KEGG   Harpia harpyja (harpy eagle): 128153148
Entry
128153148         CDS       T10541                                 
Symbol
PLCB2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
hhar  Harpia harpyja (harpy eagle)
Pathway
hhar00562  Inositol phosphate metabolism
hhar01100  Metabolic pathways
hhar04020  Calcium signaling pathway
hhar04070  Phosphatidylinositol signaling system
hhar04081  Hormone signaling
hhar04082  Neuroactive ligand signaling
hhar04261  Adrenergic signaling in cardiomyocytes
hhar04270  Vascular smooth muscle contraction
hhar04310  Wnt signaling pathway
hhar04371  Apelin signaling pathway
hhar04540  Gap junction
hhar04621  NOD-like receptor signaling pathway
hhar04912  GnRH signaling pathway
hhar04916  Melanogenesis
Module
hhar_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:hhar00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    128153148 (PLCB2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    128153148 (PLCB2)
   04371 Apelin signaling pathway
    128153148 (PLCB2)
   04020 Calcium signaling pathway
    128153148 (PLCB2)
   04070 Phosphatidylinositol signaling system
    128153148 (PLCB2)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    128153148 (PLCB2)
   04081 Hormone signaling
    128153148 (PLCB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    128153148 (PLCB2)
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    128153148 (PLCB2)
  09152 Endocrine system
   04912 GnRH signaling pathway
    128153148 (PLCB2)
   04916 Melanogenesis
    128153148 (PLCB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    128153148 (PLCB2)
   04270 Vascular smooth muscle contraction
    128153148 (PLCB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hhar04131]
    128153148 (PLCB2)
Enzymes [BR:hhar01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     128153148 (PLCB2)
Membrane trafficking [BR:hhar04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    128153148 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    128153148 (PLCB2)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2
Other DBs
NCBI-GeneID: 128153148
NCBI-ProteinID: XP_052668034
LinkDB
Position
16:complement(32886688..32948047)
AA seq 1208 aa
MSMLNPVLQPPEVKEYLSKGERFIKWDDETASASPVILRVDPKGFYLYWTNQNKEMEILD
ITSIRDTRVGRYAKIPKCQKLREVFNLDYPHSTFLLKTLTIVSGPDMVDLTFHNFVSYKE
NVGKSWAEDIMAIVRNPLTYNASRYTFLEKILVKLKMQLNAEGKIPVRNIFQMFPADRKR
VEAALTACHLPKGKNDAINPEDFPETVYKTFLMNLCPRPEIDEIFTSHHLKAKPYMTKEH
LAKFINKKQRDSRLNDILFPPAKPEQVQSLIEKYEPSGINIQRGQLSPEGMVWFLCGPEN
NVIALDKLQLYQDMTQPLSHYFINSSHNTYLTAGQFSGISSPEMYRQTLLAGCRCVELDC
WKGRPPDEEPIITHGFTMTTEILFKDAIEAIAESAFKTSLYPVILSFENHVDSPKQQAKM
AEYCRTIFGDMLLTEPLEKYPLKPGVPLPSPKDLLGKILIKNKKNQSISGKRQNSLKKGR
NVEPEIIEQPAPMDAEVWAGDGAEEEPEEEDVLLGNLDEEEIKKMQSDEGTAGLEVTAYE
EMSSLVNYIQPIKFDSFEVSAQKNRSYVISSFTELKAYDLLTKFPTQFVEYNKRQMSRIY
PKGTRMDSSNYMPQMFWNVGCQMVALNFQTMDVPMQQNMALFEFNGQCGYLLKHEFMRRP
DKQFDPFSVDRMDVVVASTLSVTILSGQFLSDRSVKTYVEVELFGLPRDTKRKYRTKLTS
TANSINPVWKEEAFVFEKIMMPELASLKIAAWEEGGKFIGHRVIPVIAVHSGYHHVCLRS
ESNMPLTMPSLFVYLEIKDYVPDAWADLTIALSNPIKFFSLQDKRSVQLKDGSVERLGTQ
RNFPSAETNGIPDSTGKFSTPLSNGPAGAAAFAKDENVIEVMQIAEPQTASLIELQQMKL
FLKLLKKQEKELRELERKGSKRREELLQKYSVLFSDPVCYGCKKRMIHTRKTQKKRSLTT
GDVGTCANPVEMAESIDSRILELRERLEMDLIHLGEEHHDGIRRKKEQHATEQVTKIIEL
AREKQTAELKALKESSESNIKDIKKKLEAKRVDRIQTMMRNTSDKAAQERLKKEINNSHI
QEVVQTIKLVTQKTARYQQKLEEKQADNLRTIKEKESQLQQEALAEYEEKLKMLNMEVQE
MVKNYVKPGFPGEPEMQKEAVQSVPEGEQGSTEQLKDKIPVAEVSRLTIAVPEPPGAETD
VEIEESIF
NT seq 3627 nt   +upstreamnt  +downstreamnt
atgtcaatgcttaaccctgtcctgcagcccccagaggtgaaggagtatctatccaagggt
gagcgcttcatcaaatgggatgatgaaacagcaagtgcttctcctgtgattcttcgagtg
gatccaaagggattttacttatactggacgaatcagaataaggaaatggaaattttggat
ataaccagcatcagagatacccgagtggggcgatatgccaaaattcccaagtgccagaag
ctccgagaggtttttaacttggattaccctcacagcaccttcctgcttaagactctgact
attgtatctggccctgacatggttgacctcactttccataactttgtgtcctacaaggag
aatgttggcaagagctgggctgaggatattatggccattgttcggaatcccctcacatac
aacgcttctcggtacaccttcctagagaaaatcctggtgaagctgaagatgcagcttaat
gcagaggggaaaattcctgtcaggaatatttttcagatgtttcctgcagacaggaagagg
gttgaagcagcattaaccgcttgtcatcttccaaagggcaagaatgatgccatcaaccca
gaggacttccctgagacagtgtataaaactttcctcatgaatctgtgtccacggcctgag
attgatgagatatttacctcacaccatttaaaagcaaagccctacatgaccaaagagcac
ttggcaaagtttatcaacaagaagcagcgagactctcgcctcaatgacatcctcttccca
ccagccaaacctgagcaggtgcagagcctgatagagaagtatgagcccagtgggattaac
atccagagagggcagttgtctccagaggggatggtctggtttctctgtggccctgagaac
aatgtgatagcactggacaaattgcagctgtaccaggacatgacccagccactctcacac
tacttcatcaattcatcacacaacacatatttaacagctggtcagttttctgggatctca
tctcctgaaatgtatcgccagacgctgctggctggctgccgctgcgtggagctggattgc
tggaagggccgtcccccggatgaggagccaatcatcactcatgggttcaccatgacaact
gagatcctcttcaaggatgccattgaggccattgcagaaagtgcttttaaaacatctctc
taccctgtcatcctgtcctttgagaaccatgtggactcgcccaagcagcaggcgaagatg
gctgagtactgccgaaccatatttggagatatgctgctgacagagccgctggaaaaatac
ccactgaagccaggagttcctctgccaagtcctaaggatctcttagggaaaatcttgatt
aagaacaaaaagaaccaatctatatctgggaagaggcagaactctctgaagaaagggagg
aatgtggaaccagaaatcatcgagcagccagcccctatggatgctgaagtctgggcaggt
gatggggctgaagaggaaccggaggaagaggatgtacttcttggaaacctggatgaagag
gaaattaaaaagatgcagtcagatgagggcactgctggtttggaagtgacagcgtatgag
gaaatgtccagcctagttaattacatacagcctatcaaatttgactcctttgaagtctct
gcccagaagaaccggagttacgtcatctcttccttcacagagctgaaggcttacgatcta
ctaaccaagttccctacacagtttgtagaatacaacaagcgacagatgagccggatttac
cccaaaggcacccggatggactcctctaattacatgccccagatgttctggaatgtcggc
tgtcagatggtggcactgaacttccagaccatggatgtccctatgcagcagaacatggct
ctgtttgagttcaatggccagtgtggctatctgctcaagcatgaattcatgcggcgtcca
gacaagcagtttgaccccttctctgtggaccgcatggacgtggtggtggcaagtaccctg
tctgtcacgatactctctggtcagttcctctcagaccgcagtgtgaagacatatgtggaa
gtagagctgttcgggttgccaagggacacaaaacgcaaatacagaaccaaactgacctcc
actgctaattccattaaccctgtgtggaaagaggaggcttttgtttttgaaaagatcatg
atgcctgagttggcgtctctcaaaattgcggcttgggaggaaggagggaagttcattggt
catcgtgtcattcctgttattgcagtgcattcaggctatcaccatgtttgtctccgcagt
gaaagtaacatgccactcaccatgccttctctatttgtgtacctggaaataaaggactat
gttcctgatgcttgggcagatctgactattgctctctccaaccccattaagttcttcagt
ctgcaagacaaaagatcagttcagctaaaagatggctcggtggagaggcttggcacacag
aggaacttcccatctgctgaaactaacgggataccagactccactgggaaattcagcact
cctctttctaatggtcctgcaggagcagcggcatttgccaaggacgaaaatgtgatagaa
gtgatgcagattgcagagcctcagacggccagcctcatagaactgcagcagatgaagctg
tttctgaagctgctgaagaaacaggagaaggaactgagggagttggagcggaaaggaagt
aaacggagggaggagctgctgcagaaatactctgtactcttttcagaccctgtctgctat
ggatgcaagaaaaggatgatacacactaggaagacacagaagaagaggagtttgacaaca
ggtgatgttggtacatgtgcaaatcctgtagaaatggctgaaagcatcgatagccgaatt
ttggaactgagagagaggctggagatggacctcatccacctgggagaggaacaccatgat
gggattcgaagaaagaaagagcagcatgcaacagagcaagttaccaagataatagagcta
gccagagagaagcagacagctgagctgaaggcactgaaggagtcatcagaaagcaacatt
aaagacattaagaagaagctggaggcaaagagagtggaccgaatccaaaccatgatgagg
aatacaagtgacaaggctgctcaggagaggttgaagaaagaaattaataactctcacatt
caggaagtggtgcaaacaatcaaactggtgacacaaaagacagccaggtatcagcagaaa
ctggaagagaagcaggcagacaatctgagaacaatcaaggagaaagaaagtcagctccag
caggaggcactggcagagtatgaggagaaattgaaaatgctgaatatggaggtgcaggag
atggtgaagaactacgtgaaaccaggctttcctggagagccagagatgcagaaggaagca
gttcagagcgttcctgagggagaacaagggtctacagaacaactgaaagacaagatccca
gtggcagaggtgtcaaggctcacaatagccgtgcctgagcccccaggagctgaaacagat
gttgagattgaagaaagcatattctga

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