Heterocephalus glaber (naked mole-rat): 101715259
Help
Entry
101715259 CDS
T02812
Symbol
Mapk8
Name
(RefSeq) mitogen-activated protein kinase 8
KO
K04440
mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:
2.7.11.24
]
Organism
hgl
Heterocephalus glaber (naked mole-rat)
Pathway
hgl01522
Endocrine resistance
hgl04010
MAPK signaling pathway
hgl04012
ErbB signaling pathway
hgl04014
Ras signaling pathway
hgl04024
cAMP signaling pathway
hgl04068
FoxO signaling pathway
hgl04071
Sphingolipid signaling pathway
hgl04137
Mitophagy - animal
hgl04140
Autophagy - animal
hgl04141
Protein processing in endoplasmic reticulum
hgl04210
Apoptosis
hgl04215
Apoptosis - multiple species
hgl04217
Necroptosis
hgl04310
Wnt signaling pathway
hgl04380
Osteoclast differentiation
hgl04510
Focal adhesion
hgl04530
Tight junction
hgl04620
Toll-like receptor signaling pathway
hgl04621
NOD-like receptor signaling pathway
hgl04622
RIG-I-like receptor signaling pathway
hgl04625
C-type lectin receptor signaling pathway
hgl04657
IL-17 signaling pathway
hgl04658
Th1 and Th2 cell differentiation
hgl04659
Th17 cell differentiation
hgl04660
T cell receptor signaling pathway
hgl04664
Fc epsilon RI signaling pathway
hgl04668
TNF signaling pathway
hgl04722
Neurotrophin signaling pathway
hgl04723
Retrograde endocannabinoid signaling
hgl04728
Dopaminergic synapse
hgl04750
Inflammatory mediator regulation of TRP channels
hgl04910
Insulin signaling pathway
hgl04912
GnRH signaling pathway
hgl04914
Progesterone-mediated oocyte maturation
hgl04917
Prolactin signaling pathway
hgl04920
Adipocytokine signaling pathway
hgl04926
Relaxin signaling pathway
hgl04930
Type II diabetes mellitus
hgl04931
Insulin resistance
hgl04932
Non-alcoholic fatty liver disease
hgl04933
AGE-RAGE signaling pathway in diabetic complications
hgl04935
Growth hormone synthesis, secretion and action
hgl04936
Alcoholic liver disease
hgl05010
Alzheimer disease
hgl05012
Parkinson disease
hgl05016
Huntington disease
hgl05017
Spinocerebellar ataxia
hgl05020
Prion disease
hgl05022
Pathways of neurodegeneration - multiple diseases
hgl05132
Salmonella infection
hgl05133
Pertussis
hgl05135
Yersinia infection
hgl05142
Chagas disease
hgl05145
Toxoplasmosis
hgl05152
Tuberculosis
hgl05161
Hepatitis B
hgl05162
Measles
hgl05166
Human T-cell leukemia virus 1 infection
hgl05167
Kaposi sarcoma-associated herpesvirus infection
hgl05169
Epstein-Barr virus infection
hgl05170
Human immunodeficiency virus 1 infection
hgl05171
Coronavirus disease - COVID-19
hgl05200
Pathways in cancer
hgl05208
Chemical carcinogenesis - reactive oxygen species
hgl05210
Colorectal cancer
hgl05212
Pancreatic cancer
hgl05231
Choline metabolism in cancer
hgl05415
Diabetic cardiomyopathy
hgl05417
Lipid and atherosclerosis
hgl05418
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
hgl00001
]
09120 Genetic Information Processing
09123 Folding, sorting and degradation
04141 Protein processing in endoplasmic reticulum
101715259 (Mapk8)
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
101715259 (Mapk8)
04012 ErbB signaling pathway
101715259 (Mapk8)
04014 Ras signaling pathway
101715259 (Mapk8)
04310 Wnt signaling pathway
101715259 (Mapk8)
04668 TNF signaling pathway
101715259 (Mapk8)
04068 FoxO signaling pathway
101715259 (Mapk8)
04071 Sphingolipid signaling pathway
101715259 (Mapk8)
04024 cAMP signaling pathway
101715259 (Mapk8)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
101715259 (Mapk8)
04137 Mitophagy - animal
101715259 (Mapk8)
09143 Cell growth and death
04210 Apoptosis
101715259 (Mapk8)
04215 Apoptosis - multiple species
101715259 (Mapk8)
04217 Necroptosis
101715259 (Mapk8)
09144 Cellular community - eukaryotes
04510 Focal adhesion
101715259 (Mapk8)
04530 Tight junction
101715259 (Mapk8)
09150 Organismal Systems
09151 Immune system
04620 Toll-like receptor signaling pathway
101715259 (Mapk8)
04621 NOD-like receptor signaling pathway
101715259 (Mapk8)
04622 RIG-I-like receptor signaling pathway
101715259 (Mapk8)
04625 C-type lectin receptor signaling pathway
101715259 (Mapk8)
04660 T cell receptor signaling pathway
101715259 (Mapk8)
04658 Th1 and Th2 cell differentiation
101715259 (Mapk8)
04659 Th17 cell differentiation
101715259 (Mapk8)
04657 IL-17 signaling pathway
101715259 (Mapk8)
04664 Fc epsilon RI signaling pathway
101715259 (Mapk8)
09152 Endocrine system
04910 Insulin signaling pathway
101715259 (Mapk8)
04920 Adipocytokine signaling pathway
101715259 (Mapk8)
04912 GnRH signaling pathway
101715259 (Mapk8)
04914 Progesterone-mediated oocyte maturation
101715259 (Mapk8)
04917 Prolactin signaling pathway
101715259 (Mapk8)
04926 Relaxin signaling pathway
101715259 (Mapk8)
04935 Growth hormone synthesis, secretion and action
101715259 (Mapk8)
09156 Nervous system
04728 Dopaminergic synapse
101715259 (Mapk8)
04723 Retrograde endocannabinoid signaling
101715259 (Mapk8)
04722 Neurotrophin signaling pathway
101715259 (Mapk8)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
101715259 (Mapk8)
09158 Development and regeneration
04380 Osteoclast differentiation
101715259 (Mapk8)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
101715259 (Mapk8)
05208 Chemical carcinogenesis - reactive oxygen species
101715259 (Mapk8)
05231 Choline metabolism in cancer
101715259 (Mapk8)
09162 Cancer: specific types
05210 Colorectal cancer
101715259 (Mapk8)
05212 Pancreatic cancer
101715259 (Mapk8)
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
101715259 (Mapk8)
05170 Human immunodeficiency virus 1 infection
101715259 (Mapk8)
05161 Hepatitis B
101715259 (Mapk8)
05171 Coronavirus disease - COVID-19
101715259 (Mapk8)
05162 Measles
101715259 (Mapk8)
05167 Kaposi sarcoma-associated herpesvirus infection
101715259 (Mapk8)
05169 Epstein-Barr virus infection
101715259 (Mapk8)
09171 Infectious disease: bacterial
05132 Salmonella infection
101715259 (Mapk8)
05135 Yersinia infection
101715259 (Mapk8)
05133 Pertussis
101715259 (Mapk8)
05152 Tuberculosis
101715259 (Mapk8)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
101715259 (Mapk8)
05142 Chagas disease
101715259 (Mapk8)
09164 Neurodegenerative disease
05010 Alzheimer disease
101715259 (Mapk8)
05012 Parkinson disease
101715259 (Mapk8)
05016 Huntington disease
101715259 (Mapk8)
05017 Spinocerebellar ataxia
101715259 (Mapk8)
05020 Prion disease
101715259 (Mapk8)
05022 Pathways of neurodegeneration - multiple diseases
101715259 (Mapk8)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
101715259 (Mapk8)
05418 Fluid shear stress and atherosclerosis
101715259 (Mapk8)
05415 Diabetic cardiomyopathy
101715259 (Mapk8)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
101715259 (Mapk8)
04936 Alcoholic liver disease
101715259 (Mapk8)
04932 Non-alcoholic fatty liver disease
101715259 (Mapk8)
04931 Insulin resistance
101715259 (Mapk8)
04933 AGE-RAGE signaling pathway in diabetic complications
101715259 (Mapk8)
09176 Drug resistance: antineoplastic
01522 Endocrine resistance
101715259 (Mapk8)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hgl01001
]
101715259 (Mapk8)
Enzymes [BR:
hgl01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.24 mitogen-activated protein kinase
101715259 (Mapk8)
Protein kinases [BR:
hgl01001
]
Serine/threonine kinases: CMGC group
MAPK family [OT]
101715259 (Mapk8)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
Kdo
ABC1
RIO1
Kinase-like
FTA2
APH
DUF530
Motif
Other DBs
NCBI-GeneID:
101715259
NCBI-ProteinID:
XP_004874593
UniProt:
G5B0W2
LinkDB
All DBs
Position
Un
AA seq
427 aa
AA seq
DB search
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq
1284 nt
NT seq
+upstream
nt +downstream
nt
atgagcagaagcaagcgtgacaacaatttttatagcgtagagattggagattctacattc
acagtcctgaaacgataccagaatttaaaacctataggttcaggagctcaaggaatagta
tgtgcagcttatgatgctattctggaaagaaatgttgcaatcaagaagctaagccggcca
tttcagaatcaaactcatgccaagcgggcctacagagagctagttcttatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagcttatggatgccaatctctgccaagtgattcag
atggaactagatcatgaaagaatgtcctaccttctctatcagatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacttaaaacccagtaacatagtagtaaaa
tcagactgcactttgaagattcttgactttggactggctaggactgcaggaacaagtttc
atgatgacaccttacgtagtgactcgctactaccgagcacctgaggtcatcttaggcatg
ggatacaaggaaaacgtggatttatggtctgtggggtgcattatgggcgaaatggtttgc
cacaaaatcctctttccaggaagggactatattgatcagtggaataaagttattgaacag
cttggaacaccatgtcctgaattcatgaagaaactacaaccaacagtaaggacttatgtt
gaaaacagacctaaatatgctggatatagctttgagaaactcttccctgatgtacttttc
ccagctgactcagaacacaacaaacttaaagccagtcaggcacgggatttgttatccaaa
atgctggtaatagatgcatctaaaaggatctccgtggatgaagcactccagcacccatac
atcaatgtctggtatgatccctccgaagcggaagctccaccaccaaagatccccgacaaa
cagttagatgaaagggaacacacaatagaagagtggaaagaattgatatacaaggaagtg
atggacttagaggagagaaccaagaatggagttatccgggggcagccttctcctttaggt
gcagcagtgatcaatggctctcagcatccatcgtcatcatcatctgtcaatgatgtgtct
tcaatgtccacagatccgactttggcctcggataccgacagcagtctagaagcatcagct
ggacctctgggctgctgtagatga
DBGET
integrated database retrieval system