Heterocephalus glaber (naked mole-rat): 101710224
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Entry
101710224 CDS
T02812
Symbol
Igf1r
Name
(RefSeq) insulin like growth factor 1 receptor
KO
K05087
insulin-like growth factor 1 receptor [EC:
2.7.10.1
]
Organism
hgl
Heterocephalus glaber (naked mole-rat)
Pathway
hgl01521
EGFR tyrosine kinase inhibitor resistance
hgl01522
Endocrine resistance
hgl04010
MAPK signaling pathway
hgl04014
Ras signaling pathway
hgl04015
Rap1 signaling pathway
hgl04066
HIF-1 signaling pathway
hgl04068
FoxO signaling pathway
hgl04081
Hormone signaling
hgl04114
Oocyte meiosis
hgl04140
Autophagy - animal
hgl04144
Endocytosis
hgl04150
mTOR signaling pathway
hgl04151
PI3K-Akt signaling pathway
hgl04152
AMPK signaling pathway
hgl04211
Longevity regulating pathway
hgl04213
Longevity regulating pathway - multiple species
hgl04510
Focal adhesion
hgl04520
Adherens junction
hgl04550
Signaling pathways regulating pluripotency of stem cells
hgl04730
Long-term depression
hgl04913
Ovarian steroidogenesis
hgl04914
Progesterone-mediated oocyte maturation
hgl05200
Pathways in cancer
hgl05202
Transcriptional misregulation in cancer
hgl05205
Proteoglycans in cancer
hgl05214
Glioma
hgl05215
Prostate cancer
hgl05218
Melanoma
hgl05224
Breast cancer
hgl05225
Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:
hgl00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
101710224 (Igf1r)
04014 Ras signaling pathway
101710224 (Igf1r)
04015 Rap1 signaling pathway
101710224 (Igf1r)
04066 HIF-1 signaling pathway
101710224 (Igf1r)
04068 FoxO signaling pathway
101710224 (Igf1r)
04151 PI3K-Akt signaling pathway
101710224 (Igf1r)
04152 AMPK signaling pathway
101710224 (Igf1r)
04150 mTOR signaling pathway
101710224 (Igf1r)
09133 Signaling molecules and interaction
04081 Hormone signaling
101710224 (Igf1r)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
101710224 (Igf1r)
04140 Autophagy - animal
101710224 (Igf1r)
09143 Cell growth and death
04114 Oocyte meiosis
101710224 (Igf1r)
09144 Cellular community - eukaryotes
04510 Focal adhesion
101710224 (Igf1r)
04520 Adherens junction
101710224 (Igf1r)
04550 Signaling pathways regulating pluripotency of stem cells
101710224 (Igf1r)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
101710224 (Igf1r)
04914 Progesterone-mediated oocyte maturation
101710224 (Igf1r)
09156 Nervous system
04730 Long-term depression
101710224 (Igf1r)
09149 Aging
04211 Longevity regulating pathway
101710224 (Igf1r)
04213 Longevity regulating pathway - multiple species
101710224 (Igf1r)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
101710224 (Igf1r)
05202 Transcriptional misregulation in cancer
101710224 (Igf1r)
05205 Proteoglycans in cancer
101710224 (Igf1r)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
101710224 (Igf1r)
05214 Glioma
101710224 (Igf1r)
05218 Melanoma
101710224 (Igf1r)
05215 Prostate cancer
101710224 (Igf1r)
05224 Breast cancer
101710224 (Igf1r)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
101710224 (Igf1r)
01522 Endocrine resistance
101710224 (Igf1r)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hgl01001
]
101710224 (Igf1r)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:
hgl04090
]
101710224 (Igf1r)
Enzymes [BR:
hgl01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
101710224 (Igf1r)
Protein kinases [BR:
hgl01001
]
Receptor tyrosine kinases (RTK)
INSR family [OT]
101710224 (Igf1r)
CD molecules [BR:
hgl04090
]
Proteins
101710224 (Igf1r)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
Pkinase
Furin-like
fn3
Ig_DSCAM-DSCAML_C
Kinase-like
Insulin_TMD
Motif
Other DBs
NCBI-GeneID:
101710224
NCBI-ProteinID:
XP_004852761
UniProt:
A0AAX6PIR9
LinkDB
All DBs
Position
Un
AA seq
1368 aa
AA seq
DB search
MKSGSGGGPPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH
ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF
EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPLCEKTTINNEYNYRCWTTNRCQKMCPSACGKRACTESNECCHPECLGSCR
APDDDTACVACRHFYYAGVCVPVCPPGTYRFEGWRCVDRDFCANIPNAESSDSSEGFVIH
DGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGN
LLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRQILGEEQLEGNYS
FYVLDNQNLQQLWDWDHRNLTIKSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINT
RNNGERASCESDVLHFTSTTTWKNRIIITWRRYRPPDYRDLISFTVYYKEAPFKNVTEYD
GQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKS
EILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYR
HNYCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYR
KVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTVADTYNVTDPEELETEYPFFE
SRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVT
WESRPENSIFLKWPEPENPNGLILMYEIKYGSQTEDQRECVSRQEYRKYGGAKLNRLNPG
NYTARIQATSLSGNGSWTDPVFFYVPAKTTYENFIHLIIALPVAILLIVGGLVIMLYVFH
RKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKIAMSRELGQGSFGMVYEGVAK
GVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIM
ELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAAR
NCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFG
VVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF
LEIISSIKDEMEPGFREVSFYYSEENKPPEPEELDLEPENMESVPLDPSASSSSLPLPDR
HSGHKAENGPGPGVLVLRTSFDERQPYAHMNGGRTNERALPLPQSSTC
NT seq
4107 nt
NT seq
+upstream
nt +downstream
nt
atgaagtctggctccggaggagggcccccgacctcgctgtgggggctgctgtttctctcc
gccgcgctctcgctctggccgacgagtggagaaatctgtgggccaggcattgacatccgc
aacgactatcagcagctaaaacgcctggagaactgcacggtgatcgagggatacctgcat
atcctgctcatctccaaggccgaggactaccgcagctaccgcttccccaagctcacagtc
atcaccgaatacttactgctgttccgagtggccggcctcgagagccttggagacctcttc
ccaaacctcacagtcatccgcggctggaaactcttttacaactacgccctggttatcttt
gagatgaccaatctcaaggatatcgggctttacaacctgaggaacattactcggggggct
atcaggattgagaaaaacgctgacctgtgttacctctctacggtggactggtctctgatc
ctggatgcagtgtccaataactatatcgtggggaacaagcccccaaaggaatgtggggac
ctgtgtccagggaccatggaggagaagccgctgtgtgagaagaccaccatcaacaatgag
tataactaccgctgctggaccacaaatcgctgccagaaaatgtgcccaagcgcctgcggg
aagcgcgcgtgcaccgagagcaacgagtgctgccaccccgagtgcctgggcagctgccgc
gcgcccgacgacgacacggcctgcgtggcctgcagacacttctactacgccggcgtctgc
gtgcccgtctgcccgcccggcacctaccgctttgagggctggcgctgcgtggaccgggac
ttctgcgccaacatccccaatgctgagagcagcgattcctctgagggcttcgtcatccat
gacggcgagtgcatgcaggagtgtccctccggcttcatccgcaatggcagccagagcatg
tactgcatcccttgtgaaggtccttgccccaaggtctgtgaggaagaaaagaagacgaaa
accattgactccgtgacttctgctcagatgctccaagggtgtaccatcttcaaggggaac
ctactcattaatatccgacgagggaataacattgcgtcggaactggagaacttcatgggg
ctcatcgaggtagtgacaggctacgtgaagatccgccattcccatgccttggtctccttg
tccttcctgaaaaaccttcgccagatcttaggggaggagcagctggaagggaactactcc
ttctacgtcctggacaaccagaacttgcagcagctgtgggactgggaccatcgcaacctg
accatcaaatcggggaaaatgtactttgctttcaatcccaaactgtgtgtttctgaaatt
taccgcatggaggaagtgacgggaacgaaagggcgccagagcaaaggggacataaacacc
aggaacaacggagagagagcctcttgtgaaagcgacgtgctgcatttcacctccaccacc
acatggaagaaccgcattattataacctggcgccggtaccggcccccggactacagggat
ctcatcagcttcaccgtttactacaaggaggcaccctttaaaaacgtcaccgaatatgat
gggcaggatgcctgtggctccaacagctggaacatggtggatgtggacctgccccctaac
aaggatgtggagcctggcatcctactgcatgggctgaagccctggacacagtatgcggtc
tacgtcaaggccgtgaccctcaccatggtggagaacgaccacatccgtggggccaagagt
gaaatcttgtacattcgcaccaatgcttcagtcccttccattcccctggatgtcctttcg
gcatcaaactcctcctctcagctcattgtgaagtggaaccccccgtctctgcccaacgga
aacctgagttattacattgtgcgatggcagcggcagcctcaggacggctacctgtaccgg
cacaattactgctccaaagacaaaatccccatcagaaagtatgccgatggcaccattgac
gttgaagaggtcacagagaatcccaagactgaagtatgtggtggggagaaagggccttgc
tgtgcttgccccaaaactgaagctgagaagcaggctgagaaggaggaggccgagtaccgg
aaagtgtttgagaatttcctgcacaactccatcttcgtgcccagacccgagaggaagcgg
agagatgttatgcaagtggccaacaccaccatgtccagccggagcaggaacaccacggtg
gcagacacctacaatgtcacagacccagaggagctggagacagaataccctttttttgag
agcagagtggataataaggaaagaactgtcatttcaaacctccgaccttttactttgtac
cgcattgacatccacagctgtaaccacgaggctgagaagctgggctgcagcgcctctaac
tttgtctttgcaagaaccatgcctgcagaaggagcagatgacattcctggcccagtcacg
tgggagtcgaggcctgaaaactccatctttttaaagtggccagaacctgagaaccccaat
ggactgattctaatgtacgaaataaaatatggatcacaaactgaggatcagcgagaatgt
gtgtccagacaggagtacaggaaatatggaggggccaagcttaaccggctgaacccaggg
aactacacagcccggattcaggctacctcactctctggaaatgggtcgtggacagatccg
gtgttcttctatgtcccggccaaaacaacgtatgaaaacttcatccatctgatcatcgcc
ctgccggtcgccatcctgttgatcgtgggagggctggtgataatgctgtacgtcttccac
aggaagagaaataacagcaggttggggaatggagtgttgtacgcctctgtgaacccagag
tacttcagtgctgcagatgtatacgttcctgacgagtgggaggtagctcgggagaagatc
gccatgagccgggagctggggcaaggctcctttgggatggtctatgagggcgtggccaag
ggcgtggtgaaagacgaaccggaaacccgggtagccatcaagacggtgaatgaggctgca
agcatgcgcgagaggatcgagtttctcaacgaggcttccgtgatgaaggagttcaactgt
caccacgtggttcggttgctgggcgtggtatcccagggccagcccacgctggtcatcatg
gaactgatgacacggggggatctcaagagctatctccggtctctgaggccagaaatggag
aataacccagtcctagcacctccaagcctcagcaagatgatccagatggccggagagatt
gcagacggcatggcatacctcaacgccaacaagtttgttcacagagaccttgctgcccga
aattgcatggtggctgaagatttcacagtcaaaattggagattttgggatgacacgagat
atctacgagacagactactaccggaaaggagggaaagggctgctgcctgtgcgctggatg
tcccccgagtccctcaaggacggagtcttcaccactcattcagatgtctggtcctttgga
gtcgtcctctgggagatcgccaccctggctgagcagccgtaccagggcttatccaatgag
caagtccttcgcttcgtcatggagggcggccttctggacaagcccgacaattgccctgac
atgctgtttgagctgatgcgcatgtgctggcagtacaaccctaagatgaggccttccttc
ctggagatcatcagcagcatcaaagacgagatggagcctggcttccgagaggtctccttc
tactacagcgaggagaacaagccgcccgagccggaggagctggacctggagcccgagaac
atggagagtgtccccctggacccctcagcctcctcgtcctccctgccgctgcccgacaga
cactcaggacacaaggccgagaatggcccgggccccggagtgctggtcctccgcaccagc
ttcgatgagagacagccctacgcgcacatgaacggagggcgcacgaacgagagggccttg
ccgctgccccagtcttcaacctgctga
DBGET
integrated database retrieval system
