Harpia harpyja (harpy eagle): 128152004
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Entry
128152004 CDS
T10541
Symbol
GCLC
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit isoform X1
KO
K11204
glutamate--cysteine ligase catalytic subunit [EC:
6.3.2.2
]
Organism
hhar Harpia harpyja (harpy eagle)
Pathway
hhar00270
Cysteine and methionine metabolism
hhar00480
Glutathione metabolism
hhar01100
Metabolic pathways
hhar01240
Biosynthesis of cofactors
hhar04216
Ferroptosis
Module
hhar_M00118
Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:
hhar00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
128152004 (GCLC)
09106 Metabolism of other amino acids
00480 Glutathione metabolism
128152004 (GCLC)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
128152004 (GCLC)
Enzymes [BR:
hhar01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.2 glutamate---cysteine ligase
128152004 (GCLC)
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Motif
Pfam:
GCS
GCS2
SANT_DAMP1_like
Motif
Other DBs
NCBI-GeneID:
128152004
NCBI-ProteinID:
XP_052665884
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Position
15:complement(26550276..26605599)
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AA seq
645 aa
AA seq
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MGLLSQGSPLSWEDTRRHAEHVRKHGILQFLHIYRALRDRHKDVLKWGDEVEYMLVKFDH
ENKKVRLVLCGEEVLQTLQDKGEKVNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
QDNMRKRRQEAASVLKENEAVCTVTSFPSLDLIVVLHRLGCPGFTLPEYEPTPVEGGASK
SLFFPDEAINKHPRFSTLTRNIRHRRGEKVVINVPIFKDKNTPSPFIETFPNDDGEAAKA
AKPDYIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYV
SDIDCRWGVISASVDDRTREERGLEPLKNNHYRISKSRYDSIDSYLSECGEKYNDIDLTI
DKDIYEHLIKEGIDHLLAQHIAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMR
FKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENM
KMAQKRDAVRQGMFYFRKDICKGGNTVVDGCGSAQNGTGTDTEEYTLMSIDTIINGKEGV
FPGLIPILNSYLENMEVDVDTRCTILNYLKLIKKRASGELMTVARWMREFIAQHPDYKQD
SMITDEMNYSLIWKCNQIAQGQAECPELLGVGFNKKQSGNKTGSL
NT seq
1938 nt
NT seq
+upstream
nt +downstream
nt
atggggctgctgtcgcagggctcgccgctgagctgggaggacacgcggcggcacgcggag
cacgtgcggaagcacggcatcctccagttcctccacatctaccgcgccctgcgcgaccgc
cacaaggacgtcctcaagtggggcgacgaggtggaatatatgttagtaaaatttgaccat
gagaataagaaagtgcgcttggtgctctgcggtgaagaagttcttcaaacactgcaagac
aagggggagaaggtaaaccccaaccacccaacactctggcgaccagaatatggaagctac
atgatagaagggacgcctgggcagccgtatgggggaaccatgtctgaattcaacaccgtg
caagacaacatgagaaaaagacggcaagaggctgcttctgtgctcaaagaaaatgaggct
gtttgtactgtgacgtcatttccaagcttggatctcattgttgtgttacataggttaggg
tgtcctgggtttacgctgccggaatatgagccaacgccagtagaaggaggagcttcaaaa
tcccttttttttccagatgaagccatcaataaacatcctagatttagtacactgaccaga
aacattcggcaccgaagaggagagaaggttgtgataaatgtaccaatatttaaagataag
aacacaccatcaccgtttatcgaaacgtttcctaatgatgatggagaagcagcaaaggcg
gctaagccagactatatatacatggatgctatggggtttggaatgggaaactgctgtctt
caggtaacattccaggcttgcagcatttctgaagcgaggtatctctatgatcagctagcc
acgatctgtcccattgtgatggcattgagtgctgcatctccattctacagaggctacgtg
tctgatattgactgtcgctggggagtgatctctgcatctgtagatgatcgaacgcgagaa
gagagggggctagagccactgaagaacaaccattatagaatcagtaaatccagatatgat
tccatagacagttatctatctgaatgtggtgagaaatacaatgacattgatttgacaata
gacaaagatatctacgagcacctaataaaggaaggtattgaccaccttttggcacagcat
attgcacacttgttcattcgagacccattgactttgtttgaggagaaaatacatctagat
gatgcaaatgaatccgaccattttgagaatattcagtctacaaactggcagacaatgagg
tttaagccacctcctccaaattcagatattggctggagagtggaattcagacctatggag
gtccagttaacagactttgaaaactctgcatatgttgtgttcgtggtactgctaaccaga
gtgattctgtcatataaactggattttctcattcctttgtccaaggtggatgaaaacatg
aagatggcccagaaaagagatgctgtccggcagggaatgttttacttcagaaaagatatt
tgcaaaggtggaaacactgttgtggatggatgtggctctgcacagaatgggacaggcacc
gacacggaagagtacaccttaatgagtattgatacaattatcaatgggaaggaaggagtc
tttcctggtttgatcccaattttgaattcctatcttgaaaacatggaagtggatgtggac
acaagatgcaccatcctaaactacctgaagctaataaaaaagagagcatctggagagtta
atgacagttgctcggtggatgagggaatttatcgcacagcatccagactacaagcaagat
agcatgataactgatgaaatgaattacagccttatttggaaatgcaaccaaatcgcacaa
ggccaggcagagtgtcctgaactattgggggtaggatttaacaagaaacaaagtggaaac
aaaactggctctttgtaa
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