Heterocephalus glaber (naked mole-rat): 101712759 Help Entry 101712759         CDS       T02812                                  Symbol Notch2 Name (RefSeq) notch 2   KO K20994   Notch 2 Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl01522   Endocrine resistance hgl04330   Notch signaling pathway hgl04658   Th1 and Th2 cell differentiation hgl04919   Thyroid hormone signaling pathway hgl05165   Human papillomavirus infection hgl05200   Pathways in cancer hgl05206   MicroRNAs in cancer hgl05207   Chemical carcinogenesis - receptor activation hgl05224   Breast cancer Brite KEGG Orthology (KO) [BR:hgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04330 Notch signaling pathway     101712759 (Notch2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     101712759 (Notch2)   09152 Endocrine system    04919 Thyroid hormone signaling pathway     101712759 (Notch2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101712759 (Notch2)    05206 MicroRNAs in cancer     101712759 (Notch2)    05207 Chemical carcinogenesis - receptor activation     101712759 (Notch2)   09162 Cancer: specific types    05224 Breast cancer     101712759 (Notch2)   09172 Infectious disease: viral    05165 Human papillomavirus infection     101712759 (Notch2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     101712759 (Notch2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  EGF hEGF EGF_TEN EGF_CA EGF_2 Ank_2 Ank NOD Notch NODP Ank_5 Ank_3 Ank_4 EGF_3 EGF_Teneurin cEGF Motif Other DBs NCBI-GeneID:  101712759 NCBI-ProteinID:  XP_004853910 UniProt:  A0AAX6PJZ9 LinkDB All DBs Position Un AA seq 2465 aa AA seqDB search MPALRPAPLWALLALWLWRAAPARALQCRDDYEPCVNEGICITFHNGTGYCKCPEGFLGE YCQHRDPCEKNRCQNGGTCVARAMLGRATCRCAPGFTGEDCQHSTSHPCFVTRPCQNGGT CHMLSRDTYECTCQVGFTGKLCQWTDACLSHPCVNGSTCTTVANQFSCRCLAGFTGQKCE TDVNECDVPGQCQNGGTCLDLPGSYQCQCSQGFTGQHCDSPYVPCAPSPCVNGGTCRQTG DFTFECSCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVD ECLLQPNACQNGGTCTNRNGGYGCVCVNGWSGNDCSENIDDCAFASCTPGSTCIDRVASF SCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGHYICTCPQGYKGADCTEDVDECA MTNSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTC LCMPGFKGVHCEMEINECQSNPCVNNGQCVDRVNRFQCLCPPGFTGPVCQIDIDDCSSTP CLNGAKCIDHPNGYECQCATGFTGLLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYM GAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPCVHGMCV DGISRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINDENGFRCICPEGPHHPSCYSQ VNECLSNPCIHGNCTGGLSGYKCLCDAGWVGTNCEVDKNECLSNPCQNGGTCDNLVNGYR CTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDVSGYTCQCSLPYTGKNCQMVLAPCSPN PCENAAVCKEAPDFESYTCLCAPGWQGRRCTVDIDECVSKPCLNHGLCHNTQGSYMCECP PGFSGMDCEEDIDDCLANPCQNGGSCVDGMNTFSCMCLPGFIGDKCQTDMNECLSEPCKN GGTCSDYVNSYTCKCQPGFDGVHCENNIDECTESSCFNGGTCVDGINSFSCLCPVGFTGP FCLHEINECNSHPCLNEGTCVDGLGTYRCTCPLGYTGKSCQTLVNLCSRSPCKNQGTCVQ EKAESRCLCPSGWTGAYCDVPDVSCETAARNKGVLAKHLCRNSGVCINAGNTHHCQCPLG YTGSYCEQQLDECTSNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGG TCIDLVNHFKCSCPPGTRGLLCEENIDDCAGGPHCLNGGQCTDRIGGYSCRCLPGFAGER CEGDINECLSNPCSSEGSLDCIQLTNDYQCVCRSAFTGRHCETFVDVCPQMPCLNGGTCS VASNMPDGFICRCPPGFSGAKCQSSCGQVKCRKGEQCVHTASGPRCFCPKPQECESGCAS SPCQHGASCYPQRQPPYYSCHCSAPFWGSRCQFYTAPTSTPSATCASQYCADKARDGVCD EACNSHACQWDGGDCSLTMEDPWANCSSPLPCWDYINNQCDELCNTAECLFDNFECQGNS KTCKYDKYCADHFKDDHCDQGCNSEECGWDGLDCASDRPENLAEGTLVIVVLMPPEQLLQ DARSFLRALGTLLHTNLRIKQDSQGVPMVYPYYGEKTATMKKQKMLRRSLPDEQEQEVAG SKVFLEIDNRQCVQDSDQCFKNTDAAAALLASHAIQGTLSYPLVSVVSESLTPERTQLLY LLAVAVVIILFIILLGVIMAKRKRKHGSLWLPEGFTLRRESSNHKRREPVGQDAVGLKNL SVQVSEANLIGSGTSELWVDDEGPQPKKAKAEDEALLSEEDDPIDRRPWTQQHLEAADIR RTPSLAPTPPQAEQEVDVLDVNVRGPDGCTPLMLASLRGGSSDMSDEDEDGEDSSANIIT DLVYQGASLQAQTDRTGEMALHLAARYSRADAAKRLLDAGADANAQDNMGRCPLHAAVAA DAQGVFQILIRNRVTDLDARMNDGTTPLILAARLAVEGMVAELINCQADVNAVDDHGKSA LHWAAAVNNVEATLLLLKNGANRDMQDNKEETPLFLAAREGSYEAAKILLDHFANRDITD HMDRLPRDVARDRMHHDIVRLLDEYNVTPSPPGAVLTSALSPVICGPNRSFLSLKHTPMG KKPRRPNAKSTMPTSLPNLAKEAKDAKGGRRKKSLSEKVQLSESSVTLSPVDSLESPHTY VSDTTSPGILQASPNSLLAAAAPPAPVHAQHALSFSNLHEMQPLAPGASTVLPSVSQLLS HHHIVPPGSSSAGSLSRLHPLTVPADWVNRVEMNETQYSEMFGMVLTPTEGTHPGMAPQS RPPEGKHITTPREPLPPIVTFQLIPKGSIAQPAGASQPQSACPPAIAGPLPTMYQIPEMA RLPSVAFPTAMMTQQDGQVAQTILPAYHPFPASVGKYPTPPSQHSYASSSAAERTPSHSG HLQGEHPYLTPSPDSPDQWSSSSPHSASDWSDVTTSPTPGSAGGGQRGPGTHMSEPPHSN MQVYA NT seq 7398 nt NT seq  +upstreamnt  +downstreamnt atgcccgccctgcgtcccgctccgctgtgggcgctcctggcgctgtggctgtggcgcgcg gcccccgcgcgtgcattgcagtgtcgagatgactatgagccctgtgtaaatgaaggaatt tgtatcaccttccacaatggcacaggatactgcaaatgtccagagggcttcttgggagaa tattgccaacatcgagatccctgtgagaagaaccgctgccagaatggtggaacctgtgtg gcccgggccatgttggggagagctacctgccggtgtgccccggggttcactggggaggac tgccagcactcgacctctcacccctgctttgtgactcgtccctgccagaatggaggcacc tgccacatgctcagccgggacacctatgagtgtacctgccaagtagggtttacagggaag ttgtgccagtggactgatgcctgcctgtcccatccctgtgtaaatggaagtacctgcacc actgtggccaaccagttctcctgcagatgcctcgcaggcttcacagggcagaagtgtgag actgatgtcaatgagtgtgacgtcccaggacagtgccagaatggtggcacctgcctcgac ctgcctggttcctaccagtgccagtgctcccagggcttcacgggccagcactgtgacagc ccctacgtgccctgtgcaccctccccctgtgtcaatggaggcacatgccggcagactggc gacttcacctttgagtgtagctgccttccaggctttgaagggagcacctgtgagcggaat attgatgactgcccgaaccacaggtgtcagaatggaggggtttgtgtggatggtgtgaac acttacaactgccgctgcccgcctcagtggacaggacaattctgcacagaggatgtagat gagtgcctgctgcaacccaatgcctgtcagaatggaggcacctgcaccaacagaaatggg ggctatggctgcgtgtgtgtgaacggctggagtggaaatgactgcagtgagaacatcgat gactgtgcctttgcatcctgcaccccgggctctacctgtatcgaccgtgtggcctccttc tcctgcatgtgtcctgaggggaaggcaggtctcttatgccatctggacgatgcctgcatc agcaatccttgccacaagggggcgctgtgtgacaccaaccccctgaatgggcactacatt tgtacctgcccacaaggctacaaaggagctgactgtacagaagacgtggatgaatgcgcc atgaccaacagcaatccttgcgagcacgcaggaaagtgtgtgaacacagatggcgccttc cactgcgagtgtctgaagggctatgctgggcctcgctgtgagatggacatcaacgaatgt cactcggacccctgccagaatgatgccacctgcctggataagataggtggcttcacctgc ctgtgcatgccaggtttcaaaggtgtgcattgtgaaatggagataaatgaatgccagagc aacccctgtgtgaacaatgggcagtgtgtggacagagtcaatcgcttccagtgtctatgt cctcctggtttcacggggccagtctgccagattgacattgacgactgctccagtactccg tgtctgaacggggccaagtgtatcgatcacccaaatggctacgaatgccagtgcgccaca ggtttcactggtctgttgtgtgaggagaacattgacaactgtgaccccgatccctgccac catggccagtgccaggatgggattgattcctacacatgcatctgcaaccccgggtacatg ggtgccatctgcagtgaccagattgacgaatgttatagcagtccgtgcctgaacgacgga cgctgtattgacctagtgaatggctaccagtgcaactgccagccgggcacgtcaggagtt aattgtgaaattaattttgatgactgtgctagcaacccttgtgtccatggcatgtgcgtg gatggcattagtcgttacagttgtgtctgctcgccaggattcacagggcagagatgtaac atcgacattgatgagtgcgcctccaatccctgccgaaagggcgcgacgtgcatcaacgat gagaatggtttccgctgcatctgccccgaaggtccccatcaccctagctgctactcgcag gtgaatgagtgcctgagcaatccctgcatccacgggaactgtactgggggcctcagtgga tataagtgcctctgtgatgcaggctgggttggaaccaactgtgaagtggataaaaatgaa tgtctttctaacccatgccagaacggaggaacttgtgacaatctggtgaacggatacaga tgcacttgcaaaaagggcttcaaaggctacaactgccaggtgaacattgatgaatgtgcc tccaatccatgtctgaaccaaggaacctgctttgatgatgtcagtggctacacttgccag tgttcactgccctacacaggcaagaactgtcaaatggtattggctccctgttccccaaac ccttgtgagaatgctgctgtttgtaaagaggcaccagattttgagagttacacttgcttg tgtgctcctggctggcaaggtcggcgatgtacggttgacattgatgagtgtgtctccaag ccctgcctgaaccacggtctctgccataacacccagggaagttacatgtgtgagtgtccc cccggcttcagtggtatggactgtgaggaggacatcgacgactgccttgccaatccttgc cagaacggaggttcctgtgtggatggcatgaacactttctcctgcatgtgccttcctggc ttcattggggacaagtgccagacagacatgaatgagtgtctcagtgagccctgtaagaat ggagggacctgctctgactatgtcaacagctacacctgcaagtgccagccgggatttgat ggggtccactgtgagaacaacatcgatgagtgtaccgagagctcctgtttcaatggtggc acctgtgtggatgggattaactccttctcttgcttgtgccctgtgggcttcactggtccc ttctgccttcacgagatcaatgaatgcaactctcatccgtgcctaaatgaggggacatgt gtggatggcctgggcacctaccgctgcacctgccccttgggctacactgggaagagctgc cagaccctggtgaatctctgcagtcggtctccatgtaaaaaccaaggcacttgtgttcag gaaaaggcagagtcccggtgcctgtgtccatctgggtggactggtgcatactgcgacgtg cctgatgtctcctgtgaaactgcagcccgcaataaaggcgtgcttgccaagcacctgtgc cggaactcaggcgtctgcatcaacgctggcaacacgcaccattgccaatgcccactgggg tacacgggaagctactgcgagcagcagctggacgagtgcacgtccaatccctgccagcac ggcgccacctgcagcgacttcattggcggatatagatgtgagtgtgttccgggatatcag ggtgtcaactgtgaatatgaggtagatgagtgtcagaatcagccatgccagaatggaggc acctgcattgaccttgtgaaccatttcaagtgctcatgcccaccaggcactcgaggcctg ctctgtgaagagaacatcgatgactgcgctgggggtccccactgcctcaatggtggccag tgcacagacaggatcgggggctacagttgtcgctgcttgcctggctttgctggggagcgg tgtgagggggatatcaacgagtgcctgtccaacccctgcagctctgagggcagcctggac tgcatccagctcaccaatgactaccagtgtgtctgccgaagcgccttcaccggccgtcac tgtgaaaccttcgtggatgtatgtcctcagatgccttgtctgaatggagggacttgttct gtggccagcaacatgcccgatggtttcatttgtcgttgtcctccgggcttctcaggagca aaatgccagagcagctgtggacaagtgaagtgcaggaaaggggagcagtgtgtgcatact gcctccgggccccgctgcttctgccccaagcctcaggaatgtgagtcaggctgtgccagt agcccctgccagcacggggccagctgctaccctcagcgtcagcctccgtattactcttgc cactgctctgcaccgttctggggcagccgctgtcaattctacacggcccctaccagcacc ccttctgccacctgtgcgagtcagtactgtgctgacaaagctcgggatggcgtgtgcgat gaggcctgcaacagccatgcctgccagtgggatggaggtgactgctccctcaccatggag gacccctgggccaactgctcctccccactgccctgctgggactacatcaacaaccagtgc gacgagctatgcaacacagccgagtgcctgtttgacaactttgagtgccaaggaaacagc aagacctgcaagtatgacaagtactgtgctgaccacttcaaagacgaccactgtgaccag ggatgcaacagtgaggaatgcggctgggatgggctggactgtgcctctgaccggcctgag aacctggcagaggggactctggtcatcgtggtgctgatgccccctgagcagctgctccag gacgctcgaagcttcctgcgggcactgggcaccttgctccataccaacctgcgcatcaaa caggactcacagggggtccccatggtgtacccctactatggggaaaagacagccaccatg aagaagcagaagatgttacgaaggtctcttcctgacgaacaagaacaggaggtggctggc tccaaagtattcctggaaattgacaaccgccagtgtgtgcaagactcagaccagtgcttc aagaacactgatgcggccgcggccctgctggcttctcatgccatccagggaaccctgtcc taccctcttgtgtctgttgtcagtgaatcactgactccagagcgcactcagcttctctat ctacttgctgtcgctgttgtcattatcctgtttattatcctgctgggagtaatcatggca aaacggaagcgcaagcatggctccctctggctgcctgaaggtttcacccttcgccgagag tccagcaaccacaagcgtcgagagcctgtgggacaggatgctgtgggcctgaaaaatctg tccgtgcaagtttcagaggccaacctcattggttccggaacaagtgaactttgggtggat gatgaaggaccccagccaaagaaagccaaggctgaagatgaggctttgctctcagaagaa gatgaccccattgatcgacgcccatggacacagcagcacctggaagccgcagacatccgt cggacgccatcgctggctcccactcctcctcaggcggagcaggaggtggatgtgctggat gtgaatgtccggggcccagatgggtgcaccccattgatgttggcttccctccgaggaggc agctcagatatgagtgatgaggatgaagatggagaggactcttctgccaacatcatcaca gacctagtctaccagggtgccagcctccaggcacagacagaccggactggtgagatggcc ctgcaccttgcggcccgatactcaagggctgatgctgccaagcgcctcctggatgcaggt gcagatgccaatgctcaggacaacatgggccgctgccctctccatgctgcagtagctgct gatgcccaaggcgtcttccagattctgatccgcaaccgggtaactgatctggatgccaga atgaatgatggcactacaccgctgatcctggctgcccgcctggctgtggagggaatggtg gcagaactgatcaactgccaagcagatgtgaatgcagtggatgaccatggaaaatctgct cttcactgggcagctgctgtgaataatgtggaggctactcttctgctgttaaaaaatgga gccaaccgagacatgcaggacaacaaggaagagactcctctgtttcttgctgcccgggag gggagctatgaagcagccaaaatcctgttagatcattttgccaatcgggacatcacagac cacatggatcgccttccccgggatgtggctcgggaccgcatgcaccatgacattgtacgc ctcctggatgagtacaacgtgacaccgagccccccaggcgctgtgctgacttctgcactc tcaccggtcatctgcgggcccaacaggtcattcctcagtctgaagcacaccccaatgggc aagaagcccagacggcccaatgccaaaagcaccatgcccactagcctccctaaccttgcc aaggaggctaaggatgccaagggaggtaggcggaagaagtctctgagtgagaaggtccag ctgtctgagagctcagtgacgttatcccctgtcgattctctcgagtctcctcacacatac gtgtctgacaccacatcccccggaatcctacaggcctcacccaactctctgttggccgct gctgcacccccagccccagtccatgcacagcatgccctatctttctctaaccttcatgaa atgcagcctttggctcccggggccagcaccgtgcttccttctgtaagtcagctcctgtcc caccaccacattgtccccccaggcagcagcagtgcaggaagcttgagtaggctccatcca ctcactgtcccagcagattgggtgaaccgcgtggagatgaacgagacccagtacagtgaa atgtttggcatggtcctgactcctaccgagggcacccaccctggcatggctccccagagc aggccacccgaagggaagcacatcaccacccctcgggagcccttgccccccattgtgact ttccagctcatccccaaaggcagcattgcccagccagctggggcttcccagcctcagtct gcctgccctccagccattgcagggcccctgcccactatgtatcagattcctgagatggcc cgtttgcccagtgtggctttccccactgccatgatgacccagcaggacgggcaggtagca cagaccattctcccagcttatcatcctttcccagcctctgtgggcaagtaccccacaccc ccttcacagcatagctatgcttcctcaagtgctgctgagcgaacacccagtcacagtggt cacctgcaaggcgagcatccctacctgacaccatccccagactctcctgaccagtggtca agctcatcgccccactctgcttctgattggtcagatgtaaccaccagccctactcctggg agtgctggaggaggtcagcgaggacctgggacacacatgtctgagccaccacatagcaac atgcaggtttacgcatga

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