Hyphomicrobium denitrificans 1NES1: HYPDE_32453
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Entry
HYPDE_32453 CDS
T02646
Name
(GenBank) Mur ligase middle domain-containing protein
KO
K01929
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:
6.3.2.10
]
Organism
hdt
Hyphomicrobium denitrificans 1NES1
Pathway
hdt00300
Lysine biosynthesis
hdt00550
Peptidoglycan biosynthesis
hdt01100
Metabolic pathways
hdt01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
hdt00001
]
09100 Metabolism
09105 Amino acid metabolism
00300 Lysine biosynthesis
HYPDE_32453
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
HYPDE_32453
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
HYPDE_32453
Enzymes [BR:
hdt01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.10 UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
HYPDE_32453
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Gene cluster
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Motif
Pfam:
Mur_ligase_M
Mur_ligase_C
Motif
Other DBs
NCBI-ProteinID:
AGK58163
UniProt:
N0B583
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Position
1963730..1965007
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AA seq
425 aa
AA seq
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MKLKTRETCAKIKRKRTSGTIIAVTGSSVKTTTVALLSHILAGDAKVSSQFLCNGYSHAI
DSLLNLRSDTRYAVIEQGTKEIGQIPRAAKLIKPDVAVITLVAIEHYRAFRTIEAVAQEK
AALVEAVPDDGLVVLNFDNPHVRAMADLTRARSITFGTMGGDYIAREVGTGTDGFLFLTL
TGGGQSIHLKTQLLGAHNWLTVAAAATTALELGVPSETVRVRIESFEPIVERMSLHVVPD
GSRIILDTVKAPYHSILLPLEALKTLAAPKKRFIMEQISDYAGNATKKYKDTYAAAAKIA
DEVCFVGPWVHKARAPAADIESGKFRAFANVEALAAYLRETALKDEVILVKSAGNLHLER
LLLDRIAKVRCWPNECGHRGSCQQCGLYERAFHEHNGQRRYRRKLRRSNKIKSWLSAFSQ
SVGNF
NT seq
1278 nt
NT seq
+upstream
nt +downstream
nt
atgaagctcaaaacgcgggaaacgtgcgctaaaatcaaacgcaaaagaacgtcggggacc
atcatcgccgtcactggcagcagcgttaagacgacaaccgttgctttactttcacatatc
ctggcgggcgacgcgaaagtctcatcgcaatttctatgcaacggatactcgcatgccatc
gattcattgctgaacttgcgttccgatacccgctacgccgtgatcgagcaaggcacgaaa
gaaatcggtcaaataccgcgggcagcgaaactcataaagcccgatgtcgccgtgatcacc
ctcgtcgccattgaacactacagggcatttcgaaccattgaagcggtggcacaggagaaa
gcggcgttggtcgaggcagttcccgacgatgggctcgtcgtcctgaacttcgacaatccg
cacgttcgggctatggcggatttgacgcgggcgcgttcgatcacctttggaaccatgggc
ggagactatattgcaagagaagtcggtacaggcacagatggctttctgttccttacgcta
accggcggcggccaaagtattcacctaaaaactcagctccttggcgcccacaattggctc
actgtcgcagcggcagccaccacagctttggaactcggcgttccctcagaaaccgttcgt
gtgcggatcgaatcattcgagccgattgtagaacgcatgagcctgcacgttgtgccggac
ggctcgagaataattcttgatactgtcaaggcaccctatcacagcatccttctcccgttg
gaggcgctgaagaccctcgctgcgcccaagaagcgattcatcatggagcagataagcgat
tacgcaggcaacgccacgaaaaaatataaggatacctacgctgccgccgccaaaatcgca
gacgaggtctgctttgtgggaccatgggtgcataaggcgcgcgcaccggcggcagacatt
gaaagcggaaagttccgcgcattcgctaacgtcgaagctctcgccgcctatttgagagaa
acagctctcaaagatgaagtcatcctcgtgaagtctgcagggaatttgcacctagaacgc
ctgctccttgacaggatcgctaaagttcgttgttggcccaacgagtgcggccacaggggt
tcatgtcaacagtgcggcctttatgagcgcgccttccacgaacataacggccagcggcga
taccgcaggaaactacgacgatcgaacaaaattaaatcttggcttagcgcgttctcccaa
tcggttggaaatttctaa
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