Heterocephalus glaber (naked mole-rat): 101711110 Help Entry 101711110         CDS       T02812                                  Symbol Nos3 Name (RefSeq) nitric oxide synthase 3   KO K13242   nitric-oxide synthase, endothelial [EC:1.14.13.39] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl00220   Arginine biosynthesis hgl00330   Arginine and proline metabolism hgl01100   Metabolic pathways hgl04020   Calcium signaling pathway hgl04022   cGMP-PKG signaling pathway hgl04066   HIF-1 signaling pathway hgl04071   Sphingolipid signaling pathway hgl04151   PI3K-Akt signaling pathway hgl04370   VEGF signaling pathway hgl04371   Apelin signaling pathway hgl04611   Platelet activation hgl04915   Estrogen signaling pathway hgl04921   Oxytocin signaling pathway hgl04926   Relaxin signaling pathway hgl04931   Insulin resistance hgl04933   AGE-RAGE signaling pathway in diabetic complications hgl05415   Diabetic cardiomyopathy hgl05417   Lipid and atherosclerosis hgl05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:hgl00001]  09100 Metabolism   09105 Amino acid metabolism    00220 Arginine biosynthesis     101711110 (Nos3)    00330 Arginine and proline metabolism     101711110 (Nos3)  09130 Environmental Information Processing   09132 Signal transduction    04370 VEGF signaling pathway     101711110 (Nos3)    04371 Apelin signaling pathway     101711110 (Nos3)    04066 HIF-1 signaling pathway     101711110 (Nos3)    04020 Calcium signaling pathway     101711110 (Nos3)    04071 Sphingolipid signaling pathway     101711110 (Nos3)    04022 cGMP-PKG signaling pathway     101711110 (Nos3)    04151 PI3K-Akt signaling pathway     101711110 (Nos3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     101711110 (Nos3)   09152 Endocrine system    04915 Estrogen signaling pathway     101711110 (Nos3)    04921 Oxytocin signaling pathway     101711110 (Nos3)    04926 Relaxin signaling pathway     101711110 (Nos3)  09160 Human Diseases   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     101711110 (Nos3)    05418 Fluid shear stress and atherosclerosis     101711110 (Nos3)    05415 Diabetic cardiomyopathy     101711110 (Nos3)   09167 Endocrine and metabolic disease    04931 Insulin resistance     101711110 (Nos3)    04933 AGE-RAGE signaling pathway in diabetic complications     101711110 (Nos3) Enzymes [BR:hgl01000]  1. Oxidoreductases   1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen    1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor     1.14.13.39  nitric-oxide synthase (NADPH)      101711110 (Nos3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1 Motif Other DBs NCBI-GeneID:  101711110 NCBI-ProteinID:  XP_004860453 UniProt:  A0AAX6PWI1 LinkDB All DBs Position Un AA seq 1206 aa AA seqDB search MGNLKSVGQDPHPPCGLGLGLGLGLCGKQGPASQAPVSASEPSLAPASPPLPPPAPDHSP PLTRPPEGLKFPRVKNWEVSSIAYDTLSAQAQQDGPCTPRRCLGSLVFPRKPQGRPSQSP PPPEQLLGQARDFINQYYSSIKRSNSLAHEHRLQEVEAEVAATGTYQLRESELVFGAKQA WRNAPRCVGRIQWGKLQVFDARDCRSAQEMFTYICNHIKYATNRGNLRSAITVFPQRSPG RGDFRIWNSQLVRYAGYRQQDGSIRGDPANVEITELCVQHGWTPGNGRFDVLPLLLQAPD EPPELFTLPPELVLEVPLEHPRLEWFAALGLRWYALPAVSNMLLEIGGLEFTAAPFSGWY MSSEIGMRNFCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLHSYQLAKVTI VDHHAATASFMKHLENEQKARGGCPADWPWIVPPISGSLTPVFHQEMVNYFLSPAFCYQP DPWKGSGAKGTGIARKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQ LGRLFRKAFDPRVLCMAEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPY NSSPRPEQHKSYKIRFNSVSCTDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAY PHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAK AAARDIFSPKRSWKRQRYRLSSQAQGLQLLPGLTHVHRRKMFQAIILSVENLQSSKSTRA TILVRLDTGDQEGLQYQPGDHIGICPPNRPGLVDALLSRVEDPPPAAEPVAVEQLEKGNP GGPPPGWVQDPRLPPCTLRQALTFFLDITSPPSPRLLQLLSTLAEESSEQQELEALSQDP RRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSAHPGEIHLTV AVLAYRTQDGLGPLHYGVCSTWLSQLKAGDQVPCFIRGAPSFRLPLDPSLPCILVGPGTG IAPFRGFWQERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQDAQQRGVFDSVLTAF SREPNSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATNVLQTVQRILATEGDM ELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDLPG SDAPSP NT seq 3621 nt NT seq  +upstreamnt  +downstreamnt atgggcaacttgaagagtgtgggccaggaccctcacccgccctgtggcctggggctaggg ctgggcctggggctgtgcggcaaacagggcccggcctctcaggcaccagtgtcagcatcg gaacccagcctggcaccagcatctccacctctgcccccgccagcaccagatcacagcccc ccactaacccggcccccggaggggctcaagttccctcgcgtgaagaactgggaagtgagc agcattgcctatgacaccctcagtgcccaggcgcaacaggacgggccctgcaccccaaga cgctgcctagggtccctcgtatttccaaggaaaccacagggccggccctcccagtcccct ccacctcctgagcagctgcttggtcaggccagggacttcatcaaccagtactacagctcc atcaagaggagcaactccctggcccacgagcaccggctgcaggaggtggaagctgaggtg gcggccacagggacgtaccaactccgggagagcgagctggtgtttggggccaagcaggcc tggcgcaacgccccccgctgcgtgggccggatccagtgggggaagctgcaggtgtttgac gcccgggactgcaggtctgcacaggagatgttcacctacatctgcaaccacattaagtat gccaccaaccggggcaacctccgctcagccatcacagtgttcccacagcgctctccaggc cgcggagacttccgcatctggaacagccagctggtgcgctacgcaggctataggcagcag gatggctccattcggggtgaccccgccaatgtggagatcacagagctctgtgtgcagcac ggctggacccctggaaacggccggtttgacgtgttgcccctgctgctgcaggcccccgat gagccccccgaactcttcactctgccccccgagctggtcctggaggtgcccctggagcac ccaaggctagagtggtttgcagccctgggccttcgctggtacgccctccccgcggtgtcc aacatgctgctggaaatcgggggcctggagttcacggcggcccctttcagcggctggtac atgagcagtgagattggcatgaggaacttctgcgacccgcaccgctacaacatcctggag gacgtggctgtctgcatggacctagacacccgcaccacctcgtccctgtggaaagacaaa gcagcagtggagattaacgtggctgtgctgcacagttaccagctggccaaagtgaccatt gtggaccaccatgctgccacagcctccttcatgaagcacctggagaatgagcagaaggcc agggggggttgccctgccgactggccctggattgtgccccccatctcgggcagcctcact cctgtcttccatcaggagatggtcaactatttcctgtcccctgccttctgctaccagcca gacccctggaaggggagtggagccaagggcactggcatcgccaggaagaagaccttcaag gaagtggccaatgcagtgaagatctctgcctcgctcatgggcacagtgatggcaaagcgg gtgaaggccaccatcctgtatggctctgagaccggccgggcccagagctatgcacagcaa cttgggaggctcttccggaaggctttcgatccaagggtcctgtgcatggctgagtatgat gtggtgtcccttgaacacgagacgctggtgttggtggtgaccagcacgtttgggaacggg gatcctccagagaacggagagagttttgcagccgccctgatggagatgtctggtccctac aacagctcccctcgaccagaacagcacaagagctacaaaatccgtttcaacagtgtgtcc tgcacagacccgctggtgtcctcttggcggcggaagaggaaggagtccagtaacacagac agcgcgggggccctgggcaccctcaggttttgtgtattcgggctgggctcccgggcatac ccacacttctgcgcctttgcccgggcagtggacacaaggctggaggagctgggtggggag cgtctactgcagctgggccagggcgacgagctgtgtggccaggaggaggccttccgtggc tgggcccaggccgccttccaggctgcctgtgagaccttctgtgtgggagaggacgccaag gctgccgccagagacatattcagtcccaaacgcagctggaaacgccagcggtaccggctg agttcccaggcccagggcctgcagctgctgccaggcctgacccacgtgcacaggcggaag atgttccaggcaataatcctctcggtggaaaacctgcagagcagcaaatccacccgggcc acgatcttggtgcgcctggacactggagaccaggaggggctacagtaccagcctggggac cacataggcatctgtccccctaatcggccaggcctggtggacgcactactgagccgtgtg gaggacccgccaccggctgctgagcctgtggcagtagagcagctggagaaaggcaaccct ggtggccctcccccgggctgggtccaagacccccggctgcctccatgcacactgcgccag gccctcaccttcttcctggacatcacctctccgcccagcccacgcctcctgcaactgctc agcaccctggctgaagagtccagcgaacagcaggagctagaggccctcagccaggacccc aggcgctacgaagagtggaagtggttccgctgccccaccctgctggaagtactggagcag ttcccatccgtggctctgcctgcacccctgctcctcacccagctgcccctgctccagcct cggtactactctgtcagctctgcacccagtgcccacccaggagagatccacctcaccgtg gccgtgctggcatataggacccaggatgggctgggccccctgcactatggggtctgctcc acgtggctgagccaactcaaggctggggaccaggtgccctgcttcatcaggggggctcct tccttccggctcccacttgaccccagcttgccctgcattctggtgggcccaggcaccggc attgcccccttccggggattctggcaggagaggctgcatgacattgagagcaaagggctg cagcccacacccatgactttggtatttggctgtcgatgttcccaacttgaccatctctac cgcgacgaggtgcaggacgcccagcagcgaggggtgttcgacagcgttctcaccgccttt tcccgggaacccaacagccctaagacctacgtgcaggacatcctgaggactgagctagct gctgaagtgcaccgcgtgctgtgcctcgagcggggccacatgtttgtctgtggggacgtc accatggcaaccaacgtcttgcagacagtacagcgaatcctggcgaccgagggcgacatg gagctagacgaggctggtgacgtcatcggcgtgctgcgggatcagcaacgctatcacgag gacatttttgggctcacactgcgcacccaggaggtgacaagccgcatacgcacccagagc ttttccttgcaggagcggcacctaaggggtgcagtgccctgggcattcgacctgccaggc tcagacgcccccagcccctga

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