Heterocephalus glaber (naked mole-rat): 101713968 Help Entry 101713968         CDS       T02812                                  Symbol Tsc2 Name (RefSeq) tuberous sclerosis 2   KO K07207   tuberous sclerosis 2 Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl04072   Phospholipase D signaling pathway hgl04115   p53 signaling pathway hgl04140   Autophagy - animal hgl04150   mTOR signaling pathway hgl04151   PI3K-Akt signaling pathway hgl04152   AMPK signaling pathway hgl04211   Longevity regulating pathway hgl04218   Cellular senescence hgl04714   Thermogenesis hgl04910   Insulin signaling pathway hgl04919   Thyroid hormone signaling pathway hgl05163   Human cytomegalovirus infection hgl05165   Human papillomavirus infection hgl05168   Herpes simplex virus 1 infection hgl05231   Choline metabolism in cancer Brite KEGG Orthology (KO) [BR:hgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04072 Phospholipase D signaling pathway     101713968 (Tsc2)    04151 PI3K-Akt signaling pathway     101713968 (Tsc2)    04152 AMPK signaling pathway     101713968 (Tsc2)    04150 mTOR signaling pathway     101713968 (Tsc2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     101713968 (Tsc2)   09143 Cell growth and death    04115 p53 signaling pathway     101713968 (Tsc2)    04218 Cellular senescence     101713968 (Tsc2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     101713968 (Tsc2)    04919 Thyroid hormone signaling pathway     101713968 (Tsc2)   09149 Aging    04211 Longevity regulating pathway     101713968 (Tsc2)   09159 Environmental adaptation    04714 Thermogenesis     101713968 (Tsc2)  09160 Human Diseases   09161 Cancer: overview    05231 Choline metabolism in cancer     101713968 (Tsc2)   09172 Infectious disease: viral    05168 Herpes simplex virus 1 infection     101713968 (Tsc2)    05163 Human cytomegalovirus infection     101713968 (Tsc2)    05165 Human papillomavirus infection     101713968 (Tsc2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:hgl01009]     101713968 (Tsc2) Protein phosphatases and associated proteins [BR:hgl01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      101713968 (Tsc2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Tuberin DUF3384 Rap_GAP Cnd1 Motif Other DBs NCBI-GeneID:  101713968 NCBI-ProteinID:  XP_004873701 UniProt:  A0AAX6QDW1 LinkDB All DBs Position Un AA seq 1809 aa AA seqDB search MAKPANKDSGLKEKFKILLGLGTPRPNPRPPEGKQTEFIITAEILRELSVECGLNNRIRM IGQICEVAKTKKFEEHAVEALWKAVADLLQPERPPEARHAVLALLKAIVQGQGDRLGVLR ALFFKVIKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDIGLSSEFLLVL VNLVKFNSCYLDEHIASMVHMICLLCIRTMSSVDIEVSLQVLDAVVCYNCLPAESLPLFI VTLCRTINVKELCEPCWKLMRNLLGTHLGHSAIYNMCRIMEDRAYMEDAPLLRGAVFFVG MALWGAHRLYSLKNSPTSVLPSFYEAMTCPNEVVSYEIVLSITRLIKKYRKELQAVTWDI LLNIMERLLQQLQDLDSSELRTIVHDLLTTVEELCDQNEFHGSKERYFELVESCADQRPE SSLLNLISYRAQSIHPAKDGWIQNLHLLMERFFRNEARSAVRIKVLDVLSFVLLINRQFY EEELINSVVISQLSHIPEDRDPQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLS LPPELEERDVTAYSASLEDVKTAVLGLLVILQTKLYTLPASHAMRVYETLISHIQLHYKH NYSLPIASSIRLQAFDFLLLLRADALHRLGLPTKDGIVRFSPYCLCDCMEPERASEKKAG GPLSPPTGPSGSASAGPAFRLGHLPYSLLFRVLLQCLKQETDWKVLKLVLSKLPESLRYK VLIFTSPCNVDQLSSALCSMLSGPKTLERLRGTPEGFSRTDLHLAVVPVLTVLISYHNYL DKTKQREMVYCLEQGLIYRCASQCVVALAICSVEMPDIMIKALPVLVVKLTHISATASMA VPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRC RLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARSTSLNERPKSLRIARAPKQGLNNS PPVKEFKESSAAEAFRCRSISVSEHVVRRIQTSLTTASLGSADENSMAQADDNLKNLHLE LTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGAGTRSLL GLDSGELQGGPESSSDPGVHVRQTKEAPAKLESQAGQQVSCGARDRVRSMSGGHGLRVSA LDAPAPHTTSGPASPGLQTIPAAKPEQTSAGARVLAPEKTNLAAYVPLLTQGWAEILVRR PTGNTSWLMSLENPLSPFSSDINNMPLQELSNALMAAERFKEHRDTALYKSLSVPAAGTA KPPPLPRSNTVASFSSLYQSNCQGQLHRSISWADSAVVLEEGSPGEAHMPGEPPELEDFE PALGTDRRCQRPDTYSRSSSASSQEEKSSHVEELAVGAIPIERVVSSEGGRPLVDLSFQP SQPLSKSSSSPELQTLQDILGDPGDKADVGQLSPEAKARSQSGILDGEGAAWSAAGEESQ GPAPPEGPLPSSSPHSPSGLRPRGYTISDSAPSRRGKRVERDAFKNRAATSNTEKVPGIN PSFVFLQLYHSPFFGDESNKPILLPNESFERSVQLLDQIPSYDTHKIAVLYVGEGQSSSE LAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDVCGEDGQFTYCWHDDIMQAV FHIATLMPTKDVDKHRCDKKRHLGNDFVSIIYNDSGEEFKLGTIKGQFNFVHVIITPLDY ECNLLSLQCRKDMEGLVDTSVAKIVSDHNLPFVARQMALHANMASQVHHSRSNPTDIYPS KWIARLRHIKRLRHRIREEAQYSNPSLPLMHPPAHAKASAQAPSEPTPAYETGQRKRLIS SVDDFTEFV NT seq 5430 nt NT seq  +upstreamnt  +downstreamnt atggccaagccagcaaacaaagattcaggcttgaaggagaagttcaagattctattggga ctgggaacaccaaggccaaatcctaggcctccagaaggcaaacagaccgagtttatcatc acagcggaaatcctgagagaactgagtgttgaatgtggcctcaacaatcgcatccggatg atagggcagatctgtgaagttgcaaaaactaagaaatttgaagagcatgcagtggaagca ctctggaaggctgtcgcagacctgttgcagccagagcggccaccagaggcccgacatgca gtgttggctctgctgaaggctattgtgcaggggcagggtgatcgcttgggagttctcaga gccctcttctttaaggtcatcaaagattacccctccaatgaagacctccatgaaaggctg gaagttttcaaggccctcacagacaatgggagacacatcacctacttggaagaagaactg gcggactttgtcttgcagtggatggatattggcttgtcctcagaattcctgctggtgctt gtgaacttggtcaagttcaacagctgttaccttgacgaacacatcgcatcaatggttcac atgatctgtctgctgtgcatccgaaccatgtcctctgtggacatagaggtctccttgcag gtgctggatgctgtggtctgctacaactgcctgccagctgagagcctccctctgttcatt gtcaccctgtgccgtaccatcaatgtcaaggaactctgtgagccttgctggaagctgatg cgtaacctcctgggcactcacctgggccacagtgccatctataacatgtgccgcatcatg gaggacagagcctacatggaagatgctccactgctgagaggagctgtgttctttgtgggc atggctctttggggagcccaccgactctattctctcaagaactccccaacatctgtattg ccatctttttatgaggccatgacctgtcccaatgaagtggtgtcctatgagattgtgctg tccataaccagactcattaagaagtataggaaggagcttcaggcggtgacatgggacatt ctgctgaatatcatggaacggctgcttcagcagctccaggacctggacagctcagagctc aggaccatcgtgcatgacctgctgaccactgtggaggagctgtgtgaccagaatgagttt cacggctcgaaggaaagatactttgagctggtggagagctgtgcagaccagaggcctgaa tcctcgctcttaaacttaatatcctatagagctcagtctattcacccagcgaaggacggc tggatccagaacctgcacttgctgatggagaggttcttcaggaatgaggctcgtagtgct gtgcgcatcaaggtgttggatgtgctatccttcgtgctgctcatcaacaggcagttctat gaggaagaactgattaactcagtggtcatctctcagctctcccatatccctgaagacaga gaccctcaagtccgaaagctggccacccaactgctggtggacctggcagaaggctgccat acccaccacttcaacagtctgctagacatcattgaaaaagtgatggcccgctccctctct ctgcctcccgagctggaagaaagggatgtgactgcctactcagcttctctggaggatgtg aaaactgcagtcctaggactcctggtcatccttcagaccaagctatacaccctgcctgcc agccatgccatgcgtgtgtatgagacgcttatcagccacatccagctccactataagcat aactactccctgcccattgccagcagcatccggctacaggcctttgacttcctgctgctg ctacgggctgatgcgctgcaccgcctgggtctgcccaccaaggatgggatcgtgagattt agcccctactgcctgtgtgactgcatggagcctgagagggcctctgaaaagaaggctggt ggccccctttcacctcccactgggccatcaggctctgcatcagcaggtcctgcctttcgg cttggtcacctgccctactctctgctcttccgagttctgctgcagtgtttgaaacaggaa actgactggaaggtgctgaagttggtccttagtaagctgccagagtcactgcgctacaaa gttctcatcttcacatctccatgcaacgttgaccagctctcttctgccctctgctctatg ctttcaggcccaaagacccttgagcgcctccgaggcaccccagaaggcttctccagaact gacctgcacttggctgtggttcctgttctgaccgtgttgatctcttaccataactacttg gacaagaccaaacagcgtgagatggtttactgcctggagcaaggcctcatctaccgctgt gccagtcagtgcgtggtggccctggccatctgcagtgtggagatgcctgacatcatgatc aaggcgctgcccgtcctggtggtgaagctcacgcacatctctgccacagccagcatggct gtccctctcctagaatttctgtccactctggccagactgccccacctctacaggaatttt gccgctgaacagtatgcgagtgtgtttgctatctccttgccgtataccaacccctccaag ttcaatcagtacatcgtgtgcctggcacatcacgtcatagccatgtggttcattaggtgc cgcctgcccttccggaaagattttgtcccgtttatcactaagggtctacgttccaatgtc ctcctgtcttttgatgacacccctgagaaggacagcttcagagcacggagcaccagcctc aatgagaggcccaaaagtttgaggatagccagagcccccaaacaaggcctgaataactcc ccacccgtgaaagaattcaaggagagctctgcagccgaggccttccggtgccgcagcatc agtgtgtctgaacatgtggtccgcagaatacagacatccctcaccactgccagccttggg tctgcagatgagaactccatggcccaggctgatgacaacttgaaaaatctccacctggag ctcacagaaacatgtctggacatgatggcccgatatgtattctccaacttcactgcagtc cccaagaggtctcctgtaggagaattcctcctggcaggtggcaggaccaaaacctggctg gttgggaataaacttgtcaccgtgacaacaagtgtcggggccgggacccggtcattgctg ggcttggactcaggcgagctacagggtggcccagagtcaagctctgatcctggtgtacac gtgagacagaccaaggaggcgcctgcaaagctggagtcccaggctgggcaacaggtgtcc tgtggggcccgtgaccgtgtccgctccatgtctgggggccatggccttcgggttagtgcc ctggatgcaccagccccccacactacaagtggccctgcctctccgggactgcagaccata ccagccgcaaagcctgagcagacttctgcaggtgcccgggttttagcaccagagaagacg aacctggcagcctatgtgccgctgctgacccagggctgggcagagatcttggtccggagg cccacagggaacaccagctggctgatgagcctggagaacccactcagccccttctcctcg gacattaacaacatgcccctgcaggagctgtccaacgccctcatggctgccgagcgcttc aaagagcaccgggacactgccttgtacaagtcactctcagtgccagcagctggcacagcc aagccccctcctctcccacggtctaatacagtggcctctttctcctccctgtaccagtcc aactgccaaggacagctgcacaggagcatttcctgggcagactccgctgtggttctggag gaaggaagtccaggcgaggctcacatgccaggggagcccccagagttggaggacttcgaa ccagcgctaggtacagacaggcgctgccagcgccctgacacgtacagcaggtcatcctca gcctctagccaggaagagaagtcatcccatgtggaggagctggctgtgggggctataccc atcgagcgggttgtctcttccgagggtggccggcccttggtggacctctctttccagcca tcacagcccctgagcaagtccagctcctctcctgagctgcagaccctgcaggacatcctt ggagaccctggggacaaggctgacgttggccagttgagtcctgaggccaaggcccgatcc cagtcagggatactggatggggaaggtgccgcctggtcagctgcaggtgaagagagccag ggtccagctccacccgagggtcccttgccatccagctctccccactctcccagtggcctc cgcccccgaggctacaccatctcggactctgccccgtcacgcaggggcaaacgggtggag agggatgccttcaaaaacagagctgccacctccaacactgagaaagtgccaggcatcaac cccagctttgtgttcctgcagctctaccattcacctttctttggggatgagtccaacaaa cccatcctattgcccaatgagtccttcgaacggtcagtgcagctgcttgaccagatcccg tcctacgacactcacaagattgctgtcctgtacgtgggagaaggccagagcagcagcgag ctggccatcctctccaatgagcatggctcctacaggtacacggagttcctgacgggcctg ggcaggctcattgagctcaaggactgccagcctgataaggtgtacctgggtggccttgat gtatgtggtgaggacggccagttcacctactgctggcatgacgacatcatgcaagctgtc tttcacattgccaccctgatgcctaccaaggatgtggacaaacaccgctgtgataagaag cggcacctgggtaacgactttgtttccatcatctacaatgactctggcgaggaattcaag ctgggtaccatcaagggccaattcaacttcgtccacgtgatcatcacgcccctggactac gagtgcaacttgctgtcattgcagtgcaggaaagacatggagggtctggtggataccagc gtggccaagattgtgtctgaccacaacctgccctttgtggcccgccagatggccctgcat gcaaatatggcctcgcaggtgcaccacagccgttctaaccccacggacatctacccctcc aagtggattgctcggctccgccacatcaagcggctccgccaccggatccgtgaggaagcc cagtactcaaaccccagcctccctctgatgcaccccccagcccatgccaaagcctcagcc caggccccatctgaacccacacctgcttatgagacaggccagcggaaacgcctcatctcc tcggtggatgacttcacagagtttgtgtga

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