KEGG   Hyaena hyaena (striped hyena): 120234701
Entry
120234701         CDS       T07257                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
hhv  Hyaena hyaena (striped hyena)
Pathway
hhv01522  Endocrine resistance
hhv04010  MAPK signaling pathway
hhv04015  Rap1 signaling pathway
hhv04068  FoxO signaling pathway
hhv04071  Sphingolipid signaling pathway
hhv04114  Oocyte meiosis
hhv04148  Efferocytosis
hhv04218  Cellular senescence
hhv04261  Adrenergic signaling in cardiomyocytes
hhv04370  VEGF signaling pathway
hhv04380  Osteoclast differentiation
hhv04517  IgSF CAM signaling
hhv04550  Signaling pathways regulating pluripotency of stem cells
hhv04611  Platelet activation
hhv04613  Neutrophil extracellular trap formation
hhv04620  Toll-like receptor signaling pathway
hhv04621  NOD-like receptor signaling pathway
hhv04622  RIG-I-like receptor signaling pathway
hhv04625  C-type lectin receptor signaling pathway
hhv04657  IL-17 signaling pathway
hhv04658  Th1 and Th2 cell differentiation
hhv04659  Th17 cell differentiation
hhv04660  T cell receptor signaling pathway
hhv04664  Fc epsilon RI signaling pathway
hhv04668  TNF signaling pathway
hhv04670  Leukocyte transendothelial migration
hhv04714  Thermogenesis
hhv04722  Neurotrophin signaling pathway
hhv04723  Retrograde endocannabinoid signaling
hhv04728  Dopaminergic synapse
hhv04750  Inflammatory mediator regulation of TRP channels
hhv04912  GnRH signaling pathway
hhv04914  Progesterone-mediated oocyte maturation
hhv04917  Prolactin signaling pathway
hhv04926  Relaxin signaling pathway
hhv04932  Non-alcoholic fatty liver disease
hhv04933  AGE-RAGE signaling pathway in diabetic complications
hhv04935  Growth hormone synthesis, secretion and action
hhv04936  Alcoholic liver disease
hhv05014  Amyotrophic lateral sclerosis
hhv05020  Prion disease
hhv05022  Pathways of neurodegeneration - multiple diseases
hhv05132  Salmonella infection
hhv05133  Pertussis
hhv05135  Yersinia infection
hhv05140  Leishmaniasis
hhv05142  Chagas disease
hhv05145  Toxoplasmosis
hhv05152  Tuberculosis
hhv05161  Hepatitis B
hhv05163  Human cytomegalovirus infection
hhv05167  Kaposi sarcoma-associated herpesvirus infection
hhv05169  Epstein-Barr virus infection
hhv05170  Human immunodeficiency virus 1 infection
hhv05171  Coronavirus disease - COVID-19
hhv05205  Proteoglycans in cancer
hhv05208  Chemical carcinogenesis - reactive oxygen species
hhv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hhv05415  Diabetic cardiomyopathy
hhv05417  Lipid and atherosclerosis
hhv05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hhv00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    120234701 (MAPK12)
   04015 Rap1 signaling pathway
    120234701 (MAPK12)
   04370 VEGF signaling pathway
    120234701 (MAPK12)
   04668 TNF signaling pathway
    120234701 (MAPK12)
   04068 FoxO signaling pathway
    120234701 (MAPK12)
   04071 Sphingolipid signaling pathway
    120234701 (MAPK12)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    120234701 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    120234701 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    120234701 (MAPK12)
   04218 Cellular senescence
    120234701 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    120234701 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    120234701 (MAPK12)
   04613 Neutrophil extracellular trap formation
    120234701 (MAPK12)
   04620 Toll-like receptor signaling pathway
    120234701 (MAPK12)
   04621 NOD-like receptor signaling pathway
    120234701 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    120234701 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    120234701 (MAPK12)
   04660 T cell receptor signaling pathway
    120234701 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    120234701 (MAPK12)
   04659 Th17 cell differentiation
    120234701 (MAPK12)
   04657 IL-17 signaling pathway
    120234701 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    120234701 (MAPK12)
   04670 Leukocyte transendothelial migration
    120234701 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    120234701 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    120234701 (MAPK12)
   04917 Prolactin signaling pathway
    120234701 (MAPK12)
   04926 Relaxin signaling pathway
    120234701 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    120234701 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    120234701 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    120234701 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    120234701 (MAPK12)
   04722 Neurotrophin signaling pathway
    120234701 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    120234701 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    120234701 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    120234701 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    120234701 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    120234701 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    120234701 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    120234701 (MAPK12)
   05161 Hepatitis B
    120234701 (MAPK12)
   05171 Coronavirus disease - COVID-19
    120234701 (MAPK12)
   05163 Human cytomegalovirus infection
    120234701 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    120234701 (MAPK12)
   05169 Epstein-Barr virus infection
    120234701 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    120234701 (MAPK12)
   05135 Yersinia infection
    120234701 (MAPK12)
   05133 Pertussis
    120234701 (MAPK12)
   05152 Tuberculosis
    120234701 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    120234701 (MAPK12)
   05140 Leishmaniasis
    120234701 (MAPK12)
   05142 Chagas disease
    120234701 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    120234701 (MAPK12)
   05020 Prion disease
    120234701 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    120234701 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    120234701 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    120234701 (MAPK12)
   05415 Diabetic cardiomyopathy
    120234701 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    120234701 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    120234701 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    120234701 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    120234701 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hhv01001]
    120234701 (MAPK12)
Enzymes [BR:hhv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     120234701 (MAPK12)
Protein kinases [BR:hhv01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   120234701 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Kdo Haspin_kinase
Other DBs
NCBI-GeneID: 120234701
NCBI-ProteinID: XP_039092590
LinkDB
Position
Unknown
AA seq 367 aa
MSSPPPARKGFYRQEVTKTAWEVRAVYQGLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADS
EMTGYVVTRWYRAPEVILNWMRYTQTVDIWSAGCIMAEMITGKTLFKGSDHLDQLKEIMK
VTGTPPEEFVQRLQSAEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRV
TAAEALTHPYFESLQDTEDEPEAQKYDESFDDVARTLDEWKRDTYKEVLSFKPPRQLGTK
VSKETAL
NT seq 1104 nt   +upstreamnt  +downstreamnt
atgagctccccgccgcctgcccgcaagggcttttaccgccaggaggtgaccaagacggcc
tgggaggtgcgcgccgtgtaccagggcctgcagcccgtgggctccggcgcgtacggcgcg
gtgtgctcggccgtggacagccgcaccggcgccaaggtggccatcaagaaactgtaccgg
ccgttccagtccgagctgttcgccaagcgcgcctaccgcgagctgcgcctcctcaagcac
atgcgtcacgagaacgtcatcgggctgctggacgtgttcactcctgatgaaaccctggat
gatttcacagacttttacctggtgatgccgttcatgggcaccgacctgggcaagctcatg
aagcatgagaagctgagcgaggaccgaatccagtttcttgtctaccagatgctgaagggg
ctaaagtacatccacgctgctggcatcatccacagggacctgaagcctggcaatctggca
gtgaatgaggactgtgagctgaagatcctggacttcggcttggccaggcaggccgacagc
gagatgactgggtatgtggtgacccggtggtaccgcgcgcctgaggtcatcttgaattgg
atgcgttatacacagacagtggacatctggtcagcgggctgcatcatggcagagatgatc
actgggaagacgctgttcaagggcagtgaccacctggaccagctgaaggagatcatgaag
gtgaccgggacgcctcccgaggaatttgtgcagaggctgcagagcgccgaggcgaagaac
tacatgaagggcctccccgagttggagaagaaggattttgcctccatcctgactaacgca
agccctctggccgtgaacctcctggagaagatgctggtgctggatgcagagcagcgggtg
actgcggccgaggcgctgacgcacccctacttcgagtcactgcaggacacagaggacgaa
cccgaggcccagaagtacgacgagtcctttgacgatgtggctcgcacgctggacgagtgg
aagcgtgacacatataaggaagtgctcagcttcaagcctccccggcagctggggaccaag
gtgtccaaggagacagcgctgtga

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