcgatcgagtactg tccggcattggggacttcctgtgtcagctgctggaggaccctgccggccgacaatctctt cggtctcatttccagacgtcacctcacttctgctctgtgctgctctcacccgtccctcct aaattaactgccatcaagtcgagctcgtcatccaaacttgccaaacgctccgtgtcggac aaggaagaggatccctcatcagaggctttgacgtctgctgagactgagagtgaacgaaat atcttacccgagcccatcctcctcttcctgatcgtgctgttccagcaggcagagaaacag cctaaggacagtgacctatctggcatttgtaaccacatttggtcttgggtcgatactggt gctctacaacgctggctcatttctgccaacaaagctcactactcggtgagttctagatcc actgaaactcctggcagcacgaaaatagttgaagttactccacagcttcccccaccttcc cgtttgccaggcttcatcagaaaacgcaaggatcggaaattccttgccaagaccatcttg tttgagagccccttccttgatccggatctggtgccacttaacttcctcagttcagcggcc acttcagcaaccaaaggcaaaatgaacgaagccatggtcctggacgatgatgacggtgac actggcgacgatgaagatgacgagacgaccaagcgtagaggcgtgcccgcgtcggacttg gtgacgcaagagatgaggctgcgtcactgctggtcgctggtgcaggccatggccaagtat gcctgcgctcaggacactcagctcgccaagagccattgtacctcgctgcttcgggccctt gaaacggtgggcaacagcatcactgacgaagccatagtcaccggcgaccccgaagagagc tgtcgcttcctcaagcccatctccaccctcgtgcctatcatgagatccttggctgggggg gcggcgcctcagggtcacgtcatattactgcgcaccgccatacagtggctacaaatatac aaatacgttgtcttccctggcgctacgatgaatgtgcacagccctggcgacgctggcacg tcctctgatgacaggaacctcagccccgcggttgtcgaacgcctcaagaaccaaattctg gtgccagcgcacttactcttctcgtacttgagcgacgtgctcgtggctcttaaaatatcc ggagaacagaccaagacctgtgctattgaaggggagcccagcggtgacattcagtcagtg acagatgcagctgacagcgaccttctcgacgatcgcaaccacgatgacggcctggacgat gaagaagttctcgaagattccgaggacgagagcgtgtgcaacaaactgtgcacttacact ctcacgcaaaaagagttcgtaagccaacactggtaccactgccatacttgccaaatggag gacggcgtgggcgtgtgttccgtgtgtgccaaagtttgccataaaggtcatgacgtcact tacgccaagtatggctcgttcttctgtgactgcggcgccaaagaggatggatcatgtcag gctctggtgaaaaggacaccaagctacagcaacagaggtgacgcaactgagtccgcaggt gccgtcttcagtgtgggtgcccttgcttctgcctcaggcttgaggaagaaacgcgccttg tctccttcgctgtcgtacactgacagcgtacgggaacaaactaacaagcgtcgtcaggtt ctggcgcggcagatcgagggcgtatggagtagcctgtgcagcagcaacacccacctaagc gtgtgtctctactttcttcacaatcttttgccgcgtctggaggacgaggctcatgccagg gctgctttgaactccctcaacgctaacaggaaggctctgcacacgcttcactctgcaccc aagaatgtacagatgggtgaccacctgatgttctctccgctgggagcccaggagaacgcg ttcgagaacgtgcgccttaactactctggggaccagggccaaactatccgtcagctggtg gccacccacgccatccgacgggtggctatgtccatcatgacgtcccctacgagccgccgc cagcacttggcggtcactcacgagaagggcaagattgtcctgcttcagctgtcgtccatc ttgcgacagaaggagttgggtttgccgtccagtaactttggggccagcaagcgcaagctg accatttctcgactgacgagtctgccactgccattcttggtgctgagtctctctgccaac ccctgcaatgacgattacttggccgtctgcggactcaaggactgccacgttcttgttttc tcatctacgtgcagcgttatggagcatctcgtgctccacctccagcttgagtcaagcggc tatatcatcaaggttgtatggctgccaggtgagcagacacaacttgctgtcgtcactgcc gacttcgtcaagatatacgacctgagtgtggacgcgctatcgccgcagtactaccttttg cttccgtcgggcaaaatcagagatgcttgttttgcttctcttccggatggctctgtgcac atgctgctgatgacgtcttcaggctacatctacacacaggagctcaatgaggacagttcc gcaaagcacggctcgttctacgtcaccaacgttctcgctgtcgaccaagcagctgccgag ctcaaggatgtctcgggtgtggtcggtggtggtggtgtatccattcactactcacaaggt ctgcaactgctctgcttcagctactcccacggacgttctttcatggcgcctcttacgcaa cttggagagaatgctaagcttgacaagcttttccccatcaacgtcaagccaagtggcagc aacgccagcctttcgagcaatggcgccagcagcagtagtagccttggatcctccggtggc agtagctcgagtgcaggttctagcagcaagatgtcacctctatgtcagtggtcagaagtg ctaggccatccaggtctattcacgtgcttcatgatccaaggcaatgtacctgtactaatc tatgtgaagccagagagcataatggtgcaggagataaaaatcccctcatcaaagaacaag gtttgcgacatagttgcacttcgtcacgcagcaggcaatgagtcccggaccactctgctg ttactcagcgaggacggttcgctgagagtcttctctgctttctcggattcagcagatttt tggacgagttctaatgaatcacgcctcgctctgcctggagataactcggctccaaggaca tcccgcaaaaagaaaaacgtcaagcatggcgcctcgtcatctggatccgtagcgttccca gttgacttctttgaacactgtaacccaatctctgacgtcgattttggtggcaatgacctc ttgcaagtgtacaacgtacagcagctgaagaataggctaaacagccagtccacctatgtg gcctgcagcaaacctggcggcttccaacttgaagtgaccaacaaagatgcaaatgtggtg atgtgcggcgcgcgtgtggcagttggaagcctccaccccctcaaaaatcctactttcgtc aaggtctttgggcgcacaattcccgtgaacacttcgcgcaatcggtggtacgacatacca tttacacgagaggagtctctgaaatctgacaaaaaactcgtgttgacattcggaccttca actgacccctctcaggtgaccatcatagatgccgttaaaatatacggggaaacaaaagaa gaatttggctggcctgacgacgaggagtacgcaactgcgagcgttggtggtaacgccacc agcacgtctgcacccacgacggctaccaattctcacgcgaacgcgtcacggagtattggt gatgataccgacatgacgacagccaaagcgtccagcaatgacagtgtattggagtcactg ttctgctctgccctcgatgccttggacggctgtttctctactatgcaaaacgtcaacagc agcgctcgcaagcaagcacttgagatcgtgactcgtatgataaaccttcagctctcaccg cgtttacagtcttgcacgcgctccctgctttcctctcttcacgagtctcggcagacgtac caccaacagctggacggagcacaactttctggagttattgaaactcttaattctctcatc gctactggtcaaaaagacccttctcttatggagtgccgagctttccataatataatcgtc ttggcccgagaagttgctgtttcaaggcctcacaacctcgtcaaattcacgcagaaagct cgagatctgaacacgacgctggtcgagtctagtgtccgagttactgtggatgctccagaa gactcggtggctgacaagactttagagaacgactctgaagaggctttgtccgaggagccg aaagcctttgtctctgaccaaagtgaggttaacgtgccgtcaggtgctccgcaagaggaa gctgcagatgaccacttcttatctctcctcatggaagccttctggctgttgctcaaagcg cgtccgctcaacccacttctgagccctgtgtaccagcctggcctcactcacgtggaagcg accgtccaggcgatgctggagatcttgcacggatattctttgtgcagcccgtcgtctgta ccgctcgtgatgcgcctctactgctccctgctgctctcacctcaccaccaggtttcgttc agcgccaagacggcgttagtgcgactgttgcgacctcgcaccaagaagcacaagcgcgtc ttcctgcctagcccgcctcgctgctctactcctggtgaaggtaaaagcagtgggctggct gttgctgggccatcaggcgcctcagctgcagcaggggagggcagcagtcatcggtcggcc ggcggtcaccgcgccgctggtaacaacgaagccagcgacctcgtgggcgccctggccgaa gtggctagagccagtggcgagcttttgggggctgctgcgccgggttctggcgccgatctg ttggcaggcatgatggagctgggcggaggtggtggcgaggatgacgacgacgccatgatg gagctcgccatcgccctctccctgcatgacgaggcgtctgctggtggccagcagctcgcc ggcatggagcgtctgcagcacctgcgcggccacgtgctgcagagtctcctcgcttcaggt gctctgcaggctcctcctagcctccaaaatcaagctcttaaccagaatgacgatggcgat gatgaagacgctgaggatgatggtgagaacgatcatgatgacgatgatgagcacgaagtg gatgaggacgatgatgatgatgatgacgatgacgacgatgatgatgatgacgatgacgac gatgatgatgatgatgatgtagatcacatggacgtcatccacgtgattggagggagcaac ttgacgcaggacttggatgatgttgccaacgatttggataacgccgcgggcaacgctgcc ggagacttggtcaatgtgggtggggagatcgtcaacgtggcggggggtctggacgtgggg gaggacaaccagggggggcagttctctgacaccacggcgtctgccaacgccagcgatgat gaggacggtgaagtgtccaacgctgcgactgatggtggcagcaaccttatgaggacgtct ccagctgatcaaggatgcagcggtggcagtgagagtgggtgttcagtggtggagagcttg ctgggtgagcagagtagcatggctacggtgggcagcgctggagcgatgagcgccaccagc acggcgtacgacgctaccacgcacgaccaaatccctgctcctgacgacgcacacaacgct gatggcaacgcacctaatccggaaggaagtggtagcagtaacccatcaagcagcggcagc accaacaatgtcagcgttcacagcctgcgtctcgctcttctggacgctctcactacgcga ctacagcgcctgcagcagctgggaggcattgctgccattccaacacttcaggtaatcctc atgctgtcaactgatttggacccgcgcaacagtcgagaccgcgttactctagatgcgctt ctcaacgctctggttgcttccctcgaccttaactcagcaggccgctcgaccgacgagccg tcggcatcgagcagcgtcgccgcaactggcgctgtttcttcctctgctggcgacagcgga ggcgagagtgatgccatcaccaacactgaccacgaacaacctccatgtcacgagcgcact cctgccagggaagttcagctgctcatcatgcgacttctgagtgtgctgatgtcgcgtagc aagactgctgctagtacaaccagcgtaacccgcggtggagtcactgcaccttctgctgga gcgtctctcatgctgccccaggtcaccgccaattgcttggtccgtgctggggctgtgact cactgcctctcgctcttgcaacaaatgcttccttactggaggtctgagtcacaagacaca aacacgactcttctgggcagtgtactactgaaacctcgtccaatgcacccgttgcctgat atgagcccatttttcttacgtcctctaaaagattctgagaatgacgtctttgcgtccttc cctcaacttctgacagaacttgtcctgcgtttgccgtatcaagtgcacaaggtgtgcgac cgtggcagcggctgtggtgtattgagcgttagttcttggtcacactatctttgcgagtac acgctcttacaacagcctgcaattgttaaaagacaagtgagaaaactactgttggctctc actggccacaaagacaaataccgaacgattcgagatctgcatgccctcgaccatcgtatc aaagaagtcaagttgctgtgtgctaagggcgggttcagcttcagcagcaacggatcgcaa tctccagtgtctctgccatatgattcactcatacaacttatcgaacatctcaaagcttgc gtagatattgctcaagtacgtacccacaactggcaaaaatactgccttaaagaagaaact gttctcagtttcctcatcgaggcttcatgccaactggatgaaggcgttgctcccacaatc ttgcaacttctgcaagctgcactatgccctgctgctactgacagcagtgctgcagtcgtc accgttggtccacccgttgcatcggcagctcaaaaagcactcgctgcagacagtagcctg agccgcgggagcagtagcagcaaacgcgcatccagtgaggatagcgaagctggtgcggga ggaagcagtgaggctaataagagtgagccccaagcccactggcctcagcttgtggcacaa gtgcacatgtatcttgacaggtctcggctctcgcagttcatccacactttccttctggtg tccaattcaacgagtgttcgttggcaagctcactctctggtgctgtctttgtaccgccac tctgcacctaaagaccaagatgcactgctcagcctcatgtggtccctgtggccacggctg cctgtctacggcaggctcgctgcccagttcgttgatttgctgggatatttctctttgaac acgactcacgaagaaaaaattgttgactatgccaacatggcggttgaacttctgcgtacc cagtcaaaacacctagcaagtcaccctaatgcttctctgtacaactcccttgcgtctctt gtgcactttgatgggtactacctagagagtgaaccttgtcttgtatgcaacaatcctgaa gttcccttcactactgcgaaacttaccagcatcaaagcagatagcaagtacacaaccaca acgcaacttgttaagctagtgaacaaccaactgattagccgcattacgctgcggatcaac gagctcaagaggactaagatggtgagggtccttaacatctactacaacaacaggaccgtc cagaacatcgtcgaactgaagaacaagcccaacatgtggcacaaggccaagcgtgtaact ttagcttctaaccagactgaagttaaaattgacttcccacttcctatcgccgcgtgcaat ctcatgcttgagtatgctgatttctacgagaacatgcaatcaaacacagagactttgcag tgccctcgctgttccgcgggtgtgccggcttcgcctggtgtgtgtaataactgcggtgaa aatgtctaccagtgtcacaaatgccgagctatcaactatgacgagaaagatccattcttg tgcacggcgtgtgggtattgcaagtacgccaaatttgactacacgctgcagtgccgcatg tgctgtgcagttgaccccattgacaacgaagaggaccgtaagaagagcaccatgttcatc aacctgatgctggacaaggcagattcttcctacaaacaactgcaggcttacaagccagcg ctggaagccttgctattgaaggctgctgaacaaggtggcgagcgaggtcttgatgatgca ctcgccggctctaacactgtggccgctgcaccgctcgttggcaacacctacgtcaataaa actattcagcagcttgctcagaaatattgtggagaatgcaagtccgctttcgatgcactc agcaaacttatccagcgcatccaagcttgtcgccgtgaactggtggcctacgaccgcagt cagaaggaagggagtaagcgcgctgtcgcgtccctgtcgtcggctcagatttcgcctgac ggtgccccttctgctgcgttcgctgccgctgcttccactatgagcatttgtcgctgttat gggtgcgcctctgctgcgagtcatcactgcatcacactgctgcgagctctggctaccaag aagccattacgagcagccctttgtggacacggtctcattcaagacctgctgcagcacaac ctcaggcgtggaaacgttcaggtgcgcaaagaagtgcgtgagctcctcgtgctgctcaca caagacgatataagggcaacgactgagctcaacgatctgataagcgagcgcatcatgagt tctgtgacgtcctcggctcatctgtcgtcgccagatctcgccgtcgccgtgcgtcacgaa gttgcgctgcttgctgccgcggccgcacacaaggactcgtgctgggaaacaaggctaaga tgcgtggcgaagctcttcctgatggcgggtgggaacaacagctcgcctgaggtgatggag catatctccctgccgtgcctgcgcatcttgcagcaagctatgatcaccacgcaagccaaa catgcgcccgaacaacttcctaaagctgccgctggcaaatctacgggaagctcaaagtcg agtggtcttccccctcgcaagcctcgtgccgatcgctcggctgctgctaaagaaagcggg cccagcaagagtacaactgcagccaagacgctcccctccccggtcatgacgggtcagtat gagaaaggctgctgtgtcgccgtcgaccttcacagttggctgataggagacccggaacat tccttcgaggcgtggaaaaagcgaactagaggcaccaagtccgatagaaagcctgtcaac ttctcgaaaatgaccaagcctcaagtacgtcaatattacctggctgagaagtacgcgtgc cggtgggtaagtcactcgatcagacccaagttccagttggcgctgacaggcgctgatgcc gcccacaacagctggctgcgtcagatgctcttcaaccccgcatctcgtctggcacgtaac gtggtctggcaggtcgtctacgtcatcgctcgcaccaaccctacctggaatgccaagctt cttgatttgctgaccgagtacttgcctgagatctgcgtggcgggtgaaagtggccaagag ttcgtagatctgtacaagtggttaatgatgggaccagaatggaagcaatatttggccgta cgaggtgtgctcacaaccctcggctctctcatcactcgcgagatccaacagctctctgtg cttgaagaaacttgtctcagcacagatctcctgcagggctatgccctgaagactgtgacg aagctgctgcagttgttccttgacgacgcgggcatcaagagtgtatacaagcgtcagctg ctgcccacagttctcagcggttacctgtcactgcgtaaactggtcgtgcagcgcaccaag tatgtcgacgacgcacaggaggagcttctcgacatgctggaggacatgacattaggcaca gaagaagaaactcgtcgtttcatggcggtgtgtatcgagacggtgcagcaatatcccgct gatgatctgcgtacacctgtcttcctgtttgagcggctctgctccatcatccatcctgaa gacaacgacgttggcgagtttttcatgcttctcgaaaaggatcctcagcaggaagatttc cttcagggccgtatgaacaacaatccatacagcagtgaggatcctgctatggggccccgg atgagggacgttaaaaacaaaatttgccaggattgtgagctcgtcgctctcctcgaagac gacaatggcatggaactgctggtttccaacaagatcatctcgttagacctcgccgtgcgc gacgtttacaagatgtggcttgcagaaaaccccgagaatcacgatatgcgcattgtgtac cgcatgcgtggtctcctgggtgacgctaccgaggagtttgtggggacgctcgttaagaag aaggaggatgacatcgacaaggagcaggtgtaccgtatggcatctgtgatggccgagtgt ggcggtctcaaagccatgctcgactgcctgcagcgtatcacagatctctcctacgcccga cctcttgtcactgttctcctgaaactcttccagctttgcgtcaaacttagagtcaacaga actgcgctgatgcagccgtcatcgggcgctgttgctgtgctgcttcacaccctgaaacag tgtctggctgctgagcctgaggtcgtcgctggggctcccggtcaacccaccttcactgag caattgctcatggtcctcgaagccattctagaagaagcttgcgtcatgcctgctggtgaa tatgctgagctggtagagacctgcggcactcttgaagacatccacctgctgcttaactac gtcgccacttcctccaccactaacgctcaggaaaagcaacgcctgatgcgcgttctgcct ttcttggtattctgccacaaagagaagatggagctgctggtcggacacttccgtccaatt ctcgatttcgatcgcttcgacgttgagcacacgcctgaagacgctgctaaaatggagtct ttttgtgtattctgcagcggcatcgaacgcagtgagatcggatctcaactcaaagacatg attctgcgcgctaacatagtcaaggatgcaatttcgtacatagaacgacacatccctaaa aaccagaagattgtagtcgtttgcaacaacgaatggaaggacttcctctcacgaccttca ctcaagtacatcctgcgccttctcactggcatggcctgtaaacaccccggcagccaacgc gctgtggctgagtcctgtatccccgccattcaccgtcttgagcaaatatcatctgacgaa cacgtcggctccctcgctgaaaacctgctggaggctctaacggatgatcctgccatcgcc aagcaggttggcgaagttcgtcgccagacgcggcaggagaagaagcgattggcgatgaag actcgttcaaaggagctcaaccgcctcggactttgcgctaatgaaaaagaacaaatcact tcaaagtcatccttgttgcagcacatgtctgacatcactgacgagcaaggattggtgtgc gccatatgcctggaggggtaccgcaatgctcctcaaaaagtcctcgctatctacacctac agcaaacgtcgagccgtcgaagaccgcgagaacaaacctcataaaactttcggctacagc accgtctcgcatttcaatgtcgttcacgtcgactgccatcttgctgctgtcaaagcttca cgggcaagggacgagtgggagagcgctgcgctgcacaacgccaacactctggctaatggt ctcctgccgctgtggggacctcaggtgccggagagcgccttcgtcagttgtctcgctcgc cacaacacgtacctgcaagagtacacaatgcacagagacatcaattacacttggacgctg cacgacctgaagctgctgctgctcaggtttgctcgtgagcgttcgttcagcgaggactcg ggtggaggcggccctcagtccaacatgaatttggcgccttacatcttgcacatggcgctc tacgtcatcaacactactcgggctaacattcgtgaagagcgccgagtggagattttcatc gagtctaccgctaaagaccctgcgcgttgggtggacgcatcttacgaagtcgaaggtcct tacttctttgtaactttggcgttagcggtctgttcttccggtaaatggaacagtgggctg cgcaaggaaatgctgaagcgactgctggccactgctcatgtgaggtcggtctccgccgta ccgccaatgggttccaaagtggccaccaaagctgccaaagactggaccgtctacaagagt gccgccatattctggactctcatcgacaagctccactcaattatgtttacgaacgtaagc gttgaacgcaacaacgagtggtccgtggcgctggctgcatacattcgtcataacgacacg gcgatactggacgctgctggccgcgtcctcaacgtgtaccagaacgagctgctgccttgc tcaagaaatatttacaggcctacacaaccttag

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