KEGG   Heterocephalus glaber (naked mole-rat): 101724287
Entry
101724287         CDS       T02812                                 
Symbol
Atf4
Name
(RefSeq) activating transcription factor 4
  KO
K04374  cyclic AMP-dependent transcription factor ATF-4
Organism
hgl  Heterocephalus glaber (naked mole-rat)
Pathway
hgl04010  MAPK signaling pathway
hgl04022  cGMP-PKG signaling pathway
hgl04137  Mitophagy - animal
hgl04141  Protein processing in endoplasmic reticulum
hgl04151  PI3K-Akt signaling pathway
hgl04210  Apoptosis
hgl04211  Longevity regulating pathway
hgl04261  Adrenergic signaling in cardiomyocytes
hgl04668  TNF signaling pathway
hgl04720  Long-term potentiation
hgl04722  Neurotrophin signaling pathway
hgl04725  Cholinergic synapse
hgl04728  Dopaminergic synapse
hgl04911  Insulin secretion
hgl04912  GnRH signaling pathway
hgl04915  Estrogen signaling pathway
hgl04918  Thyroid hormone synthesis
hgl04922  Glucagon signaling pathway
hgl04925  Aldosterone synthesis and secretion
hgl04926  Relaxin signaling pathway
hgl04927  Cortisol synthesis and secretion
hgl04928  Parathyroid hormone synthesis, secretion and action
hgl04932  Non-alcoholic fatty liver disease
hgl04934  Cushing syndrome
hgl04935  Growth hormone synthesis, secretion and action
hgl05010  Alzheimer disease
hgl05012  Parkinson disease
hgl05014  Amyotrophic lateral sclerosis
hgl05020  Prion disease
hgl05022  Pathways of neurodegeneration - multiple diseases
hgl05030  Cocaine addiction
hgl05031  Amphetamine addiction
hgl05034  Alcoholism
hgl05161  Hepatitis B
hgl05163  Human cytomegalovirus infection
hgl05166  Human T-cell leukemia virus 1 infection
hgl05203  Viral carcinogenesis
hgl05207  Chemical carcinogenesis - receptor activation
hgl05215  Prostate cancer
hgl05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    101724287 (Atf4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101724287 (Atf4)
   04668 TNF signaling pathway
    101724287 (Atf4)
   04022 cGMP-PKG signaling pathway
    101724287 (Atf4)
   04151 PI3K-Akt signaling pathway
    101724287 (Atf4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    101724287 (Atf4)
  09143 Cell growth and death
   04210 Apoptosis
    101724287 (Atf4)
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    101724287 (Atf4)
   04922 Glucagon signaling pathway
    101724287 (Atf4)
   04912 GnRH signaling pathway
    101724287 (Atf4)
   04915 Estrogen signaling pathway
    101724287 (Atf4)
   04926 Relaxin signaling pathway
    101724287 (Atf4)
   04935 Growth hormone synthesis, secretion and action
    101724287 (Atf4)
   04918 Thyroid hormone synthesis
    101724287 (Atf4)
   04928 Parathyroid hormone synthesis, secretion and action
    101724287 (Atf4)
   04925 Aldosterone synthesis and secretion
    101724287 (Atf4)
   04927 Cortisol synthesis and secretion
    101724287 (Atf4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101724287 (Atf4)
  09156 Nervous system
   04725 Cholinergic synapse
    101724287 (Atf4)
   04728 Dopaminergic synapse
    101724287 (Atf4)
   04720 Long-term potentiation
    101724287 (Atf4)
   04722 Neurotrophin signaling pathway
    101724287 (Atf4)
  09149 Aging
   04211 Longevity regulating pathway
    101724287 (Atf4)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    101724287 (Atf4)
   05203 Viral carcinogenesis
    101724287 (Atf4)
  09162 Cancer: specific types
   05215 Prostate cancer
    101724287 (Atf4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101724287 (Atf4)
   05161 Hepatitis B
    101724287 (Atf4)
   05163 Human cytomegalovirus infection
    101724287 (Atf4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101724287 (Atf4)
   05012 Parkinson disease
    101724287 (Atf4)
   05014 Amyotrophic lateral sclerosis
    101724287 (Atf4)
   05020 Prion disease
    101724287 (Atf4)
   05022 Pathways of neurodegeneration - multiple diseases
    101724287 (Atf4)
  09165 Substance dependence
   05030 Cocaine addiction
    101724287 (Atf4)
   05031 Amphetamine addiction
    101724287 (Atf4)
   05034 Alcoholism
    101724287 (Atf4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101724287 (Atf4)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    101724287 (Atf4)
   04934 Cushing syndrome
    101724287 (Atf4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hgl03000]
    101724287 (Atf4)
Transcription factors [BR:hgl03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    101724287 (Atf4)
SSDB
Motif
Pfam: bZIP_1 bZIP_2 DUF4407 OVT1 AAA_13 Asd-4 KIF21A Fez1 DUF4192 Nop53 COG3_N DUF3450
Other DBs
NCBI-GeneID: 101724287
NCBI-ProteinID: XP_004845624
UniProt: A0AAX6P7I8
LinkDB
Position
Un
AA seq 353 aa
MAEMSFLSSEVLAGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSD
WLAVDEFVSASDTGKEDAFSGTDWMLEKMDLKEFDFDALLNVDDLETVPDELLATLDDTC
DPFASLVQETNKEPPQAVNPIGHLPESLTKTDQVAPFTLQPLPLSSRVLSSTPDHSFSLE
LGSEVDISEGDRKSDCIAYITLIPQCVKEEDAPSDNDSGTCMSPESYPGSPQHSPSTSRG
SPNRSLPCAGVPCGSSRPKPYDPPGEKMVVAKVKGEKLDKKLKKMEQNKTAATRYRQKKR
AEQEALTGECKELEKKNEALKEKADSLAKEIQYLKDLIEEVRKARGKKKGPLG
NT seq 1062 nt   +upstreamnt  +downstreamnt
atggccgagatgagcttcctgagcagcgaggtgttggcgggggacttgatgtcccccttc
gaccagtcgggtttgggggctgaagaaagtctaggtctcttagatgactacctggaggtg
gccaagcacttcaaacctcatgggttctccagcgacaaggctaaggcgggctcctccgat
tggctggctgtggatgagtttgtcagtgcctctgacaccggcaaggaggatgccttctct
gggacagattggatgttggagaaaatggatctgaaggagtttgattttgatgccctgttg
aacgtagatgacctggaaaccgtgccagatgagcttttggccacgttggatgacacatgt
gatccctttgcatccctagtccaggagactaataaggagcccccccaggcagtgaaccca
attggccatcttccagaaagtttaaccaaaacagaccaggttgcccctttcaccttgcaa
cctcttcccctttcctccagggttctgtcctctactccagatcattcctttagcttagag
ctaggcagtgaagtggatatctctgaaggagataggaaatccgactgtattgcttatatt
accttgattcctcagtgtgtaaaggaggaagatgccccctcagataatgacagtggtacc
tgtatgagccctgagtcctaccctggttctccccagcacagtccttctacttccaggggc
tcaccgaatagaagcctgccatgtgcaggagtcccctgtggttcttcccgtcccaaaccc
tatgatccccctggagagaagatggtagtggctaaagttaagggtgaaaagctggataag
aaactgaaaaaaatggagcaaaacaagacagcagccactaggtaccgccagaagaagcgg
gctgagcaagaggccctcactggtgagtgtaaagagctagaaaagaaaaatgaggctctg
aaagagaaggcagattctctggccaaggagattcaatatctgaaagatttgatagaagag
gtccgcaaagcaagggggaagaaaaagggtcccttagggtag

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