Heterocephalus glaber (naked mole-rat): 101716905 Help Entry 101716905         CDS       T02812                                  Symbol Gnas Name (RefSeq) GNAS complex locus   KO K04632   guanine nucleotide-binding protein G(s) subunit alpha Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl01522   Endocrine resistance hgl04015   Rap1 signaling pathway hgl04020   Calcium signaling pathway hgl04024   cAMP signaling pathway hgl04072   Phospholipase D signaling pathway hgl04081   Hormone signaling hgl04082   Neuroactive ligand signaling hgl04261   Adrenergic signaling in cardiomyocytes hgl04270   Vascular smooth muscle contraction hgl04540   Gap junction hgl04611   Platelet activation hgl04713   Circadian entrainment hgl04714   Thermogenesis hgl04724   Glutamatergic synapse hgl04726   Serotonergic synapse hgl04728   Dopaminergic synapse hgl04730   Long-term depression hgl04750   Inflammatory mediator regulation of TRP channels hgl04911   Insulin secretion hgl04912   GnRH signaling pathway hgl04913   Ovarian steroidogenesis hgl04915   Estrogen signaling pathway hgl04916   Melanogenesis hgl04918   Thyroid hormone synthesis hgl04921   Oxytocin signaling pathway hgl04922   Glucagon signaling pathway hgl04923   Regulation of lipolysis in adipocytes hgl04924   Renin secretion hgl04925   Aldosterone synthesis and secretion hgl04926   Relaxin signaling pathway hgl04927   Cortisol synthesis and secretion hgl04928   Parathyroid hormone synthesis, secretion and action hgl04934   Cushing syndrome hgl04935   Growth hormone synthesis, secretion and action hgl04961   Endocrine and other factor-regulated calcium reabsorption hgl04962   Vasopressin-regulated water reabsorption hgl04970   Salivary secretion hgl04971   Gastric acid secretion hgl04972   Pancreatic secretion hgl04976   Bile secretion hgl05012   Parkinson disease hgl05030   Cocaine addiction hgl05031   Amphetamine addiction hgl05032   Morphine addiction hgl05034   Alcoholism hgl05142   Chagas disease hgl05146   Amoebiasis hgl05163   Human cytomegalovirus infection hgl05165   Human papillomavirus infection hgl05200   Pathways in cancer hgl05207   Chemical carcinogenesis - receptor activation hgl05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:hgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     101716905 (Gnas)    04020 Calcium signaling pathway     101716905 (Gnas)    04072 Phospholipase D signaling pathway     101716905 (Gnas)    04024 cAMP signaling pathway     101716905 (Gnas)   09133 Signaling molecules and interaction    04082 Neuroactive ligand signaling     101716905 (Gnas)    04081 Hormone signaling     101716905 (Gnas)  09140 Cellular Processes   09144 Cellular community - eukaryotes    04540 Gap junction     101716905 (Gnas)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     101716905 (Gnas)   09152 Endocrine system    04911 Insulin secretion     101716905 (Gnas)    04922 Glucagon signaling pathway     101716905 (Gnas)    04923 Regulation of lipolysis in adipocytes     101716905 (Gnas)    04912 GnRH signaling pathway     101716905 (Gnas)    04913 Ovarian steroidogenesis     101716905 (Gnas)    04915 Estrogen signaling pathway     101716905 (Gnas)    04921 Oxytocin signaling pathway     101716905 (Gnas)    04926 Relaxin signaling pathway     101716905 (Gnas)    04935 Growth hormone synthesis, secretion and action     101716905 (Gnas)    04918 Thyroid hormone synthesis     101716905 (Gnas)    04928 Parathyroid hormone synthesis, secretion and action     101716905 (Gnas)    04916 Melanogenesis     101716905 (Gnas)    04924 Renin secretion     101716905 (Gnas)    04925 Aldosterone synthesis and secretion     101716905 (Gnas)    04927 Cortisol synthesis and secretion     101716905 (Gnas)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     101716905 (Gnas)    04270 Vascular smooth muscle contraction     101716905 (Gnas)   09154 Digestive system    04970 Salivary secretion     101716905 (Gnas)    04971 Gastric acid secretion     101716905 (Gnas)    04972 Pancreatic secretion     101716905 (Gnas)    04976 Bile secretion     101716905 (Gnas)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     101716905 (Gnas)    04961 Endocrine and other factor-regulated calcium reabsorption     101716905 (Gnas)   09156 Nervous system    04724 Glutamatergic synapse     101716905 (Gnas)    04728 Dopaminergic synapse     101716905 (Gnas)    04726 Serotonergic synapse     101716905 (Gnas)    04730 Long-term depression     101716905 (Gnas)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     101716905 (Gnas)   09159 Environmental adaptation    04713 Circadian entrainment     101716905 (Gnas)    04714 Thermogenesis     101716905 (Gnas)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101716905 (Gnas)    05207 Chemical carcinogenesis - receptor activation     101716905 (Gnas)   09172 Infectious disease: viral    05163 Human cytomegalovirus infection     101716905 (Gnas)    05165 Human papillomavirus infection     101716905 (Gnas)   09174 Infectious disease: parasitic    05146 Amoebiasis     101716905 (Gnas)    05142 Chagas disease     101716905 (Gnas)   09164 Neurodegenerative disease    05012 Parkinson disease     101716905 (Gnas)   09165 Substance dependence    05030 Cocaine addiction     101716905 (Gnas)    05031 Amphetamine addiction     101716905 (Gnas)    05032 Morphine addiction     101716905 (Gnas)    05034 Alcoholism     101716905 (Gnas)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     101716905 (Gnas)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     101716905 (Gnas)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     101716905 (Gnas)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hgl04147]     101716905 (Gnas)    04031 GTP-binding proteins [BR:hgl04031]     101716905 (Gnas) Exosome [BR:hgl04147]  Exosomal proteins   Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)    101716905 (Gnas)   Exosomal proteins of other body fluids (saliva and urine)    101716905 (Gnas)   Exosomal proteins of colorectal cancer cells    101716905 (Gnas)   Exosomal proteins of bladder cancer cells    101716905 (Gnas) GTP-binding proteins [BR:hgl04031]  Heterotrimeric G-proteins   Alpha Subunits    Alpha type 2 (Gs)     101716905 (Gnas) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  G-alpha Arf Gtr1_RagA GTP_EFTU Motif Other DBs NCBI-GeneID:  101716905 NCBI-ProteinID:  XP_004841012 LinkDB All DBs Position Un AA seq 975 aa AA seqDB search MGMRNCLHGSNMPGQCNIPAQIGEQPEQHPVEAPGEAAPGAGPGPAEEMEAQPPSHEPVP VEVEGEACGLPEVSGPGVQAAEEDRVCGNYSPAPEEAVPFELDQPAQGGCGQPVLQIPDL APGGPCAVVPRDPPDEPRSLSPKNAGFRGGYSPLPEEAVPFELEGEAFGDSSPRPGLPRV IPQVGGGRLFAAVAVPSSVWLAPAANAPALRVGGAGGSPSREAVRSPLNFPGDGPPMQIS GPPIKIGRSPTGVDDTPVNADIPPIARHGPPIEVSGAPDKREPPEGPPVGRDAAAMEGGS PGATAEGGKVPSPGDGGAAARAAAAAPAEPDSGAAAAAPSEPATPADPDSGGAPADPDAA GTARADPDSGGTPVPQAQPAAARALAAAPANPGPRAARAAPADPEVRRAPAGAAALGAPA ARAGPALGSVSAALAARGAPIARGAPIARAAPNAGPASFAPASGASRKLHLLRPPSPEIQ AADPPTPEPARATAWRAKSECGSGHLRYADEGQVCDDSSSDESDARTTGCFHCCLRRNRH RKVRHSLLRNFLSRALSRCFRRGRGSRAANLSKVKKDSLGDKRRQMCKEAIEMRVQKRAA KKRSKLIDKQLEDEKMGFVCTHRLFLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQA ARSNSEGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPD FDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLR CRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIRE DNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYT TPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDC RDIIQRMHLRQYELL NT seq 2928 nt NT seq  +upstreamnt  +downstreamnt atgggcatgcgcaactgcctccacggcagtaatatgccaggacaatgcaatatccccgcc cagatcggggaacagcccgaacagcaccctgtggaggccccaggggaagctgcccccggt gctgggcctggcccagccgaagagatggaggcccaaccgccttcccatgagcccgtcccg gtcgaggtcgaaggagaggcctgcggactcccagaggtctccggccccggcgtccaggca gccgaggaagatcgagtctgtggaaactacagccccgcaccagaagaagctgtgccattt gagttggaccagcctgcgcagggaggctgtggccaacctgtcttgcagatcccagacctt gctccaggcggtccatgtgcagtggtcccccgagaccctcccgacgagcctcgatccctc agtcccaaaaatgctggcttcagaggaggatatagccctctccctgaggaggctgtgcca tttgaacttgaaggagaagcatttggggacagcagcccacgccccggcttgccccgagtt atcccgcaagtcggtggtggtcggcttttcgcggctgtcgcagtcccgagttcggtctgg ctcgctcccgccgcaaacgcgcctgccctgcgggtcggaggcgccggcggaagcccctcc cgagaggctgtcagatctcctctcaacttcccgggcgacggccccccgatgcagatctcc ggacccccaatcaagattggtagatctcccactggggtcgacgacactcccgtcaatgcg gacatccccccaatcgcgagacacggcccgcccatcgaagtctcgggagccccagataag agagagcccccagagggacccccagtcgggagagacgcagccgcgatggaaggaggctcc cctggcgccactgcggaaggggggaaagtcccctctccgggggacggaggcgctgccgcc agggcagccgctgccgcgccagcagagcccgactccggggcagccgctgccgcgccaagc gagcctgccaccccggctgatcccgactccgggggagcccctgccgaccctgacgccgcc gggacagcccgggccgatcccgactctgggggaacccctgtcccccaggcccagccggcc gccgcccgggccctcgctgctgcaccagccaatcccggccccagggcagcccgcgccgcc ccagccgatcctgaagtccggcgagccccggccggagcggccgcactgggagcccctgcc gcccgagccggtcctgctctcggatccgtctcagcagcgctcgctgcccgtggagcgccc atcgcccgcggggcacccatcgcccgggcggcgcccaatgccgggcccgcctccttcgcc cctgcctctggggccagccgcaagctccatctcctcagaccccccagccccgagatccag gctgctgacccgcctactccggagcctgctcgggcgactgcctggcgggccaaatccgag tgcggcagcggccatctccggtacgcagatgagggtcaggtttgcgacgactcttccagc gacgagtccgatgcccggaccaccggatgcttccactgctgcctgcgccgaaaccgccac cgaaaggttcggcacagcttactccgcaactttctctcccgggctttgtcgcgctgcttc cgtagaggcaggggctccagagccgcgaacctctccaaggtcaagaaggactctctgggc gacaagcgcaggcagatgtgcaaagaagccattgagatgcgcgtccagaagcgcgccgcg aagaagcgcagcaagctcatcgacaagcaactcgaggacgagaagatgggctttgtgtgc acgcaccgcctcttccttctaggtgctggagaatctggtaaaagcaccattgtgaagcag atgaggatcctgcatgttaatgggtttaatggagagggcggcgaagaggacccgcaagct gcaaggagcaacagcgaaggtgagaaggccaccaaagtacaggacatcaaaaacaacctg aaggaggctattgaaaccattgtggccgccatgagcaacctggtgccccccgtggagctg gccaaccctgagaaccagttcagagtggactacattctgagcgtgatgaacgtgcccgac tttgacttcccgcctgaattctatgagcatgccaaggctctgtgggaggatgaaggggtg cgagcctgctacgagcgctccaacgagtaccagctgatcgactgtgcccagtactttctg gacaagatcgatgtcatcaagcaggccgactacgtgcccagcgaccaggacctgcttcgc tgccgtgtcctgacctctggaatctttgagaccaagttccaggtggacaaagtcaacttc cacatgttcgatgtgggcggccagcgtgatgaacggcgcaaatggatccagtgcttcaat gatgtgactgccatcatcttcgtggtggccagcagcagctacaacatggtcatccgggag gacaaccagaccaaccgcctgcaggaggctctgaacctcttcaagagcatctggaacaac agatggctgcgtaccatctctgtgattctgttcctcaataagcaagatcttctcgctgag aaagtccttgctgggaaatcgaagattgaggactactttccagaatttgctcgctacact actcctgaggatgctactcccgagcccggagaggacccacgtgtgacccgggccaagtac ttcattcgagatgagtttctgagaatcagcactgctagtggagatgggcgccactattgc tatcctcactttacctgcgctgtggacaccgagaacattcgccgtgtgttcaacgactgc cgcgacatcatccagcgcatgcaccttcgtcagtacgagctgctctaa

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