Heterocephalus glaber (naked mole-rat): 101724077 Help Entry 101724077         CDS       T02812                                  Symbol Rps6kb1 Name (RefSeq) ribosomal protein S6 kinase B1   KO K04688   ribosomal protein S6 kinase beta [EC:2.7.11.1] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl01521   EGFR tyrosine kinase inhibitor resistance hgl01522   Endocrine resistance hgl04012   ErbB signaling pathway hgl04066   HIF-1 signaling pathway hgl04140   Autophagy - animal hgl04150   mTOR signaling pathway hgl04151   PI3K-Akt signaling pathway hgl04152   AMPK signaling pathway hgl04211   Longevity regulating pathway hgl04213   Longevity regulating pathway - multiple species hgl04350   TGF-beta signaling pathway hgl04371   Apelin signaling pathway hgl04666   Fc gamma R-mediated phagocytosis hgl04714   Thermogenesis hgl04910   Insulin signaling pathway hgl04931   Insulin resistance hgl05163   Human cytomegalovirus infection hgl05165   Human papillomavirus infection hgl05170   Human immunodeficiency virus 1 infection hgl05200   Pathways in cancer hgl05205   Proteoglycans in cancer hgl05207   Chemical carcinogenesis - receptor activation hgl05210   Colorectal cancer hgl05212   Pancreatic cancer hgl05221   Acute myeloid leukemia hgl05224   Breast cancer hgl05225   Hepatocellular carcinoma hgl05226   Gastric cancer hgl05231   Choline metabolism in cancer hgl05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:hgl00001]  09130 Environmental Information Processing   09132 Signal transduction    04012 ErbB signaling pathway     101724077 (Rps6kb1)    04350 TGF-beta signaling pathway     101724077 (Rps6kb1)    04371 Apelin signaling pathway     101724077 (Rps6kb1)    04066 HIF-1 signaling pathway     101724077 (Rps6kb1)    04151 PI3K-Akt signaling pathway     101724077 (Rps6kb1)    04152 AMPK signaling pathway     101724077 (Rps6kb1)    04150 mTOR signaling pathway     101724077 (Rps6kb1)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     101724077 (Rps6kb1)  09150 Organismal Systems   09151 Immune system    04666 Fc gamma R-mediated phagocytosis     101724077 (Rps6kb1)   09152 Endocrine system    04910 Insulin signaling pathway     101724077 (Rps6kb1)   09149 Aging    04211 Longevity regulating pathway     101724077 (Rps6kb1)    04213 Longevity regulating pathway - multiple species     101724077 (Rps6kb1)   09159 Environmental adaptation    04714 Thermogenesis     101724077 (Rps6kb1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101724077 (Rps6kb1)    05205 Proteoglycans in cancer     101724077 (Rps6kb1)    05207 Chemical carcinogenesis - receptor activation     101724077 (Rps6kb1)    05231 Choline metabolism in cancer     101724077 (Rps6kb1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     101724077 (Rps6kb1)   09162 Cancer: specific types    05210 Colorectal cancer     101724077 (Rps6kb1)    05212 Pancreatic cancer     101724077 (Rps6kb1)    05225 Hepatocellular carcinoma     101724077 (Rps6kb1)    05226 Gastric cancer     101724077 (Rps6kb1)    05221 Acute myeloid leukemia     101724077 (Rps6kb1)    05224 Breast cancer     101724077 (Rps6kb1)   09172 Infectious disease: viral    05170 Human immunodeficiency virus 1 infection     101724077 (Rps6kb1)    05163 Human cytomegalovirus infection     101724077 (Rps6kb1)    05165 Human papillomavirus infection     101724077 (Rps6kb1)   09167 Endocrine and metabolic disease    04931 Insulin resistance     101724077 (Rps6kb1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     101724077 (Rps6kb1)    01522 Endocrine resistance     101724077 (Rps6kb1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:hgl01001]     101724077 (Rps6kb1) Enzymes [BR:hgl01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.11  Protein-serine/threonine kinases     2.7.11.1  non-specific serine/threonine protein kinase      101724077 (Rps6kb1) Protein kinases [BR:hgl01001]  Serine/threonine kinases: AGC group   RSK family [OT]    101724077 (Rps6kb1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Pkinase PK_Tyr_Ser-Thr Pkinase_C Kinase-like Pkinase_fungal ABC1 DUF1015 Motif Other DBs NCBI-GeneID:  101724077 NCBI-ProteinID:  XP_004870428 UniProt:  G5C898 LinkDB All DBs Position Un AA seq 525 aa AA seqDB search MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSEEELEEGGQLNESMDHGGVG PYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIF AMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL FMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLC KESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKK TIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEEL LARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLE SVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSG IEQMDVTMSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL NT seq 1578 nt NT seq  +upstreamnt  +downstreamnt atgaggcgacgacggaggcgggacggcttttacccagcgcctgacttccgagacagggaa gctgaggacatggcaggagtgtttgacatagacctggaccagccagaggacgcaggctct gaggaggagctggaggaggggggtcagttaaatgaaagcatggaccatgggggagttgga ccatacgaacttggcatggaacattgtgagaaatttgaaatctcagaaactagtgtgaac agagggccagaaaaaatcagaccagaatgttttgagctacttcgggtacttggtaaaggg ggctatggaaaggtttttcaagtgcgaaaagtaacaggagcaaatactgggaaaatattt gccatgaaggtgcttaaaaaggcaatgatagtaagaaatgctaaagatacagctcataca aaagcagaacggaatattctggaggaagtaaagcatcccttcattgtggatttaatttat gcctttcagaccggtggaaaactctacctcatccttgagtatctcagtggaggagaacta tttatgcagttagaaagagaggggatatttatggaagatacagcctgcttttacttggca gaaatctccatggctttggggcatttacatcaaaaagggatcatctacagagacctgaag ccggagaacatcatgcttaatcaccaaggtcacgtgaaactaacagactttggactatgc aaagaatctattcatgatggaacagtcacacatacattttgtggaacaatagaatacatg gcccctgaaatcttgatgagaagtggccacaatcgtgctgtggattggtggagtttggga gcattaatgtatgacatgctgactggagcacctccattcactggggagaatagaaagaaa acaattgacaaaatcctcaaatgtaagcttaacttgcctccctacctcacacaagaagcc agagatctgcttaaaaagctgctgaaaagaaacgctgcttctcgtcttggagctggtccc ggggacgctggagaagttcaagctcatccattcttcagacacattaactgggaagaactt ctggctcggaaggtggaacccccctttaaacctctgttgcaatctgaagaggatgtgagt cagtttgattcaaagtttacacgtcagacacctgtcgatagcccagatgactcaactctc agtgaaagtgccaaccaggtctttctgggttttacatatgtggctccatctgtacttgaa agtgtaaaagaaaagttttcatttgaaccaaaaatccgatcaccacgaagatttattggc agcccacgaacacctgtcagcccagtcaaattttctcctggggatttctggggaagaggt gcttcagccagcacagcaaatccccagacgcctgtggaatacccaatggaaacaagtgga atagagcagatggatgtgaccatgagtggggaagcatcagcaccacttccaatacggcag ccgaactctgggccatacaaaaaacaagcttttcccatgatctccaaacggccagagcac ctgcgtatgaatctatga

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