Hyaena hyaena (striped hyena): 120228197
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Entry
120228197 CDS
T07257
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
hhv
Hyaena hyaena (striped hyena)
Pathway
hhv00562
Inositol phosphate metabolism
hhv01100
Metabolic pathways
hhv01521
EGFR tyrosine kinase inhibitor resistance
hhv04012
ErbB signaling pathway
hhv04014
Ras signaling pathway
hhv04020
Calcium signaling pathway
hhv04062
Chemokine signaling pathway
hhv04064
NF-kappa B signaling pathway
hhv04066
HIF-1 signaling pathway
hhv04070
Phosphatidylinositol signaling system
hhv04072
Phospholipase D signaling pathway
hhv04360
Axon guidance
hhv04370
VEGF signaling pathway
hhv04380
Osteoclast differentiation
hhv04611
Platelet activation
hhv04613
Neutrophil extracellular trap formation
hhv04625
C-type lectin receptor signaling pathway
hhv04650
Natural killer cell mediated cytotoxicity
hhv04662
B cell receptor signaling pathway
hhv04664
Fc epsilon RI signaling pathway
hhv04666
Fc gamma R-mediated phagocytosis
hhv04670
Leukocyte transendothelial migration
hhv04722
Neurotrophin signaling pathway
hhv04750
Inflammatory mediator regulation of TRP channels
hhv04919
Thyroid hormone signaling pathway
hhv04933
AGE-RAGE signaling pathway in diabetic complications
hhv04935
Growth hormone synthesis, secretion and action
hhv05167
Kaposi sarcoma-associated herpesvirus infection
hhv05169
Epstein-Barr virus infection
hhv05170
Human immunodeficiency virus 1 infection
hhv05171
Coronavirus disease - COVID-19
hhv05200
Pathways in cancer
hhv05205
Proteoglycans in cancer
hhv05206
MicroRNAs in cancer
hhv05214
Glioma
hhv05223
Non-small cell lung cancer
hhv05225
Hepatocellular carcinoma
Module
hhv_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
hhv00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
120228197 (PLCG2)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
120228197 (PLCG2)
04014 Ras signaling pathway
120228197 (PLCG2)
04370 VEGF signaling pathway
120228197 (PLCG2)
04064 NF-kappa B signaling pathway
120228197 (PLCG2)
04066 HIF-1 signaling pathway
120228197 (PLCG2)
04020 Calcium signaling pathway
120228197 (PLCG2)
04070 Phosphatidylinositol signaling system
120228197 (PLCG2)
04072 Phospholipase D signaling pathway
120228197 (PLCG2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
120228197 (PLCG2)
04613 Neutrophil extracellular trap formation
120228197 (PLCG2)
04625 C-type lectin receptor signaling pathway
120228197 (PLCG2)
04650 Natural killer cell mediated cytotoxicity
120228197 (PLCG2)
04662 B cell receptor signaling pathway
120228197 (PLCG2)
04664 Fc epsilon RI signaling pathway
120228197 (PLCG2)
04666 Fc gamma R-mediated phagocytosis
120228197 (PLCG2)
04670 Leukocyte transendothelial migration
120228197 (PLCG2)
04062 Chemokine signaling pathway
120228197 (PLCG2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
120228197 (PLCG2)
04919 Thyroid hormone signaling pathway
120228197 (PLCG2)
09156 Nervous system
04722 Neurotrophin signaling pathway
120228197 (PLCG2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
120228197 (PLCG2)
09158 Development and regeneration
04360 Axon guidance
120228197 (PLCG2)
04380 Osteoclast differentiation
120228197 (PLCG2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
120228197 (PLCG2)
05206 MicroRNAs in cancer
120228197 (PLCG2)
05205 Proteoglycans in cancer
120228197 (PLCG2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
120228197 (PLCG2)
05214 Glioma
120228197 (PLCG2)
05223 Non-small cell lung cancer
120228197 (PLCG2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
120228197 (PLCG2)
05171 Coronavirus disease - COVID-19
120228197 (PLCG2)
05167 Kaposi sarcoma-associated herpesvirus infection
120228197 (PLCG2)
05169 Epstein-Barr virus infection
120228197 (PLCG2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
120228197 (PLCG2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
120228197 (PLCG2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hhv04131
]
120228197 (PLCG2)
Enzymes [BR:
hhv01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
120228197 (PLCG2)
Membrane trafficking [BR:
hhv04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
120228197 (PLCG2)
Endocytosis
Macropinocytosis
Phospholipase C
120228197 (PLCG2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
EF-hand_PLCG2
C2
SH3_1
PH
SH3_9
PH_12
EF-hand_PLCG1
SH2_1
SH3_2
PH_14
EF-hand_like
GDPD
Motif
Other DBs
NCBI-GeneID:
120228197
NCBI-ProteinID:
XP_039082377
LinkDB
All DBs
Position
Unknown
AA seq
1265 aa
AA seq
DB search
MTAMVNVDTLPEYEKSQIKRTLELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGSQFVLSTLSLAADSKEDAT
KWLSGLKILHQEAMSASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLVNFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKNLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLLHEQQEVWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCCVEQQRHMARV
FKEVFGDLLLTKPTEASADQLPSPSQLRGKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTAEEELPQDVPPTELHFGEEWFHKKLEKR
TSAEKLLQEYCAETGGKDGTFLVRESKTFPNDYTLSFWRSGRVQHCRIRSVMEGGTMKYF
LTDNIMFSSIYDLIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDGLSRGEAEDML
MRVPRDGAFLIRRREGTDSYAITFRARGKVKHCRIHRDGRHFVLGTSAYFESLVELVSYY
EKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRNDELSFCRGALIHNVSKEPWGWWKGDYGTRIQQYFPSNYVEDISTVDVEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDSLENPDFREIRSFVE
TKADSVVRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTPDKY
MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEEIELASLLVFCEMQPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNRRLREKRVSN
SRFYS
NT seq
3798 nt
NT seq
+upstream
nt +downstream
nt
atgaccgccatggtcaacgtggacacccttcccgaatatgagaagagtcagatcaagaga
accctggagctgggcacggtgatgaccgtgttcagcttccgcaagtccacccccgagcgg
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagacggcggacaag
atcgagggcttcttggatatcatggaaatcaaggaaatccgccccgggaagaactccaag
gattttgagcgcgcgaaggcggtccgtcagaaggaggactgctgtttcaccatcttgtac
ggctcccagttcgtcctcagcacgctcagtttggcagctgactctaaagaagatgccacc
aagtggctctctggcttgaaaatcttacaccaggaagcgatgagtgcgtctacacccacc
attattgagagttggctgagaaaacagatttactcagtggatcaaaccagaagaaacagc
atcagcctccgagagttgaagaccatcttgcctctggtcaacttcaaagtgagcagtgcc
aagttcctcaaagataagtttgtggaaatcggtgctcacaaagatgaactcagcttcgag
cagttccaccttttctataaaaatctaatgtttgagcagcaaaaatcgattcttgatgag
ttcaaaaaagattcttccgtgttcatcttgggcaacaccgaccggccggacgcctccgcc
gtctacctgcatgacttccagcgctttctcttacatgagcagcaggaggtttgggctcag
gatctgaacaaagtccgtgagcggatgacaaagtttatcgatgacaccatgagggaaacc
gccgagcccttcttgtttgtcgatgagttcctcacgtacctgttttcgcgggagaacagc
atctgggatgagaagtacgacgtggtcgacatgcaggacatgaacaaccccttgtcccac
tactggatctcctcctcgcataacacgtacctcactggagaccagctgcggagcgagtcg
tccacggaggcgtacatccgctgcctgcgcatgggctgtcgctgcatcgagctggactgc
tgggatgggcccgatgggaagcccatcatctaccatggctggacgcggaccaccaagatc
aagtttgacgatgtcgtgcaggccatcaaagaccatgcctttgtcacctcaagcttcccg
gtgatcctgtccatcgaagagcactgctgtgtggagcagcagcgccacatggccagggtg
ttcaaggaggtgttcggggacctgctgctgaccaagcccacggaggccagcgctgaccag
ctgccctcgcccagccagctgcgggggaagatcatcatcaagcataagaagctgggcccc
cgaggcgacgtggatgtcaacatggaagacaagaaagatgagcataagcaacagggtgaa
ctgtacatgtgggattccatcgaccagaaatggactcggcactactgtgccatcgctgat
gccaagctgtcgttcagcgatgacattgaacagactgcagaggaggagctgccccaggat
gtaccgcccacggagctgcattttggggaggagtggttccacaagaagctggaaaagagg
acgagcgccgagaaactgctgcaggagtactgtgcggagacggggggcaaggacgggacc
ttcctggtgcgggagagcaagaccttccccaacgactacaccctgtccttctggcggtcg
ggccgggtgcagcactgccggatccgctccgtcatggagggcgggaccatgaagtacttc
ctgactgacaacatcatgttcagcagcatctacgacctcatccagcactatcgcgagacg
cacctgcgctgcgccgagttcgagctccggctcaccgaccccgtgcccaaccccaacccc
cacgagtcaaagccgtggtactacgacggactgagccgcggcgaagcggaggacatgctg
atgagagttccccgcgacggggccttcctgatccggaggcgggaaggcaccgactcctac
gccatcaccttcagggccaggggcaaggtgaagcattgccgcatccatcgggacggccgg
cactttgtgctggggacctccgcctacttcgagagcctcgtggagctagtcagttactac
gagaagcacgcactctaccgaaagatgcggctgcgctaccccgtgacgcctgagctgctg
gagcgctacaatatggaaagagatataaactccctctatgacgtcagcagaatgtacgtg
gaccccagcgaaatcaacccttctatgcctcagaggaccgtcaaagctctgtacgactac
aaagccaagcgaaacgatgagctgagcttctgccgtggggccctcattcacaacgtctcc
aaggagccctggggctggtggaaaggggactatgggaccagaatccagcagtacttcccg
tccaattatgtcgaggacatttcaacggtcgacgtggaagaactggaaaagcagattatt
gaggacaatcccttagggtctctctgcagaggaatactggatctcaacacctataacgtc
gtgaaagccccacaggggaaaaaccagaagccgttcgtgttcatcctggagcccaagaag
cagggcgaccccccggtggagtttgccacggacagggtggaggagctctttgagtggttt
cagagcatccgggagatcacctggaagatcgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctcggacctggtggtctactgcaagccgacc
agcaagaccaaggacagtttagaaaaccccgacttccgagaaatccgctcctttgtggag
acgaaggctgacagtgttgtcagacagaagcccgtcgacctcctcaagtacaatcagaag
ggcctgacccgtgtctacccgaagggacagagggtggactcctccaactacgaccccttt
cgcctctggctgtgcggctcccagatggtggcactcaatttccagactccagacaagtac
atgcagatgaatcacgccttgttctcactcaacgggcggacgggctacgtcctacagccc
gagagcatgaggaccgagaagtacgaccccatgccgcccgagtcccagcgcaagatcctg
atgactctgacggtcaaggttctcggggctcgccatctgcccaaacttggccgaagcatc
gcctgtccctttgtggaggtggaaatctgtggggctgaatacgacaacaacaagtttaag
acgacagttgtgaatgacaatggcttaagccccatttgggctccaacacaggagaaggtg
acctttgaaatttatgaccccaacctcgcgtttctgcgctttgtggtctacgaggaagat
atgttcagtgatcccaacttccttgcccatgccacttaccccatcaaaggaatcaaatca
ggattcagatctgttcctctgaagaacgggtacagtgaagaaatcgagctggcttcccta
ctggtgttctgtgagatgcagccagtcctggagagcgaagaggagctttactcctcctgt
cgccagctgcgaaggcgtcaggaagagctgaacaaccagttgtttctgtacgacacacac
cagaatctgcgcaatgccaaccgggatgccctcgtgaaagagttcaacgtcaacgagaac
cagctccagctgtaccaggagaagtgcaatcggaggttaagagagaagagagtcagcaac
agcaggttttactcatag
DBGET
integrated database retrieval system
