Heterocephalus glaber (naked mole-rat): 101715321 Help Entry 101715321         CDS       T02812                                  Symbol Plcg2 Name (RefSeq) phospholipase C gamma 2   KO K05859   phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl00562   Inositol phosphate metabolism hgl01100   Metabolic pathways hgl01521   EGFR tyrosine kinase inhibitor resistance hgl04012   ErbB signaling pathway hgl04014   Ras signaling pathway hgl04020   Calcium signaling pathway hgl04062   Chemokine signaling pathway hgl04064   NF-kappa B signaling pathway hgl04066   HIF-1 signaling pathway hgl04070   Phosphatidylinositol signaling system hgl04072   Phospholipase D signaling pathway hgl04360   Axon guidance hgl04370   VEGF signaling pathway hgl04380   Osteoclast differentiation hgl04611   Platelet activation hgl04613   Neutrophil extracellular trap formation hgl04625   C-type lectin receptor signaling pathway hgl04650   Natural killer cell mediated cytotoxicity hgl04662   B cell receptor signaling pathway hgl04664   Fc epsilon RI signaling pathway hgl04666   Fc gamma R-mediated phagocytosis hgl04670   Leukocyte transendothelial migration hgl04722   Neurotrophin signaling pathway hgl04750   Inflammatory mediator regulation of TRP channels hgl04919   Thyroid hormone signaling pathway hgl04933   AGE-RAGE signaling pathway in diabetic complications hgl04935   Growth hormone synthesis, secretion and action hgl05167   Kaposi sarcoma-associated herpesvirus infection hgl05169   Epstein-Barr virus infection hgl05170   Human immunodeficiency virus 1 infection hgl05171   Coronavirus disease - COVID-19 hgl05200   Pathways in cancer hgl05205   Proteoglycans in cancer hgl05206   MicroRNAs in cancer hgl05214   Glioma hgl05223   Non-small cell lung cancer hgl05225   Hepatocellular carcinoma Module hgl_M00130   Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Brite KEGG Orthology (KO) [BR:hgl00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     101715321 (Plcg2)  09130 Environmental Information Processing   09132 Signal transduction    04012 ErbB signaling pathway     101715321 (Plcg2)    04014 Ras signaling pathway     101715321 (Plcg2)    04370 VEGF signaling pathway     101715321 (Plcg2)    04064 NF-kappa B signaling pathway     101715321 (Plcg2)    04066 HIF-1 signaling pathway     101715321 (Plcg2)    04020 Calcium signaling pathway     101715321 (Plcg2)    04070 Phosphatidylinositol signaling system     101715321 (Plcg2)    04072 Phospholipase D signaling pathway     101715321 (Plcg2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     101715321 (Plcg2)    04613 Neutrophil extracellular trap formation     101715321 (Plcg2)    04625 C-type lectin receptor signaling pathway     101715321 (Plcg2)    04650 Natural killer cell mediated cytotoxicity     101715321 (Plcg2)    04662 B cell receptor signaling pathway     101715321 (Plcg2)    04664 Fc epsilon RI signaling pathway     101715321 (Plcg2)    04666 Fc gamma R-mediated phagocytosis     101715321 (Plcg2)    04670 Leukocyte transendothelial migration     101715321 (Plcg2)    04062 Chemokine signaling pathway     101715321 (Plcg2)   09152 Endocrine system    04935 Growth hormone synthesis, secretion and action     101715321 (Plcg2)    04919 Thyroid hormone signaling pathway     101715321 (Plcg2)   09156 Nervous system    04722 Neurotrophin signaling pathway     101715321 (Plcg2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     101715321 (Plcg2)   09158 Development and regeneration    04360 Axon guidance     101715321 (Plcg2)    04380 Osteoclast differentiation     101715321 (Plcg2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101715321 (Plcg2)    05206 MicroRNAs in cancer     101715321 (Plcg2)    05205 Proteoglycans in cancer     101715321 (Plcg2)   09162 Cancer: specific types    05225 Hepatocellular carcinoma     101715321 (Plcg2)    05214 Glioma     101715321 (Plcg2)    05223 Non-small cell lung cancer     101715321 (Plcg2)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     101715321 (Plcg2)    05171 Coronavirus disease - COVID-19     101715321 (Plcg2)    05167 Kaposi sarcoma-associated herpesvirus infection     101715321 (Plcg2)    05169 Epstein-Barr virus infection     101715321 (Plcg2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     101715321 (Plcg2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     101715321 (Plcg2)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:hgl04131]     101715321 (Plcg2) Enzymes [BR:hgl01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.11  phosphoinositide phospholipase C      101715321 (Plcg2) Membrane trafficking [BR:hgl04131]  Exocytosis   Calcium ion-dependent exocytosis    Phospholipases     101715321 (Plcg2)  Endocytosis   Macropinocytosis    Phospholipase C     101715321 (Plcg2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PI-PLC-X SH2 PI-PLC-Y EF-hand_PLCG2 C2 SH3_1 SH3_9 SH2_1 EF-hand_PLCG1 PH_12 PH EF-hand_like PH_14 Motif Other DBs NCBI-GeneID:  101715321 NCBI-ProteinID:  XP_004843278 LinkDB All DBs Position Un AA seq 1195 aa AA seqDB search MTTMVDVDALPEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTHFVLSTLSLATDSREDAI MWLSGLKILHQEVMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKAILPLVNFKVSSA KFLKDKLVEISAHKDELSFEQFHLFYKKLMFEQQKLILDEFKKDSSVFILGNTDRPDASA VYLQDFQRFLVHEQQELWAQDVNKVREQMTKFIDDTMRETAEPFLFVDEFLMYLFSRENS IWDGKHDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDC WDGPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFVTSSFPVILSIEEHCSVEQQRHMARM FKEVLGELLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGE LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQAAEEELSQDLPPMELHLREKWFHKKMEKR TNAEKLLQEYCAEAGAKDGTFLVRESESHPNAYTLSFWRSGRVQHCLIRSTLENGAMKYY LTDNLKFSSIYDLIQHYRESHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML MRIPRDGAFLIRKREKKHEGLEDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVE LVSYYEKHTLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVK ALYDYEAKHSDELSXCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADGEEL EKQENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQK PEDLLRYNQKGLTRIYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQLNHALFSL NGRTGYVLQPEIMRTGKYDPMPPESQRKIQMTLTIKVLGARHLPKPGRSIACPFVEVEIC GAEYDNNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYEEDIFSDPNFLAH ATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSCRQLRRRQEEL NNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSNSKFYS NT seq 3588 nt NT seq  +upstreamnt  +downstreamnt atgaccaccatggtcgatgtggacgcccttccggaatacgagaagagtcagatcaagcga gccctggagctggggacggtcatgacggtgttcagcttccgaaagtccacccctgagcgg aggacagtccaggtgatcatggaaacgaggcaggtggcctggagcaagactgcggacaag atcgagggcttcttggatatcatggaaatcaaggaaattcgcccagggaagaactccaag gacttcgagcgtgcaaaagcagtccgccagaaggaagactgctgcttcaccatcttgtac ggcacccatttcgtcctcagcacactcagtttggcaactgactccagagaggatgcaatt atgtggctctcaggcctgaaaatcttgcaccaggaagtgatgagcgcatccacgcccact atcatagagagttggctgagaaaacagatttattctgtagatcaaaccagaagaaacagc atcagcctccgagagttgaaggccatcctacccctggtcaacttcaaagtgagcagtgcc aagttcctcaaagataagcttgtggaaattagtgcacacaaagacgaactcagctttgag cagtttcatctcttctataaaaaacttatgtttgagcagcaaaaactgattcttgacgaa ttcaaaaaggattcctccgtgtttatcctggggaacactgaccgacctgatgcctctgcc gtttacctgcaggacttccagaggtttcttgtacacgagcagcaggagctttgggctcag gatgtaaacaaagtccgggagcagatgacaaagtttattgacgacaccatgagggagacg gctgagcccttcttgtttgtggacgagttcctcatgtacctgttttcccgagaaaacagc atctgggatgggaagcacgatgtggtggacatgcaggacatgaacaaccccttgtcccat tactggatctcttcgtcccacaacacgtacctcacaggtgaccagctgcgcagcgagtcg tccacagaagcctacatccgctgcttgcgcatgggctgccgctgcattgagctggactgc tgggatgggcccgacgggaagcccattatctaccacggctggacgcggaccaccaagatc aagttcgatgatgtcgtgcaggccatcagagaccacgccttcgtcacctcgagcttcccc gtgatcctgtccatcgaggagcactgcagtgtggagcagcagcggcacatggccaggatg ttcaaggaggtgcttggcgagctgctgctgaccaagcccacggaggccagcgccgaccag ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc cgaggtgatgtcgatgtgaacgtggaggacaagaaagatgagcacaagcaacagggtgaa ctgtacatgtgggactccatcgaccagaagtggactcggcactactgcgccattgctgac gccaagctgtccttcagtgacgacattgagcaggccgcggaggaggaactgtcccaggac cttccacccatggagctgcatttgagggagaaatggttccacaagaagatggagaagagg acgaacgcggagaagctgctgcaggagtactgtgccgaggcgggtgccaaggacggcacc ttcctggtgcgggagagcgagagccaccccaacgcctacaccctgtccttctggcggtcg ggccgtgtgcagcactgcctgatccgctccaccttggagaatggcgccatgaagtactac ctgaccgacaacctcaagttcagcagcatctacgacctcatccagcactaccgagagtcg cacctgcgctgtgccgagtttgagctgcggctgaccgacccggtgccgaaccccaaccca catgagtccaagccgtggtactatgacgggctgagccgtggagaggcggaggacatgctg atgcggattccccgagatggagccttcctcatccggaagcgggaaaagaagcatgaaggg ctggaggactcctacgccatcaccttcagggccaggggcaaggtgaaacactgtcgcatc aaccgggatggccgtcactttgtgctggggacatctgcctattttgagagcttggtggag cttgtcagttactatgagaaacataccctctaccgaaagatgcggctgcggtaccctgtg acccctgagctcttggagcgctacaatatggaaagagacataaactccctctatgacgtc agcaggatgtatgtggatccgagtgagatcaacccttctatgcctcagagaaccgtgaaa gctctgtatgactacgaagccaagcacagtgacgagctgagtnnctgccgaggtgccctc atccacaacgtctccaaggaacccgggggctggtggaaaggagactatggcacccgaatc cagcagtacttcccgtccaactacgtggaggacatttccacggcggatggggaggagctg gagaagcaggagaacaacatgaagtactgggagaagaaccagtcgatcgccattgagctc tctgacctggttgtctattgcaaaccaaccagcaaaaccaaggataacttagagaaccct gacttccgagaaattcgctcctttgtggagacaaaggctgacagcatcatcagacagaag cccgaggatctcttgaggtataaccagaagggcctgacccgcatctatccgaagggacag agggttgactcttcaaactacgatccctttcgcctgtggctgtgtggttcccagatggtg gcgctcaatttccagaccgcagacaagtacatgcagctgaatcatgcattgttttcactc aatgggcggacgggctacgttctgcaaccagagatcatgcggacagggaagtatgacccg atgccaccagagtcgcagcggaagatccagatgactctcaccatcaaggtcctaggtgcc cgccacctacccaagcctggacgaagtattgcttgtccctttgtagaggtggaaatctgt ggggcagagtatgacaacaacaagttcaagacaacagttgtgaatgacaacggcctcagc cctgtctgggctccaacgcaggagaaggtgacatttgaaatttatgacccaaacctcgcg tttctgcgctttgtagtttatgaggaagacatattcagcgatcccaacttcctcgctcac gccacttatcccattaaagggatcaagtcagggtttcgatctgttcctctcaagaatggg tacagtgaggacatcgagctggcttccctcctggttttctgtgagatgcggccagtcctg gagagtgaggaagaactctactcctcctgtcgccagctgcggagacggcaagaagagctg aacaaccaactatttctgtatgacacacatcagaacctgcgcaatgcgaaccgggatgcc cttgtcaaagagttcaacgtcaatgagaaccagctccagctgtatcaggagaagtgcaat cgaaggttgcgagagaagagagtcagcaacagcaagttctactcttag

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