Harpia harpyja (harpy eagle): 128140606 Help Entry 128140606         CDS       T10541                                  Symbol SYNE1 Name (RefSeq) nesprin-1 isoform X1   KO K19326   nesprin-1 Organism hhar  Harpia harpyja (harpy eagle) Pathway hhar04820   Cytoskeleton in muscle cells Brite KEGG Orthology (KO) [BR:hhar00001]  09140 Cellular Processes   09142 Cell motility    04820 Cytoskeleton in muscle cells     128140606 (SYNE1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03036 Chromosome and associated proteins [BR:hhar03036]     128140606 (SYNE1) Chromosome and associated proteins [BR:hhar03036]  Eukaryotic type   Centrosome formation proteins    LINC complex     128140606 (SYNE1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Spectrin Spectrin_SYNE1 SYNE1 CH KASH ATG17_like Motif Other DBs NCBI-GeneID:  128140606 NCBI-ProteinID:  XP_052640657 LinkDB All DBs Position 4:71074463..71401812 Genome browser AA seq 8826 aa AA seqDB search MASSRLVARSRDIANVMQRLQDEQESVQKRTFTKWINTHLAKRNPPMLVNDLFEDIKDGV MLIALLEVLSGQKLPCEQGRQLKRIHWVANIGTALKFLEGRRSIYRGSPIKLVNINSTDI ADGRPSIVLGLVWTIILYFQIEELTSNLPQLQSLSSSASSVESVVSSETASPPSKRKVVT KVQGSARKALLKWIQYTAAKQVGIEIKDFGQSWRSGVAFHSVIHAIRPDLVDMEKVRGRS NRENLEEAFTLAEAELGIPRLLDPEDVDVDKPDEKSVMTYVAQFLKYYPDPHHTVTDMQE NDELQAIPTFVISFMKFKKEDRLMLRDLKVWAEQFERDLARAQVAETSLQEKYQSFKHFR VQYEVKRKQIELVTQSLRKDGKLSLDQAMVKQAWDRVSSRLLDWHIHLDKSLPAPLGTIG AWLYRAEAALREEVTIHQAHEETANTIHRKLEQHKDLLKNIDGHKKAFHEIHGARSVNGV PVPPDQLEDMAERFNFVVSSSELHLLKMEFLELKYRLLSLLVLAESKLKSWIIKYGRRES VELLLQNYISVIENSKFFEQYDVTYQILKRAAEMYAKANGSVEEVENVMKFMSETTAQWR NLSVEVRSVRSMLEEVIANWDRYSSTVAGLQAWLEDAEKMLNEPEHSKKDFFRHLPHWIQ QHTAMNDAGNFLIETCDETISRDLKQQLLLLNGRWRELFMQVKQYARADELDKMKEEYLD GVAHLTAFIDGSNRKFSVPVEMSFLDVKMFVQDLENIKQKLPAMEAQYKIVTRTAQLVTK EVSQEEVNEMLATLTRIKEQLSKVKEYSCALLYECQHLLSPLEELEKQITHFYESLEKVN EIISILDPEAQPTTVLKQKAQDLVAYQENCKKDLSLIERNSQSILQCVASSEVLQHFHQS TFQKKVTQVQITFQNMVRKAGDWRKNIEANSRLMKKFEESRAELEKVIQIANCCLKEKGN PEELLRKHSEFFNQLDQRVLNAFLKACDELTDILPEQEQHNLQEAVRKLHRQWKDLQTEA PYHLIHLKIEVQKSKFLVTVEECKAELARQNKVLSREANERMIKEHMLFFGDKGSYQLCA KRLQRIEELCQKLPVSDPVRVTLESSQRILKELKSQIDSTYVKLTEHSDTWRGYKNRFSE LANWILSTERELKKIKESVNDTAQYKQLEASVGEIRKHINKQGENHSWLKSRLAVLTAVC PDLEAKKTEDELCKLSSDFKGLLDFLAEIEKTLGTVGDCVQYKEEVKSAIEELISNSKEA QAEAEKILDTESLLQAQQLLLHHQQRTRRLRAKRQDVQQQISQAKQLQIEGGLPSTMQED LQKLEGTLENIQQTMEKREEQLQVTINKWEQFERDKKTVVKYLNQASSALERILNFSSLE SLSSELDQTKELSKQTEAMAVQAENLVKNSSEIQLGSKNKQSLQQQAKSIQEQVKKVEVT LEEDIKSMEMVKNKWDHFGNNFEALSIWIAEQEKELENLETSSSPLDIQISQIKVINKEI DGKITGISKLEEESESFSQFVTSGECAHIKAKLTQVKRYWEELRGHAQRLEGTITGNASA QQKYEESLKQVQQAVSEFEAKLAEPLTLCSSAAATYAALQDCTDLCHTVEKLSNMLASLS ACARKVANKGAAAQEVTALQQKYEKVLENAKEKQTLLETLLTQWQKQEKELSAFLTWLEG CEATARPSEQYVSADRVKLEGELQSLQDLRADIESRASVYASLLQLNESLFPTASEQCMK TIEEKFEELDERWKALPQIVDKRINFLQSLVAEHGQFDELLLRFSDWIKQFLAELQATSE INTADQQLAASHNKNHSMEVESKKQQLQSLKEHVDKLCSFSCPEDRQTLQGKTEDCFQIF QEASQITSQRQEALDQLRVFLELRSAASGVLRRLRQTVEKTGNMDKAKSGLLEKELNDVI QDLNKLESAAVSLDGSLTKAQYHLKHSISEQRTSCRAVVDNLYLELEAVQNLLGTKQSEA EALGALRRSFMERKEQLLKSIEDTEEKADKEGLKEATLQALQQRLRIFNQLDEELNSHQH ELQWLMDKAKQIAHKDTTLAPEIDKEINRLESLWEDTKKVIHEKKEQSCILIDLMKEYQS LKSTVMKVIDSADSASAIKSIWKDHEDVRRTLSKHEAAKNDLSDKQKDLDNFTNKGKHLL AELKRVHNCDSTALKTDMNCTVDKWLDVSERIEDNIDRLRVSVSLWDDILKTGDEMDGWC IKCISQLNEGISNLSNSQRMEVLLKDFQSEVKDKELKLEQLSSKISDLKELTHSQQSPAD LQFIESELRQKLEHAKEISETAKETLKDFSTQKMQLQKFIDQMTDWLTNVEETLLSCAHN LNPEALNKVKETQKDLQLQQSSIDSTRENLNSLCRKYHSAELETLGGTVTSLIKKYEAVN LLCSRTQASMQESLEKHFLYSMQEFWEWFSGVKAAVKESSDRSGDSKAIETKLHDLQSVL DSVSEGQNKLDAACKEGESLYACLPKPVVSHIQEQIAKSNQNFQEFLNQCLNDKKALETC ASHLGSFEDQHKKLGLWMHDMEERISTEALGESKQLIPEKKKEVQKVEKFLEELLNSRES FDKLSQMAQTLNEEGHDAGREVRLASQHLANYQNMVKTVKEKLRTCQLALQEHLTLEEAL QSMWSWVKEVQDKLVSSESTVGSKATLERRLTQIQEILLLKGDGEVKLNMAIGKGEQALR SSNEEGQKVIQTELQKLKDVWNDIISTSVNCQSCLESVISKWNEYLERKKQLEQWLEKLD HEVEQPLEPQIGLKEKFAQLDHFQAIVSEIEDHSGDLQQLIEKAVELYEKTKDDSLGEAA QEELKTQFNDITTVAKEKMRKVEDIVKDHLLYLDAVHEFTDWLHSAKEELHRWSDSSGDT STIQKKLAKINELVESRQTGAGRLGRVETLAPAAKRSTTAGGCQLLAAEMQALRSDWKEW EENAFRSQSSLRDALSRMALSEQEFAGRVEQLEEAARRFGGLLAGWSRSLAPLDGRHTDG EVVESWRREKETLDALVKSEHMTDEIKTQLNDLCRFSRDLSTHSSKVSGLIKEYNSLCLQ ASKGCQSKEQILQQRFRTAFRDFQQWLVNARVTTAKCFDVPQNISEASASLQKIQEFLSE SENGQQKLNLVASKGELLCSILPKEKAKVIWDKSATAKEDWKNFITTLHQKESALENLKI QMKDFEATAEPLQEWLTTTEKMVQGSNSRLHDLPSKRREQQKLQSVLEEVSCHEHQLNRL KEKAQQLWEEQAVSKSFMRRVSQLSSQYLTLSNLTKEKVSRMDRVVAEHQQFSHSVKDLQ DWVTDAVHMLDSYCHSTADKSVLDSRMLKLEGLLAVKQEKEIQMKMVLTRGESVLQNTSL EGVPAIERQLQTLKDSWASLLSACIQCKSQLEGALSKWTSYQDDVRQFSSWMDKVEASMN ASERQHAELREKTAALSKAKLLSEEVLSHSSLLETIEVKGSGMAEHYVTQLELQDLQERY KFLKDRTREAVTKAEGLLNLHQEYQRNLKAFEVWLEKEQEKLDCLSHLDGDAQKQEATLR ELQELQVHCTEGQALLNAAVHAREEVIPWGIPQIEDRALESLRQDWQVYQHRLSEARSQL NATVSRLRLMEKKFQKVNDWLTDLEEKVAIRTGRQSGRATKEMQLQQMKKWHEEITVYKD DVEEVGVLAQQILEESLTTSRTGSQATQLTSRYQTLLLHVLEQIKFLEEEIRCMEESELA FSAYTDWYGATNKNFRNVITNFDVVDKTAMEKKVQKLELLLSDMDIGHSLLKSAREKGER AIRYMEENEVDQLRKEIGDHVEQLEELAGSIRKEHMTSEKCLQLAKEFSDKYKTQTQWVM EYQAMLRAPVEPKSELYEKKAQLSKYKSIQQTVLSHEPSIKSVIEKGEALFDLVNDMTLK NNIQDLQRSYQELCSTTKAYVETLEVRVKEHEDYNSDLQEGEKWLLHMSSRLVSPDLMES NNLEVITQQLANHKAIMEEIAGFEDRLNSLKSKGDYLISQCTEHLQAKFKQNIQSHLQGT KDSYSAICSTAQRVYQSLEHELQKHVNHQDTLQQCQTWLSTVQSELKPTTWLPFSLADAV KQVKHFRALQEQANTYLDLLCSMCDLSDATVKSTATDIQQTKHTIEQQIMHSQYLAQGWE EIKQMKAELWIYFQDADQQLQNLKRRRAELELNIAQNMVLQVKEFSQKLQSKQSALTSVT EKMNKLTQGQESPEHKEIGELSNQWLDLCLQAHSLLIQREEDLQRTGDYHDRMNVVEVFL EKLTKEWDNLARSDAESTNVHLEALQKLALALQERRFALEDLKDQKQKMMEHLNLDDKEL VKEQLGHFEQRWTQLEDLVKRKIQVSVSTLEELSLVHSKFQELLEWAEEQQPSISEALKQ SPPPDLAQSLLVDHLTICSELEAKQLVLKTLVKDADRVMANLGLNERQELQKALSDAQHR VDCLSDLVGQRRKHLNKALSEKTQFLMAVFQATNQIHQHEKKVTFPEHICLLPEDVNKQI RTCKNAQANLKAYQNEVTGLWAQGRDLMKEATEQEKSEVLGKLQELQNVYDTVLQKCNQR LLELEKNIVSRKYFKEDLDKACHWLKQADIVTFPEVNVMNSNSELYSQLAKYQQILEQSP EYENLLLALQRDGQEILPSLNEVDHSYLDEKLNILPQQFNIVTALAKEKLYKVQEAIYAR KEYASLIELTSKALTELEDQFINMAKAPGAVLAKEAVSLQQAYRDLLGEVVSLGAAVDEL NQKKEAFRSTGQPWQPDEMLKLVTLYHKLKRQIEQKISLLEDTIEACQEHEKMCMQFEAQ LEAVKKEQIKVNEETLPIEEKLKIYHSLVGSLQDSGSLLKRITEHLEALSPQLDSSARET TNHQVQSWQEKLKSLHAAIGDTVMECENRLVQSIDFQTEICRSLNWLRWVKTELNGTLSL DLKLRSIQEEIRKVQIYQEEVQSSLRIMNALSNKEKERYMKAKELIPADLENTLAELTEL DGEVQEAIHVRQATLNKLYSLCQRYYQVVQIANDWLEDAQEFLLLARNGLDVENSEENLR NHIEFFSTESQCTNHMKELQGLVSEIEPFIQAAAREQLMQNVATLEEKAKGTKQEAKTQQ EQLQRCASEWQEYQTARQKVIEVMNEAEKKLSEFSVAKAASSHEAEEKLLTHKTLVSVVN SFHEKITALEEKASQLEKVSNDASKATISRSMTTVWQRWTRLRNVAQEQEKILEEAVQEW KGFNDKIQKATIAIDQLQGRLPESSVEKASKTELLELLDYHSSFLLEVEHQLSSLGLLKQ HTVSMLQDVEVKPPSQEELPVMQEIKAMQDRCHNMQQKVKKGVKMVKQELKEREEVEAEI NIVKSWIQETKEYLLSPDTEVDTQLQELQSLLGEVTTHRQAVEKMAEQQQNKYLGLYTIL PSELSLHLAEVGLALVTVQDQIQTKERETQQIKTLNQEFGQKIQGIANELNAILSKLKKK TNDIAQAKLEQKILGEELDSCNIKLLELDASVQDFTEQNALLAKQLANRIGKLTALHQQT IRQAEYRAAKLSQAASHLEEYNEMLEFILKWIEKANILVHGSITWNSSSQLRDQFKAYQT MLDESGEIHGDLEAMSERIEYLASVYCTEGMSQQVLELGRRTEELQQVIKVRLPNLQDAA KDMKKLEVELRALQAALEQAQATLTSPELGHLSLKEQLSHRQHLLSEMESLKPKVHAVQV CQSALRIPEEVVTGLPLCHSALRLQEEASRLQHTAIQQCNIMQATVVQYEQYEQEMKHLQ QMIESAHHEIQDKPIATSNIQELQVQISRHEELAQKIKGYQEQIAALNSKCKMLTMKAKH ATMLLTVTEVEGLSDGMEELDSDLLPAHPTHPSVVMMTAGRCHTLLSPVTEESGEEGTNS EISSPPVCRSPSPVANTDASVNQDIAYYQALSAEQLQTEAAKIQPSTSATQEFYEPGLES AASAKLDDLQRSWETLKNVISEKQRTLYEALERQQKYQDTLQSISTKMETIEVKLNESLE PAKSPESQMAEHQALMDEILMLQEEITELQTSLAQELVSEPLDAEAADQLALQSTLTVLA ERMATIRMKASGKRQLLEEKLNEQLEEQRQEQALQRYRCEADELDHWLLNTRATLDTALV TAEEPMDMEAQLVDCQNMLVEIEQKVVALSELSVHNENLLMEGKAHTKDEAEQLAVKLRT LKGSLLELQRVLHDKQINIRQGSLQEKEESNLDFISSQSPSVQEWLAQARTTRSQQQQST LQQQKELEQELEEQKNLLRSVACRGEEILTQQGAPEGLCISEKPDTLSEELGLEGEKPSP EEQMKVKWESLNQEFNTKQRLLQKTLEQEQLQLCSRPNRLISGMPLYKEEGQDEDKSVSP VLVELNQAFEDVSSEAGRVEESLHLEQKLYNGVTATSLWLDGVEEQVFVATALLPEEETE TYLCKQESLAKEIKDVTEEMDKNKNLFAQVFPENGDNRDIIEDTLDCLLRRLTLLESAVN QRCHQMKGRLQQIVTFKNDLKLLFTSVADNKYLVLQKLAEAVERPETEQMQVILQAEEGL KELDAGINELKKRVDKLQIDQSSVQELSKIQDKYDELMMIIGSRRSDLNQNLALKRQYER ALQDLADLVETGQEKMSGGQKMIVASKEEVRLLLDKHKEYFQGLESHMILTETLFRKMSS FALLKETQSHSELMTQASAVLKLAHKRGVELEYILETWMHLDEDYQQLSRQLESVEGSIP TVGLVEETEDRLTDRITLFQHLRSNLTEYQPKLYQVLDDGKRLLFSVSCSDLESQLNQLG ECWLSNTSKVTKELHRLETILKHWTRYQSESNELTHWLQSAKERLEFWSQQSLTVPQELE TVRDHLNSFLEFSKEVDAKSSQKSSVLSTGNQLLRLKKVDTAALRAGLSHIDSQWTELLT QIPAVQEKLHQLQMDKIPSRHAITEVMSWISLMENVIQQDEENIKNVVGQKVIQDYVQKY KGFKIDLNCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNRRWQILQGLITEK IQLLESLQESWTEYENNVQCLKSWFETQEKKLKQQQKIGDQASVQNALKDCQELEEAIRT KEKEVENVEQSGLSLIQNKKEEVSSAVMNTLQEINHSWANLDHMVSQLKMLLQSVLDQWS IYKVTYEELNSYLTEARYSLSRFYLLTGSLEAVKVQVDNLQSLQDELEKQENSLQKFGSV TNQLLKECHPPVTETLTNTLKEVNMRWNNLLQETAERLRASKGLLQLWQRYKDCYQQCSS TVRQREDQANELLKTATSKDIADEVTTWIQDCNDVLTDLKTAQESLVVLQELGEELKSQV EASAAAAIQSDHLSLNQNLSTLEQALRKQQAVLQAGVLDYQTFAKSLQVLEAWITEAEEI LKGQDPSHSSDLSAIRSRMEELKSQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLN RHWSLISSQTTERFSKLQSFLLQQQTFLEKCETWMDLLVQTEQKLAAEISGNYQSLLEQQ RAHELFQAEMFSRQQILHSIISDGQHLLEQGQVDDRDEFNLKLTLLSNQWQGVIRRAQQR RGIIDSQIHQWQRYREMAEKLRKWLVEISFQAVSGLRNAPIPLQQARALLDEVQLKEKVL LRQQGSYILTVEAGKQLLLSADSGAEAALQTELTEIQERWKIVSNQLEQQKKELALLLKD WEKSEKGIGDSLEKLRSFKKNLSQPLPEHHDELHAEQIRCKELENAVEGWTDDLAHLSLL KETLSIYISADDISILSERIELLHRQWEELCHQVSLRRQQVSERLNEWAVFSEKNKELCE WLTQMESKVSQNGDILIEEMIEKLKKDYQEEIAVAQKNKTQLQQMGERLAKASHESKASE IEYKLGKINDRWQHLLDLIAARVKKLKETLVAVQQLDKNMSSLRSWLAHIESELSKPIVY ETCDSEEIQRKLNEQQELQRDIEKHSTGVASVLNLCEVLLHDCDACATEAECDSIQQATR NLDRRWRNICAMSMERRLKIEETWRLWQKFLDDYSRFEDWLKISERTAAFPSSSGVLYTV AKEELKKFEAFQRQVHESLTQLELINKQYRRLARENRTDSDCSLKQMVHEGNQRWDNLQK RVTSILRRLKHFIGQREEFETARDSILVWLTEMDLQLTNIEHFSECDVQAKIKQLKAFQQ EISLNNNKIEQIIVQGEQLIEKSEPMDAAVIEEELDELRRYCQEVFGRVERYHKKLIHLP LTDDEHDLSDREVDLDESADLSDIHWHDKSADSVLSPHPSSNLSLPLSQPVRSERSGRDT PASVDSIPLEWDHDYDLSRDLETAVSQALHSEEEDGGQEKDFYLRGAAGIADVEIPETLE AYVTLTENALKNISGEPGALEAHIRQLDKALDTSRFQIQQTENIIRSKTPTGPELDSSYK GYMKLLGECSGSIESVKRLGYKLKEEEEKLSGLINLNSTETQTAGVIDRWELIQAQALSK ELRMKQNLQQWQQFNSDLNSIWAWLGETEEELETLRRLDLSTDIQTIELRIKKLKELQKA IDNRKAIILSINLCSSEFTQSDSEESKKLQERLSQMNVRWDHVCNMIEEWRSSLQDALMQ CQDFHEMSHGLLLWLENIDRRKNEIVPINPNLDSEILQEHHRLLMQIRRELLESQLKVAS LQDMSCQLLVNAEGKDCLEAKEKVHVIGNRLKLLLKEVTRHIKDLEKILDISSSQLELSS WSSADELDTSGSVSPVSGRSTPSRQRTPRGKCSLSQPGPSVSSPHSRSIRGGSGSSPSEA GPAWRHPSFFLRVLRAALPLQLLLLLLIGLACLVPMTEEDYSCTMANNFARSFHPMLKYM NGPPPL NT seq 26481 nt NT seq  +upstreamnt  +downstreamnt atggcctcatcccgactagtggcaagatctagagatattgccaatgtcatgcaacgactt caagatgagcaagagtcagtgcagaaaaggactttcacaaaatggatcaatactcatctg gctaagcgcaatcctcctatgctggtgaatgatctgtttgaagatatcaaagatggggta atgctaattgcccttttggaggttctttcagggcagaagctgccttgtgagcagggacgt cagctgaagagaattcactgggttgccaacattggcacagctcttaaatttctagaggga agacggtccatatacagaggatctccgattaagcttgtcaacataaactcaacagatatt gctgatggcaggccttctattgttcttggcttggtgtggaccataattttatattttcag attgaagagcttaccagcaacctcccacagctgcagtcattgtctagcagcgcttcttct gtggagagtgttgtcagttcagaaactgcaagtcccccaagcaaacggaaggtggtaacc aaggtccaaggaagcgccaggaaggctttgttaaaatggatacagtacacagcagcaaag caagttggaattgaaatcaaagattttggacaaagttggaggagtggtgttgcatttcat tctgttattcatgctatccgcccagatttagtggacatggagaaagtaaggggaaggtca aatagagaaaatctggaagaagccttcacacttgcagaagcagaactaggaattccaagg ctccttgatccagaagatgtggatgttgacaagccagatgaaaagtctgtcatgacctat gtagcccagtttttgaagtactatcctgatcctcatcatacagtgactgacatgcaggag aatgacgaacttcaagcaatcccaacttttgtcatttcttttatgaaatttaagaaggaa gacagactgatgctgagagacctaaaggtgtgggcagaacaatttgaaagagacttagcc cgagcacaggtggcagaaacaagcttacaggagaaataccagtcttttaagcatttcaga gtacaatatgaggtaaaaaggaaacagattgaacttgtaacccagtcattaaggaaagat ggtaaattatcacttgatcaagctatggtgaagcaagcatgggacagagtttcttccagg ctacttgattggcacatacaccttgataaatctcttcctgcacctttgggtaccataggt gcttggctctatagagcagaggctgctctgagggaagaagtaactattcaccaagctcat gaggaaacagcaaatacaatacaccggaagcttgaacaacataaggatctgcttaaaaac atagatggtcacaaaaaggcattccatgagatccacggggccaggtctgttaacggagtg cctgttccacctgaccaattagaggatatggcagagaggtttaattttgttgtctcttca tctgagctccatctgttgaagatggagtttctggaactgaagtaccgtctactgtcactc ttagtccttgcagaatcaaagttaaaatcatggattatcaaatatggaaggcgagagtcg gtggaactacttcttcaaaattatatttctgttattgaaaatagtaagttctttgagcag tatgacgttacttaccagatcttgaaaagagcagctgaaatgtatgccaaagcaaatggt tcagtggaagaagttgagaatgtgatgaaattcatgagtgaaacaacagcacagtggaga aacctctcagtagaggtgaggagtgtaagaagcatgttggaagaagtaattgctaattgg gacagatatagcagcactgtggcaggtctacaagcttggctggaagatgctgaaaaaatg ctgaatgagcctgaacattctaaaaaggatttcttccggcacttacctcattggatccaa cagcacacagccatgaatgatgctggtaattttctgattgagacatgtgatgagaccatt tccagagaccttaagcagcagcttctgttactaaatggaagatggagagaattgtttatg caagttaagcagtatgctcgagcagatgaactggacaaaatgaaggaggaatacttagat ggtgttgcccatttgacagcttttattgatggaagcaataggaaattttcagtccctgta gaaatgtccttccttgatgtcaaaatgtttgtacaagatttagaaaatattaagcagaaa ttgcctgcaatggaagctcagtacaaaatagttacaagaacagcgcaacttgttacaaag gaagtttcccaagaggaagtgaatgaaatgcttgcaactttgacaaggatcaaagagcag ctgagcaaggttaaggagtattcctgtgccctgctgtatgaatgccagcatctgctgtct ccgctggaagaactggagaaacaaatcacacatttttatgaatctcttgaaaaagtcaat gaaatcatttctatcctggatcctgaagcacaacctacaactgttcttaaacaaaaagcc caagatttggtagcttatcaagaaaactgcaagaaagatttgtccctgattgagagaaat agtcagagtatcctgcagtgtgtggcttcaagtgaagtgttgcagcatttccatcagtca acctttcagaaaaaagttacacaagttcaaattacttttcagaatatggtcaggaaagct ggtgactggagaaaaaacatagaagcaaatagccgtttgatgaagaaatttgaggagtct agagcagagctggagaaagtaatacagattgccaattgttgcttaaaagaaaaaggaaat cctgaagaacttctcaggaaacatagcgaattctttaaccagttggatcagagagtccta aatgcctttctgaaagcatgtgatgaacttactgacatccttccagaacaagagcaacac aacctgcaggaagctgtgagaaaactccataggcagtggaaggatcttcaaacagaagcc ccatatcacttgatccacttgaagattgaagtacagaaaagcaagttcctggtcacagtg gaggagtgcaaagctgaactagctcgacagaacaaggtgttatcaagagaagccaatgaa aggatgatcaaggaacacatgttgttctttggtgacaagggatcttaccagctttgtgcg aaaaggctacaacggattgaagaactgtgccaaaaactgccagtttctgatccagtgagg gttaccttggaaagcagccaacgaatcctgaaggagctcaaatcccagatagacagcaca tatgtaaagttaacagagcactcggacacctggaggggctataagaacagattttctgag ttggcaaattggattttgtcaacagaaagagagctaaagaagataaaggaaagtgtcaat gatactgcccaatacaagcaacttgaagcctctgtgggggaaattaggaagcatattaac aagcaaggagaaaatcacagctggctgaaatctagacttgctgttttgactgcagtatgt cctgatttggaggccaaaaagacagaggatgagctttgtaaactttccagtgacttcaag ggactcctagattttctggctgagattgaaaagactttaggcactgttggagactgtgtc cagtacaaagaagaagttaaaagtgcaattgaagagttaatcagcaactctaaagaagcc caagcagaagctgaaaagatcctggatacagaaagtttattacaagctcagcaactacta cttcatcatcagcaaaggacaaggagactccgtgcaaagaggcaagatgtgcaacaacag atttcccaagctaaacagttgcagattgaaggtggacttcccagcacgatgcaggaggat ttacaaaagttggaaggaacattagagaacatacagcagactatggagaaacgtgaagag caactgcaggtcacaataaataaatgggagcagtttgaaagggacaaaaaaacagtagta aaatatctcaatcaagcaagttctgcacttgaacgtatcttaaactttagcagtttagag agcctctcctcagaactggatcagacaaaggaactttctaaacagactgaagcaatggca gtgcaggctgagaatttggtgaagaattcttctgagatacagcttggttcaaagaacaag cagtcccttcagcagcaggcaaaatcaatccaagaacaagtgaaaaaagtggaagttact cttgaagaagatattaaaagcatggaaatggtgaaaaacaagtgggatcattttggcaat aattttgaagctctgtccatctggatagctgaacaagaaaaagaactggaaaatttggaa acatcatcatctcctttggacatacagatcagccaaatcaaggttattaataaagaaata gatggtaaaataactggcatctcaaaactagaagaggaatctgagtctttttcccagttc 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agacagcatctgttgtctgaaatggagtcgctgaagccaaaagttcacgccgtgcaagtc tgccagagtgccctgaggattcccgaagaggtggtcaccggcctgccactgtgccacagt gctctccggctccaggaggaggccagccgcctgcagcacactgccattcagcagtgcaac atcatgcaggcgacagtggttcagtatgagcaatacgagcaagaaatgaaacatttgcag caaatgatagagagtgcccatcatgagatccaagacaagccaatagcaaccagcaacatt caggaactccaggtccagatttcacgtcatgaggagctggctcagaagatcaaaggatac caggagcaaattgctgctttgaattcgaagtgcaagatgctgacaatgaaagcaaaacat gccaccatgctgctgacagtgacagaagtggaggggctttcagacggaatggaggagctg gattcagacctgctcccagcacaccccactcatccctcggtggttatgatgactgctggt cgctgtcacacgctgctctcccctgtcactgaggagtctggggaggagggaaccaacagt gagatttcttctccacccgtctgtcgctctccctcacctgtggctaatacagatgcttct gttaaccaggacattgcttattaccaagccttatctgctgaacagttgcagacagaagct gctaaaattcaacccagcacttcagccacccaggagttttatgaaccaggcttagaatca gccgctagtgccaaattggatgatttgcagcgttcttgggaaacactgaaaaatgtgatc agtgaaaagcagcgcaccctctatgaagctcttgagcgtcaacagaaatatcaggacaca ctccagtctatatccacaaaaatggagaccattgaggtcaaactaaatgagagtctggaa ccagccaaaagcccggagagccagatggctgaacatcaggctttgatggatgagatttta atgttacaagaagaaatcactgagcttcagacatcattagcccaggagctggtttcagaa ccactggatgcagaagctgccgatcagctggcattgcagtccactctcacagtcttggca gaacggatggccacaattcgaatgaaggcatcaggaaaacgacaactattagaggaaaaa ctgaacgagcagctggaagaacagcggcaagagcaggctcttcaaaggtaccgttgtgaa gctgatgagcttgaccactggctactcaatacccgagcaacgctggacaccgctctggtt actgctgaggagcctatggacatggaagcacagctggtagactgtcagaacatgctggtt gaaatagagcagaaggtggtagccttgtcagagttgtctgtgcacaacgagaacttgctt atggaggggaaggctcacaccaaggacgaggcagagcagctggctgtgaagctcaggacg ctgaagggcagtctcctggagctgcagagagtgctccacgacaaacagatcaacattcgg cagggatcattacaagaaaaggaggagagcaatctggactttatttcctcacaaagcccc agtgtccaagaatggctggcacaagcaagaaccactcgctcacagcaacagcagagcacc ctgcagcaacagaaagagctggaacaagagctagaagagcagaagaatctgcttcggtca gtagcatgccgtggagaagaaatcctaacacagcaaggtgctccagaaggcctatgtata agtgagaagcctgatacactctctgaggaattaggcttggaaggtgagaagccatcacct gaagaacagatgaaggtgaaatgggaaagcctgaaccaggaattcaataccaagcagaga ctgctccagaaaactttggaacaagaacagctgcagctttgtagcagaccaaacagactg atatctggaatgcctttgtataaggaggaaggacaggatgaagacaaatcagtgtcacca gtattggttgaactgaatcaggcctttgaagatgtgtcatctgaggctggacgggtggag gagagcctgcatcttgaacagaagctgtataatggtgtcacagccacctcgttgtggcta gatggtgtggaagaacaggtctttgttgctacagctctgttgccagaggaagaaacagaa acatacctctgcaagcaagagtcacttgccaaagaaatcaaagatgtaacagaagaaatg gataagaacaagaacttatttgctcaggtatttcctgagaatggtgataatagggatatt atagaagacactttggattgtctcctgagaagactgaccttactggagtcagcagtaaac cagagatgccatcagatgaaaggacgactccagcaaatagtgactttcaagaatgatctg aagctcctgtttacatcggtggctgataacaaatacttagttctacagaaactagcagag gcagttgagagaccagaaacagaacaaatgcaggtcatactgcaggcagaagaaggtttg aaggaactagacgctggaatcaatgaattaaagaagcgtgtagacaagctacaaattgac caatcttctgtgcaagagctgtctaagatccaggataagtatgatgagctcatgatgatc attggatccagacggagtgacctgaatcagaatctggctcttaagaggcagtatgaacgg gctttgcaggacctggctgacctggtagaaacaggccaagaaaagatgtctggtggccag aaaatgattgttgcttctaaggaagaggttcgattgttacttgacaaacataaggaatat tttcaggggttggagtctcacatgatcctgacggaaacactctttagaaagatgagtagc tttgctctcttgaaggaaactcagtcacattcagagctaatgacacaagcttcagctgta ttaaagctggctcataaacgaggtgtggagctggaatacattctagagacctggatgcat ctggatgaagattaccagcaacttagcagacagctggagtctgttgaaggtagcatcccc actgttggtttggtggaagagacggaggacaggcttacagatcggattacactttttcag catctgagatctaacctcactgaataccaacctaaattataccaagtgctagatgatggg aaaaggctccttttctctgttagctgttcagatcttgaaagtcagctgaaccaactagga gaatgctggttaagtaacaccagcaaggttaccaaggagcttcacaggctggagacaata ctgaagcactggacaaggtatcagagtgaatcaaatgaattgacacattggttgcaatct gcaaaggagcgactcgagttttggagccagcagtctttgacagttcctcaggaactggaa acagtccgagaccacctgaactcctttttggagttttcaaaagaagtggatgctaaatca tcacagaaatcttctgtcctgagtactgggaaccagctcctcaggctgaagaaggtggat acagcagcactgcgtgcagggttgtcccacattgacagtcagtggacagagctgctcaca caaatcccagcagtacaagagaaattgcaccagctccagatggacaaaattccctctcgc catgctatcactgaagttatgagctggatttccctgatggaaaatgtcattcagcaggat gaagagaacataaaaaatgtagtaggacagaaagtcattcaggattatgtccagaagtac aagggtttcaagatagatttaaattgcaaacaattgacggtagactttgtgaaccaatca gtgctacaaattagcagccaggatgttgaaagtaaacgtagcgacaaaactgattttgct gaacaactcggagcaatgaacagacgttggcagatcctgcaaggcctgataacagaaaag atccagctgttggaaagtctgcaggaatcctggacagaatatgaaaataacgtgcagtgc ctaaaatcttggtttgaaacccaagagaagaagctgaaacagcaacagaaaattggagac caggcttcagtacagaatgctttgaaagactgtcaggaattagaagaagcaataagaaca aaggaaaaagaagtagaaaatgtagaacagagtggtctgtctttgatacagaacaagaag gaagaagtctcttctgctgttatgaatacactgcaagaaattaaccattcctgggccaat ttggatcacatggttagccaactgaagatgttgttgcaatctgttcttgatcagtggagc atttacaaagtgacttatgaagaactgaatagttacctgacagaagccagatattctttg tcccggttttatcttcttactggttctttggaagctgtgaaagtccaagttgataacctt cagagcctacaagatgaattggaaaagcaagaaaatagcttacagaaatttggttctgtg accaatcaattgttgaaagaatgtcacccaccagtgactgaaacacttaccaacactttg aaagaagtgaatatgaggtggaacaaccttctgcaggagactgcagagcggctgcgtgcc agtaagggcctccttcagctgtggcagaggtacaaggactgttaccagcaatgctcttcc actgtccgtcagcgggaagaccaggccaatgaactcctgaagactgccaccagcaaagac attgctgatgaagttactacttggattcaggactgcaatgatgtactcacagatttgaag acagcacaggagtcactggttgttcttcaagaactgggagaagagctaaaaagccaggtg gaggcttcagcagcagccgccatacagtctgatcacctttctctgaaccagaatctgtca accctggaacaggctctccgcaagcaacaggctgtacttcaggctggagtgctggactat caaacctttgccaagagcctgcaagtccttgaggcctggataacagaagcagaagaaata ttgaaaggacaggatcccagtcactcatctgatctctcagcaatacggagtagaatggag gaactcaagagtcagatgttgaagttcagcagcatggccccggatttggaccgtcttaat gagctgggttacaggcttcctctgaatgataaagaaatcaaaaggatgcagaacctgaac agacattggtctctgatctcatctcagactacggagagattcagtaagctgcagtctttc ttgctgcagcagcagaccttcttggagaaatgtgagacttggatggatttattagttcag actgagcagaagctggcggcagagatttcaggaaattaccagagccttttagagcaacag agggcacatgagctattccaggcagagatgttcagccgccagcagattttgcattcgatt atctctgatgggcagcacctcctagaacaaggacaggtggatgacagggatgaatttaat ctgaagctgactcttctaagtaatcaatggcaaggagtaattcgccgggcacagcagagg agggggatcattgacagccagattcatcagtggcaacgctacagggagatggcagagaag ctgcgcaagtggctggtggaaatatcctttcaggcagtgagtgggctgcgcaatgctcct atcccattgcagcaagccagagcgctactggatgaagtgcagcttaaagaaaaagttctc ctaaggcagcaagggagttacatcctcactgtggaagctgggaagcaactgctgctctct gctgacagtggagctgaggcagccctccagacagagcttaccgaaattcaggagcgctgg aagatagttagcaaccaactggagcaacaaaagaaagagcttgctttactactgaaagac tgggaaaaatccgaaaagggcataggagactccctggagaagctcagatcattcaaaaaa aacctttctcagcccttgccagaacaccatgatgagttgcatgctgagcagattcgttgc aaggagttggagaatgctgttgaaggatggacagatgacctcgcacacctctctctgctg aaggagaccctgtctatatatatcagtgcagatgatatctcaatcctcagtgagcgcata gagcttctgcacagacagtgggaagagctgtgccaccaggtctccttacgtcgacaacaa gttagtgagagactgaatgagtgggctgtcttcagtgagaagaacaaggagctctgtgag tggctgacacaaatggaaagtaaggtttctcaaaatggtgacatcctcatagaagaaatg attgagaaacttaaaaaggattatcaagaggaaattgctgtagcccagaagaacaaaacc cagctccagcaaatgggagagcgacttgctaaagccagccatgagagtaaggcatcagag attgagtacaaactcggcaagattaatgacaggtggcaacatcttctagatcttattgca gccagggtaaagaagttgaaggagaccctcgttgcagtgcagcagctggataaaaacatg agtagcctgagatcttggcttgcccacattgagtcagagctgtccaaacctattgtctac gaaacttgtgactctgaggagatacaaaggaagctaaatgaacagcaggaacttcagagg gacatagagaaacacagcactggagtggcatctgttctcaatctgtgtgaagtgctgctt catgactgtgatgcttgtgccacggaagcagagtgtgactctatccagcaggctacacgc aatctggacagaaggtggaggaacatttgtgcaatgtcaatggaaaggcgacttaaaatt gaagagacatggcggctatggcaaaagtttttggatgactactctagatttgaagactgg ctaaaaatctctgagaggacagctgctttcccaagctcctctggtgtgctttacacggtt gctaaggaagaactgaagaaatttgaggccttccagagacaagtgcatgaaagtctgact cagctggaactgatcaataaacagtatcgccgcctggcccgagagaaccgcactgactct gactgcagcctcaagcagatggttcatgaggggaaccagagatgggacaacttacaaaag agagttacctccatcttgcgcaggctaaaacattttattggccagcgtgaggagtttgag acagcacgtgatagcatcctggtatggctaacagagatggacctgcagctgaccaacatt gagcatttctcagagtgtgatgtccaagcaaagataaagcaacttaaggctttccagcaa gaaatttcactgaacaacaacaaaattgagcagataattgtgcagggtgagcaactcatt gagaaaagtgagcccatggatgcagctgtcattgaagaagaattagatgagctgcgtcgt tactgtcaagaggtctttggacgtgtggaacgctatcacaagaaactcatccaccttcct ctgacagatgacgaacacgacctctctgacagggaggtggatctggatgaatcagcagat ctctctgacatacactggcatgacaaatctgcggacagcgttctctccccgcacccctct tccaacctttcgctgcctctttcccagccggtgagaagcgagcgatcagggcgagatacc cctgcaagcgtggactccattcccctggagtgggatcatgactacgacttaagcagagac ctggagacagccgtttcacaggcactgcactctgaggaagaagacggaggacaagagaag gacttctacctgagaggagcagctggtatagcagatgtagagatccctgaaactcttgag gcctatgtaacactcacagaaaacgcactcaaaaatatctctggagaacctggtgccctg gaagcacatatccgacagctggacaaggccttagacaccagtcgtttccaaatacagcaa acagaaaacatcatccgcagcaaaacacctacaggaccagagctggattccagttacaaa ggctatatgaagctactaggggagtgcagtggaagcatagaatcagtaaaaaggcttgga tataaactgaaagaggaagaagaaaaattatctggacttattaacctgaacagtactgaa acacaaacagctggtgtaattgaccgatgggaattaattcaggctcaagctctaagcaag gagctgaggatgaagcaaaaccttcagcaatggcagcagtttaactctgaccttaatagc atttgggcttggctgggagaaactgaagaggaactggagacgctccgccgccttgatctc agcactgacatacaaactattgagctcagaattaaaaaactgaaagagctgcagaaagca attgataaccgcaaagccatcatcttatccatcaatctgtgcagctcagagttcactcag tctgacagtgaagagagcaagaagcttcaagagcgcctgtctcagatgaatgtgcgctgg gaccacgtatgcaatatgattgaagagtggcgctcctcgttgcaggatgcattaatgcag tgccaggatttccatgaaatgagccatggtttgctgctttggttagagaatattgacaga aggaaaaatgagattgtgcccatcaatccaaacctggactcagaaatcctgcaggagcat cacagacttctaatgcaaatcagacgtgaactgctggagtctcagttgaaggtggcgtca ctgcaagatatgtcctgccaattgctagtcaatgctgaaggcaaggattgtcttgaagcc aaagaaaaggtgcatgtcattggaaacagactgaagctcctcttgaaagaggtcacccgt catattaaagacctagagaaaattctagacatttcaagtagtcaactggaattgtcctca tggtcctctgctgatgaattggacacatcaggctcagtgagtcctgtatctggaagaagc actccaagcagacagagaacgccacggggcaaatgtagtctctcacagcctggaccctct gtcagcagtccacatagcaggtccataagaggtggctcaggttcctccccttctgaggct gggccagcatggcggcacccgtcgttcttcctcagagtcctcagagctgctctgccactt cagctcctcttgctgctcctgatcgggctggcttgcctggtgccgatgaccgaggaggac tacagctgtactatggccaacaactttgcccgctctttccaccccatgctaaaatacatg aatggtccacctccattatga

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