Heterocephalus glaber (naked mole-rat): 101711993 Help Entry 101711993         CDS       T02812                                  Symbol Nos1 Name (RefSeq) nitric oxide synthase 1   KO K13240   nitric-oxide synthase, brain [EC:1.14.13.39] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl00220   Arginine biosynthesis hgl00330   Arginine and proline metabolism hgl01100   Metabolic pathways hgl04020   Calcium signaling pathway hgl04081   Hormone signaling hgl04145   Phagosome hgl04371   Apelin signaling pathway hgl04713   Circadian entrainment hgl04730   Long-term depression hgl04926   Relaxin signaling pathway hgl04970   Salivary secretion hgl05010   Alzheimer disease hgl05014   Amyotrophic lateral sclerosis hgl05022   Pathways of neurodegeneration - multiple diseases hgl05410   Hypertrophic cardiomyopathy hgl05412   Arrhythmogenic right ventricular cardiomyopathy hgl05414   Dilated cardiomyopathy hgl05416   Viral myocarditis Brite KEGG Orthology (KO) [BR:hgl00001]  09100 Metabolism   09105 Amino acid metabolism    00220 Arginine biosynthesis     101711993 (Nos1)    00330 Arginine and proline metabolism     101711993 (Nos1)  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101711993 (Nos1)    04020 Calcium signaling pathway     101711993 (Nos1)   09133 Signaling molecules and interaction    04081 Hormone signaling     101711993 (Nos1)  09140 Cellular Processes   09141 Transport and catabolism    04145 Phagosome     101711993 (Nos1)  09150 Organismal Systems   09152 Endocrine system    04926 Relaxin signaling pathway     101711993 (Nos1)   09154 Digestive system    04970 Salivary secretion     101711993 (Nos1)   09156 Nervous system    04730 Long-term depression     101711993 (Nos1)   09159 Environmental adaptation    04713 Circadian entrainment     101711993 (Nos1)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     101711993 (Nos1)    05014 Amyotrophic lateral sclerosis     101711993 (Nos1)    05022 Pathways of neurodegeneration - multiple diseases     101711993 (Nos1)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     101711993 (Nos1)    05412 Arrhythmogenic right ventricular cardiomyopathy     101711993 (Nos1)    05414 Dilated cardiomyopathy     101711993 (Nos1)    05416 Viral myocarditis     101711993 (Nos1) Enzymes [BR:hgl01000]  1. Oxidoreductases   1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen    1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor     1.14.13.39  nitric-oxide synthase (NADPH)      101711993 (Nos1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  NO_synthase FAD_binding_1 Flavodoxin_1 NAD_binding_1 PDZ PDZ_6 PDZ_2 Motif Other DBs NCBI-GeneID:  101711993 NCBI-ProteinID:  XP_004843759 UniProt:  A0AAX6STK2 LinkDB All DBs Position Un AA seq 1465 aa AA seqDB search MEDHMFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQA GDIILAVNGRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFMGDGTPKTI RVTQPLGAPTKAVDLSHQQPASKEQPLAVDGATGPGNGPQHAQDSGQEATLLSHTNGLAL QAPGQDPAKKSVNVDLQGSQEHNELLREIEPVLSLLTSGGSRGAPAKVEMKDTGVQVDRD VDSKSHKALALGGENDRVFNDLWGKGNVPVVLNNPYSEKEQPPASGRQSPTKNGSPSKCP RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICIGSVMLPSQHTRRPEDVRTKDQLFPLA KEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNAARCVGR IQWSKLQVFDARDCTTAHGMFNYICNHIKYATNKGNLRSAITIFPQRMDGKHDFRVWNSQ LIRYAGYKQPDGSILGDPANVAFTEICIQQGWKPPRCRFDVLPLLLQANGNDPELFQIPP ELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEVGGLEFSACPFSGWYMGTEIGVRDY CDSSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLFSFQSDKVTIVDHHSATESF IKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPCFEYQPDPWNTHVWKG TNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFK HAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEER KYPEPLRFFPRKGPSLPRGDTEVHGLAAARDSQHRSYKVRFNSVSSYSDSHKSSGDGPDL RDNFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQE EAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTYVAEAPELTQGL SNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGNQELQYQPGDHLGVFPGNHEDLV NALIERLEDAPPVNQMVKVELLEERNTALGVISNWKDEPRLPPCTIFQAFKYYLDITTPP TPLQLQQFASLATNEKEKQRLLVLSKGLQEYEEWKWGKNPTMVEVLEEFRSIQMPATLLL TQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPIHHGVCSSWLNRIPADEVV PCFVRGAPSFHLPQNPQVPCILIGPGTGIAPFRSFWQQRQFDIQHKGINPCPMVLVFGCR QSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAEAVYRALKEQGG HIYVCGDVTMAADVLKAIQRIMAQQGRFSEEDAGVFISRLRDDNRYHEDIFGVTLRTYEV TNRLRSESIAFIEESKKDADEVFSS NT seq 4398 nt NT seq  +upstreamnt  +downstreamnt atggaagatcacatgttcggtgttcagcagatccaacccaatgtcatttctgtccgcctc ttcaagcgcaaagtggggggcctgggattcctggtaaaggagcgggtcagcaagccaccc gtgatcatctctgatctgattcgcggtggggccgcggagcagagtgggctcatccaggcc ggagacatcattcttgcagtcaatggccgccccttggtggacttgagctacgacagtgcc ctggaagtgctcaggggcatcgcctccgagacccatgtggtcctcatcctgaggggccct gagggcttcacaacgcacctggagaccaccttcatgggggatgggacccccaagaccatc cgagtgacacagcccctgggtgcccccaccaaagcagtcgatctatcccaccaacaaccg gccagcaaagagcagccactggcagtggatggggccactggtcctgggaacgggcctcag catgcccaagacagtgggcaagaagccaccttgctctcccacaccaacggcctggctctc caggccccaggccaggaccctgccaagaaaagtgtcaacgttgatctccaaggcagccag gagcacaatgagctgctccgagaaatagagcctgtgctgagcctcctcaccagtgggggc agtagaggggcacctgccaaggtagagatgaaagacaccggagtccaagtggacagagac gtggacagcaagtcacacaaagctctggcccttggcggggaaaatgaccgagtcttcaat gacctgtgggggaaaggcaacgtacccgtcgtcctcaacaacccatattcagaaaaggag cagccccctgcctcaggcagacagtcccccaccaagaatggcagcccctccaagtgcccc cgcttcctcaaggtcaagaactgggagactgacgtggttctcacagacaccctccacctt aaaagcacactggaaacgggctgcacggagcacatctgcataggctctgtcatgctgccc tctcagcacacacgaaggcccgaagatgtccgcaccaaggaccagctcttccccctcgcc aaagagttcctggatcagtactactcatcaattaaaagatttggctccaaagctcacatg gacaggctggaagaggtgaacaaggagatcgaaagcaccagcacctaccagctcaaggac acagagctcatctatggggccaaacatgcctggcggaatgccgcccgctgcgttggcagg atccagtggtccaagctgcaggtgttcgatgcccgcgactgcaccacagcgcatgggatg ttcaactacatctgcaaccacatcaagtatgccaccaacaaagggaacctcaggtcagcc atcaccatatttccccagaggatggacggcaagcacgacttccgagtctggaactcccag ctcatccgttacgccggctacaagcagcctgacggctccatcctgggggaccccgcaaat gtggcattcacagagatatgcatccagcagggctggaaacctccgaggtgccgcttcgat gtcctgccgctcctgctccaggccaatgggaatgaccccgagctcttccagatcccgccc gagctggtgctggaagtgcccatcaggcaccccaagtttgactggttcaaggacctgggc ctgaagtggtacggcctccctgctgtgtccaacatgctgctggaggtcggcggcctggag ttcagcgcctgtcccttcagcggctggtacatgggcaccgagatcggcgtccgagactac tgtgacagctctcgctacaacatcctggaggaagtagccaagaagatgaacttggacatg aggaagacgtcctcactgtggaaggaccaggcgctggtggagatcaacattgccgtcctc ttcagcttccagagtgacaaagtgaccatcgttgaccatcactctgccaccgagtccttc atcaagcacatggagaatgagtaccgctgtcggggtggctgcccagccgactgggtgtgg atcgtgccccccatgtctggcagtatcacccccgtcttccaccaggagatgctcaactat cgactcacgccctgcttcgagtaccagcctgatccttggaacacccacgtctggaaaggc accaatgggacccccaccaagcgacgagccatcggcttcaagaagctggcagaagccgtc aagttctcggccaagctgatggggcaggccatggccaagagggtcaaagccaccattctc tacgccacagagacaggcaaatcgcaagcctacgccaagaccttgtgtgagatcttcaaa catgccttcgatgccaaggtgatgtctatggaggaatacgacattgtgcacctggagcat gaaactctggtcctggtggtgaccagcacctttggcaatggggacccccctgagaacgga gagaaattcggctgtgcgttgatggaaatgaggcaccccaactctgtgcaagaggaaagg aagtacccggaacccttgcgtttctttccccgtaaagggccttccctcccccgtggtgac actgaagtccacggtctggctgcagcccgtgacagccagcacaggagctacaaggtccgg ttcaacagtgtctcctcctactctgactcccacaaatcatcgggcgatgggcctgacctc agagacaactttgagagtgctggacccctggccaacgtgaggttctcagtatttggcctc ggctcccgggcttacccgcacttctgcgccttcggacatgctgtggacactctcctggaa gagctgggaggggagaggatcctgaagatgagggagggggacgagctctgtgggcaggaa gaggctttcaggacctgggccaagaaggtcttcaaggcagcctgcgatgtgttctgcgtg ggggatgatgtcaacatcgagaaggcgaacaattcactcatcagcaatgaccgaagctgg aagagaaacaagttccgcctcacctatgtggctgaggcaccagaactcacacaaggtctt tccaatgtccacaaaaagcgagtctccgctgcacgactcctgagccgtcagaacctgcaa agtcctaaatccagccgatcaaccatcttcgtgcgtctgcacaccaacggaaaccaggag ctgcagtaccagcccggagaccacctgggggtcttccctggcaaccatgaagaccttgtg aatgccctcatcgagcggctggaagatgcaccccctgtcaaccagatggtcaaggtggaa ctgctagaggagcggaacacggctttgggcgtcatcagtaactggaaggatgagccccgc ctccctccctgcaccatcttccaggccttcaagtactacctggacataactacaccaccc acacccctgcagctgcagcagttcgcctccctggccaccaacgagaaggagaagcagcgc ctgctggtcctcagcaaggggttgcaggagtatgaggagtggaagtggggcaagaacccc accatggtggaggtgctggaggagtttcggtccatccagatgccagccaccctgctgctc acccagctgtccctgctccagcctcgctattactccatcagctcctccccggacatgtac cctgacgaggtacacctcaccgtggccatcgtctcctaccacacccgagatggagaagga ccaattcaccacggcgtgtgttcctcttggctcaaccggataccggctgacgaagtggtc ccctgttttgtgagaggcgcacccagcttccacctaccccaaaacccccaggtcccttgc atcctgattggcccgggcaccggcatcgcgcccttccggagcttctggcagcaacggcaa ttcgacatccagcacaaaggaataaatccctgcccgatggtcctggtgttcgggtgccgg caatcgaagatagatcacatctacagggaggagaccctgcaggccaagaacaagggggtc ttcagagagctgtacacagcctactcccgagagccggacaaaccaaagaagtatgtgcag gacatcctacaagagcagctggcagaggccgtgtaccgagccctcaaggagcaagggggc cacatctacgtctgcggggacgtcaccatggccgctgatgtcctcaaagccatccagcgc atcatggctcagcaggggagattctcagaggaggatgctggcgtgttcatcagcaggctg agggatgacaaccggtaccatgaagatatttttggagtcaccctgcgcacgtatgaagtg accaaccgccttagatctgagtccattgccttcattgaagagagcaaaaaagacgctgac gaggttttcagctcctaa

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