Hippocampus comes (tiger tail seahorse): 109522005 Help Entry 109522005         CDS       T04969                                  Name (RefSeq) obscurin-like isoform X1   KO K17531   obscurin-RhoGEF [EC:2.7.11.1] Organism hcq  Hippocampus comes (tiger tail seahorse) Pathway hcq04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:hcq00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     109522005  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hcq01001]     109522005   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:hcq04131]     109522005 Enzymes [BR:hcq01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      109522005 Protein kinases [BR:hcq01001]  Serine/threonine kinases: CAMK group   Trio family [OT]    109522005 Membrane trafficking [BR:hcq04131]  Others   Rho GTPase associated proteins    Rho guanine nucleotide exchange factors (GEFs)     109522005 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  I-set Ig_3 ig Ig_2 V-set Pkinase Ig_5 PK_Tyr_Ser-Thr Ig_4 Izumo-Ig C1-set SOS1_NGEF_PH RhoGEF C2-set_2 Kdo IQ_SEC7_PH ABC1 PH fn3 Kinase-like APH Motif Other DBs NCBI-GeneID:  109522005 NCBI-ProteinID:  XP_019735715 LinkDB All DBs Position Unknown AA seq 5945 aa AA seqDB search MSSMEVTEPEPALFQVETSLKSGRPPRWTLNGKVLEPSEVVDMYREGTIHSLCLTSTDSS MSGPVVFVAGKSRSSAELTVKERPLQVVRNLEDVEAKENSSVTLSCEFAPSPRVVRWFKG RTALKASNKYSMRRDRKRAELTIHGLVGMDGGQYRCMAGGSQSIAHVEVEVRKLKLVRHL EPVELEEDSVASFACELNYVVANVEWLLNNVRLYSSATNRIQHMGTMHSLFIKKLRPQHS RVTFRAGLLSETTTLKVKERPAVFLRPLEDAVGEEQGEVCLQCEVSKVSVIPVWRKNSIV LTPDEKHELCQYGRSLALIIHCLSKDDAGQYTCDLGTSQTKAKVTVHDLHITIIQRLKTT SIMEGESCTFECQLSHVLSDEPFWTINGQLVVSNSHFQVINNGRKYKLRIKDAVLSNAGE VIFGIKDLSCRTMLFVKERPVHIFRDLLNVKTVPGEDAELSCEITKPEVSIHWLKNGHMI RQSHKYKMSVEKNLARLIVKNTAIRDSGEYCCQADGVASHAKLEVRDLQHSFERELKDSK AEEKGKVTLECETRQPAKRVTWLKGMMELRSSRKYVMRQKGVVLSLTITYLEKSDTDIYT CDVGTMQSRAQLTVQGQRVVILDELEDIECLESDTVTFKCQICPSDYTAVKWYLDETLLY NNQLNEIQMLAGGYHTLTFRQLARKDTGTISFSAGDKRSYASLLVRERRPTICKALEDCE AIEGGGLVLSCVTSKPCHILWYKDCCLMWNSSRYFASRSGCEARLAIREVCQSDAGVYEC SAGSVSTRAVVTVKAIPAEFTKPLQNVESREGETATLTCEYSLPGVQFHWKKGSESLRPG DKYVMKQRQTINSLIIRAVKPEDSGEYTCQCRGHHTTARLKVQAIPITFIQQLKNLHAEE GSNVILRCELSKSGIPIEWMRGQEVLKNGVKYQMRRWETTLELLIWKAVPEDSGLYKCLC ADQVTSATVKVKALPLTFKQKLHNVSFEEGNMATLRCELSKASLFVEWWKGGDELIKNSD KYHMRQSDTLIELRILDVTPEDSNIYTCICGSIETTATLTVNALPITFKQKLKNLQVEEG HNITLSCEISKPGVAVEWRLAGELLEDGEKYQMKQRGSVLTLTIRDALPEDSGIYACVCR DQKTKATVKVVAIPATFKGSLKSQEAEEGSSVTLRCQVSKTDARVEWQKNGQVLSEEMSG RKYQLKLEGKTAELTIVSVEVQDAGRYSCITGDEKTTAELKVKSLPVTFKHGLKNLEVKE GDSGLFCCELSKPGAPVEWRKGRVLLSSGGKYEMKQEGPYTKMVVNNVQDSDAGKYICKT KDSQSTAELSVQGLPPCFTLMLANQEVIEGNSVFLRCELNKPAHSVEWRRGGLVLRQGDK YQMRKKDLQLEMTINNVTLEDAGDYTCTCGEETTTACLAVNERPVKFLHELSNIEVQEGN GVTLCCQLSKAGLTAQWMKGDELLTTGERYQLKQRGSTLELLIGKSQPEDSGVYSCICEA IKTTATLIITAIPVTFKQKLKNQETVEESSVMLYCELSKPGVPVEWRKDAQLLREGAKYQ MKQEGRVCEMLIADLTLKDTGEYSCSGGTAVTSAEIKVRALPVTFKQEVQNLELKEGDSG VFCCELSKPEAPVDWRKGRVILKPGYKYEMKQEGNFTKLFVNHVEECDAGKYTCKTKDSQ STAELIVIAPPITFKTKLKNLQVEEENSVTLICELSKPGLSVEWRKGQELLKNNFKYQLR NRNSMLELTIKNTQLDDSGVYSCIYGDTKTVANITVTPIPLTFKMGLKNQEAAEGGNVTL RCELSRSGMSVQWWKGEDQLHQGGRYQMTLKENVAEMSIRNIQPEDVGEYSCVFGEQKTT AEVNVRAAASVFFEKELESQAVTEGKSVLMSCEVSSANVPVTWKKDNTVIEAGPRLIITK KGPMHMLAIKQLNLEDAGEYCCITRGKKTTAKLIVRERVRIVTELKDITVTAGEDAMFVC ELSHANVNEGVWWLDSSPLQRNDMNQMTCQGRTHRLVLTMTTPDETGIVAFVIGEERTSA SLSVVPKLKVLFEEKPQDVRISEGEIATLSCTTSDFTTPVTWRRNHIPLRNGDKFEIRKE GKVNLLLIHAVEPGDAGVYSCDTGDAQASAKLTVTELPPFFQEELQSVETEEDGSAILCC ELSKLGLPVQWRKNSLPIRAGRKYEMKQDGCFLQLHIKELKLEDSGSYTCQAGNAETTAT VTVKELQPFFKKDLENVRVDEGGSVSLSCEVSKPGLPVQWKKNKLPLRANRRYEMKQDGC LLQLSIVNVKPEDSGSYSCHVGSVESTATIIVKELPPFFKENLENVQAEEGGIASLRCQV SKPDTAIQWKKNKLPLRASNKYEMTQDGCLLQLTISDLKPEDEASYTCEAGSAETTATVS VKELPVIFKADLQSTEAEEGDKAFLSCELSKPGVPVQWKKNKLPLSANRKYVMKQDGCLL QLNIMDLKPEDSGTYTCQAGSAMSSATVTVRELPLFFKQQLQSVETEEGGSVSLYCELSK PGVPVQWKKNRLPLKASRKFEMKQDGSLLQLNISDLEPEDGGRYTCQAGSAETIATLSVR ERPISFKNELQSMEAEEGDTAVLSCELSKPGVAVQWKKNRLPLRDDRKFEMKQDGCLQQL IIIDLRPEDSGSYTCFAGSAETSATIAVRELPLFFKEKLQKVEIEEGHSTSLCCELSKPG VPVQWKKDKLPLRANKKYEMKQDGCLLQLNIKDLKLEDSGSYSCQAGSAETATTLSVKEL PPLFVTGLQSAERDEGSSFSLCCELSKPGVPVQWKKNNLPLRANKKYEMKQDGCLLQLNI EDLKPEDSGSYTCQAGSAETTATLSIKALPPLFKKKLQRIEADEGATAVLSCELSKPEVS VQWKKNALPLKADRKYDIKQDGCLLQLHIKELHPEDCGSYTCQAGSAETTATVSVKELPC FFKKELQNTETEEGATAVLCCELSTLGVSAQWKKNGIPLRANRKYAMKKDGCLLELHIKE LNPEDSGSYSCQAGNAETTAAVSVKAPETTLSKNEPSMVRPRTRSTTSEPENVNLPNAHL IPPEPKKRTVRKASITAVEQDAETMFNIKQPIQSLQIADQKEMQTEKQTENAQDSNQQVH NVDQNVEVSTRPANLDEKEHVIERIETEKTQPAKPQMKAELSQPGRNLGNNGVDQQKQLF KSLETNPTQNEKPFEKVREVEILDDHPETILWKRVEEEKKAMKPSTTAFEIETLERDVKS TIKDGDVGKTGDGVLPPVRSKGKAAGGRETPEVVKKETEEFTQQPSNAALNDSRDGNTLR NHVKELATTEKVEEQVMQVPSVNQLDSHSGKRKELPQDIKTEPIPPKPPVRSKSKTRTGM EKRPSRDTETDQDEQMVTTAKDQLLKETGRSLKDEESRLEKKQSASADADLVEKLVLPKQ LIKHPVKPMRKEPEMDKEVAAGSMAREEEHQEVQMMEEIPLLYISEDETFSEALTEIPII EPGGFFDETSTKPYTQPIILDLQKPVQDASPEVYISAEDEPQMQEATVKIQTPLKGYETG KDTRPVLKEVFSNQCADVDGNITLMCTVEGHYNSVRWLKDGQTISRDERHGIEAAEGGVC SLVITQLTLSDSGIYTCEVVNKFGMTSYSGNITVVPLQEPAQTVGRQVHPPLAAITPLQL APLRPEDKTQIQDQATSGTDADNYVENIDVSLWEAYNLTEQHIQMGQQKRRPSSLIATSS VSSPSDYDTAPDVIEPVEITTHPARELPEATDQMPLKDSNQHSADPCLFKTFLQVQGTQE GQMRTPSPKHLRAHTPLASTVSGSESEGEEDQCETFEMYVARAACNPNSGSKDSFLLKEG QYVEVLDSVHPDKWLVRTKPTKTNPARQGWVCPAYLEKKRKEAFTQLRAPQEDLDGIGST GEEYRRALSQLIQGLIDGEEEFVKEMRLFISHPLNYLDSSLNVPIHIINQKDIIFRNIKD IVLLHEKSILPGLRACTTDDDVAMHLILHFEDLEKYVHYMLGQSQAEACIADKATQQYLK ELPGSGRPEAPVIDTLTFLQRPVERIQTYQALLKELIKNKAKSGQSCCLLEDAFSLVSCL PWRSDNLHQVSLIENYPAPLTALGEPVRQGAFTVWDETPETKKTSRGHQRQVFLFKECIV LCKLRRDASKSCDVYTFKNKMKLNDVELRETMGGDEKTWELWHEHRGSVRRYALQGRSPL VRLSWLKDLKELQQRSILTTNNAPVFTSLLSDCTAKIGQTVKLSCQVTGSPQPVITWLKD GLALEDDPRHIITADRSGTCILILDSLTAEDSGQYVCYATSSMGSTGTLATVVVQAPPRF ISRLESTCLIKSEDLHFTCSTLTTPVPRIRWMKDGKELSDTQKYSVSNDRRSGILSLTVV SATEADIGLYECELSNEFGCVKCKAGLCPSYVAPNESESDQTHDLPPKDEDSEGWSSAFV KKWLQTDFTPSSIAEGTFPPIHEQAEGGIAEVPQPACMDQPAQPQAPCYLEEEEEEIYIS EQMQEITDVPPFIQVPPEDVCVEPGQPATFTVIITGRPMPQIQWYKDGEELPASHNVEIV QHAARCSVTIVCPEVEDSGIYTCFSYNDSGHVSCQAHLTVEEGPLGSQEREMELGKRRKL FTVYDVGDEIGRGTFGVVKRVIHRGTGEVFAAKFLPLRSSTRTRAFQERDLLSRLAHPRV ACLLDFFCTRRTLVLITEICCSHSLVDHLLLRGLVSEKEVQSYIQQILEGVGHIHSMNIL HLDIKPENILMVYPPRDEIKICDFGFCQEVDTSRHQYSMFGTPEFVAPEVVHQEPVSVGT DIWSVGVMTYLCLLCRCPFAGETDRATLLRVGEGTLNWDAPDVMSRSPEAQAFLRSLLQP DPEKRPSAFECLSHEWFQDEHAGEDTDEINTKGLKLFISKRKWQRSLTCVGSVLTLRQIP ELLDAPLRDTAVTVPREHQQNSSTSMSSGSSSDYDEADSWDFFQHYSPTEEEEEETEEDY DPLSERARIPEPFTQLQQGPYEEEEVTFGEAEEEDDDELAGRRSVLERSVSRQSVASSDV SYLQTPQNERRFDKGSSPSLHFSDGDEGSGSDAGRIPRGSVIRSTFYSSSHQLSPMSARR MTLRDKFQAKKQERGRKPLRRSLSGRLNEPLIEYVEDDTETNRSQRRGSTQPTMQKSTSF DGSVTRTNVPPHRRSRSLDDYSRRSPSSPKPSKAGDEEGTQSLKEDFTDDEVGGKKLLMI PSPRRPARRRGSTIPVQGTATLGGGSAPLSLLVGDRMSHRMDQEQSEGDAFTGSQGSLAG SSILEHGGSESSSRLGSYEELRGRYRSEESEGYDDPREPRTSSSPRSFQELKPRGPFPQV PPRNRTRSNPNICHLQMSSTPSPSPSLSSLQAPKRPPRAKDKKESHGLQRHASAPALEVQ PPAGKSPKLGLLNIFRRQSWASHSYSQLDSTELGPTLGEIMKPATPTMSFRKKMRASASS LTKLFSRSSSKEDLSQGGPIVKGSILPEKEHGLESPKMRTSKRLTTFKIPAFKKSKDLLV RPNKADVLQLDGGGVLLVWKPVQSSDPVTYCVQYCTDGGEWTVLSEDVTDSSYVAKDLPR GASYAFRVGCITKTGAGPFSDASAPIVMATHLEDVNIPLIQTDCLGSKVTGSESQATQRN YNFLSEINRGRFSVVNLCRDAETSQVFAAKITPYRAEHRQLVLREYQLLRRLHHAHLVQL HTAYITSCYLVLVEELCPGKELLYSLAARDVYSEASVAELLGQILSAVDYLHGRRVVHLD LKSDNMLVDDGNHLKIVDFGSALSFTPGQPLHTEHLQGLSESKDYIVLPKAPEILEGQGV GPETDVWAIGVLLFIMLSADSPFHAEQSWEQDRNIKKGKIQFGRCYPGLSEGALNLMKSS LNNKSWGRPTAAECLQNPWLRAHRAPHRSHHSKVCFSTDKLKAYLTQKEEKRDQVRTKLQ GPFFQ NT seq 17838 nt NT seq  +upstreamnt  +downstreamnt atgagctcaatggaagtgacagaaccagagccagcgctcttccaagtggagacaagcctg aagtcaggaaggccgccgagatggaccctgaatgggaaagtgttggagcccagcgaagtg gtggatatgtacagggagggtaccatccacagcctctgcctcacttccacagacagctcc atgtcggggcctgtggtttttgtcgctggcaagagccgttcttctgctgaacttacggta aaagagcggcccctccaagttgtccgcaatttggaagatgtggaagccaaggagaacagc tctgtcactctgagctgcgagtttgccccctcccccagggtggtgaggtggtttaaaggt cgtacagctttgaaggcttcaaacaagtacagcatgaggagagatcggaaacgtgcagag ctgacaatccatggcttggtagggatggatggagggcagtatcgctgcatggcggggggt tcgcagagcatagcacacgtggaagtcgaagtgcgaaagctgaagctggtcagacacctt gaaccagtggaacttgaagaagacagcgtcgccagttttgcttgtgaactcaactatgtg gttgccaacgtcgagtggctcctcaacaatgtccgcctgtattccagcgccacaaacagg atccaacacatgggcaccatgcacagccttttcattaagaagctgagaccgcagcacagc cgggtcacctttagagctggccttctttcggagacgacaactttaaaggtcaaagagcgc cctgcggtatttctaagacctctggaggatgcagttggggaagaacaaggggaggtctgc cttcagtgtgaagtctccaaagtgtctgtgatcccagtctggaggaagaatagtattgtt ctgacacctgatgaaaagcatgagctgtgccagtacggaaggtccctggcactgattatt cattgcttgagcaaagatgatgctgggcagtacacctgtgatctgggcaccagccaaacc aaggctaaagttactgtacatgatttacatatcactattatccagcgcttgaagacaacg tccataatggagggtgaaagctgcacttttgaatgtcaactctctcacgttcttagtgat gagcctttctggaccatcaacggtcaactggttgtctccaacagccacttccaggtcatc aacaatggtcgcaagtacaagctgaggattaaagatgcagttttgtccaacgctggagaa gtgatctttggaattaaagacttaagctgcaggacaatgctctttgtcaaagagaggcca gtgcacatttttagggatctgctgaatgtcaagactgtgccaggtgaggatgcggagctg agttgtgagatcaccaaacctgaggtcagcatccactggctgaaaaatggccatatgatc aggcagagtcacaaatataagatgagcgtggaaaagaacctggcaaggctgatagtcaag aataccgcaatcagagattcaggagagtactgctgtcaggctgatggggttgcctcccat gccaaactggaggttagagatctgcagcactcattcgagagggagttaaaggacagcaaa gcagaggaaaaaggtaaagtgaccctggagtgcgagaccagacagccagccaagcgagtg acctggctcaagggcatgatggagctgaggtcgagcaggaaatatgtcatgaggcagaag ggtgtggtgctttcgctcaccatcacttatctggagaaatcggacacagatatctacaca tgtgatgttgggaccatgcagagccgtgcgcagctgactgtgcagggccagagggtggtg atcctggatgaactggaggacattgagtgccttgaaagtgatacagtcaccttcaaatgt caaatctgtcccagtgactacacagcagtgaagtggtacttggatgagactctgctctac aataatcagcttaatgaaatccagatgctggcgggtggctaccacacgctgacatttaga cagttagcccgcaaagacactggtaccatttcgttttcagccggtgacaaacgatcatat gcgtcactgttggtcagagagagacgtccaaccatttgcaaagccctcgaggactgtgag gctattgaaggagggggtctggttttgtcctgcgtgacctcaaagccatgccatatccta tggtacaaagattgttgcttgatgtggaactcgtcaaggtactttgcaagtcgttcggga tgtgaggctcggctggcaattcgggaggtctgccaaagtgatgctggggtgtatgagtgc agtgctggatctgtttcaacaagggctgttgtaaccgtcaaagctatcccagctgaattc acaaagcctctgcagaacgtagagtcccgagaaggtgaaaccgctacattgacctgtgaa tactctctgccgggagtccaattccactggaaaaaaggcagtgagagcctcaggcctgga gacaagtatgtgatgaaacagagacagaccatcaattcactcataatccgagctgtgaag ccggaggactcgggggagtacacctgtcaatgcaggggccaccacactacagcaaggctc aaagtgcaagccattccgattacattcatccagcaactgaagaacctgcatgcggaggaa gggagcaatgtcattttgcgatgcgaactctccaaatctggaataccaatagaatggatg agaggccaagaagtgttgaagaatggagtgaagtaccagatgagaagatgggagacaaca ttagagcttttgatatggaaagctgttcctgaagacagtggactttacaagtgtttgtgt gctgatcaggtcacatccgccactgtcaaagtcaaagctctgccactcaccttcaagcag aaactgcacaacgtgagctttgaggagggcaatatggcaacgttgcgatgtgagctttcc aaagcatctctctttgtggagtggtggaaggggggtgatgagctcatcaagaatagtgat aaatatcacatgcgccagagtgacacactgatcgaactgaggatcctagatgtgacgcca gaagacagcaacatctacacctgcatttgtgggagcatagagaccacagcaaccctcact gtgaatgcactccccatcaccttcaagcaaaagctgaagaaccttcaagtggaagaagga cacaacatcacgctgtcttgtgagatctccaagcctggtgtcgctgtggagtggaggcta gccggtgagcttctcgaggatggggaaaagtaccagatgaagcagagaggctccgtgctc acgctgacgatcagagatgctctgccagaggacagcggcatctacgcctgtgtctgcaga gaccagaagacaaaggccacagttaaagtcgttgcgatccccgccacgtttaaagggagt ctgaaaagccaggaggcggaggaggggagtagtgtgacgctccgctgccaagtgtcaaaa acagatgcccgagtagaatggcagaaaaatggacaggtgctgtctgaggagatgtccgga agaaagtatcagttgaagcttgaagggaagacagctgagctgaccattgtcagcgttgaa gtacaggatgcggggaggtacagctgtattacaggagatgagaaaacaactgccgaactc aaagtgaaatcacttccagtcacattcaaacatgggctcaagaatttggaggtgaaggaa ggcgacagcgggcttttctgttgtgagctctccaaacctggagctccagtggagtggagg aaaggtcgtgtacttctgagcagtggaggcaagtatgagatgaagcaggaagggccttac accaagatggttgtcaacaacgtgcaagacagcgatgctgggaaatacatttgcaaaact aaggacagccaatcaactgcagagctgtcggtccagggtttaccaccatgtttcacgctc atgcttgctaaccaggaggtgattgaaggcaacagcgtgtttctgcgctgtgagctcaac aaacctgcccactcagtggagtggaggagaggaggcttggtgttgaggcaaggagacaag taccagatgaggaaaaaggatttgcagctggagatgactattaataatgtcactctcgaa gacgctggtgattacacctgtacttgtggtgaagaaactactacagcttgcctcgcagtg aatgaacgacctgtcaaattcctccatgaactgagtaacattgaagtgcaagaaggcaac ggggtaacactttgctgccagctctccaaagcagggctcactgctcagtggatgaaggga gatgagttgttaaccactggtgagaggtatcagctgaagcagagaggctccacactcgag ctgctcatcgggaagagtcagcctgaagacagtggtgtttacagctgcatctgtgaagcc attaaaactactgcgacactcatcataaccgcaattccagtgacgttcaagcaaaagttg aagaaccaagaaacagtggaggagagcagtgtgatgctctactgcgagctctccaaacca ggagtcccggttgagtggagaaaggatgctcagctcctgagggagggagccaaatatcag atgaagcaagagggcagggtgtgtgagatgctgatcgcagatctcactctcaaggatact ggcgaatacagctgctctggtggtacagctgttacttccgctgagatcaaagtaagagct cttccggttacatttaagcaagaagttcagaatttggagctgaaggaaggtgacagtgga gtgttctgctgcgagttgtccaaacctgaagcaccagtggactggaggaaaggaagagtc attcttaagcccggttacaaatatgaaatgaaacaggagggaaatttcaccaaactgttt gtcaaccatgtagaagagtgtgacgctgggaagtacacttgcaagacaaaagacagccaa tccactgctgagctcatcgtgatagcacctcccatcacattcaaaaccaagttaaagaac ctccaagtggaagaggagaacagcgtgacattgatatgtgaattgtccaagcccggcctt tctgttgagtggaggaaaggccaggagctgctgaagaataatttcaaataccagctaaga aatcgaaacagcatgctggagctgaccatcaaaaacactcagctggatgacagtggagtc tacagctgtatctatggcgataccaagacagtagccaacatcactgtgacacctattcca ctcacctttaagatgggtttgaagaaccaggaggccgctgagggaggcaacgtgacccta agatgtgaactgtccaggagtgggatgtctgtacagtggtggaagggagaggaccagctc catcaaggtgggaggtatcagatgaccctcaaggagaacgtagctgagatgagcatcaga aacatccagccggaggacgttggggagtacagttgtgtctttggcgagcagaagacaact gctgaagtgaatgtgagagcggcggcatcagtgttctttgagaaggaactggagagccaa gcggtgacggagggcaaatcggtgctgatgtcatgtgaagtttctagcgcgaatgtccct gtcacttggaagaaggacaatacggtcattgaagctgggccacgactaattattaccaaa aaaggacctatgcatatgttggcgatcaagcagctgaacctggaggatgctggcgaatac tgttgcatcaccaggggcaagaagaccaccgccaagttgattgtgagggagcgggtacga atcgttacagagcttaaagacatcactgtaactgcgggggaagatgccatgtttgtgtgc gagctgagccatgccaatgtgaatgagggtgtgtggtggctggactccagtccactgcag aggaatgatatgaaccagatgacatgccaaggtcgcacacaccgacttgttctcaccatg acaacacctgacgagacaggcattgtggcatttgtgatcggggaagaaaggacatcggca agtctttcagtggtgccaaagctcaaagttttatttgaggagaagcctcaagatgttcga atatcggaaggagaaattgctactttgtcctgcacaacctctgacttcaccaccccggtt acctggaggcgcaaccatatccctctccgaaatggcgacaaatttgagatacgaaaagag ggaaaagtcaacttactgctgatccatgccgtggagcccggggatgctggagtttactct tgtgatacaggcgatgcacaggccagtgccaagcttactgtgacagagctgccaccattc ttccaggaagagttgcaaagcgttgagactgaggaggacggttcggccatcctgtgctgt gaactgtccaaactcgggttgccagtacaatggaggaagaacagtttgccaattcgggct ggcaggaagtacgagatgaagcaggatggttgcttccttcagcttcacatcaaggagctt aaacttgaggacagtggcagctacacgtgtcaagcaggaaatgcagaaactactgctact gttacagtcaaagagctacagccattcttcaagaaagatttggaaaatgtgcgggtggat gagggcggttccgtttctttgagctgtgaggtgtctaaacctggattgccagttcaatgg aaaaagaacaagcttcctctgagggccaacaggaggtatgagatgaagcaagatggctgc cttctccagcttagcattgtgaacgtcaaacctgaagacagcggcagctactcatgtcat gtaggaagtgtagaatcaactgcaactataatcgtgaaagaacttccaccatttttcaaa gaaaacttagagaatgtacaggctgaggagggaggtattgcctccctgcgctgtcaggta tcgaagcccgacactgccatacaatggaagaagaacaagttgccattaagagccagcaac aagtatgaaatgacacaagatggctgcctcctgcagctcacaatcagtgacctcaaacct gaggatgaagctagctacacatgtgaagcaggaagcgcagaaaccactgcaactgtttct gtaaaagaattgccagttatattcaaagctgacttgcagagtacagaggcagaggaagga gataaagccttcctatcctgtgagctgtctaaacctggagtgccagttcaatggaaaaag aacaagcttcctctgagtgccaataggaaatatgtaatgaaacaagatggctgccttctt cagctgaacattatggacctcaaacctgaagatagcggaacatacacatgtcaagcagga agtgcaatgagttcagcaactgtaactgtgagagagttgcccttattcttcaaacaacaa ttgcaaagtgtggagacagaggagggcggttcagtctctctatactgtgaattgtctaaa cctggagtgccagtgcaatggaagaagaacaggctgcctttgaaggccagcaggaagttt gagatgaaacaagatggctccctccttcagctcaacatcagtgacctcgagcctgaggat ggtggtagatacacgtgtcaagcaggcagtgcagagaccattgcaacgctgtctgtaaga gagcgcccaatctcattcaaaaacgaattgcaaagtatggaggcagaagaaggagacaca gccgttctgtcctgtgagctgtcgaaacctggagtggcagtgcaatggaaaaagaacaga ctgcctctgagggatgacaggaagtttgagatgaaacaagatggctgccttcaacaactc atcatcattgatctcagacctgaagacagcggaagctacacatgctttgcaggaagtgca gagacttctgcaactatagctgtgagagagcttccattattcttcaaagaaaaattacaa aaagtggagatagaagagggacattcaacctctctgtgctgtgagctgtcgaaacctgga gtgccagtgcaatggaagaaagacaaattgcctctgagggccaacaagaagtacgagatg aaacaggatggctgccttctacaactcaacatcaaggacctcaaattggaggacagtggt agttactcgtgtcaagcaggaagtgcagagactgcaaccactttatcagtgaaagagctc ccaccgttgtttgtgacaggcctacaaagtgcagagcgagatgagggaagctcattctct ttatgctgcgagctctctaaacctggggtgccagtgcaatggaaaaaaaacaatctgcct ctcagggccaacaagaagtatgagatgaagcaagatggctgccttcttcagctcaacatc gaggatcttaaacctgaggacagtggcagctacacatgtcaagcagggagtgcagaaacc acagcaactctttctatcaaagcgctgcctccactgttcaagaaaaagctacaaaggata gaggcagacgagggggctacagctgtcctgtcttgcgagctgtcgaaacctgaagtctca gtacagtggaagaagaatgcgctgccattaaaagctgacaggaagtatgacattaaacag gatggctgtctactccagcttcatattaaggagctccatcctgaagactgtgggagctac acatgtcaagcaggaagtgcagagaccactgcaactgtgtctgtcaaagaactgccttgc tttttcaagaaagaattgcaaaacaccgaaacggaagagggagccacagcagtcttgtgt tgtgaactgtccacacttggtgtgtcggcacagtggaaaaaaaatggaattccactaaga gcaaataggaagtatgcgatgaagaaggatggctgtttgctggaacttcatatcaaggag ctaaatccagaagatagtggaagttactcatgtcaagcaggaaatgcagaaaccactgca gcggtgtctgtaaaagcacctgagactactttgtcaaagaatgaaccctccatggtacga ccacgaacacggagtaccacctccgaacccgagaatgtgaatctccccaatgcacaccta atccctcctgaacccaagaagaggacagtgcgaaaagcatcgatcactgctgtagaacaa gatgcagagaccatgtttaatatcaaacagcccattcagtctttgcaaatagcagaccag aaggagatgcagactgaaaaacagacagaaaatgctcaggattcaaaccagcaggtgcac aatgtggaccaaaatgtggaggtttccacaagaccagcaaatttagatgagaaggagcat gtgattgaaagaattgagacggagaagactcaaccagcaaagccacaaatgaaggcagaa ctcagtcaaccaggcagaaatcttggaaataatggtgttgatcaacagaagcagttattt aaatctctggaaacaaatccaacgcaaaacgaaaaaccattcgaaaaagtcagagaagtt gaaatactagatgaccatccagaaacaatattgtggaagagagttgaggaggagaaaaag gcaatgaaaccatcaacaacagcctttgagatcgaaacattggaacgagatgttaagtct actattaaggatggtgacgtggggaagacaggggatggtgtgttacctcctgtgaggtca aaaggaaaagcagcaggaggaagagagactcctgaagttgttaaaaaagaaactgaggag ttcactcaacagccatcaaacgctgccctcaatgattctagggacgggaatacactgaga aaccacgtaaaagaactcgcgaccacagagaaagtagaggagcaagtaatgcaagtgcca tcagtaaatcagctggacagccactccggaaaaagaaaagaactgcctcaagatataaag actgaacctattcccccaaagccacctgtgaggtcaaagagcaaaactaggacaggaatg gaaaaacgaccatcaagagacactgaaacagatcaagatgaacaaatggtgacaacggcc aaagatcagctactaaaagagacgggaaggtcgttgaaagatgaggaatcaagactcgag aaaaaacagtcagcatcagcagacgctgatctggtggagaagttggttctacccaaacag ctgataaaacatccagtcaaacctatgagaaaagagcctgaaatggacaaagaagtcgct gctggttcaatggcaagggaggaggaacaccaagaagtgcaaatgatggaagaaattcct ctcctctacatctctgaagatgaaactttctcagaagctttgaccgagatccccataatc gaacccggtggcttctttgatgaaacgtcaaccaaaccctacacccagcctatcattttg gatctccagaagccggtccaggatgcttcaccagaggtttacatcagtgctgaagatgaa ccacaaatgcaagaagctaccgtcaagatccagactcccttaaaaggctacgaaaccggc aaagatacacggccggtcttgaaagaggtctttagcaaccagtgtgcagatgttgatggt aacatcactctaatgtgtactgtagaaggacattataacagcgtgcgctggcttaaagat ggtcaaacaatcagtcgtgatgaacgacatggtattgaagccgcagagggtggggtatgc tctctagttatcactcaactgaccctgagtgacagtggcatctacacatgtgaggtggtc aataaatttggtatgacgtcctacagtggaaacataaccgtggttccgctgcaagagcct gctcagacagtcggcaggcaagtgcacccacctcttgccgcaatcactccactgcagttg gccccgctgaggcctgaggacaaaacacagattcaagatcaggcaacttcggggaccgat gctgataactatgtcgagaatatcgacgtctctttatgggaggcctacaacctgacagag cagcacattcagatgggccaacaaaagaggagaccatcatctctcatcgccaccagctcc gtgtcaagtccatctgattatgacactgcaccagatgtgattgaacctgtcgaaattacg acccatccagcaagggaacttcctgaggcaacggaccaaatgcctctgaaggactcgaat caacactctgctgatccctgccttttcaagacctttttacaagtccaaggcacccaagaa ggccaaatgagaacaccatctcctaaacaccttagggcgcacacacctttagctagcact gtgtcgggatcagaatccgaaggggaagaggatcaatgcgagacatttgaaatgtatgtg gcgagagcagcctgcaaccccaacagtggaagcaaggacagttttttactgaaggagggt caatacgtcgaggttctagactctgtccatccagacaaatggctcgtgagaaccaaaccc accaaaaccaaccctgcccgccagggatgggtgtgtccggcctatctggagaagaagaga aaggaggccttcacacagttgcgggcacctcaagaggatcttgacggaatcggttccaca ggagaagagtataggagggctttgagccaactgattcaaggtctgattgatggtgaagag gagtttgtgaaagaaatgaggctgtttatttctcatccactaaattacttggactcaagt ctcaatgttcctatccacatcatcaaccaaaaagatatcattttcagaaatataaaggac attgtccttcttcacgagaagtctattctccctgggttgagagcatgtactacagatgat gacgtcgctatgcatctgatccttcactttgaggaccttgaaaagtatgttcactacatg ctcgggcaatcacaagcagaggcctgcattgctgataaagctacccaacaatatctcaaa gagttaccaggatctggtagacctgaggctcccgtcatagataccttgaccttcctccaa agaccagttgaaaggattcagacatatcaagcattgctgaaggagctaattaagaacaag gccaaaagcggccagagctgttgtttgttggaggatgcattctcccttgtgtcctgtcta ccctggaggtctgacaatctgcaccaggtctccctcattgaaaactaccccgcccctttg actgccctgggcgagcctgtgcggcagggagcctttacggtgtgggacgaaacgccagaa actaaaaagacctctagagggcatcagagacaagtctttctgttcaaggaatgtattgtc ctatgcaaactgagaagagatgccagtaagagctgtgatgtgtacaccttcaagaataaa atgaagctgaatgatgtcgagctacgggaaacaatgggaggtgatgagaagacttgggag ctgtggcatgagcacaggggctcggtgcggagatatgcactgcagggccgttcaccactg gtgagactttcctggctcaaagacctgaaggagctgcagcaacgatccatcctgaccact aacaacgcccccgtgtttacatcactgctgtcggattgcacggcaaagatcgggcagaca gttaaactgagctgccaggttacaggatcgcctcagccagtgatcacttggctcaaagat ggccttgcgttggaagatgaccctcggcacatcatcacagcggacagatccggcacgtgc attctgatcttagacagtttgactgcagaagactctggacaatatgtgtgctacgctacc agcagcatgggcagcactggcactctggctactgttgtagtgcaggctccaccgagattt attagtcggctggaaagtacttgtctgatcaagagtgaggaccttcactttacttgttcc actctcacaactcctgttccccgaatcaggtggatgaaagatggcaaagagttgagtgac acgcaaaaatattcagtctcgaatgaccgtcgaagtggaatattgtctctcacagtcgtc agtgcaacagaggcagacatcggactttatgagtgcgagctttcgaatgagtttggttgt gtcaagtgcaaggccggactgtgcccctcatatgtcgccccgaatgaatctgaaagtgac caaacgcacgacctacctccaaaagatgaagactcagagggttggtcctctgcctttgtg aagaagtggctacaaacagatttcaccccctcttctattgctgaagggactttcccaccc attcatgaacaagctgagggtggtattgcagaggttcctcagccagcatgcatggatcag ccagcacagccgcaggctccatgttacctggaggaagaagaagaagaaatctacatctcg gagcaaatgcaggaaataacagatgttcctcccttcatccaagtaccccctgaagatgtg tgtgttgaaccaggccaaccagccacatttaccgtcatcataacaggaaggcccatgcca cagatacagtggtacaaggatggggaagaacttccagccagtcacaatgtggagatcgtt caacatgccgcccgctgctcagtgaccatagtgtgcccggaagttgaagacagtggcatt tacacctgcttctcttacaatgactctggccatgtgtcgtgtcaggctcatcttaccgtt gaggaaggtccactggggtctcaggagagagagatggaattggggaagagaaggaagcta ttcactgtctatgatgtgggtgacgaaattggaaggggaacatttggggtagtgaagcgt gtgatccatagagggacaggtgaagtctttgctgccaaattcttacccctgcgaagtagc acccgcacacgagccttccaggagagagatttgctctctcgtctggctcatccaagggtg gcttgtctactggacttcttttgcactcggcgcacactggtgctcattacagaaatctgc tgttctcatagccttgttgaccatttgttactcagaggattggtctcagagaaagaggtt cagtcatatatccagcaaattcttgaaggagttgggcatattcatagcatgaacattttg catctggacatcaaaccagagaatattctcatggtatatccacccagagatgaaatcaag atctgtgactttggcttctgccaggaagtagacacatccagacatcagtacagcatgttt ggtacgcctgagtttgttgcacccgaagttgttcaccaagaacctgtcagtgtgggcaca gatatttggtctgtgggtgtgatgacctatttatgtctgttatgtcgttgcccatttgcg ggtgaaacggaccgtgctacactgctgagagtgggagaagggaccctaaactgggatgcc cctgacgtcatgagtaggagtcctgaagcccaggcctttcttcgcagtcttcttcaacca gaccccgagaagcgaccatctgcctttgaatgcttgagccatgaatggttccaggatgaa catgcaggagaagacacggatgaaattaacacaaagggtttaaagctgttcatctcaaaa agaaaatggcagcggtccttgacttgtgttggttccgtgctcacgttaaggcaaattcca gagctcctcgatgctcctctcagagataccgcagtgacggttccccgtgaacaccagcag aacagcagcacctctatgagcagtggttcatcatccgattacgatgaggctgactcttgg gacttcttccagcactacagcccgacagaggaggaggaagaagaaaccgaggaggactat gaccctttgagcgagagagcgcggatcccagaacctttcacccaacttcagcaaggtcca tatgaggaggaagaagtaacgtttggggaggcggaggaggaggacgatgacgagctggct ggtaggaggagcgtgttagaacggagtgtgagtaggcagtctgttgcctcatcagatgtt tcgtaccttcaaacacctcagaatgaaagaaggttcgacaagggcagtagtccgtctctc cacttttctgatggtgatgaaggttcagggagcgatgcgggtcgaatccctcgtggcagc gtgatccggagcactttctacagctcatctcatcagctttcgcccatgtcagccagacgc atgacattacgggataaatttcaggccaaaaagcaggaaagaggtcgcaagccactacgg aggagcttgtcagggcgcctcaatgaaccgctcatagaatacgtggaggatgacacggag accaaccgaagccagagacgtgggtccacccaacccacaatgcaaaagtctacctccttt gatggcagtgtcacccgaaccaatgttccacctcacagaaggagcaggtctcttgatgac tactctcggcgatctccaagctcacccaagccctcaaaggcaggtgacgaagaaggtacg caaagtttgaaggaggatttcacagacgatgaagtgggaggaaagaaattgctgatgatt ccaagccctcggagacccgcaagaagaagaggttccactattcccgtacagggcactgca acattgggtggtggatctgctccattaagtctacttgtgggtgacaggatgagccacagg atggatcaggaacaatcagagggcgacgccttcactggctcccagggttccttggctggc tcatctattttggagcatggtggctctgagtcttccagtagactcggttcatatgaagag ctcagagggaggtacaggtcagaagagagtgaagggtatgatgacccaagggagcccagg acttcatcatcccctcgctcatttcaagaactcaaacccagaggcccctttcctcaagtt cctccacgcaatcgcacacgctccaaccccaacatatgtcacttgcagatgtcatcaacc cccagtccaagtccgagcctctcctctctccaggctcccaaaaggccacccagggcaaaa gataagaaggaaagccacggccttcaaagacatgcatctgcgccagctcttgaagtccag ccacccgcaggaaaatccccaaaactgggactgctgaatatcttccgcaggcagtcctgg gctagccattcctactcccagctggacagcacagagttaggaccaacgctaggagagata atgaagccagctacgcctaccatgtcattcagaaagaaaatgagagcttcggcttccagt ttgacgaagctgttttcaaggtcatccagtaaagaggatctaagtcaaggagggccaatt gttaagggctcaattttgcctgaaaaggagcatgggcttgaaagtccaaaaatgagaacc tccaagcgcctgactacttttaagataccagcattcaaaaaatcgaaagatcttctagtc cgtcccaacaaggctgatgtgcttcagttggacggaggtggagtactgctagtgtggaag cctgttcagtctagtgacccggtcacctactgtgtgcaatactgtacagatggtggggag tggacagtcttgtcggaggatgtgactgacagcagctatgtcgcgaaagatctacccaga ggagcttcatatgctttcagggtaggttgtatcaccaagacaggagcaggacctttcagt gatgcttccgcccccattgtcatggcaacacaccttgaagatgtaaatattcctctcatc cagactgactgcctcggttcaaaggtgactgggtcagaaagtcaggcaacccagaggaat tacaacttcctgtcagagatcaacaggggtcgtttcagcgtggtcaacttatgtcgcgat gctgaaaccagccaagtgtttgccgccaagatcacgccgtaccgggcggagcacagacag ttggtcctgagggaatatcagctgctgaggaggcttcatcatgcccacctggtacaactg cacactgcttacatcacttcctgttacctggtgctggtggaggagctttgtcctggcaaa gagttgctctacagtctagctgcaagagatgtgtactcagaggctagtgtggccgagctg cttggtcagatcctgagtgcggtcgactaccttcatggccggcgagtggtccacttggac ctcaagtcggacaacatgctcgtggacgacggcaaccacctgaagattgtggactttggc tcggctctgtctttcacgcctggtcagccccttcacactgagcacctgcagggtctgtcg gagagcaaagattatattgtccttcctaaagctccggaaatcctggagggccagggtgtt ggacctgagaccgatgtttgggcaatcggagttctcttgtttattatgttgagtgccgac agcccgtttcatgcagaacagagctgggaacaagacagaaacatcaagaaagggaagatc cagtttggacgctgttaccctggtttgtccgaaggagccttgaacttgatgaagagcagc ctgaataacaaatcctgggggagacccactgcggcagagtgtctccagaatccttggctg cgtgctcatcgcgccccccaccgatcacaccactccaaggtgtgtttctccaccgataaa ctcaaagcgtacctcacgcagaaggaggagaagcgagatcaagtgcgcaccaagcttcag ggtcccttcttccagtag

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