KEGG   Hyaena hyaena (striped hyena): 120221655
Entry
120221655         CDS       T07257                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
hhv  Hyaena hyaena (striped hyena)
Pathway
hhv01521  EGFR tyrosine kinase inhibitor resistance
hhv01522  Endocrine resistance
hhv04010  MAPK signaling pathway
hhv04012  ErbB signaling pathway
hhv04014  Ras signaling pathway
hhv04015  Rap1 signaling pathway
hhv04022  cGMP-PKG signaling pathway
hhv04024  cAMP signaling pathway
hhv04062  Chemokine signaling pathway
hhv04066  HIF-1 signaling pathway
hhv04068  FoxO signaling pathway
hhv04071  Sphingolipid signaling pathway
hhv04072  Phospholipase D signaling pathway
hhv04114  Oocyte meiosis
hhv04140  Autophagy - animal
hhv04148  Efferocytosis
hhv04150  mTOR signaling pathway
hhv04151  PI3K-Akt signaling pathway
hhv04210  Apoptosis
hhv04218  Cellular senescence
hhv04270  Vascular smooth muscle contraction
hhv04370  VEGF signaling pathway
hhv04371  Apelin signaling pathway
hhv04380  Osteoclast differentiation
hhv04510  Focal adhesion
hhv04517  IgSF CAM signaling
hhv04519  Cadherin signaling
hhv04540  Gap junction
hhv04550  Signaling pathways regulating pluripotency of stem cells
hhv04613  Neutrophil extracellular trap formation
hhv04620  Toll-like receptor signaling pathway
hhv04650  Natural killer cell mediated cytotoxicity
hhv04660  T cell receptor signaling pathway
hhv04662  B cell receptor signaling pathway
hhv04664  Fc epsilon RI signaling pathway
hhv04666  Fc gamma R-mediated phagosome formation
hhv04668  TNF signaling pathway
hhv04720  Long-term potentiation
hhv04722  Neurotrophin signaling pathway
hhv04725  Cholinergic synapse
hhv04726  Serotonergic synapse
hhv04730  Long-term depression
hhv04810  Regulation of actin cytoskeleton
hhv04910  Insulin signaling pathway
hhv04912  GnRH signaling pathway
hhv04914  Progesterone-mediated oocyte maturation
hhv04915  Estrogen signaling pathway
hhv04916  Melanogenesis
hhv04917  Prolactin signaling pathway
hhv04919  Thyroid hormone signaling pathway
hhv04921  Oxytocin signaling pathway
hhv04926  Relaxin signaling pathway
hhv04928  Parathyroid hormone synthesis, secretion and action
hhv04929  GnRH secretion
hhv04934  Cushing syndrome
hhv04935  Growth hormone synthesis, secretion and action
hhv05010  Alzheimer disease
hhv05022  Pathways of neurodegeneration - multiple diseases
hhv05034  Alcoholism
hhv05132  Salmonella infection
hhv05135  Yersinia infection
hhv05160  Hepatitis C
hhv05161  Hepatitis B
hhv05163  Human cytomegalovirus infection
hhv05164  Influenza A
hhv05165  Human papillomavirus infection
hhv05166  Human T-cell leukemia virus 1 infection
hhv05167  Kaposi sarcoma-associated herpesvirus infection
hhv05170  Human immunodeficiency virus 1 infection
hhv05200  Pathways in cancer
hhv05205  Proteoglycans in cancer
hhv05206  MicroRNAs in cancer
hhv05207  Chemical carcinogenesis - receptor activation
hhv05208  Chemical carcinogenesis - reactive oxygen species
hhv05210  Colorectal cancer
hhv05211  Renal cell carcinoma
hhv05212  Pancreatic cancer
hhv05213  Endometrial cancer
hhv05214  Glioma
hhv05215  Prostate cancer
hhv05216  Thyroid cancer
hhv05218  Melanoma
hhv05219  Bladder cancer
hhv05220  Chronic myeloid leukemia
hhv05221  Acute myeloid leukemia
hhv05223  Non-small cell lung cancer
hhv05224  Breast cancer
hhv05225  Hepatocellular carcinoma
hhv05226  Gastric cancer
hhv05230  Central carbon metabolism in cancer
hhv05231  Choline metabolism in cancer
hhv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:hhv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    120221655 (MAP2K1)
   04012 ErbB signaling pathway
    120221655 (MAP2K1)
   04014 Ras signaling pathway
    120221655 (MAP2K1)
   04015 Rap1 signaling pathway
    120221655 (MAP2K1)
   04370 VEGF signaling pathway
    120221655 (MAP2K1)
   04371 Apelin signaling pathway
    120221655 (MAP2K1)
   04668 TNF signaling pathway
    120221655 (MAP2K1)
   04066 HIF-1 signaling pathway
    120221655 (MAP2K1)
   04068 FoxO signaling pathway
    120221655 (MAP2K1)
   04072 Phospholipase D signaling pathway
    120221655 (MAP2K1)
   04071 Sphingolipid signaling pathway
    120221655 (MAP2K1)
   04024 cAMP signaling pathway
    120221655 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    120221655 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    120221655 (MAP2K1)
   04150 mTOR signaling pathway
    120221655 (MAP2K1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    120221655 (MAP2K1)
   04519 Cadherin signaling
    120221655 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    120221655 (MAP2K1)
   04148 Efferocytosis
    120221655 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    120221655 (MAP2K1)
   04210 Apoptosis
    120221655 (MAP2K1)
   04218 Cellular senescence
    120221655 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    120221655 (MAP2K1)
   04540 Gap junction
    120221655 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    120221655 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    120221655 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    120221655 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    120221655 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    120221655 (MAP2K1)
   04660 T cell receptor signaling pathway
    120221655 (MAP2K1)
   04662 B cell receptor signaling pathway
    120221655 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    120221655 (MAP2K1)
   04666 Fc gamma R-mediated phagosome formation
    120221655 (MAP2K1)
   04062 Chemokine signaling pathway
    120221655 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    120221655 (MAP2K1)
   04929 GnRH secretion
    120221655 (MAP2K1)
   04912 GnRH signaling pathway
    120221655 (MAP2K1)
   04915 Estrogen signaling pathway
    120221655 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    120221655 (MAP2K1)
   04917 Prolactin signaling pathway
    120221655 (MAP2K1)
   04921 Oxytocin signaling pathway
    120221655 (MAP2K1)
   04926 Relaxin signaling pathway
    120221655 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    120221655 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    120221655 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    120221655 (MAP2K1)
   04916 Melanogenesis
    120221655 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    120221655 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    120221655 (MAP2K1)
   04726 Serotonergic synapse
    120221655 (MAP2K1)
   04720 Long-term potentiation
    120221655 (MAP2K1)
   04730 Long-term depression
    120221655 (MAP2K1)
   04722 Neurotrophin signaling pathway
    120221655 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    120221655 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    120221655 (MAP2K1)
   05206 MicroRNAs in cancer
    120221655 (MAP2K1)
   05205 Proteoglycans in cancer
    120221655 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    120221655 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    120221655 (MAP2K1)
   05230 Central carbon metabolism in cancer
    120221655 (MAP2K1)
   05231 Choline metabolism in cancer
    120221655 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    120221655 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    120221655 (MAP2K1)
   05212 Pancreatic cancer
    120221655 (MAP2K1)
   05225 Hepatocellular carcinoma
    120221655 (MAP2K1)
   05226 Gastric cancer
    120221655 (MAP2K1)
   05214 Glioma
    120221655 (MAP2K1)
   05216 Thyroid cancer
    120221655 (MAP2K1)
   05221 Acute myeloid leukemia
    120221655 (MAP2K1)
   05220 Chronic myeloid leukemia
    120221655 (MAP2K1)
   05218 Melanoma
    120221655 (MAP2K1)
   05211 Renal cell carcinoma
    120221655 (MAP2K1)
   05219 Bladder cancer
    120221655 (MAP2K1)
   05215 Prostate cancer
    120221655 (MAP2K1)
   05213 Endometrial cancer
    120221655 (MAP2K1)
   05224 Breast cancer
    120221655 (MAP2K1)
   05223 Non-small cell lung cancer
    120221655 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    120221655 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    120221655 (MAP2K1)
   05161 Hepatitis B
    120221655 (MAP2K1)
   05160 Hepatitis C
    120221655 (MAP2K1)
   05164 Influenza A
    120221655 (MAP2K1)
   05163 Human cytomegalovirus infection
    120221655 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    120221655 (MAP2K1)
   05165 Human papillomavirus infection
    120221655 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    120221655 (MAP2K1)
   05135 Yersinia infection
    120221655 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    120221655 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    120221655 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    120221655 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    120221655 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    120221655 (MAP2K1)
   01522 Endocrine resistance
    120221655 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hhv01001]
    120221655 (MAP2K1)
Enzymes [BR:hhv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     120221655 (MAP2K1)
Protein kinases [BR:hhv01001]
 Serine/threonine kinases: STE group
  STE7 family
   120221655 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 120221655
NCBI-ProteinID: XP_039075104
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggctttgcagaagaagctggaggagctg
gagctcgatgagcagcagcggaagcgcctggaggcttttcttacccagaagcagaaggtc
ggggaattgaaggatgacgacttcgagaagatcagtgagctgggcgccggcaacggtggt
gtggtgttcaaggtctcccacaagccgtctggcctggtcatggccagaaagctaattcac
ctggagatcaaacccgcaatccggaaccagatcataagggagctgcaggttctacacgag
tgcaactccccgtacattgtgggcttctatggcgcgttctacagtgacggcgagatcagt
atctgcatggagcacatggatgggggctccttggatcaagtcctgaagaaggctggaaga
attccggaacaaatcttaggaaaagttagcattgctgtaataaaaggtctgacctacctg
agggagaagcacaagattatgcacagagatgtcaagccttccaacatcctagtgaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgattccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactgcaggggactcactac
tctgtgcagtcggacatctggagcatggggctgtctctggtggagatggcagtcgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaagtggag
ggagatgcggcagagacaccacccaggccgaggaccccgggaaggcccctcagctcttat
ggaatggacagccgacctcctatggcgatttttgagttgttggattacatagtcaacgag
cctcctccaaagctgcccagtggagtattcagtctggaatttcaagattttgtgaataaa
tgcctcataaaaaatccagcagagagagcggatctgaagcaactcatggttcatgccttt
atcaagagatctgacggcgaggaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcccagcactccgacccacgcagctggcgtctaa

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