KEGG   Hyaena hyaena (striped hyena): 120220979
Entry
120220979         CDS       T07257                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
hhv  Hyaena hyaena (striped hyena)
Pathway
hhv00562  Inositol phosphate metabolism
hhv01100  Metabolic pathways
hhv01521  EGFR tyrosine kinase inhibitor resistance
hhv01522  Endocrine resistance
hhv01524  Platinum drug resistance
hhv04012  ErbB signaling pathway
hhv04014  Ras signaling pathway
hhv04015  Rap1 signaling pathway
hhv04024  cAMP signaling pathway
hhv04062  Chemokine signaling pathway
hhv04066  HIF-1 signaling pathway
hhv04068  FoxO signaling pathway
hhv04070  Phosphatidylinositol signaling system
hhv04071  Sphingolipid signaling pathway
hhv04072  Phospholipase D signaling pathway
hhv04081  Hormone signaling
hhv04140  Autophagy - animal
hhv04150  mTOR signaling pathway
hhv04151  PI3K-Akt signaling pathway
hhv04152  AMPK signaling pathway
hhv04210  Apoptosis
hhv04211  Longevity regulating pathway
hhv04213  Longevity regulating pathway - multiple species
hhv04218  Cellular senescence
hhv04360  Axon guidance
hhv04370  VEGF signaling pathway
hhv04380  Osteoclast differentiation
hhv04510  Focal adhesion
hhv04550  Signaling pathways regulating pluripotency of stem cells
hhv04611  Platelet activation
hhv04613  Neutrophil extracellular trap formation
hhv04620  Toll-like receptor signaling pathway
hhv04625  C-type lectin receptor signaling pathway
hhv04630  JAK-STAT signaling pathway
hhv04650  Natural killer cell mediated cytotoxicity
hhv04660  T cell receptor signaling pathway
hhv04662  B cell receptor signaling pathway
hhv04664  Fc epsilon RI signaling pathway
hhv04666  Fc gamma R-mediated phagocytosis
hhv04668  TNF signaling pathway
hhv04670  Leukocyte transendothelial migration
hhv04722  Neurotrophin signaling pathway
hhv04725  Cholinergic synapse
hhv04750  Inflammatory mediator regulation of TRP channels
hhv04810  Regulation of actin cytoskeleton
hhv04910  Insulin signaling pathway
hhv04914  Progesterone-mediated oocyte maturation
hhv04915  Estrogen signaling pathway
hhv04917  Prolactin signaling pathway
hhv04919  Thyroid hormone signaling pathway
hhv04923  Regulation of lipolysis in adipocytes
hhv04926  Relaxin signaling pathway
hhv04929  GnRH secretion
hhv04930  Type II diabetes mellitus
hhv04931  Insulin resistance
hhv04932  Non-alcoholic fatty liver disease
hhv04933  AGE-RAGE signaling pathway in diabetic complications
hhv04935  Growth hormone synthesis, secretion and action
hhv04960  Aldosterone-regulated sodium reabsorption
hhv04973  Carbohydrate digestion and absorption
hhv05010  Alzheimer disease
hhv05017  Spinocerebellar ataxia
hhv05020  Prion disease
hhv05100  Bacterial invasion of epithelial cells
hhv05132  Salmonella infection
hhv05135  Yersinia infection
hhv05142  Chagas disease
hhv05146  Amoebiasis
hhv05160  Hepatitis C
hhv05161  Hepatitis B
hhv05162  Measles
hhv05163  Human cytomegalovirus infection
hhv05164  Influenza A
hhv05165  Human papillomavirus infection
hhv05166  Human T-cell leukemia virus 1 infection
hhv05167  Kaposi sarcoma-associated herpesvirus infection
hhv05168  Herpes simplex virus 1 infection
hhv05169  Epstein-Barr virus infection
hhv05170  Human immunodeficiency virus 1 infection
hhv05171  Coronavirus disease - COVID-19
hhv05200  Pathways in cancer
hhv05203  Viral carcinogenesis
hhv05205  Proteoglycans in cancer
hhv05206  MicroRNAs in cancer
hhv05207  Chemical carcinogenesis - receptor activation
hhv05208  Chemical carcinogenesis - reactive oxygen species
hhv05210  Colorectal cancer
hhv05211  Renal cell carcinoma
hhv05212  Pancreatic cancer
hhv05213  Endometrial cancer
hhv05214  Glioma
hhv05215  Prostate cancer
hhv05218  Melanoma
hhv05220  Chronic myeloid leukemia
hhv05221  Acute myeloid leukemia
hhv05222  Small cell lung cancer
hhv05223  Non-small cell lung cancer
hhv05224  Breast cancer
hhv05225  Hepatocellular carcinoma
hhv05226  Gastric cancer
hhv05230  Central carbon metabolism in cancer
hhv05231  Choline metabolism in cancer
hhv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hhv05415  Diabetic cardiomyopathy
hhv05417  Lipid and atherosclerosis
hhv05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hhv00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    120220979 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    120220979 (PIK3CB)
   04014 Ras signaling pathway
    120220979 (PIK3CB)
   04015 Rap1 signaling pathway
    120220979 (PIK3CB)
   04370 VEGF signaling pathway
    120220979 (PIK3CB)
   04630 JAK-STAT signaling pathway
    120220979 (PIK3CB)
   04668 TNF signaling pathway
    120220979 (PIK3CB)
   04066 HIF-1 signaling pathway
    120220979 (PIK3CB)
   04068 FoxO signaling pathway
    120220979 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    120220979 (PIK3CB)
   04072 Phospholipase D signaling pathway
    120220979 (PIK3CB)
   04071 Sphingolipid signaling pathway
    120220979 (PIK3CB)
   04024 cAMP signaling pathway
    120220979 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    120220979 (PIK3CB)
   04152 AMPK signaling pathway
    120220979 (PIK3CB)
   04150 mTOR signaling pathway
    120220979 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    120220979 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    120220979 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    120220979 (PIK3CB)
   04218 Cellular senescence
    120220979 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    120220979 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    120220979 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    120220979 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    120220979 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    120220979 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    120220979 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    120220979 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    120220979 (PIK3CB)
   04660 T cell receptor signaling pathway
    120220979 (PIK3CB)
   04662 B cell receptor signaling pathway
    120220979 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    120220979 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    120220979 (PIK3CB)
   04670 Leukocyte transendothelial migration
    120220979 (PIK3CB)
   04062 Chemokine signaling pathway
    120220979 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    120220979 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    120220979 (PIK3CB)
   04929 GnRH secretion
    120220979 (PIK3CB)
   04915 Estrogen signaling pathway
    120220979 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    120220979 (PIK3CB)
   04917 Prolactin signaling pathway
    120220979 (PIK3CB)
   04926 Relaxin signaling pathway
    120220979 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    120220979 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    120220979 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    120220979 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    120220979 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    120220979 (PIK3CB)
   04722 Neurotrophin signaling pathway
    120220979 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    120220979 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    120220979 (PIK3CB)
   04380 Osteoclast differentiation
    120220979 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    120220979 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    120220979 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    120220979 (PIK3CB)
   05206 MicroRNAs in cancer
    120220979 (PIK3CB)
   05205 Proteoglycans in cancer
    120220979 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    120220979 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    120220979 (PIK3CB)
   05203 Viral carcinogenesis
    120220979 (PIK3CB)
   05230 Central carbon metabolism in cancer
    120220979 (PIK3CB)
   05231 Choline metabolism in cancer
    120220979 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    120220979 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    120220979 (PIK3CB)
   05212 Pancreatic cancer
    120220979 (PIK3CB)
   05225 Hepatocellular carcinoma
    120220979 (PIK3CB)
   05226 Gastric cancer
    120220979 (PIK3CB)
   05214 Glioma
    120220979 (PIK3CB)
   05221 Acute myeloid leukemia
    120220979 (PIK3CB)
   05220 Chronic myeloid leukemia
    120220979 (PIK3CB)
   05218 Melanoma
    120220979 (PIK3CB)
   05211 Renal cell carcinoma
    120220979 (PIK3CB)
   05215 Prostate cancer
    120220979 (PIK3CB)
   05213 Endometrial cancer
    120220979 (PIK3CB)
   05224 Breast cancer
    120220979 (PIK3CB)
   05222 Small cell lung cancer
    120220979 (PIK3CB)
   05223 Non-small cell lung cancer
    120220979 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    120220979 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    120220979 (PIK3CB)
   05161 Hepatitis B
    120220979 (PIK3CB)
   05160 Hepatitis C
    120220979 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    120220979 (PIK3CB)
   05164 Influenza A
    120220979 (PIK3CB)
   05162 Measles
    120220979 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    120220979 (PIK3CB)
   05163 Human cytomegalovirus infection
    120220979 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    120220979 (PIK3CB)
   05169 Epstein-Barr virus infection
    120220979 (PIK3CB)
   05165 Human papillomavirus infection
    120220979 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    120220979 (PIK3CB)
   05135 Yersinia infection
    120220979 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    120220979 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    120220979 (PIK3CB)
   05142 Chagas disease
    120220979 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    120220979 (PIK3CB)
   05017 Spinocerebellar ataxia
    120220979 (PIK3CB)
   05020 Prion disease
    120220979 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    120220979 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    120220979 (PIK3CB)
   05415 Diabetic cardiomyopathy
    120220979 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    120220979 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    120220979 (PIK3CB)
   04931 Insulin resistance
    120220979 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    120220979 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    120220979 (PIK3CB)
   01524 Platinum drug resistance
    120220979 (PIK3CB)
   01522 Endocrine resistance
    120220979 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hhv04131]
    120220979 (PIK3CB)
Enzymes [BR:hhv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     120220979 (PIK3CB)
Membrane trafficking [BR:hhv04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    120220979 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 120220979
NCBI-ProteinID: XP_039074137
LinkDB
Position
Unknown
AA seq 1070 aa
MCFSFIMPPAMADILDIWAVDSQLASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRIKMRKFSEEKIQSLVGLSWMDWLKQTYPPEH
EPCILENLEDKLYGGKLIVAVHFENCQDVFSFQISPNMSPIKINELAIQKRLTIHGKEDE
VSPSDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFMLVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKMRIISHVWENNNPFQIVLVKGNKLNTEESVKVHVRAGLFHG
TELLCKTIVSSEISGKNDHIWNEPLEFDINTCDLPRMARLCFAIYAVLDKVKTKKSTKTI
NPSKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLQQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAMKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEDEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttcagtttcataatgcctcctgctatggcagacatccttgacatctgggcagtg
gattcacagttagcgtctgatggctccatacctgtggatttccttttgcccactgggatt
tatattcagttggaggttcctcgggaagctaccatttcctatattaaacagatgttatgg
aagcaagttcacaattacccaatgtttaacctccttatggaaattgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggagcttgaagatgaaacaagaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctgcatgaatttgatgcactg
aaggatcctgaagtgaatgaattccgaataaaaatgcgcaaattcagtgaagaaaagatt
cagtctcttgtgggattgtcttggatggactggctaaaacagacatatccaccagaacat
gaaccgtgtatccttgaaaacttagaagataaactttatggaggaaagctcattgtggct
gttcattttgaaaattgtcaggatgtgtttagctttcagatatctcctaatatgagtcct
atcaaaataaatgaacttgcaatccaaaaacgtttgactattcatggaaaagaagatgaa
gttagcccctctgactatgtgttacaagtcagtgggagagtagaatatgtgtttggtgat
cacccactaattcagttccagtatatccggaactgtgtaatgaacaggaccttgccccat
tttatgcttgtggaatgttgcaagatcaagaagatgtatgaacaggaaatgattgccata
gaggctgccataaatcgaaattcatcaaaccttcctcttcctttaccaccaaagaaaatg
cgaattatatctcatgtttgggaaaataacaaccctttccaaattgtcttggttaaggga
aataaacttaacacagaagaaagtgtaaaagttcatgtcagggctggcctttttcatggt
accgaactcctgtgtaaaaccattgtaagctcagagatatcagggaaaaatgaccacatt
tggaatgaaccactggaatttgatataaatacttgtgacctgccacgaatggctcgatta
tgttttgctatttatgcagttttggataaagtgaaaacgaaaaaatcgactaaaactatt
aatccatctaagtatcagaccatccggaaatctgggaaagtgcattatcctgtagcttgg
gtaaatacaatggtttttgactttaaaggacagttgagatctggagacataatattgcac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcag
acaaatccatatactgaaaatgcaacagccttgcatatcaaattcccggagaataaaaaa
caaccttattattatcctccctttgataagataatcgaaaaggcagctgagattgcaagc
agtgacagtgctaatgtatcaagtcgaggtggaaaaaagtttcttgctgtactgaaagaa
atcttggacagggatcctttgtctcaactgtgtgagaacgaaatggatcttatttggact
ttgcgacaagattgcagagagaatttcccacagtcactgccgaaattactgctgtcgatc
aagtggaataaacttgaggatgttgctcagcttcaagcactacttcagatttggcctaaa
ctgcccccccgggaggccttggagcttctagatttcaactatccggatcaatatgtgcga
gagtatgctgtgggctgcttgcaacagatgagtgatgaagaactctctcagtatctttta
caactggtgcaagttttaaaatacgagcctttccttgactgtgccctctcaagattcctg
ttagaaagagcacttggtaaccggaggatagggcagtttctgttttggcaccttaggtca
gaagtgcatattcctgctgtgtcagtacagtttggtgtcatccttgaagcatactgccgg
ggaagtgtagggcacatgaaagtgctttctaagcaggttgaagcactcaataaattaaaa
actttaaatagtttaatcaaactgaatgcaatgaagttaaacagagccaaagggaaggag
gccatgcatacttgtttaaaacagaatgcttaccgggaagccctctctgacctgcagtcg
cctctgaatccttgtgtcatcctctcagaactctatgttgagaagtgtaaatacatggat
tccaaaatgaagcctttgtggctcgtttacaacaacaaagtgtttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaagatatgttgacactccagatgttg
cgcttgatggatttactttggaaagaagctggtctggatcttcggatgctgccttatggc
tgtttagcaacaggagaccgatctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgcggcagcagccttcaacaaagacgcc
cttctgaactggcttaaagaatacaactctggggatgacctagatcgagccattgaagag
tttaccttgtcctgtgccggctactgtgtagcttcttacgtccttgggattggtgataga
catagtgacaacatcatggtcaaaaaaaccggccagctcttccacattgactttggacat
atacttggaaatttcaagtctaaatttggcattaaaagggaacgagtgccttttattctt
acctatgatttcattcatgtgattcaacaaggaaaaacaggaaatacagaaaaatttggc
cgtttccgccagtgttgtgaggatgcatatctgattttacgacgtcacgggaatctcttc
atcactctttttgcactgatgttgactgcagggcttcctgagctcacatcagtcaaggat
atacagtatcttaaggactctcttgccttagggaagagtgaagatgaagcactcaagcaa
tttaagcaaaaatttgatgaggcactcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

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