KEGG   Heterocephalus glaber (naked mole-rat): 101711466
Entry
101711466         CDS       T02812                                 
Symbol
Pde10a
Name
(RefSeq) phosphodiesterase 10A
  KO
K18438  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 [EC:3.1.4.17 3.1.4.35]
Organism
hgl  Heterocephalus glaber (naked mole-rat)
Pathway
hgl00230  Purine metabolism
hgl01100  Metabolic pathways
hgl04024  cAMP signaling pathway
hgl05032  Morphine addiction
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    101711466 (Pde10a)
 09130 Environmental Information Processing
  09132 Signal transduction
   04024 cAMP signaling pathway
    101711466 (Pde10a)
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    101711466 (Pde10a)
Enzymes [BR:hgl01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.17  3',5'-cyclic-nucleotide phosphodiesterase
     101711466 (Pde10a)
    3.1.4.35  3',5'-cyclic-GMP phosphodiesterase
     101711466 (Pde10a)
SSDB
Motif
Pfam: PDEase_I GAF GAF_2 GAF_3 SpoVT_C HD HD-CE DUF7334
Other DBs
NCBI-GeneID: 101711466
NCBI-ProteinID: XP_004856991
UniProt: A0AAX6PRP5
LinkDB
Position
Un
AA seq 799 aa
MEDGSSNSTSCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRK
NNKLEDDSAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNHLLLYELSSIIKVATKAD
GFALYFLGECNNSLCMFTPPGIKERKPRLIPAGPITQGTTISAYVAKSRKTLLVEDILGD
ERFPRGTGLESGTRIQSVLCLPIITAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWA
SVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALF
QVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP
RFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCAL
ALHCANMYHRIRHSEYIYRVTMEKLSYHSICTAEEWQGLMHFTLPVRLCKEIELFHFDIG
PFENMWPGIFVYMVHQSCGTSCFDLEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI
LQNNDGLFTDLERKGLLIACLCHDLDHRGFSNTYLQKFDHPLAALYSTSTMEQHHFSQTV
SILQLEGHNIFSALSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLHNQA
HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKD
EVPQGQIGFYNAVAIPCYSTLTQILPPTEPLLKACRDNLSQWEKVIRGEETGLWISAPAP
ASPPAPVAEGTSEKHPVKD
NT seq 2400 nt   +upstreamnt  +downstreamnt
atggaagatggatcttctaatagtacgagctgcttccgaaggctgaccgagtgtttcctg
agccccagtttgacagatgaaaaggtgaaggcatacctatctcttcatccccaggtgtta
gatgagtttgtatctgaaagtgttagtgcagagactgtagagaaatggctgaagaggaaa
aacaacaaacttgaagatgactcggctcctaaggaagtcagcaggtaccaagatacaaat
atgcaaggagttgtatatgagctaaacagctacatagaacaacgattggatacaggagga
gacaaccatttgctcctctatgagttgagtagcatcattaaagtagccacgaaagctgat
ggatttgcactgtacttccttggagagtgcaataatagtctgtgcatgttcacaccacct
ggaataaaggaaagaaaacccaggctcatccctgcagggcccataacccagggcactact
atctctgcttatgtggccaagtccaggaaaacattgctcgtagaagacatccttggggat
gaacgttttccaagaggtactggactagaatcagggactcgtatccagtctgttctctgc
ttgccaattatcactgcgattggtgatttgattggcatcctggagctgtaccggcactgg
ggcaaggaagccttctgcctcagtcatcaggaggttgcaacagcaaatcttgcctgggct
tcagtagcaatacatcaggtgcaggtatgcaggggtcttgccaagcagactgaattgaat
gactttctactagatgtatcaaaaacgtattttgataacatagtcgcaatagattcccta
cttgaacacataatgatatatgcaaaaaacctggtgaatgccgatcgttgtgcacttttc
caggtagaccataagaacaaggagttgtattcagaccttttcgatattggagaggaaaaa
gaaggaaaacccgtcttcaagaagaccaaagagataagattttccattgagaaaggaatc
gctggtcaagtggcaagaacaggggaagtcctgaacatcccagatgcctatgcggatcca
cgctttaacagagaagtggatttgtacacgggctacaccacccggaatatcctgtgcatg
cccattgtgagccgaggtagtgtgattggggtagtgcagatggtgaacaaaatcagtggc
agtgccttctccaagacggatgagaacaatttcaagatgttcgctgtcttctgtgccctg
gccttacactgtgctaacatgtatcatagaattcggcactcagagtacatttatcgggta
actatggaaaagctgtcctatcatagcatttgcaccgcggaagagtggcaaggactcatg
catttcacactccctgtacgactctgcaaagaaatcgaactattccactttgacattggt
ccttttgaaaatatgtggcctggaatttttgtctatatggttcatcagtcctgtgggaca
tcctgctttgaccttgaaaagttgtgccgtttcattatgtctgtgaagaagaactaccgg
cgagtgccataccacaactggaagcatgcggtcacagtggcacactgtatgtacgccatc
ctgcagaacaatgatggcctcttcactgacctcgagcgcaaaggactgctaatcgcctgc
ctgtgtcatgacctggaccacaggggctttagtaacacctatctgcagaaattcgaccac
cccttggcagcactgtactccacctccacaatggagcagcaccacttctcccagacggtg
tccatcctgcagctggaaggacacaacatcttctcggccctgagctccagtgagtatgag
caggtgctggagatcatccgcaaagccatcatcgccacagatcttgctttgtactttgga
aacaggaaacagttggaagagatgtaccagaccggatctctaaaccttcataatcaggca
catagagaccgtgtaattggcttgatgatgacagcctgtgacctttgttctgtgacaaaa
ctgtggccagttacaaagttgacggcaaatgatatatatgcagaattctgggcagagggt
gatgaaatgaagaaattgggaatacagcccatacctatgatggacagagacaagaaagat
gaagtcccacaaggccagattggattctacaatgctgtggccattccctgctatagtaca
ctgacccagatcctgcctcccacagagcctctcctcaaagcctgcagggataatctgagt
cagtgggagaaggtgattcgaggggaggagactggactgtggatctcagccccagcccca
gcctcacccccagccccagtggcagaggggacttctgagaagcatcctgtgaaggattga

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