Heterocephalus glaber (naked mole-rat): 101711934
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Entry
101711934 CDS
T02812
Symbol
Pik3ca
Name
(RefSeq) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
KO
K00922
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:
2.7.1.153
]
Organism
hgl
Heterocephalus glaber (naked mole-rat)
Pathway
hgl00562
Inositol phosphate metabolism
hgl01100
Metabolic pathways
hgl01521
EGFR tyrosine kinase inhibitor resistance
hgl01522
Endocrine resistance
hgl01524
Platinum drug resistance
hgl04012
ErbB signaling pathway
hgl04014
Ras signaling pathway
hgl04015
Rap1 signaling pathway
hgl04024
cAMP signaling pathway
hgl04062
Chemokine signaling pathway
hgl04066
HIF-1 signaling pathway
hgl04068
FoxO signaling pathway
hgl04070
Phosphatidylinositol signaling system
hgl04071
Sphingolipid signaling pathway
hgl04072
Phospholipase D signaling pathway
hgl04081
Hormone signaling
hgl04140
Autophagy - animal
hgl04150
mTOR signaling pathway
hgl04151
PI3K-Akt signaling pathway
hgl04152
AMPK signaling pathway
hgl04210
Apoptosis
hgl04211
Longevity regulating pathway
hgl04213
Longevity regulating pathway - multiple species
hgl04218
Cellular senescence
hgl04360
Axon guidance
hgl04370
VEGF signaling pathway
hgl04380
Osteoclast differentiation
hgl04510
Focal adhesion
hgl04550
Signaling pathways regulating pluripotency of stem cells
hgl04611
Platelet activation
hgl04613
Neutrophil extracellular trap formation
hgl04620
Toll-like receptor signaling pathway
hgl04625
C-type lectin receptor signaling pathway
hgl04630
JAK-STAT signaling pathway
hgl04650
Natural killer cell mediated cytotoxicity
hgl04660
T cell receptor signaling pathway
hgl04662
B cell receptor signaling pathway
hgl04664
Fc epsilon RI signaling pathway
hgl04666
Fc gamma R-mediated phagocytosis
hgl04668
TNF signaling pathway
hgl04670
Leukocyte transendothelial migration
hgl04722
Neurotrophin signaling pathway
hgl04725
Cholinergic synapse
hgl04750
Inflammatory mediator regulation of TRP channels
hgl04810
Regulation of actin cytoskeleton
hgl04910
Insulin signaling pathway
hgl04914
Progesterone-mediated oocyte maturation
hgl04915
Estrogen signaling pathway
hgl04917
Prolactin signaling pathway
hgl04919
Thyroid hormone signaling pathway
hgl04923
Regulation of lipolysis in adipocytes
hgl04926
Relaxin signaling pathway
hgl04929
GnRH secretion
hgl04930
Type II diabetes mellitus
hgl04931
Insulin resistance
hgl04932
Non-alcoholic fatty liver disease
hgl04933
AGE-RAGE signaling pathway in diabetic complications
hgl04935
Growth hormone synthesis, secretion and action
hgl04960
Aldosterone-regulated sodium reabsorption
hgl04973
Carbohydrate digestion and absorption
hgl05010
Alzheimer disease
hgl05017
Spinocerebellar ataxia
hgl05020
Prion disease
hgl05100
Bacterial invasion of epithelial cells
hgl05132
Salmonella infection
hgl05135
Yersinia infection
hgl05142
Chagas disease
hgl05146
Amoebiasis
hgl05160
Hepatitis C
hgl05161
Hepatitis B
hgl05162
Measles
hgl05163
Human cytomegalovirus infection
hgl05164
Influenza A
hgl05165
Human papillomavirus infection
hgl05166
Human T-cell leukemia virus 1 infection
hgl05167
Kaposi sarcoma-associated herpesvirus infection
hgl05168
Herpes simplex virus 1 infection
hgl05169
Epstein-Barr virus infection
hgl05170
Human immunodeficiency virus 1 infection
hgl05171
Coronavirus disease - COVID-19
hgl05200
Pathways in cancer
hgl05203
Viral carcinogenesis
hgl05205
Proteoglycans in cancer
hgl05206
MicroRNAs in cancer
hgl05207
Chemical carcinogenesis - receptor activation
hgl05208
Chemical carcinogenesis - reactive oxygen species
hgl05210
Colorectal cancer
hgl05211
Renal cell carcinoma
hgl05212
Pancreatic cancer
hgl05213
Endometrial cancer
hgl05214
Glioma
hgl05215
Prostate cancer
hgl05218
Melanoma
hgl05220
Chronic myeloid leukemia
hgl05221
Acute myeloid leukemia
hgl05222
Small cell lung cancer
hgl05223
Non-small cell lung cancer
hgl05224
Breast cancer
hgl05225
Hepatocellular carcinoma
hgl05226
Gastric cancer
hgl05230
Central carbon metabolism in cancer
hgl05231
Choline metabolism in cancer
hgl05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hgl05415
Diabetic cardiomyopathy
hgl05417
Lipid and atherosclerosis
hgl05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
hgl00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
101711934 (Pik3ca)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
101711934 (Pik3ca)
04014 Ras signaling pathway
101711934 (Pik3ca)
04015 Rap1 signaling pathway
101711934 (Pik3ca)
04370 VEGF signaling pathway
101711934 (Pik3ca)
04630 JAK-STAT signaling pathway
101711934 (Pik3ca)
04668 TNF signaling pathway
101711934 (Pik3ca)
04066 HIF-1 signaling pathway
101711934 (Pik3ca)
04068 FoxO signaling pathway
101711934 (Pik3ca)
04070 Phosphatidylinositol signaling system
101711934 (Pik3ca)
04072 Phospholipase D signaling pathway
101711934 (Pik3ca)
04071 Sphingolipid signaling pathway
101711934 (Pik3ca)
04024 cAMP signaling pathway
101711934 (Pik3ca)
04151 PI3K-Akt signaling pathway
101711934 (Pik3ca)
04152 AMPK signaling pathway
101711934 (Pik3ca)
04150 mTOR signaling pathway
101711934 (Pik3ca)
09133 Signaling molecules and interaction
04081 Hormone signaling
101711934 (Pik3ca)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
101711934 (Pik3ca)
09143 Cell growth and death
04210 Apoptosis
101711934 (Pik3ca)
04218 Cellular senescence
101711934 (Pik3ca)
09144 Cellular community - eukaryotes
04510 Focal adhesion
101711934 (Pik3ca)
04550 Signaling pathways regulating pluripotency of stem cells
101711934 (Pik3ca)
09142 Cell motility
04810 Regulation of actin cytoskeleton
101711934 (Pik3ca)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
101711934 (Pik3ca)
04613 Neutrophil extracellular trap formation
101711934 (Pik3ca)
04620 Toll-like receptor signaling pathway
101711934 (Pik3ca)
04625 C-type lectin receptor signaling pathway
101711934 (Pik3ca)
04650 Natural killer cell mediated cytotoxicity
101711934 (Pik3ca)
04660 T cell receptor signaling pathway
101711934 (Pik3ca)
04662 B cell receptor signaling pathway
101711934 (Pik3ca)
04664 Fc epsilon RI signaling pathway
101711934 (Pik3ca)
04666 Fc gamma R-mediated phagocytosis
101711934 (Pik3ca)
04670 Leukocyte transendothelial migration
101711934 (Pik3ca)
04062 Chemokine signaling pathway
101711934 (Pik3ca)
09152 Endocrine system
04910 Insulin signaling pathway
101711934 (Pik3ca)
04923 Regulation of lipolysis in adipocytes
101711934 (Pik3ca)
04929 GnRH secretion
101711934 (Pik3ca)
04915 Estrogen signaling pathway
101711934 (Pik3ca)
04914 Progesterone-mediated oocyte maturation
101711934 (Pik3ca)
04917 Prolactin signaling pathway
101711934 (Pik3ca)
04926 Relaxin signaling pathway
101711934 (Pik3ca)
04935 Growth hormone synthesis, secretion and action
101711934 (Pik3ca)
04919 Thyroid hormone signaling pathway
101711934 (Pik3ca)
09154 Digestive system
04973 Carbohydrate digestion and absorption
101711934 (Pik3ca)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
101711934 (Pik3ca)
09156 Nervous system
04725 Cholinergic synapse
101711934 (Pik3ca)
04722 Neurotrophin signaling pathway
101711934 (Pik3ca)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
101711934 (Pik3ca)
09158 Development and regeneration
04360 Axon guidance
101711934 (Pik3ca)
04380 Osteoclast differentiation
101711934 (Pik3ca)
09149 Aging
04211 Longevity regulating pathway
101711934 (Pik3ca)
04213 Longevity regulating pathway - multiple species
101711934 (Pik3ca)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
101711934 (Pik3ca)
05206 MicroRNAs in cancer
101711934 (Pik3ca)
05205 Proteoglycans in cancer
101711934 (Pik3ca)
05207 Chemical carcinogenesis - receptor activation
101711934 (Pik3ca)
05208 Chemical carcinogenesis - reactive oxygen species
101711934 (Pik3ca)
05203 Viral carcinogenesis
101711934 (Pik3ca)
05230 Central carbon metabolism in cancer
101711934 (Pik3ca)
05231 Choline metabolism in cancer
101711934 (Pik3ca)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
101711934 (Pik3ca)
09162 Cancer: specific types
05210 Colorectal cancer
101711934 (Pik3ca)
05212 Pancreatic cancer
101711934 (Pik3ca)
05225 Hepatocellular carcinoma
101711934 (Pik3ca)
05226 Gastric cancer
101711934 (Pik3ca)
05214 Glioma
101711934 (Pik3ca)
05221 Acute myeloid leukemia
101711934 (Pik3ca)
05220 Chronic myeloid leukemia
101711934 (Pik3ca)
05218 Melanoma
101711934 (Pik3ca)
05211 Renal cell carcinoma
101711934 (Pik3ca)
05215 Prostate cancer
101711934 (Pik3ca)
05213 Endometrial cancer
101711934 (Pik3ca)
05224 Breast cancer
101711934 (Pik3ca)
05222 Small cell lung cancer
101711934 (Pik3ca)
05223 Non-small cell lung cancer
101711934 (Pik3ca)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
101711934 (Pik3ca)
05170 Human immunodeficiency virus 1 infection
101711934 (Pik3ca)
05161 Hepatitis B
101711934 (Pik3ca)
05160 Hepatitis C
101711934 (Pik3ca)
05171 Coronavirus disease - COVID-19
101711934 (Pik3ca)
05164 Influenza A
101711934 (Pik3ca)
05162 Measles
101711934 (Pik3ca)
05168 Herpes simplex virus 1 infection
101711934 (Pik3ca)
05163 Human cytomegalovirus infection
101711934 (Pik3ca)
05167 Kaposi sarcoma-associated herpesvirus infection
101711934 (Pik3ca)
05169 Epstein-Barr virus infection
101711934 (Pik3ca)
05165 Human papillomavirus infection
101711934 (Pik3ca)
09171 Infectious disease: bacterial
05132 Salmonella infection
101711934 (Pik3ca)
05135 Yersinia infection
101711934 (Pik3ca)
05100 Bacterial invasion of epithelial cells
101711934 (Pik3ca)
09174 Infectious disease: parasitic
05146 Amoebiasis
101711934 (Pik3ca)
05142 Chagas disease
101711934 (Pik3ca)
09164 Neurodegenerative disease
05010 Alzheimer disease
101711934 (Pik3ca)
05017 Spinocerebellar ataxia
101711934 (Pik3ca)
05020 Prion disease
101711934 (Pik3ca)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
101711934 (Pik3ca)
05418 Fluid shear stress and atherosclerosis
101711934 (Pik3ca)
05415 Diabetic cardiomyopathy
101711934 (Pik3ca)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
101711934 (Pik3ca)
04932 Non-alcoholic fatty liver disease
101711934 (Pik3ca)
04931 Insulin resistance
101711934 (Pik3ca)
04933 AGE-RAGE signaling pathway in diabetic complications
101711934 (Pik3ca)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
101711934 (Pik3ca)
01524 Platinum drug resistance
101711934 (Pik3ca)
01522 Endocrine resistance
101711934 (Pik3ca)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hgl04131
]
101711934 (Pik3ca)
Enzymes [BR:
hgl01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.1.153 phosphatidylinositol-4,5-bisphosphate 3-kinase
101711934 (Pik3ca)
Membrane trafficking [BR:
hgl04131
]
Endocytosis
Rab GTPases and associated proteins
Rab associated proteins
101711934 (Pik3ca)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI3Ka
PI3_PI4_kinase
PI3K_C2
PI3K_rbd
PI3K_p85B
DUF2321
ABC1
Motif
Other DBs
NCBI-GeneID:
101711934
NCBI-ProteinID:
XP_004834677
UniProt:
A0A0P6JG58
LinkDB
All DBs
Position
Un
AA seq
1068 aa
AA seq
DB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
CHGGEPLCDNVNTQRVPCSNPRWNEWLNYDMYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq
3207 nt
NT seq
+upstream
nt +downstream
nt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttattaccaaatggaatgatcgtgactttagaatgcctccgtgaggct
acattaataaccataaagcatgaactatttaaggaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggag
gaattttttgatgaaacaagacgactttgtgaccttcgcctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaggaaaagatcctcaatcgagaaattggttttgtt
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtgcaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatacaataaattagataaaggacaaataattgtggtgatttgggtaatagtttctcca
aataatgacaagcagaaatatactttgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaagaaaactcgaagtatgttgctatcctctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtatgtggatgtgatgaatac
ttcctagaaaaatatcccctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactctcaactaccaatggac
tgttttacaatgccatcctattccagacgcatctctacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacttatgtaaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
tgccacggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cctaggtggaatgaatggctgaattatgatatgtacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggagcactgt
ccattggcctggggaaatataaacttgtttgattatacagacaccctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagacttgctaaaccctattggt
gttaccgggtcaaatccaaacaaagaaactccatgcctagagttggagtttgattggttc
agcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgcaaattggtctgta
tcccgagaagcaggatttagttattcacatgcaggactgagtaacagactagctagagac
aatgaattaagagaaaatgacaaagaacagctccgagcaatttgtacacgagaccctctg
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacctaaattgcttctgtccgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcccccaatcaaacctgagcaggcaatggag
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcgatgcttggaa
aaatatttgacagatgacaagctttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacaatatttggataatctgcttgtgagatttttactcaagaaagcactaacaaat
caaaggattggacactttttcttttggcatttaaaatctgagatgcataataaaacagtt
agtcaaagattcggtctgcttttggaatcctattgtcgtgcctgtgggatgtatctgaag
cacctgaataggcaagttgaagctatggaaaagctcattaacttaactgacattctcaag
caggaaaagaaggatgagacacaaaaggtacagatgaagtttttagttgagcagatgagg
caaccagatttcatggatgctctacagggctttctatctcctctaaaccctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcttctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttacgccaagatatgctaacgcttcaaattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgctgccttacggttgtctctca
attggtgactgcgtgggacttattgaggtggtgagaaattctcacactatcatgcagatt
cagtgcaaagggggcctgaaaggtgcactgcagttcaatagccacacactgcatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctctttacacgttca
tgtgctggatattgcgtggctaccttcattttgggaattggagaccgtcacaatagtaac
atcatggttaaagatgatggacaactatttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgtgtcccatttgttttgacacaagatttc
ttaatagtgataagtaaaggggcccaagaatgtacaaagacgagagaatttgaaaggttt
caggagatgtgttacaaggcatatctagctattcggcagcatgccaatctcttcataaac
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgacattgca
tatattcgaaagaccctagccttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggaggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgcattgaactga
DBGET
integrated database retrieval system
