Heterocephalus glaber (naked mole-rat): 101708380 Help Entry 101708380         CDS       T02812                                  Symbol Plcb2 Name (RefSeq) phospholipase C beta 2   KO K05858   phosphatidylinositol phospholipase C, beta [EC:3.1.4.11] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl00562   Inositol phosphate metabolism hgl01100   Metabolic pathways hgl04015   Rap1 signaling pathway hgl04020   Calcium signaling pathway hgl04022   cGMP-PKG signaling pathway hgl04062   Chemokine signaling pathway hgl04070   Phosphatidylinositol signaling system hgl04071   Sphingolipid signaling pathway hgl04072   Phospholipase D signaling pathway hgl04081   Hormone signaling hgl04082   Neuroactive ligand signaling hgl04261   Adrenergic signaling in cardiomyocytes hgl04270   Vascular smooth muscle contraction hgl04310   Wnt signaling pathway hgl04371   Apelin signaling pathway hgl04540   Gap junction hgl04611   Platelet activation hgl04613   Neutrophil extracellular trap formation hgl04621   NOD-like receptor signaling pathway hgl04713   Circadian entrainment hgl04720   Long-term potentiation hgl04723   Retrograde endocannabinoid signaling hgl04724   Glutamatergic synapse hgl04725   Cholinergic synapse hgl04726   Serotonergic synapse hgl04728   Dopaminergic synapse hgl04730   Long-term depression hgl04742   Taste transduction hgl04750   Inflammatory mediator regulation of TRP channels hgl04911   Insulin secretion hgl04912   GnRH signaling pathway hgl04915   Estrogen signaling pathway hgl04916   Melanogenesis hgl04918   Thyroid hormone synthesis hgl04919   Thyroid hormone signaling pathway hgl04921   Oxytocin signaling pathway hgl04922   Glucagon signaling pathway hgl04924   Renin secretion hgl04925   Aldosterone synthesis and secretion hgl04926   Relaxin signaling pathway hgl04927   Cortisol synthesis and secretion hgl04928   Parathyroid hormone synthesis, secretion and action hgl04929   GnRH secretion hgl04933   AGE-RAGE signaling pathway in diabetic complications hgl04934   Cushing syndrome hgl04935   Growth hormone synthesis, secretion and action hgl04961   Endocrine and other factor-regulated calcium reabsorption hgl04970   Salivary secretion hgl04971   Gastric acid secretion hgl04972   Pancreatic secretion hgl04973   Carbohydrate digestion and absorption hgl05010   Alzheimer disease hgl05016   Huntington disease hgl05017   Spinocerebellar ataxia hgl05022   Pathways of neurodegeneration - multiple diseases hgl05142   Chagas disease hgl05143   African trypanosomiasis hgl05146   Amoebiasis hgl05163   Human cytomegalovirus infection hgl05200   Pathways in cancer hgl05415   Diabetic cardiomyopathy hgl05417   Lipid and atherosclerosis Module hgl_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:hgl00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     101708380 (Plcb2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     101708380 (Plcb2)    04310 Wnt signaling pathway     101708380 (Plcb2)    04371 Apelin signaling pathway     101708380 (Plcb2)    04020 Calcium signaling pathway     101708380 (Plcb2)    04070 Phosphatidylinositol signaling system     101708380 (Plcb2)    04072 Phospholipase D signaling pathway     101708380 (Plcb2)    04071 Sphingolipid signaling pathway     101708380 (Plcb2)    04022 cGMP-PKG signaling pathway     101708380 (Plcb2)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     101708380 (Plcb2)    04081 Hormone signaling     101708380 (Plcb2)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04540 Gap junction     101708380 (Plcb2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     101708380 (Plcb2)    04613 Neutrophil extracellular trap formation     101708380 (Plcb2)    04621 NOD-like receptor signaling pathway     101708380 (Plcb2)    04062 Chemokine signaling pathway     101708380 (Plcb2)   09152 Endocrine system    04911 Insulin secretion     101708380 (Plcb2)    04922 Glucagon signaling pathway     101708380 (Plcb2)    04929 GnRH secretion     101708380 (Plcb2)    04912 GnRH signaling pathway     101708380 (Plcb2)    04915 Estrogen signaling pathway     101708380 (Plcb2)    04921 Oxytocin signaling pathway     101708380 (Plcb2)    04926 Relaxin signaling pathway     101708380 (Plcb2)    04935 Growth hormone synthesis, secretion and action     101708380 (Plcb2)    04918 Thyroid hormone synthesis     101708380 (Plcb2)    04919 Thyroid hormone signaling pathway     101708380 (Plcb2)    04928 Parathyroid hormone synthesis, secretion and action     101708380 (Plcb2)    04916 Melanogenesis     101708380 (Plcb2)    04924 Renin secretion     101708380 (Plcb2)    04925 Aldosterone synthesis and secretion     101708380 (Plcb2)    04927 Cortisol synthesis and secretion     101708380 (Plcb2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     101708380 (Plcb2)    04270 Vascular smooth muscle contraction     101708380 (Plcb2)   09154 Digestive system    04970 Salivary secretion     101708380 (Plcb2)    04971 Gastric acid secretion     101708380 (Plcb2)    04972 Pancreatic secretion     101708380 (Plcb2)    04973 Carbohydrate digestion and absorption     101708380 (Plcb2)   09155 Excretory system    04961 Endocrine and other factor-regulated calcium reabsorption     101708380 (Plcb2)   09156 Nervous system    04724 Glutamatergic synapse     101708380 (Plcb2)    04725 Cholinergic synapse     101708380 (Plcb2)    04728 Dopaminergic synapse     101708380 (Plcb2)    04726 Serotonergic synapse     101708380 (Plcb2)    04720 Long-term potentiation     101708380 (Plcb2)    04730 Long-term depression     101708380 (Plcb2)    04723 Retrograde endocannabinoid signaling     101708380 (Plcb2)   09157 Sensory system    04742 Taste transduction     101708380 (Plcb2)    04750 Inflammatory mediator regulation of TRP channels     101708380 (Plcb2)   09159 Environmental adaptation    04713 Circadian entrainment     101708380 (Plcb2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101708380 (Plcb2)   09172 Infectious disease: viral    05163 Human cytomegalovirus infection     101708380 (Plcb2)   09174 Infectious disease: parasitic    05146 Amoebiasis     101708380 (Plcb2)    05142 Chagas disease     101708380 (Plcb2)    05143 African trypanosomiasis     101708380 (Plcb2)   09164 Neurodegenerative disease    05010 Alzheimer disease     101708380 (Plcb2)    05016 Huntington disease     101708380 (Plcb2)    05017 Spinocerebellar ataxia     101708380 (Plcb2)    05022 Pathways of neurodegeneration - multiple diseases     101708380 (Plcb2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     101708380 (Plcb2)    05415 Diabetic cardiomyopathy     101708380 (Plcb2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     101708380 (Plcb2)    04934 Cushing syndrome     101708380 (Plcb2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:hgl04131]     101708380 (Plcb2) Enzymes [BR:hgl01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      101708380 (Plcb2) Membrane trafficking [BR:hgl04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     101708380 (Plcb2)  Endocytosis   Macropinocytosis    Phospholipase C     101708380 (Plcb2) SSDB OrthologParalogGFIT Motif Pfam:  PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 DUF3896 M_domain Motif Other DBs NCBI-GeneID:  101708380 NCBI-ProteinID:  XP_004861606 UniProt:  A0AAX6PX73 LinkDB All DBs Position Un AA seq 1170 aa AA seqDB search MSLLNPVLQPPEVKAYLSQGERFIKWDDETAIASPVILRVDPKGYYLYWTYQSKEVEFLD ITSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKALTVVSGPDMVDLTFHNFVSYKE NVGKDWVEDVLALAKHPLIANAPRSTFLDKILVKLKRHLNPEGKIPVKNFFQMFPADRKR VEAALTACHLPKGKNDTINPEDLPESVFKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH LAKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSVINMQRGQLSPEGMVWFLCGPEN SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC WKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSARQQAKM AEYCRVMFGDTLLTEPLERFPLKPGLPLPSPEDLRGKILIKNKKNQFSGPAAPSKEPGGE AEDSCLPRAPTGEGTGAELEEEEEEEDEELGTLDEEEMKKMQSDEGTAGLEVTAYEEMSS LVNYIQPTKFLSFELSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGT RMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRPDKQF NPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSSNS INPVWKEEPFVFEKILVPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHNESNM ALTMPALFVFLEMKDYVPDTWADLTVALANPIKYFSAHDKKSVKLKEAMGGLPEKPFPFG GPVACQVNGAPGPASSGSEAAGAKAREEAIKEAAASPEPKTASMEELRELKGLMKLQRRQ EKELRELERRGARRREELLQRSTAQLTELGTPGCKLRPGKGSRKKRTLPAEDTAGTMPGK GFEGTDPRVQELKDRLEQELQQQGEEQYRSILKCKEQHVAEQITKMMELAREKQASELKA LKETSEIDTKELKKKLEIKRQERIQAVTKTTTDKMAQERLKREINNSHIQEVVQAIKQMT DTLERHQEKLEEKQAACLEQIQEMEKQFQQEALAEYKARMKGLEAEVKESVRGCFPSKAD DKAQRAGEASREPCDQDLLTDEEDTEESRL NT seq 3513 nt NT seq  +upstreamnt  +downstreamnt atgtctctgctcaaccctgtcctgcagccccctgaggtgaaggcctatctgagccaagga gagcgtttcatcaaatgggatgatgaaactgcaatagcctccccggttatcctccgcgtg gaccccaagggctactatttatactggacgtatcaaagcaaggaggtggagtttctggat atcactagtatccgggacacccgttttgggaagtttgccaagattcccaagagccagaag ctccgcgaggtcttcaacatggactttccagacaaccacttcctgctgaaggcactcaca gtggtgtccgggcctgacatggtggacctcaccttccacaactttgtctcctacaaggag aatgtgggcaaggactgggttgaggatgtgctggccctggccaagcacccgctgatagcc aacgccccccgcagcaccttcctggacaagatcctggtaaagctcaagaggcacctaaat cctgaagggaagattcctgtgaagaattttttccagatgtttcctgctgaccggaagcgg gtggaagctgctctcactgcctgccaccttccaaaaggaaagaatgatactatcaatcca gaggacctcccagaatctgtcttcaagagcttcctcatgagcctctgtcctcggccagaa atagatgagatcttcacttcctaccatgctaaggccaaaccctacatgaccaaggagcac ctggccaaattcatcaaccaaaagcagcgagactcccgacttaactccttgctgtttcca ccagcacggcctgaccaggtgcagggcctcattgacaagtatgagcccagcgtcatcaac atgcagaggggccagctgtcacctgagggcatggtctggtttctctgtgggccagagaac agcgtgctggcccaggacaagctgctgctccaccatgacatgacccagccactcaatcac tactttatcaactcctcccacaacacctacctgacagccggccagttctcaggcctgtcc tcggctgagatgtaccgccaggtgctgctgtccggctgccgctgtgtggagctggactgc tggaaggggaagcctcctgacgaggagcccattatcactcacggcttcaccatgaccaca gacatcttgttcaaagaagcaattgaagcaattgcagaaagtgcctttaagacatccccc tatcctgtcatcctgtcatttgaaaaccacgtggactcagcccgccagcaggctaagatg gctgagtactgccgggtgatgtttggggatacactgctcacagagcccctggaaaggttc ccactgaaaccaggcctccctctgcccagcccagaggatctgcgcggcaagatcctcatc aagaacaaaaagaaccaattttctggtccggcagcccccagcaaggagcctggtggagaa gctgaggacagctgtctccccagagcccccactggggaaggcacaggagccgagctggag gaggaagaagaggaagaggatgaggagttgggaaccctggatgaagaggagatgaagaag atgcagtcagatgagggcacagcgggcctggaggtgacggcttacgaggaaatgtccagc ctggtcaattacatccagcccaccaagttcctctcctttgagctctctgcccagaagaac cgaagttacgtcatctcctccttcacggagctcaaggcttatgaccttctctccaaggcc tcggtgcagttcgtggactacaacaagcgccagatgagccgcatttaccccaagggtact cgcatggactcctccaactacatgccccagatgttctggaatgctggatgccagatggtt gccctcaacttccagacgatggacctgcccatgcagcagaacatggcactgtttgagttc aacgggcagagcggctacctcctcaagcatgagttcatgcgccggccagacaagcagttc aatcccttctccgtggaccgaattgatgtggtggtagccaccaccctttccattacggtt atctctgggcagttcctgtctgagcgaagtgtgcgcacctacgtggaagtggagctgttt ggcctcccaggggaccccaagaggcgctatcgcaccaagctgtcacccagcagcaactcc atcaaccctgtctggaaggaggagccctttgtctttgagaagatcttggtgcctgagctg gcctccctcagggtggctgtaatggaagaaggcaacaaatttctgggacaccgaatcatc cccatcaatgccctaaattctggataccaccatctgtgcctgcacaatgagagcaacatg gccctcaccatgcctgcactctttgtctttctggagatgaaggactacgtacctgacacc tgggcagatctcactgtggcccttgccaaccccatcaaatacttcagtgctcatgacaag aaatccgtgaagctcaaggaagctatgggaggtctgcctgagaagcccttcccatttggt ggtccagttgcctgccaggtcaacggggcaccagggcctgcaagcagtgggtctgaagca gcaggggccaaggccagggaggaagccatcaaagaagctgcagcctccccagagccaaag acggccagcatggaggaactgcgtgagctgaaaggcctcatgaagctgcagcggcggcag gagaaggagcttcgggagctggagcgccgaggggcacggcgtcgagaggagctgctgcag cgcagcacagctcagctgacagagctggggacaccaggctgtaagctccgcccggggaaa ggctcccgaaagaagaggaccctgcccgcagaggacactgcagggaccatgccaggcaag ggctttgaaggcacggacccacgagtgcaggagctcaaggacaggctggagcaggagctg cagcagcagggcgaggagcagtaccggagcatcctgaagtgcaaggaacagcacgtggca gagcaaatcaccaagatgatggagctggccagagagaaacaggcctcagagctgaaggcc ctcaaggagacctcagagattgacaccaaagagctgaagaagaagctggagatcaagagg caggagcggatccaggccgtgaccaaaaccaccacagacaagatggcccaggagaggttg aagagagagattaacaactcccacatccaggaagtggtgcaggccatcaagcagatgaca gacaccctggagcggcaccaggagaaactggaagagaagcaggcagcctgcctggagcag atccaggagatggaaaagcagttccaacaggaggctctggcagagtacaaggccaggatg aagggcctggaggccgaggtgaaggagtcagtgaggggctgcttcccctccaaggccgac gacaaggcccagagggctggtgaggcctccagggagccctgtgaccaggacctactcaca gacgaggaagacactgaagagagccgcctctga

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