Heterocephalus glaber (naked mole-rat): 101720293
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Entry
101720293 CDS
T02812
Symbol
Fpgs
Name
(RefSeq) folylpolyglutamate synthase
KO
K01930
folylpolyglutamate synthase [EC:
6.3.2.17
]
Organism
hgl
Heterocephalus glaber (naked mole-rat)
Pathway
hgl00790
Folate biosynthesis
hgl01100
Metabolic pathways
hgl01240
Biosynthesis of cofactors
hgl01523
Antifolate resistance
hgl04981
Folate transport and metabolism
Brite
KEGG Orthology (KO) [BR:
hgl00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
101720293 (Fpgs)
09150 Organismal Systems
09154 Digestive system
04981 Folate transport and metabolism
101720293 (Fpgs)
09160 Human Diseases
09176 Drug resistance: antineoplastic
01523 Antifolate resistance
101720293 (Fpgs)
Enzymes [BR:
hgl01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.17 tetrahydrofolate synthase
101720293 (Fpgs)
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Ortholog
Paralog
GFIT
Motif
Pfam:
Mur_ligase_C
Motif
Other DBs
NCBI-GeneID:
101720293
NCBI-ProteinID:
XP_004849355
UniProt:
A0AAX6PD72
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Position
Un
AA seq
585 aa
AA seq
DB search
MSRARNRLRMALSLVAVSTRGATTEVSARRGLGVRPAPQEPGMEYQDAVRTLNTLQTNAS
YLEQVKRQRGDPQKQLEAMELFLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRN
YGLKTGFFSSPHLVQVRERIRINGQPIRPELFTKHFWRLYRRLEETKDGSCVSMPAYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKPGVPAFTVLQPEGPLAVLRERAQQISCPLYLCPPLEALEEGGPTLTLGLEGE
HQRSNAALALQLAHCWLQQQGHQDLGELKMSRPSVPCQLPLAPVFQPTSHMRHGLQDTEW
PGRTQVLQHGPLTWYLDGAHTTSSMQACVRWFRQVLQCNQRPPSGPEVRVLLFNSTGDRD
SSALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQMLIRCLDHQRHWSHLDKE
QDGPDLWGPPQPSRPAPLLLAPHPPHPCIASSLVFSCVSHALQWISQGRDPVFQPPHPPK
SLLSHPTATSGASVLQEAAAIHVLVTGSLHLVGSVLKLLEPSLSQ
NT seq
1758 nt
NT seq
+upstream
nt +downstream
nt
atgtcgagggcgcggaaccgcctgcgcatggctctgtccctggtagctgtttctacgcgt
ggtgcaacgaccgaggtctcggcgcggcggggattgggtgtgcggccggcgccgcaggag
ccgggcatggagtatcaggatgcagtgcgcacactcaacaccctgcagaccaatgctagt
tacctggagcaggtgaagcgccagcggggtgacccccagaagcagctggaagccatggag
ctgttcctggcacggagcgggcttcaggtggaggacttggaccggctgaacatcattcat
gtcactgggaccaaggggaagggttctacctgtgccttcacagagtgcatcctccggaat
tacggcctgaagaccggattctttagctctccccacctggtgcaggtgcgtgagcggatc
cgcatcaatgggcagcccatcaggcctgagctcttcaccaagcacttctggcgcctctac
cgtcggctggaggagaccaaggatggcagctgtgtgtccatgcccgcctacttccgcttc
ctcacgctcatggccttccacgtcttcctccaagagaaggtggacctggcggtggtggaa
gttggcataggcggggcttacgactgcaccaacattatcaggaagcctgtagtgtgcgga
gtgtcctctcttggcatcgaccacaccagccttctgggggacacggtggagaagattgca
tggcagaagggaggcatctttaagcctggcgttcctgcctttacggtgctgcagccggaa
ggtcccctggcagtgctgagggagcgtgcccagcagatttcatgccctctttacctgtgc
ccaccactggaagccctggaggaagggggaccaacgctgaccctgggcctggagggcgag
caccagaggtccaatgcggccttggctttacagctggcccactgctggctgcagcagcag
gggcaccaggacctcggggagctgaagatgtccaggccgagcgtcccctgccagctgccc
ctggccccggtgttccagcccacgtcccacatgcggcatgggcttcaggacacggagtgg
ccgggccggacacaggtgctgcagcacgggcccctcacctggtacctggacggtgctcac
accaccagcagcatgcaggcctgtgtgcgctggttccgccaggtgctgcagtgcaaccag
aggccccccagtgggcctgaagtgcgggtcttgctcttcaactccactggggacagggac
tcctcagccctgctgaagctgctacagccctgccagtttgactatgctgtcttctgcccc
aacctcacggaggtgtcatccacaggcaatgcagaccagcagaacttcacagtgacgctg
gaccagatgctgatccgctgcctggaccaccagcggcactggagccacctggacaaggag
caggacggccccgacctctggggccccccacagcccagcaggcctgcgcccttgttgctg
gcacctcacccaccccacccctgcattgccagctccctggtcttcagctgcgtctcccat
gccttgcagtggatcagccaaggccgagaccctgtcttccagccaccccatcccccaaag
agcctcctctcccaccccacagcaaccagcggggccagcgtcctccaggaggctgctgcc
atccacgtgctggtcaccggcagcctgcacctggtgggcagtgtcctcaagctactagag
ccctccctgtcccagtag
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