Heterocephalus glaber (naked mole-rat): 101714734
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Entry
101714734 CDS
T02812
Symbol
Ern1
Name
(RefSeq) endoplasmic reticulum to nucleus signaling 1
KO
K08852
serine/threonine-protein kinase/endoribonuclease IRE1 [EC:
2.7.11.1
3.1.26.-]
Organism
hgl
Heterocephalus glaber (naked mole-rat)
Pathway
hgl04140
Autophagy - animal
hgl04141
Protein processing in endoplasmic reticulum
hgl04210
Apoptosis
hgl04932
Non-alcoholic fatty liver disease
hgl05010
Alzheimer disease
hgl05012
Parkinson disease
hgl05014
Amyotrophic lateral sclerosis
hgl05016
Huntington disease
hgl05017
Spinocerebellar ataxia
hgl05022
Pathways of neurodegeneration - multiple diseases
hgl05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
hgl00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
101714734 (Ern1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
101714734 (Ern1)
09143 Cell growth and death
04210 Apoptosis
101714734 (Ern1)
09160 Human Diseases
09164 Neurodegenerative disease
05010 Alzheimer disease
101714734 (Ern1)
05012 Parkinson disease
101714734 (Ern1)
05014 Amyotrophic lateral sclerosis
101714734 (Ern1)
05016 Huntington disease
101714734 (Ern1)
05017 Spinocerebellar ataxia
101714734 (Ern1)
05022 Pathways of neurodegeneration - multiple diseases
101714734 (Ern1)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
101714734 (Ern1)
09167 Endocrine and metabolic disease
04932 Non-alcoholic fatty liver disease
101714734 (Ern1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hgl01001
]
101714734 (Ern1)
Enzymes [BR:
hgl01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
101714734 (Ern1)
Protein kinases [BR:
hgl01001
]
Serine/threonine kinases: Other
IRE family
101714734 (Ern1)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
Ribonuc_2-5A
PK_Tyr_Ser-Thr
PQQ_2
PQQ
Pkinase_fungal
Kdo
APH
Motif
Other DBs
NCBI-GeneID:
101714734
NCBI-ProteinID:
XP_004868697
UniProt:
A0A0P6JWE7
LinkDB
All DBs
Position
Un
AA seq
975 aa
AA seq
DB search
MRVRRLLLLLALLLPGPGIFASTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDP
VLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEGLTKLPFTIPELVQASPCRSSDGILYMGK
KQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYF
DYAASLPEDDGDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKV
MHINVAVETLRYLTFMPGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMV
HEGVVVVPRGSTLPLLEGPQTDGVTIGDKGECVITPSTDLKFDPGLKGKSKLNYLRNYWL
LIGHHETPLSASTKMLERFPNNLPKHRENVIPADLEKKSFEEVINLVDQTSENAPTTMFQ
DVEEKLAHAPAKPEAPVDSMLKDMATIILSTFLLVGWVAFIISYPLSIHQQRQLQHQQFK
KELEKIQLLQQQQLPFHPPGELTQDTELLDTSSPYSESSGTSSPSPSPRASNHSLHSSSS
ASKAGTSASLEQDDKDEETSMVIVGKISFCPRDVLGHGAEGTIVYRGMFDSRDVAVKRIL
PECFSFADREVQLLRESDEHPNVIRYFCTERDRQFQYIAIELCAATLQEYVEQKDFAHLG
LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGR
HSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQ
ANILLGAYSLDCFHPEKHEDIIARELIEKMITMDPQQRPSAKHVLKHPFFWSVEKQLQFF
QDVSDRIEKESLDGPIVRQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLR
AMRNKKHHYRELPVEVQETLGSLPDDFVRYFTSRFPHLLSHTYWAMELCSHERLFQPYYF
HEPPEPPPPVTPDVL
NT seq
2928 nt
NT seq
+upstream
nt +downstream
nt
atgcgggtccggcgtctactgctactgctggcgctgttgctgcccggccctgggattttt
gcaagtaccagcacagtgacactgcctgaaaccttgctgtttgtgtcaaccttggatgga
agtttgcacgctgtcagcaagaggacaggctcaatcaaatggactttaaaagaagatccg
gtcctgcaggtcccaacacacgtggaagagcctgcctttctcccagatcccaatgatgga
agcctgtatacacttgggggcaagaataacgaaggcctgacgaaacttccctttaccatc
ccagagttggtacaggcatccccatgccgaagctcagatggaatcctatacatgggtaaa
aagcaggatatttggtatgtcattgacctcctgactggtgagaagcagcagactttgtca
tcagcctttgcagatagtctctgcccatcaacctcccttctgtatcttggacgaacagaa
tacactatcaccatgtatgacaccaaaacccgagagctccgctggaacgccacctacttt
gactatgcagcctcactgcctgaggacgatggggactacaagatgtcccactttgtgtcc
aatggcgatgggctggtggtgactgtggacagtgagtctggggatgtcttgtggatccaa
aactatgcatccccggtggtggccttctacgtctggcagagggagggtctgaggaaggtg
atgcacatcaacgttgctgtggagaccctacgctacctgaccttcatgcctggggaggtg
ggccgcatcaccaagtggaagtacccatttcctaaggagactgaggccaagagcaagctg
acgcctaccctgtatgttgggaagtattccaccagcctctacgcctctccctccatggtg
cacgaaggggtcgtcgttgtgccccgaggcagcactcttcctttgctggaaggtccccag
acggatggtgtcaccattggggacaaaggagagtgtgtgatcacacctagcacagacctc
aagtttgaccctggactcaaagggaagagcaaactcaattacttgaggaattactggctc
ctgataggacaccatgaaaccccactgtctgcatctaccaagatgctggagagatttccc
aacaatctgcccaaacatcgggaaaatgtgattcctgctgacttggagaaaaagagcttt
gaggaagttatcaacctggttgaccagacctcagaaaacgcacccaccaccatgtttcag
gatgtggaagagaagttggctcatgctcccgccaagcctgaggcccctgtggactccatg
ctcaaggacatggccaccatcatcctgagcaccttcctactggtcggctgggtggccttc
atcatctcctacccactgagcatacaccagcagcggcagctccagcaccagcagttcaag
aaggagctggagaaaatccagctcctgcagcagcagcagctgcccttccacccgcctgga
gagttgacgcaggacaccgagctcctggacacatccagcccttactcagagagctcaggg
accagcagccccagcccatcccccagagcctccaaccattcactccactccagcagctct
gcctccaaggctggtaccagcgcctccctggagcaggatgacaaggatgaggaaaccagc
atggtgatagttgggaaaatttcgttctgtcccagagatgtgctgggccatggagctgag
ggcaccattgtgtaccggggcatgtttgatagtcgtgacgtggccgtgaagaggatcctt
cctgaatgttttagctttgcagaccgggaggtccagctgctgcgagaatcggatgagcac
cccaatgtgatccgttacttctgcacagagagggaccggcagttccagtacattgccatt
gagctatgtgcagccaccctgcaggagtatgtggagcagaaggactttgcccacctcggc
ctggagcccatcaccttgctgcagcagaccacctcaggcctggcacatctccactccctc
aacattgttcacagagacctgaagccccacaatattctcctctccatgcccaatgcacac
ggcaggatcaaggccatgatctctgactttggcctctgcaagaaattagcagtgggcagg
cacagttttagccgccgttctggggtgcctggcaccgaaggctggatcgccccagagatg
ctgagtgaagactgcaaggagaaccctacctacacagtggacatcttctctgcaggctgt
gttttttactatgtcatctccgagggcagccatccttttggcaagtccctgcagcggcag
gccaacatcctcctgggtgcctacagtctggattgcttccacccagagaagcatgaagat
atcattgcacgtgagctgatagagaaaatgatcacaatggatccccagcagcggccctcg
gcaaagcacgtgctgaaacatcccttcttctggagtgtggaaaagcagctccagtttttt
caggacgtgagtgaccgaatagaaaaggaatccctggatggcccaattgtgaggcagtta
gagagaggtgggcgagctgtggtgaagatggactggcgggagaatatcactgtgcccctc
cagacagatttgcgtaaattcagaacctacaagggtggctctgtcagagatctcctgcga
gccatgagaaacaagaaacaccactaccgagagctccctgtggaggtgcaggaaacactg
ggctccctccccgatgactttgtgcgctacttcacatcgcgcttcccccacctcctctca
cacacctactgggccatggagttgtgcagccacgagagactcttccagccctactacttc
cacgagcccccagagcccccacccccagtgactccagatgtcctctga
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