Hyaena hyaena (striped hyena): 120230974
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Entry
120230974 CDS
T07257
Symbol
JAK2
Name
(RefSeq) tyrosine-protein kinase JAK2 isoform X1
KO
K04447
Janus kinase 2 [EC:
2.7.10.2
]
Organism
hhv
Hyaena hyaena (striped hyena)
Pathway
hhv01521
EGFR tyrosine kinase inhibitor resistance
hhv04062
Chemokine signaling pathway
hhv04081
Hormone signaling
hhv04148
Efferocytosis
hhv04151
PI3K-Akt signaling pathway
hhv04217
Necroptosis
hhv04550
Signaling pathways regulating pluripotency of stem cells
hhv04630
JAK-STAT signaling pathway
hhv04658
Th1 and Th2 cell differentiation
hhv04659
Th17 cell differentiation
hhv04725
Cholinergic synapse
hhv04917
Prolactin signaling pathway
hhv04920
Adipocytokine signaling pathway
hhv04933
AGE-RAGE signaling pathway in diabetic complications
hhv04935
Growth hormone synthesis, secretion and action
hhv05140
Leishmaniasis
hhv05145
Toxoplasmosis
hhv05152
Tuberculosis
hhv05161
Hepatitis B
hhv05164
Influenza A
hhv05167
Kaposi sarcoma-associated herpesvirus infection
hhv05168
Herpes simplex virus 1 infection
hhv05200
Pathways in cancer
hhv05207
Chemical carcinogenesis - receptor activation
hhv05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
hhv05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
hhv00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
120230974 (JAK2)
04151 PI3K-Akt signaling pathway
120230974 (JAK2)
09133 Signaling molecules and interaction
04081 Hormone signaling
120230974 (JAK2)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
120230974 (JAK2)
09143 Cell growth and death
04217 Necroptosis
120230974 (JAK2)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
120230974 (JAK2)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
120230974 (JAK2)
04659 Th17 cell differentiation
120230974 (JAK2)
04062 Chemokine signaling pathway
120230974 (JAK2)
09152 Endocrine system
04920 Adipocytokine signaling pathway
120230974 (JAK2)
04917 Prolactin signaling pathway
120230974 (JAK2)
04935 Growth hormone synthesis, secretion and action
120230974 (JAK2)
09156 Nervous system
04725 Cholinergic synapse
120230974 (JAK2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
120230974 (JAK2)
05207 Chemical carcinogenesis - receptor activation
120230974 (JAK2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
120230974 (JAK2)
09172 Infectious disease: viral
05161 Hepatitis B
120230974 (JAK2)
05164 Influenza A
120230974 (JAK2)
05168 Herpes simplex virus 1 infection
120230974 (JAK2)
05167 Kaposi sarcoma-associated herpesvirus infection
120230974 (JAK2)
09171 Infectious disease: bacterial
05152 Tuberculosis
120230974 (JAK2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
120230974 (JAK2)
05140 Leishmaniasis
120230974 (JAK2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
120230974 (JAK2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
120230974 (JAK2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
120230974 (JAK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hhv01001
]
120230974 (JAK2)
Enzymes [BR:
hhv01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
120230974 (JAK2)
Protein kinases [BR:
hhv01001
]
Non-receptor tyrosine kinases
JAK family [OT]
120230974 (JAK2)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
FERM_F2
FERM_F1
SH2_1
Jak1_Phl
ABC1
FERM_C_FAK1
RIO1
Kinase-like
FERM_M
Motif
Other DBs
NCBI-GeneID:
120230974
NCBI-ProteinID:
XP_039086738
LinkDB
All DBs
Position
Unknown
AA seq
1131 aa
AA seq
DB search
MGMACLTMTEMEGTSVSPVHQNGDIPGNASSVKDIDPLLQVYLYHSLEKADGEYLKFPTG
EYVAEEICVAASKACGVTPVYHSMFALMSETERIWYPPNHVFHIDESTRHSVLYRIRFYF
PYWYCNGSNRTYRHGVSRGAEAPLLDDFVMSYLFAQWRHDFLHGWIKIPVTHETQEECLG
MAVLDMMRLAKEKDQTPLDIYSSISYKTFLPKSVRAKIQDYHILTRKRIRYRFRRFIEQF
SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIVITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPDIIDVTIKQANQEGSNESRIVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPILMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAIERDNVIEYKHCLITKNESGEYNLSGTKKNFSNLKDLLNC
YQMETVRSDSIIFQFTKCCPPKLKDKSNLLVFRTNGVSDVPTSPTLQRHNNVNQMVFHKI
RNEDLVFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSISILWKLEVAKQLAWA
MHFLEEKALIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSHRKLQFYEDRHQLPAPKWTEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNRIGTLGFSGAFEDRDP
TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEI
LKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQIC
KGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWY
APESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIEL
LKNNGRLPRPDGCPDEIYLIMTECWNNNVNQRPSFRDLALRVDQIRDTMAG
NT seq
3396 nt
NT seq
+upstream
nt +downstream
nt
atgggaatggcttgccttacaatgacggaaatggaaggaacgtccgtatctccggtacat
cagaatggtgatattcctggaaatgccagttctgtgaaggacatagatccactcctacag
gtgtacctttatcattctcttgagaaagctgatggagaatatctgaagttcccaacgggg
gagtatgttgcagaagaaatttgtgttgctgcttctaaagcttgtggagtcacacctgtg
tatcatagtatgtttgctttaatgagtgaaacagaaaggatctggtatccgcccaatcat
gtcttccatatagatgaatcaaccaggcacagtgtactctacagaataagattttacttt
ccttactggtattgtaatggcagcaacagaacctatcggcatggagtgtctcgaggtgct
gaagctcctcttcttgacgactttgtcatgtcttacctttttgctcagtggcggcatgat
tttttacatggatggataaaaatacctgtgactcatgaaacacaggaagaatgtctcgga
atggcagtgttagatatgatgagactagccaaagagaaggatcagacccccctggacatc
tatagctctatcagctacaagacattcttaccaaaatctgttcgagccaagatccaagac
tatcatattttgacaaggaaacgaataaggtatagatttcgcagatttattgagcagttc
agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaaca
cttcagtctgccttctacacagagcaatttgaagtaaaagaacctggaagaggtccttca
ggtgaggagatttttgcaaccattgtaataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggacttacagctatattgtgacttt
cctgatatcattgatgttactattaagcaagcaaaccaagaaggctcaaatgaaagtaga
attgtaactatccataagcaagatggtaaaaatctggaaattgaactgagctcattaaga
gaagctttatcctttgtgtcattaattgacggctattatagattaactgcagatgcacat
cattacctctgtaaagaagtagcacctccaatggtgcttgaaaacatacaaagcaactgt
catggcccaattttaatggattttgccatcagtaaactgaagaaagcaggtaatcagact
ggactctatgtacttcgatgcagtcctaaggacttcaataaatattttctgacttttgct
atcgagcgagacaatgtcatcgaatataagcactgtttgattaccaaaaatgagagtgga
gaatacaacctcagtgggaccaagaagaacttcagtaatcttaaagatcttttgaattgc
taccagatggaaactgttcgctcagacagtataattttccagtttacgaaatgctgtccc
ccaaagttgaaagataaatcaaaccttctagtctttagaaccaatggcgtttctgatgta
ccaacatcaccaacattacagaggcataataatgtgaaccaaatggtgtttcacaaaatc
agaaatgaagatttggtatttaatgaaagccttggccaaggcacttttacaaaaattttt
aaaggtgtaagaagagaagtaggagactatggtcaactgcatgaaacagaagttctttta
aaagttctggataaagcacacagaaactattcagagtctttctttgaagcagcaagcatg
atgagccaactttctcacaagcatctggttttaaattatggagtgtgtgtctgtggagag
gagaatattctggttcaggagtttgtaaaatttggatcattagatacatacctgaaaaag
aataaaaattctataagtatattatggaaacttgaagtggctaaacagttggcatgggcc
atgcattttctagaagaaaaagcccttattcatgggaatgtgtgtgccaaaaatattctg
cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct
ggcattagtattacagttttgccaaaggacattcttcaggaaagaataccgtgggtacca
cctgaatgcattgaaaatcctaaaaatctaaacctggcaacagacaaatggagttttggt
accactttgtgggaaatctgcagtggaggagataagccgctgagtgctttggattctcat
agaaagctccagttttatgaagataggcaccagcttcctgcaccaaagtggacagaatta
gctaatcttattaataattgtatggattatgaaccagattttagaccttctttcagagcc
atcatacgagatcttaatagtttatttactccagattatgaactattaacagaaaatgac
atgttaccaaataggataggcaccctagggttttctggagcctttgaagaccgagacccg
acacagtttgaagagagacacttgaaatttctgcagcaacttggcaagggtaattttggc
agtgtggagatgtgccggtatgaccctctgcaagacaacacgggggaggtggtggctgtg
aagaagctccagcacagtacagaagagcacctgagggactttgagagagagatcgaaatc
cttaagtccctgcagcatgacaacattgtaaagtacaagggagtgtgctacagtgctggc
cggcgtaatttaagattaattatggaatatttaccatatggaagtttacgagactatctc
caaaaacataaggaacggatagatcataaaaaacttctgcagtatacatctcagatatgc
aagggcatggagtatcttggtacaaaaaggtatatccacagggatctagcaacaaggaat
atattggtggagaatgaaaacagagttaaaattggagattttggtttaaccaaagtcttg
ccacaagacaaagagtactacaaagtgaaagaacctggtgaaagtcctatattctggtat
gctccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagttttgga
gtggttctctatgaacttttcacatatatcgagaagagcaaaagcccaccagcggaattt
atgcgtatgattggcaatgacaaacaaggacagatgattgtgtttcatttgatagaactc
ctaaaaaataatggaaggttaccaagaccagatggatgtccagatgagatttatttgatc
atgacagaatgctggaacaataatgtaaatcagcgcccctcttttagagacctagctctt
cgagttgatcaaataagggacaccatggctggatga
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integrated database retrieval system
