Heterocephalus glaber (naked mole-rat): 101723771 Help Entry 101723771         CDS       T02812                                  Symbol Egfr Name (RefSeq) epidermal growth factor receptor   KO K04361   epidermal growth factor receptor [EC:2.7.10.1] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl01521   EGFR tyrosine kinase inhibitor resistance hgl01522   Endocrine resistance hgl03272   Virion - Hepatitis viruses hgl04010   MAPK signaling pathway hgl04012   ErbB signaling pathway hgl04014   Ras signaling pathway hgl04015   Rap1 signaling pathway hgl04020   Calcium signaling pathway hgl04066   HIF-1 signaling pathway hgl04068   FoxO signaling pathway hgl04072   Phospholipase D signaling pathway hgl04144   Endocytosis hgl04151   PI3K-Akt signaling pathway hgl04510   Focal adhesion hgl04520   Adherens junction hgl04540   Gap junction hgl04630   JAK-STAT signaling pathway hgl04810   Regulation of actin cytoskeleton hgl04912   GnRH signaling pathway hgl04915   Estrogen signaling pathway hgl04921   Oxytocin signaling pathway hgl04926   Relaxin signaling pathway hgl04928   Parathyroid hormone synthesis, secretion and action hgl04934   Cushing syndrome hgl05160   Hepatitis C hgl05163   Human cytomegalovirus infection hgl05165   Human papillomavirus infection hgl05171   Coronavirus disease - COVID-19 hgl05200   Pathways in cancer hgl05205   Proteoglycans in cancer hgl05206   MicroRNAs in cancer hgl05207   Chemical carcinogenesis - receptor activation hgl05208   Chemical carcinogenesis - reactive oxygen species hgl05210   Colorectal cancer hgl05212   Pancreatic cancer hgl05213   Endometrial cancer hgl05214   Glioma hgl05215   Prostate cancer hgl05218   Melanoma hgl05219   Bladder cancer hgl05223   Non-small cell lung cancer hgl05224   Breast cancer hgl05225   Hepatocellular carcinoma hgl05226   Gastric cancer hgl05230   Central carbon metabolism in cancer hgl05231   Choline metabolism in cancer hgl05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:hgl00001]  09120 Genetic Information Processing   09125 Information processing in viruses    03272 Virion - Hepatitis viruses     101723771 (Egfr)  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     101723771 (Egfr)    04012 ErbB signaling pathway     101723771 (Egfr)    04014 Ras signaling pathway     101723771 (Egfr)    04015 Rap1 signaling pathway     101723771 (Egfr)    04630 JAK-STAT signaling pathway     101723771 (Egfr)    04066 HIF-1 signaling pathway     101723771 (Egfr)    04068 FoxO signaling pathway     101723771 (Egfr)    04020 Calcium signaling pathway     101723771 (Egfr)    04072 Phospholipase D signaling pathway     101723771 (Egfr)    04151 PI3K-Akt signaling pathway     101723771 (Egfr)  09140 Cellular Processes   09141 Transport and catabolism    04144 Endocytosis     101723771 (Egfr)   09144 Cellular community - eukaryotes    04510 Focal adhesion     101723771 (Egfr)    04520 Adherens junction     101723771 (Egfr)    04540 Gap junction     101723771 (Egfr)   09142 Cell motility    04810 Regulation of actin cytoskeleton     101723771 (Egfr)  09150 Organismal Systems   09152 Endocrine system    04912 GnRH signaling pathway     101723771 (Egfr)    04915 Estrogen signaling pathway     101723771 (Egfr)    04921 Oxytocin signaling pathway     101723771 (Egfr)    04926 Relaxin signaling pathway     101723771 (Egfr)    04928 Parathyroid hormone synthesis, secretion and action     101723771 (Egfr)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101723771 (Egfr)    05206 MicroRNAs in cancer     101723771 (Egfr)    05205 Proteoglycans in cancer     101723771 (Egfr)    05207 Chemical carcinogenesis - receptor activation     101723771 (Egfr)    05208 Chemical carcinogenesis - reactive oxygen species     101723771 (Egfr)    05230 Central carbon metabolism in cancer     101723771 (Egfr)    05231 Choline metabolism in cancer     101723771 (Egfr)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     101723771 (Egfr)   09162 Cancer: specific types    05210 Colorectal cancer     101723771 (Egfr)    05212 Pancreatic cancer     101723771 (Egfr)    05225 Hepatocellular carcinoma     101723771 (Egfr)    05226 Gastric cancer     101723771 (Egfr)    05214 Glioma     101723771 (Egfr)    05218 Melanoma     101723771 (Egfr)    05219 Bladder cancer     101723771 (Egfr)    05215 Prostate cancer     101723771 (Egfr)    05213 Endometrial cancer     101723771 (Egfr)    05224 Breast cancer     101723771 (Egfr)    05223 Non-small cell lung cancer     101723771 (Egfr)   09172 Infectious disease: viral    05160 Hepatitis C     101723771 (Egfr)    05171 Coronavirus disease - COVID-19     101723771 (Egfr)    05163 Human cytomegalovirus infection     101723771 (Egfr)    05165 Human papillomavirus infection     101723771 (Egfr)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     101723771 (Egfr)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     101723771 (Egfr)    01522 Endocrine resistance     101723771 (Egfr)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hgl01001]     101723771 (Egfr)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:hgl04147]     101723771 (Egfr) Enzymes [BR:hgl01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      101723771 (Egfr) Protein kinases [BR:hgl01001]  Receptor tyrosine kinases (RTK)   EGFR family [OT]    101723771 (Egfr) Exosome [BR:hgl04147]  Exosomal proteins   Exosomal proteins of colorectal cancer cells    101723771 (Egfr)   Exosomal proteins of pancreatic cancer cells    101723771 (Egfr)   Exosomal proteins of bladder cancer cells    101723771 (Egfr) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 Kinase-like ABC1 Haspin_kinase Motif Other DBs NCBI-GeneID:  101723771 NCBI-ProteinID:  XP_004839898 UniProt:  A0AAX6NYS0 LinkDB All DBs Position Un AA seq 1211 aa AA seqDB search MRPCGVAGPALCALLALVGASAAPEEKRVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVV LGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTAERIPLENLQIVRGNVLYENTYALAV LSNYGGTNSANRTGLRELPLRSLQEILQGTVRFSNNPVLCSVDTIQWRDIMDSRFLSNMS LDLQSHQSSCQKCDPSCPNGSCWAPGEENCQKLTRIICAQQCSGRCRGKSPSDCCHNQCA AGCTGPRESDCLVCQKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPR NYVVTDHGSCVRACGPDSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDTLSINATNIK HFRNCTAISGDLHILPVAFRGDSFTRTPPLDPKELDILKTVKEITGFLLIQAWPENRTDL HAFENLEIIRGRTKQHGQFSLAVVGLNLTSLGLRSLKEISDGDVIVSGNRHLCYANTINW RKLFGTSGQKTKIINNRGEKACTTDGHICHPLCSAEGCWGPQPWDCVSCRNVSRGRECVA TCNVLEGEPREFVENSECIQCHPECLPQAMNVTCTGRGPDSCIQCAHYIDGPHCVKTCPA GIMGENNTLVWKYADSSHVCRLCHPNCTYGCAGPGLEGCPIKGPRIPSIATGIVGGLFLL VVLALGVGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKAKV LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRL LGICLTSTVQLVTQLMPFGCLLDYVREHKDNIGSQHLLNWCVQIAKGMNYLEDRRLVHRD LAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDV WSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADS RPKFRELIVEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMEDVVDADEYL IPQQGFFSSPSTSRTPLLSSLSANSNNSTGACVHRNGQSCPAQGDNFLQRYSSDPTGAPA EDSLDAEFLPAPEYINQSFSRRPAGSMQNPMYHNQPEHPAPGRDPHYLNPHSYAVGNPEY LNTLLRTCVSDSDGSIPWTQKGNHQISLDNPDYQQDFFPKEAKPNGIFKGPTAENAEYLR VAPPSSEFIGA NT seq 3636 nt NT seq  +upstreamnt  +downstreamnt atgcggccgtgcggggtggcggggccggcgctgtgcgcgttgctggcgctggtcggggcg agtgcggcgcccgaagagaagcgcgtttgccaaggcacaagtaacaagctcacccagctg ggcacctttgaggaccactttctgagcctccagcgcatgttcaacaactgtgaggtggtg ctcgggaacctggagatcacctatgtgcaaaggaattacgacctttccttcctgaagacc atccaggaggtggctggctatgtgctcattgctctcaacacggcagagaggatcccgctg gagaacctgcagattgtgcgtgggaatgtgctctacgaaaacacctacgcccttgccgtc ctgtctaattatgggggcaccaacagtgccaaccggaccgggcttcgggagctgccactg aggagcctgcaggagatcctgcagggcaccgtgcgctttagcaacaaccccgtgctctgc agcgtggacaccatccagtggagggacatcatggatagcagattcctgagcaacatgtca ctggacctgcagagccaccagagcagctgccaaaagtgtgatccaagctgtcccaacggg agctgctgggccccaggagaggaaaactgccagaaattgaccaggatcatctgtgcccag cagtgctcggggcgctgccgaggcaagtcccccagcgactgctgccataaccagtgtgcg gccggctgcacaggaccccgggagagtgactgcctggtctgccaaaagttccgcgacgaa gccacctgcaaggacacctgcccgccgctcatgctctacaaccccaccacgtaccagatg gatgtcaaccccgaggggaagtacagctttggcgccacctgcgtgaagaagtgtccccgg aactacgtggtgacagaccatggctcctgtgtccgggcctgcggccccgacagctacgag atggaggaggacggcgtccggaagtgcaagaagtgcgaaggcccctgccgcaaagtttgc aacggaatagggatcggggaattcaaagacacgctttccataaatgccacaaacatcaag cacttccggaactgcacagccataagcggcgacctgcacatcctcccggtggccttccgg ggggactccttcacgcgcacgccgcccctggaccccaaggagctggacatcctgaagaca gtgaaggagatcacagggttcttgctgattcaggcctggcctgagaacaggaccgacctc cacgcctttgagaacctggaaatcatccgcggcaggacaaagcaacatggccagttttct ctcgctgtcgttggcctgaacctgacgtccctggggctgcgctccctgaaggagatcagt gatggggacgtgattgtctctggaaaccgacacctatgctatgccaacaccatcaactgg agaaagctgtttgggacttccggtcagaaaaccaagattatcaacaacagaggcgagaag gcctgcaccactgatggccacatctgccacccgctgtgctcagctgagggctgctggggt ccccagccctgggactgcgtctcctgccggaacgtgagccggggcagagagtgcgtggcc acgtgcaacgtcctggagggggagccccgggagttcgtggagaattctgagtgcatccag tgccaccccgagtgcctgccccaggccatgaacgtgacctgcaccggcaggggccctgac agctgcatccagtgtgcacactacatcgatggcccccactgtgtcaagacctgcccagcc gggatcatgggggagaacaacacgctggtgtggaagtacgcggacagcagccacgtgtgc cgcctgtgccaccccaactgcacctacggatgtgccgggccaggtctggaaggctgtcca ataaaagggcccaggatcccctccatcgccactgggattgtgggcggcctcttcctgctg gtggtgctggccctgggcgtcggcctcttcatgcggaggcgccacattgtccgcaagcgc acactgcgccggctgctgcaggagcgtgagctggtggagcccctcacacccagtggagag gcccccaaccaggccctgctgcggatcctaaaggagacagaattcaagaaggccaaggtg ctaggctccggagcatttggcaccgtctacaagggactgtggatcccagaaggcgagaaa gtgaagatccctgtggccatcaaggaattgcgagaagccacatccccgaaagccaacaag gagatcctggacgaagcctatgtgatggccagcgtggacaacccccacgtgtgccgactg ctgggcatctgcctaacctccaccgtgcagctggtcacacagctcatgcccttcggctgc ctgctggactacgtgcgtgagcacaaggacaacatcgggtctcagcacctcctcaactgg tgtgtgcagatcgccaagggcatgaactacctggaggaccggcgcctggtgcaccgggac ctggcggccaggaacgtcctggtgaagacaccacagcatgtgaagatcacagacttcggg ctggccaagctgctgggcgcggaggagaaggagtaccacgctgagggcggcaaggtgccc atcaagtggatggctttggaatcgattttacaccgcatttatacccaccagagtgacgtc tggagctatggagtcacagtgtgggagctgatgacctttgggtccaagccatatgacggg atccctgcaagcgagatctcgtccatcctggagaaaggagagcgcctcccgcagccgccc atctgcaccatcgacgtctacatgatcatggtcaagtgctggatgatagatgcagacagt cgcccgaagttccgcgagttaatcgttgagttctccaaaatggcccgagacccccagcgc taccttgtcattcagggggatgaaaggatgcatctgccaagccctacggactccaacttc taccgtgccctgatggacgaggaggacatggaggatgtcgtagatgcagacgaatacctc attccacagcagggcttcttcagcagcccctccacctcccggactccactcctgagttct ctgagtgcaaacagcaacaactccacgggagcttgtgttcacagaaacgggcagagctgc cctgcccagggagacaacttcctgcagcgctacagctcggaccccacgggcgccccagcc gaggatagcctggatgccgagttcctcccagcacccgaatacataaaccagtccttctcc agaaggcctgcaggctccatgcagaaccccatgtatcacaatcagcccgagcaccccgct cctggcagagacccacactacctaaacccccacagctatgccgtgggcaaccctgagtat ctcaacaccctcctgcggacctgtgtcagcgactcagacggctccatcccctggacccag aagggcaaccaccaaattagcctggacaaccctgactaccagcaggacttcttccccaag gaagccaagcccaacggcatctttaagggccccacagcggaaaatgcagaataccttcgg gtggccccgccaagcagtgagtttattggagcgtga

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