Heterocephalus glaber (naked mole-rat): 101701753
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Entry
101701753 CDS
T02812
Symbol
Sos2
Name
(RefSeq) SOS Ras/Rho guanine nucleotide exchange factor 2
KO
K03099
son of sevenless
Organism
hgl
Heterocephalus glaber (naked mole-rat)
Pathway
hgl01521
EGFR tyrosine kinase inhibitor resistance
hgl01522
Endocrine resistance
hgl04010
MAPK signaling pathway
hgl04012
ErbB signaling pathway
hgl04014
Ras signaling pathway
hgl04062
Chemokine signaling pathway
hgl04068
FoxO signaling pathway
hgl04072
Phospholipase D signaling pathway
hgl04150
mTOR signaling pathway
hgl04151
PI3K-Akt signaling pathway
hgl04510
Focal adhesion
hgl04540
Gap junction
hgl04630
JAK-STAT signaling pathway
hgl04650
Natural killer cell mediated cytotoxicity
hgl04660
T cell receptor signaling pathway
hgl04662
B cell receptor signaling pathway
hgl04664
Fc epsilon RI signaling pathway
hgl04714
Thermogenesis
hgl04722
Neurotrophin signaling pathway
hgl04810
Regulation of actin cytoskeleton
hgl04910
Insulin signaling pathway
hgl04912
GnRH signaling pathway
hgl04915
Estrogen signaling pathway
hgl04917
Prolactin signaling pathway
hgl04926
Relaxin signaling pathway
hgl04935
Growth hormone synthesis, secretion and action
hgl05034
Alcoholism
hgl05160
Hepatitis C
hgl05161
Hepatitis B
hgl05163
Human cytomegalovirus infection
hgl05165
Human papillomavirus infection
hgl05200
Pathways in cancer
hgl05205
Proteoglycans in cancer
hgl05206
MicroRNAs in cancer
hgl05207
Chemical carcinogenesis - receptor activation
hgl05208
Chemical carcinogenesis - reactive oxygen species
hgl05210
Colorectal cancer
hgl05211
Renal cell carcinoma
hgl05213
Endometrial cancer
hgl05214
Glioma
hgl05215
Prostate cancer
hgl05220
Chronic myeloid leukemia
hgl05221
Acute myeloid leukemia
hgl05223
Non-small cell lung cancer
hgl05224
Breast cancer
hgl05225
Hepatocellular carcinoma
hgl05226
Gastric cancer
hgl05231
Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:
hgl00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
101701753 (Sos2)
04012 ErbB signaling pathway
101701753 (Sos2)
04014 Ras signaling pathway
101701753 (Sos2)
04630 JAK-STAT signaling pathway
101701753 (Sos2)
04068 FoxO signaling pathway
101701753 (Sos2)
04072 Phospholipase D signaling pathway
101701753 (Sos2)
04151 PI3K-Akt signaling pathway
101701753 (Sos2)
04150 mTOR signaling pathway
101701753 (Sos2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04510 Focal adhesion
101701753 (Sos2)
04540 Gap junction
101701753 (Sos2)
09142 Cell motility
04810 Regulation of actin cytoskeleton
101701753 (Sos2)
09150 Organismal Systems
09151 Immune system
04650 Natural killer cell mediated cytotoxicity
101701753 (Sos2)
04660 T cell receptor signaling pathway
101701753 (Sos2)
04662 B cell receptor signaling pathway
101701753 (Sos2)
04664 Fc epsilon RI signaling pathway
101701753 (Sos2)
04062 Chemokine signaling pathway
101701753 (Sos2)
09152 Endocrine system
04910 Insulin signaling pathway
101701753 (Sos2)
04912 GnRH signaling pathway
101701753 (Sos2)
04915 Estrogen signaling pathway
101701753 (Sos2)
04917 Prolactin signaling pathway
101701753 (Sos2)
04926 Relaxin signaling pathway
101701753 (Sos2)
04935 Growth hormone synthesis, secretion and action
101701753 (Sos2)
09156 Nervous system
04722 Neurotrophin signaling pathway
101701753 (Sos2)
09159 Environmental adaptation
04714 Thermogenesis
101701753 (Sos2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
101701753 (Sos2)
05206 MicroRNAs in cancer
101701753 (Sos2)
05205 Proteoglycans in cancer
101701753 (Sos2)
05207 Chemical carcinogenesis - receptor activation
101701753 (Sos2)
05208 Chemical carcinogenesis - reactive oxygen species
101701753 (Sos2)
05231 Choline metabolism in cancer
101701753 (Sos2)
09162 Cancer: specific types
05210 Colorectal cancer
101701753 (Sos2)
05225 Hepatocellular carcinoma
101701753 (Sos2)
05226 Gastric cancer
101701753 (Sos2)
05214 Glioma
101701753 (Sos2)
05221 Acute myeloid leukemia
101701753 (Sos2)
05220 Chronic myeloid leukemia
101701753 (Sos2)
05211 Renal cell carcinoma
101701753 (Sos2)
05215 Prostate cancer
101701753 (Sos2)
05213 Endometrial cancer
101701753 (Sos2)
05224 Breast cancer
101701753 (Sos2)
05223 Non-small cell lung cancer
101701753 (Sos2)
09172 Infectious disease: viral
05161 Hepatitis B
101701753 (Sos2)
05160 Hepatitis C
101701753 (Sos2)
05163 Human cytomegalovirus infection
101701753 (Sos2)
05165 Human papillomavirus infection
101701753 (Sos2)
09165 Substance dependence
05034 Alcoholism
101701753 (Sos2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
101701753 (Sos2)
01522 Endocrine resistance
101701753 (Sos2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
RasGEF
RasGEF_N
RhoGEF
SOS1_NGEF_PH
PH
RHG20_PH
IQ_SEC7_PH
PH_13
Motif
Other DBs
NCBI-GeneID:
101701753
NCBI-ProteinID:
XP_004835636
UniProt:
A0AAX6NS18
LinkDB
All DBs
Position
Un
AA seq
1324 aa
AA seq
DB search
MQQAPQPYEFFSEENSSKWRGLLVSALRKVQVQVHPTLSANEESLYYIEELIFQLLSKLC
MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY
KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD
IGLISLCEDEPSSSGELNYYDLIRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPSDI
EKIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI
LSPAYNEHFSKLMARPTVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKA
CSEEQEDRECLNQAITALMNLQGSMDRIYKQHSPRRRPGDPVCPFYNRQLRSKHLAIKKM
NEIQKNIDGWEGKDIGQCCNEFIMEGSLTRIGAKHERHIFLFDGLMISCKPNHGQTRLPG
YSSAEYRLKEKFVMRKIQICDKEDTCECKHAFELVSKDENSIIFAAKSAEEKNNWMAALI
SLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYHFVVKDSEENIVFEDNLQSRSGIPIIK
GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLA
IEKGEQPISADLKRFRKEYVQPVQLRVLNVFRHWVEHHFYDFERDLELLERLESFISSVR
GKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPI
EVARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA
ENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRKILD
EAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLRKKGKDLINFSKRR
KVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGSSSEKEFTDYLFNKSLEIEPRNCK
QPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPYKISFSRIAESELESTV
SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPQSRSFFSSCSSLNKLS
EEPLVPPPLPPRKKFDHDASNSKGTMKSDDDPPAIPPRQPPPPKVKPRVPVPTGAFDGPL
HSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHFHRDVSTCPNSPSTPPSTP
SPRVPRRVLSSSHNSLAHPPAPPVPPRQNSSPHLPKLPPKTYKRELSHPPLYRLPLVENA
ETPQ
NT seq
3975 nt
NT seq
+upstream
nt +downstream
nt
atgcagcaggcgccgcagccgtatgagttcttcagcgaggaaaacagctcgaaatggcgg
ggactgctggtctcggccctgcggaaggttcaagtgcaagtacatccaactctctcagct
aatgaagagtctctctattacattgaagagctgatttttcagctgcttagtaaattatgc
atggcccaaccaaggactgttcaagatgtggaggaacgagttcaaaagacctttcctcat
ccaattgataaatgggctattgcggatgcacaatctgccatagagaaacgaaagcgaaga
aatcctcttttattgcctgtggacaaaatccatccttctttgaaggaagttttggggtat
aaagtggactaccatgtgtccctgtatattgtggctgtactggagtacatctcagcagat
attttaaaattggctggtaattatgtttttaatatccgacattatgaaatatctcagcag
gacatcaaagtgtcgatgtgtgcagataaggttttgatggacatgtttgatcaggatgat
ataggtttgatttctttgtgcgaagatgaacctagttcttcaggtgaattaaactactat
gacctcatcagaactgaaattgcagaagaaagacagtatcttcgggaactgaacatgatc
ataaaagtgtttcgagaagcctttctttctgacagaaagttatttaaaccttctgatatt
gaaaagatttttagtaacatttcagatatacatgaattgactgtgaaacttttaggtttg
attgaagacacagttgaaatgactgatgaaagcagtcctcatcccttagcgggcagctgt
tttgaggatttggcagaagagcaagcatttgatccttatgaaacattatcacaggacatt
ctatcaccagcatataatgaacatttcagtaagctgatggccagacctacagttgctctg
cactttcagtccattgctgatggctttaaagaggcagtccgctatgtacttccacgcctt
atgttggtaccagtgtatcattgttggcattattttgaattattaaagcaattgaaagca
tgtagtgaagagcaagaagacagagaatgtttgaatcaagctatcactgctctcatgaat
ctccaaggtagcatggaccggatttacaagcagcattctcctcggcgccggcccggggat
cctgtttgccctttttataatcgtcaattaagaagcaagcacctggctatcaaaaaaatg
aatgaaattcagaaaaacatagatggatgggaaggcaaagatattggacagtgttgtaat
gaattcataatggaaggatcgttgacaagaattggtgctaaacatgagcggcacattttt
ctctttgatggcctaatgatcagctgtaaacctaatcatggccagactcggcttccaggt
tacagtagtgcagaatatagattaaaagaaaagtttgtcatgaggaaaatacaaatctgt
gataaagaagatacttgtgagtgcaaacatgcctttgaattagtatccaaagatgaaaac
agcataatatttgctgctaagtctgctgaagagaaaaataattggatggcagcacttatt
tctcttcattatcgtagcactctagatcgaatgctagattctgtattactgaaggaagaa
aatgagcaaccactgagattaccaagtccagaagtgtatcattttgtggtaaaagactct
gaggaaaacattgttttcgaagacaacttgcaaagtagaagtggaatccccattattaaa
ggaggaactgtggtgaagttaattgaaaggttaacatatcatatgtatgcagatcccaat
tttgtccgtacttttcttaccacatatcgttcattttgtaaaccacaggaattgctaagc
ttactgatcgaacgatttgaaatcccagagccagaacctactgaagcagacaaattggca
atagagaaaggcgagcaaccaatcagtgctgacttaaaaagatttcgcaaggaatatgtt
cagccagtacaacttagggtcttaaatgtgtttcggcactgggtcgaacaccatttttat
gactttgaaagagacttggaattgcttgaaagactagaatccttcatttcaagtgtaaga
gggaaagccatgaagaaatgggtagagtcaattgctaagatcatcaagaggaagaagcaa
gcgcaggcaaatggaataagccataatattacctttgaaagtccacctcctccaattgaa
tggcatatcagtaggcctggacagtttgaaacatttgatctcatgacccttcatccaata
gaagttgcacgtcagctaacacttttggaatctgatctctacaggaaagtccaaccttct
gaacttgtagggagtgtgtggaccaaagaagataaagaaataaattctccaaatttattg
aaaatgattcgccataccacaaatctcactctctggtttgaaaaatgcattgtggaagct
gaaaattttgaagaacgggtggcagtactaagtagaattatagaaattctgcaagttttt
caagatttgaataatttcaatggtgtattggagatagtcagtgccgtaaattcagtgtca
gtgtacagactagaccatacctttgaggcattgcaggaaagaaaacggaaaattttggat
gaagctgtggaattaagtcaagatcactttaaaaaatacctagtaaaactgaagtcaatc
aatccaccttgtgtgcctttttttggaatatatttaacaaatattctgaagaccgaagaa
gggaataatgattttttaagaaagaaagggaaagatctaatcaatttcagtaaaaggagg
aaagtagctgaaattactggagaaattcagcagtatcagaatcagccttattgtttacgg
atagaaccagaaatgaggaggttctttgaaaatcttaaccccatgggaagttcatctgaa
aaagagtttacagattatttgttcaacaagtcactagaaattgaaccccgaaactgcaaa
cagccacctcgatttcctaggaaatcaactttctccttaaaatctcctgggataaggcct
aatacaggccgacatggctctacctcaggcactttacgaggtcatccaacaccgttggaa
agagaaccatataagataagctttagtcggattgctgaaagtgagctggaatcaacagtt
tcagcacccacctctccaaatacaccatctactccaccagtttctgcttcttcagacctt
agtgtgtttttagatgtggatctcaatagttcctgtggcagcaatagcatctttgctcca
gtgctcttgccacaatcaaggtctttcttcagttcatgcagtagtttaaataaactaagt
gaagagccactggttcctcctcctcttcctcctcgaaagaagtttgatcatgatgcttcg
aattccaagggaactatgaaatctgatgatgaccctcctgctattccaccaagacagcct
cctcctccaaaggtaaaacccagagttcctgttcctactggtgcatttgatgggcctctt
catagtccacctccaccaccaccaagagatcctcttcctgacacccctcctccggttccc
cttcggcctccagaacattttataaactgtccatttaatcttcagccacctccactggga
cattttcacagagatgttagtacatgtccaaattcgccaagcactcctcctagcacaccc
tctccaagggtgccgcgtcgtgttctcagttctagtcacaacagtctggctcatcctcca
gctccccctgttccaccacggcaaaattcaagccctcaccttccaaaactgccaccaaag
acttacaaacgggagctttcgcaccccccactgtacagactgcctttggtagaaaatgca
gaaactcctcaatga
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integrated database retrieval system
