Hyaena hyaena (striped hyena): 120241877 Help Entry 120241877         CDS       T07257                                  Symbol RYR3 Name (RefSeq) ryanodine receptor 3   KO K04963   ryanodine receptor 3 Organism hhv  Hyaena hyaena (striped hyena) Pathway hhv04020   Calcium signaling pathway hhv04371   Apelin signaling pathway hhv04713   Circadian entrainment hhv04921   Oxytocin signaling pathway hhv04970   Salivary secretion hhv05010   Alzheimer disease hhv05012   Parkinson disease hhv05020   Prion disease hhv05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:hhv00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     120241877 (RYR3)    04020 Calcium signaling pathway     120241877 (RYR3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     120241877 (RYR3)   09154 Digestive system    04970 Salivary secretion     120241877 (RYR3)   09159 Environmental adaptation    04713 Circadian entrainment     120241877 (RYR3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     120241877 (RYR3)    05012 Parkinson disease     120241877 (RYR3)    05020 Prion disease     120241877 (RYR3)    05022 Pathways of neurodegeneration - multiple diseases     120241877 (RYR3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:hhv04040]     120241877 (RYR3) Ion channels [BR:hhv04040]  Voltage-gated cation channels   Ryanodine receptor    120241877 (RYR3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  120241877 NCBI-ProteinID:  XP_039103189 LinkDB All DBs Position Unknown AA seq 4875 aa AA seqDB search MCSPFLYHAQKHVLLGGRDDDTEDEVVLQCVANIHKEQRKFCLAAEGLGNRLCFLEPTSE AKYVPPDLCVCNFVLEQSLSVRALQEMLANTGENGGEGAAQGGGHRTLLYGHAILLRHSF SGMYLTCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVS VSSERYLHLSVSNGNIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLT IPSTDQNDSQHRRIFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYL ALTEDQGLILQDRAKSDTKSTAFSFRASKEIKEKLDSSHKRDIEGMGVPEIKYGDSVCFV QHIASGLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQCEESQAARIIRNTT ALFSQFLSGNNRTAAPVTLPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNL FKEEGMLALVLNCIDRLNIYNSVAHFAGIAREESGMAWKEILRLLYKLLAALIRGNRNNC AQFSNNLDWLISKLDRLESSSGILEVLHCILIESPEALNLIAEGHIKSIISLLDKHGRNH KVLDVLCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSA QYKKWYFELIIDQVDPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFD GLHLWSGRIPRAVASINQHLLRSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLF FPVVSFSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDAEGVR DLLGTTQFLSQASFIPCPIDTSQVVLPPHLEKIRDRLAENIHELWGMNKIELGWTFGKTR DDNKRQHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHINPAAGEDLKKVKLPK NYMMSNGYKPAPLDLSDVKLLPPQEILVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKR NPRLVPYALLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELADPAVEKVSIDKIRFFR VERSYAVRSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQGS GYFGRTWQPGDVVGCMINLDDASMIFTLNGELLITSKGSELAFADYEIENGFVPICSLGL SQIGRMNLGMDASTFKFYTMCGLQEGFEPFAVNMNRDVAMWFSKRLPTFVNVPKDHPHIE VVRIDGTMDSPPCLKVTHKTFGTQNSNANMIYCRLSMPVECHSSFSHSPCLDSEAFQKRK QMQEILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLSKNCTVTVTLGDER GRVHESVKRSNCYMVWGGDIVATSQRSSRSNVDLEIGCLVDLAMGMLSFSANGRELGTCY QVEPNTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPVPQCPPRLDVQTI QPVLWSRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDVLELCEQEDLM QFHYHTLRLYSAVCALGNSRVAYALCGHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHL ANAKERKLMMKNEYIIPITSATGKIRLYPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVT SEEHQKQSPEIPLEILKTKALSMLTEAVQHSGAHIRDPVGGSVEFQFVPVLKLIGTLLVM GVFDDDDVRQILLLIDPSVFGEHSGEMENRAEKEEMTQVEEKAVEAGEKASKEAPVKGLL QTRLPESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMS AALTARKTREFRSPPQEQINMLLNFQLGENCPCPEEIREELYDFHEDLLIHCGVPLEEEE EEEEDMSWAGKLRALVYKIKGPPKPEKEQPTEEEERCPTTLKELISQTMIRWAQEDQIQD AELVRMMFNLLRRQYDSIGELLQALRKTYTISQASVSDTINLLAALGQIRCLLSVRMGKE EELLMINGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGAEKSQIAFPKMVASCCR FLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLE EPDLEKVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENAS VVVKLLIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKREVMEDGEDEE EIVHMGNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIP LKLPSLNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRAS ASLDTVSLSTTEAALALNRYLCSAVLPLLTRCAPLFAGAEHHTSLIDSTLQTIYRLSKGR SLTKAQRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLNEYCKMPLKLLTNHYEQCWK YYCLPSGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDPDLFRMALPCLSAIAGALPPD YLDTRISAALEKQISVDADGNFDPKPINTMNFSLPEKWEYIVTKYAEHSHDKWACDKSQN GWKYGISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWSVERTKEGEALV QQRENEKLRSVSQASQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELE SKGGGSHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIVVSRGMKDMELDASSMEKRF AYKFLKKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRL YFLSSPLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTL DTRTVMKSGSELVKAGLRAFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVA LLPILTSIFEHVAQHQFGVDLLLGDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLA SLAAAIPVAFLEPTLNRYNPLSVFNTKTPRERSILGMPDTVEEMCPDIPQLEGLMKEISD LAESGARYTEMPHVIEVILPMLCNYLSYWWERGPEHLPPSTGPWCTKVTSEHLSVILGNI LKIINNNLGIDEASWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKKKAVKTVQEEEQL KADTKGDTQEAELLILDEFAVLCRDLYAFYPMLIRYVDNNRSNWLKSPDADSDQLFRMVA EVFILWCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRR GDLYSIQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSYRDTDEEVKEHLRNNLHL QEKSDDPAVKWQLNLYKDVLKSEEPSNPEKTVERVQRISAAVFHLEQVEQPLRSKKAVWH KLLSKQRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEEYSFEEKLVQDLAKCP KVEEEEEEETEKYPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEE EEDKEKTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAIL NGGNAGVQQKMLDYLKEKKDAGFFQSLSSLMQSCSVLDLNAFERQNKAEGLGMVTEEGTL IVRERGEKVLQNDEFTRDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNIIISTVDYLLR LQESISDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCTGNQQSLAHSRL WDAVVGFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMV DTLVESSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISKKEFQKAMEGQKQYTQ SEIDFLLSCAEADENDMFNYIDFVDRFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLD PAESVLNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEG GEQEKMELFVNFCEDTIFEMQLASQISESDSTDRPEEEEEEDEDSSYMLEIEGEEEDDKS FESASAFAMACASVKRNVANFLKKATLKNLRKQYRKVKKMTVKELVKVFFSFFWMLFVGL FQLFFTILGGIFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDAMDAERAEV TEPGITPELIHFVRGERGDADGMSDLFGFRSKKEGGLKHGPDVGLGDLSEIIGKDEPPTL ESTVRKKRKAQAAEMKAVHEAEGRGEPEKTDMEDGEKEGMAKEEDQADALWAEATKKRKR RRGQKVEKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTE EPLEEETEDVANLWNSFNDEEEEEAMVFFVLQESTGYMAPALRALAVIHTIISLVCVVGY YCLKVPLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPNNYWDKFVK RKVINKYGDLYGAERIAELLGLDKNALDFSPVEESKAEAASLVSWLSSIDMKYHIWKLGV VFTDNSFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVG LLAVVVYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIE DPAGDPYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICG IGNDYFDTIPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFF PAGDCFRKQYEDQLG NT seq 14628 nt NT seq  +upstreamnt  +downstreamnt atgtgctctccttttctgtaccatgctcaaaagcatgtgcttctcggtggacgtgatgac gatacagaagatgaagtggttctccagtgcgtcgcaaacattcacaaggagcaaaggaag ttctgcctggcagctgagggcctgggaaaccgcctgtgcttcttggaacccacttctgaa gccaagtatgttcctccagatctctgcgtctgcaattttgtgctggaacagtccctctct gtgagagccctgcaggaaatgcttgccaacacaggtgaaaatggcggagaaggggcagca caaggaggtggccacaggaccctgctgtatggccatgcgattctcctgcggcactccttc agcggaatgtatctaacatgtttgaccacatcaagatcccagacagataaacttgccttt gatgtaggtctacgggaacatgccacaggagaagcctgttggtggaccatacatcctgct tccaaacagagatccgagggagagaaagttcgaattggtgatgacctcatcctcgtcagt gtgtcttctgaaagataccttcatctctccgtttccaatgggaacatacaagtggatgcc tcttttatgcaaacactgtggaacgtacatcctacgtgctcaggaagtagcattgaagaa gggtacctacttggtgggcatgtcgtacgtctcttccatggtcatgatgagtgtttgacg ataccatctacagaccagaatgactcccagcacaggaggatattctatgaagctggggga gctgggactcgagccagatctctgtggagagtggaaccccttcggataagttggagtggc agtaacatcagatggggccaggctttccgactccggcatctcaccacaggccactacctg gccttgacagaggaccaaggccttatactgcaggaccgggcaaagtcagacaccaagtcc acagccttctctttccgggcttccaaggaaatcaaggagaaattggattctagtcataag cgagatatagaaggcatgggagttccagaaatcaagtatggagattctgtctgctttgtc cagcatatagccagtggtctgtgggtgacctacaaagcacaagatgccaagacctcccgc cttggacctctgaaaagaaaggtcatactccatcaggaaggccacatggatgacgggcta acactgcagaggtgccagtgcgaggagtcccaggctgctcggatcatccggaacacgaca gccttattcagccagtttctaagtggaaacaaccgcacagcggcccctgtcaccctgccg atagaagaggtcctgcagaccttacaggacctgatcgcctacttccagcccccagaggag gagatgcagcatgaagacaaacagaacaagctccgttcacttaagaacagacagaatctt ttcaaggaagaaggaatgttggcacttgtgttaaactgcattgatcgcttaaatatctac aacagcgtggcacactttgcaggaattgcaagggaggagagcggcatggcttggaaagag atcttgcgcctgctgtacaaactgctggctgctctcattcgtggaaacagaaacaactgc gctcaattctctaataaccttgattggctaatcagcaaattggacagactagaatcttcc tcaggtatcttggaagttttgcactgcatcttgattgaaagcccagaagccttaaatctg atagcagagggccacatcaagtctatcatctccctgttggataagcatgggcggaaccac aaggttctggatgtgctgtgctccctctgtctctgcaatggggtcgccgtgagagccaac cagaatctgatttgtgacaacttgctcccccggcgaaacctcctcctgcagacgcggctg attaacgatgtgacaagcattcggccaaacatcttcctgggagttgctgagggctcagca cagtacaagaagtggtactttgagctgatcatcgaccaggtggaccccttcctaacagcc gagcccacacacctgcgtgtgggctgggcatcttcctcaggctatgctccgtatcccgga ggaggagaaggatggggaggcaacggtgttggcgatgacctgtattcctatggctttgat ggtcttcacctttggtcaggccgcatacccagagctgtggcctccatcaaccagcacctc ctgagatcagacgatgtggtaagctgctgcctcgacctcggagtgcccagcatctctttc cgcatcaacgggcagccggtgcaggggatgtttgagaacttcaacacagacgggctcttc tttcccgtggtgagcttctccgcaggtgtcaaagtgcgtttcctgatgggtggacgtcat ggagaatttaagttcctgcctccctctggctatgccccttgctacgaagctttacttcca aaagaaaagatgagattggagcctgtcaaagaatataaacgtgatgctgaaggagttaga gatctgttgggtaccacccagttcctctctcaagcctcttttatcccatgccccatagac accagtcaggtggttttgccacctcacctggagaagatccgagacagactggctgaaaac atccacgaactttggggaatgaataaaatagagcttggctggacttttggcaagacacgg gatgacaataaaagacaacacccctgtcttgtggagttttcaaagctgcctgaaactgag aagaattataacctacaaatgtcaaccgaaaccttaaaaacccttctggccctgggatgc cacattgctcacattaacccagctgctggggaggatctcaagaaggtcaagttgcccaaa aactatatgatgtccaatggctacaagccagcccctttggatttgtctgatgtgaagctg ttacctcctcaagaaattttagtggataagcttgcagaaaatgcacataatgtttgggcc aaagaccgaataaaacaaggatggacctatggcatccaacaggatttgaagaacaaaaga aatccccggctagtgccctatgcattactggatgagcgtacgaagaagtctaatagggac agccttcgtgaagctgttcgcacattcgttggctatggctacaacatcgagccatcagac caagaactagctgaccctgctgtggagaaagtcagcatagacaagattcgatttttccgt gtagagcggtcttatgcagtgagatctggaaagtggtattttgagtttgaagtggtgacc ggaggagacatgcgtgttggctgggccaggccaggctgtcggcccgacattgagctgggg gctgatgaccaagcctttgtgtttgaaggcagcaggggccagcgttggcatcaaggcagt gggtactttggacgcacgtggcagccaggagatgtggttggatgtatgattaaccttgac gatgcctcaatgatcttcacactgaatggggagctgctgattaccagcaaaggctctgaa ctggcctttgctgattatgagattgagaatggctttgtgcccatctgctctctgggactg tctcagattggccgcatgaatctcgggatggatgccagtaccttcaagttttataccatg tgcggcctccaggagggctttgagccgtttgctgtcaacatgaaccgagatgttgccatg tggttcagcaagcgcctcccgacgtttgtcaacgtgccaaaggatcatccgcatatagag gttgtgaggatcgatggcactatggacagccctccatgcctcaaggtgacccacaagaca ttcggcacacagaatagcaatgccaacatgatctactgccgcctgagcatgcccgttgaa tgccactcctccttcagtcacagcccctgtctggacagtgaggctttccaaaaaaggaaa cagatgcaagaaatactctctcatacaacaacacagtgctactacgcaatccgcatcttc gctggacaggacccctcctgcgtctgggtaggatgggtgactccagactatcacttgtac agcgaaaagtttgacctgagtaaaaactgcacggtgactgttactctaggggatgaaaga ggccgggtccatgaaagtgtgaagcgcagcaactgctacatggtatggggtggggatatt gtggccacttcccaaagatcaagccggagcaacgtggacctggagatcggctgcctcgtg gatctggcgatgggcatgttgtctttctcagccaatgggagagaactcggcacctgctat caggtggagcccaataccaaagtgtttccagcagtcttcctgcagcccacgagcacttcc ttgtttcagtttgaacttgggaagctgaagaatgcaatgcccttgtcagcggccatattt aagagtgaagagaagaaccccgtgccacagtgcccacctcggctggacgtccaaaccatc cagcccgtgctctggagtcgcatgcccagcagcttcctgaaggtggagacagagcgggtg agcgagcgccacggctgggtggtgcagtgcctggagcccttgcagatgatggccctccac attcctgaggagaacaggtgtgtggacgtcttggagctctgtgagcaggaagaccttatg cagttccattaccacacactgcgactctacagtgccgtgtgcgccctgggaaacagccgc gtggcctatgccctctgtggccacgtggacctctcccagctcttctacgccattgacaac aagtacctccctggcctccttcggtctggtttctatgacctgctcatcagcatccacctg gccaacgccaaggagaggaagctgatgatgaagaatgagtacatcatccccatcaccagt gccaccgggaaaatccgcctgtacccagatgagtccaaaaggcacgggctgcctggggtg ggcctcagaacgtgcctcaagccaggattcaggttctccaccccttgctttgtcgtgacc agtgaagagcaccagaagcagagccctgagatccccttggagatccttaagacgaaggcg ctgagcatgctgaccgaggcagtgcagcacagtggggctcacatccgggaccccgtcggc gggtctgtagagttccagtttgtgcctgtgctgaaactcattggaaccctgctggtcatg ggggtgtttgatgatgatgacgtccggcagatcctcctcctgatcgatccctctgtgttt ggggagcacagtggggagatggagaacagagctgagaaagaggaaatgacccaggtggag gagaaggcagtggaggctggagaaaaggccagcaaggaggctccagtcaaaggcttgttg cagacccgactgccagagtcggtcaagttgcagatgtgtgagctcctcagctatctctgt gactgtgagctgcagcatcgagtggaagccattgtggcatttggcgacatttatgtctct aagcttcaggcaaatcagaagttccgctacaatgagctcatgcaggccttgaacatgtcc gcagccctgactgcccggaagaccagggagttccgctcacccccacaggagcagatcaac atgcttcttaactttcaactgggagagaattgcccctgcccagaagagatccgagaggag ctatatgacttccatgaggaccttcttattcactgtggtgttcccctagaggaagaagag gaggaggaggaagacatgtcctgggctgggaaactccgtgccttggtgtataaaatcaaa ggccctcccaagcctgagaaggaacagccaacagaggaggaagagagatgccctacaacc ttgaaggagctcatctcacagaccatgatccgctgggcccaggaggaccagatccaggac gccgagttggtccggatgatgttcaacctcctccggaggcagtatgacagcatcggggag ttgctgcaagcactacggaagacctacaccatcagtcaggcctccgtgagcgataccatc aacctgctggctgccctgggccagatccgctgcctcctcagtgtcaggatgggcaaggaa gaggagctgcttatgatcaatgggctgggagacattatgaacaacaaggtgttctaccag catcccaacctcatgcgagtgcttggcatgcacgagacggtgatggaggtgatggtgaac gtcttgggggcagagaagtctcagattgcctttccaaaaatggttgctagctgttgtcgc ttcctctgctatttctgtcgaattagccggcagaatcagaaggccatgtttgagcatcta agttacctgttggagaacagcagtgttggcctagcctccccttcgatgaggggatctacc ccgctggatgtggcagcttcctctgtgatggacaataacgaattagcactgggcttagag gaaccagacctcgagaaggtggtgacctacttggcaggctgtggcctgcagagctgcccc atgctcctggccaaagggtaccctgatgtcggctggaaccccattgaaggggaacgctac ctgtccttcctgaggtttgccgtctttgtgaacagtgaaagtgtggaagaaaatgctagc gtcgtggtcaagctgctcatcagacggcctgagtgctttggcccagccttgcgaggtgaa ggaggaaatggtctcttggcagccatgcagggtgccattaagatctctgagaacccagct ctcgaccttccctctcaaggatataagagagaagtcatggaggacggtgaagatgaagaa gagatcgtgcacatgggcaacgcaatcatgtctttttattcagcacttatagatctcctg ggccgctgtgctcctgaaatgcaccttatccagacaggaaagggggaagccatccggatc aggtcaatcctgcgctccctggttcccactgaggacctggttggcatcatcagcatcccc ttgaagctgccttccctgaacaaagatgggtcggtcagcgagccagatatggcagccaac ttctgccctgaccataaggcacccatggtgctgttcttggatcgtgtttatggcattaag gatcaaacttttctgctccacttgctagaggttggatttttacctgacttaagagcctct gcctctctcgatacagtttccctaagcaccacagaggctgcgctggcactaaataggtat ctatgttctgccgtgctcccgctcctcacaagatgcgcccctctctttgccggagcagaa caccacacctctttgatcgattctacactacagacaatatataggctttccaagggacgt tccctcaccaaagctcagagggacaccatagaagaatgtttgcttgccatttgcaaccac ttgagaccgtcaatgctacagcaactcttgcgacgtcttgtctttgatgtgccgcagctc aacgaatactgcaaaatgcctcttaagcttctgacgaatcactacgaacagtgctggaag tattactgtctgccttcgggatgggggagctacgggctagctgtggaggaggaattgcac ctgacagagaagctcttctgggggattttcgactccctctcccataagaagtatgaccca gaccttttccgaatggcccttccttgtctcagtgctatcgctggggccctgccaccagat tatttagataccagaatctcagccgcgttggagaaacagatctcagtggatgcagatggc aactttgaccccaaacccatcaacaccatgaatttttccttgcctgaaaaatgggagtac atcgtcaccaagtacgcggagcattcacatgataaatgggcctgtgacaagagtcagaat ggatggaaatacggaatttccctggatgaaaatgtgaagacccatccactgataaggcct ttcaagacattaacggaaaaggagaaggaaatttaccgctggcccgctagagagtccctg aagaccatgctggctgtgggctggtctgtggagaggaccaaagagggagaggccctggtt caacagcgggaaaatgagaagcttcggagtgtgtcccaggccagccagggcaacagctac agcccagctcccctggacctctccaacgtggtgctctccagggagctccagggaatggtg gaggtcgtggccgagaactatcacaacatctgggccaagaagaagaagctggaactggag agcaaaggtggtggcagtcaccctctgctggtaccatatgacacattgacagccaaggag aagttcagggaccgagaaaaggcacaggacctgtttaaattcctccaggtgaatggcatc gtggtttctagaggcatgaaggacatggagctggatgcctcctccatggaaaagaggttt gcctataaatttttgaagaagatcctgaaatatgttgattccgcccaagagtttattgcc cacttggaagccattgtcagcagtgggaaaaccgaaaagtctccccatgaccaggagatc aaattctttgccaaagttctcctcccgctggttgaccagtacttcaccaatcaccgcctc tacttcctgtcatcccctctaaaacccctcagcagcagtggctatgcctcccataaggag aaagaaatggtggccagcctgttctgcaaacttgctgctcttgtgcgacacaggatttcc ctctttgggagcgattctactacaatggtgagctgtcttcacatcttagctcagacactt gacaccaggactgtcatgaagtcaggctcagagctagtgaaggctgggttacgagctttc tttgaaaatgcagcggaagacttagagaagacttcggaaaatctgaagctcgggaagttt acacattccagaacacagattaaaggcgtgtcccagaatattaactacaccacggtggcc ctgctccccatcctgacgtccatctttgagcatgttgctcagcatcagtttggggtggat ttactcttaggagatgtgcagatttcatgctaccacatcctctgcagcctctactccctt gggaccggaaagaacatctacgttgaaaggcaacgtcctgcccttggagaatgtctggcc tcactggcagccgccattccagtggcgttcttggagcccactcttaaccgctacaatcca ctctcagtcttcaacactaaaacccccagagagaggtctattctggggatgccagacaca gtggaagagatgtgtcctgacatccctcagctggagggcctgatgaaggaaatcagcgac ctggccgagtcaggggcccggtacacggagatgccccatgtcatcgaggtgatcttgccc atgctctgcaactacctgtcctactggtgggagcgggggccagagcacctcccccccagc acagggccctggtgcaccaaggtcacctctgaacacctcagtgtcatcctggggaacatt ctgaaaatcatcaacaacaacctgggcatcgacgaggcgtcctggatgaagcgtatcgca gtgtacgcccagccaatcatcagcaaagccaggcccgacctgctgaaaagccacttcatc ccgactctggagaagctgaagaaaaaggccgtcaagactgtgcaggaggaggagcagctg aaggctgacaccaaaggggacactcaggaggcggagctcctcatcctggatgagtttgcg gtcctttgcagagacctctatgccttctaccccatgctaatccgctacgtggacaacaac agatcaaactggctcaaaagtcccgatgctgattctgaccagctcttccgcatggtggca gaggtcttcatcctgtggtgcaaatctcacaacttcaagagggaagagcaaaattttgtg attcagaatgaaattaataatttggcatttttaactggagacagcaaaagcaagatgtca aaagccatgcaagtaaagtctggaggacaggaccaggaacggaagaagaccaagcggaga ggagacttgtactccatccagacctctctcatcgtggctgcgctcaagaaaatgctgccc attggtttgaatatgtgcacgccaggcgatcaggagctaatctcccttgcaaaatcacga tacagctatagggataccgacgaagaggtgaaggaacatctacggaataacttgcacctg caggaaaagtcagatgacccagcagtaaagtggcagctgaacctctacaaagatgtcttg aagagtgaagaaccttctaatccagaaaagactgtagagcgcgtacagagaatttctgca gccgtcttccacctggagcaggtggaacagcctttgcggtccaagaaggcggtctggcac aaactgttatcaaagcagcggaaacgggcagtggtggcctgtttccggatggcccctctg tataacctgcccaggcaccgctccattaacctcttcctccatggctatcagagattttgg atagaaacagaggagtattcctttgaagagaaactagtacaggatttggctaaatgcccc aaggtggaagaggaggaggaggaggagacggagaagtacccggacccactgcatcagatc attctccattttagccgcaatgccctcacggagaggagcaaattggaagacgatcccttg tacacctcctattccagcatgatggccaagagttgtcagagtggggaggacgaagaagaa gaggaagacaaggaaaagacatttgaagagaaagaaatggaaaagcagaaaaccctctac cagcaagctcggctgcatgagcgtggagccgcggagatggtcctccagatgataagcgcc agcaaaggtgagatgagccccatggtggttgagactctgaagctggggatcgccattctg aacgggggcaacgctggtgtacaacagaaaatgctagattacctaaaggagaaaaaggat gctggattctttcaaagcctgtccagtcttatgcagtcttgcagtgtccttgatttgaat gcatttgagaggcagaataaagctgaaggcctggggatggttactgaggaaggaacactc attgttcgtgagcgtggtgaaaaagtactccagaatgacgagtttacacgagatctcttt agattcctgcagttactttgtgaaggacataacagtgacttccagaacttcctgcggact cagatgggcaataccaccaccgttaacatcatcatcagtaccgtggactacctactgcgt ctgcaggaatcaatcagtgatttctactggtattattcagggaaggacatcatcgatgag tctggacagcacaatttttccaaagctctggcagtcacgaaacagattttcaattccctt acagaatacatccagggcccttgcactgggaaccagcagagcctggcccacagcaggctg tgggatgcagtggtcggcttcctccatgtatttgctaacatgcagatgaaactctctcag gattccagtcagatcgagctgctgaaggaactcttggatctccttcaggacatggtggtg atgcttctgtccctcctggaagggaatgtggtaaatggaactattggcaagcagatggtt gacacactggtagagtcatctaccaatgtagaaatgatcttgaaattctttgacatgttc ttgaaactcaaagacctaaccagctcagacaccttcaaagaatatgacccagatggtaaa gggattatctccaaaaaagaattccagaaggccatggaggggcaaaaacagtacacacag tcagagattgactttctcctttcatgtgcagaagctgatgagaatgatatgtttaattac attgattttgtagaccggtttcatgagccggccaaggacatagggtttaatgtggcagtg ctactgacaaatctctccgaacacatgccaaatgattctcgccttaagtgtcttttggac ccagcagaaagtgtactaaattacttcgaaccctacctaggacggattgagatcatgggt ggggccaagaaaattgagcgtgtttattttgagatcagtgaatccagtcgaacccagtgg gagaagccccaagtgaaggaatctaagcggcagttcatctttgatgtggtcaatgaaggt ggagagcaagaaaagatggaactgtttgtgaacttctgtgaggataccatctttgaaatg cagttagcatctcagatctctgaatctgactccactgacaggccggaagaggaggaagag gaagacgaagattcttcttacatgttagaaattgagggcgaagaggaagatgacaagtct tttgagtctgcctctgcattcgccatggcctgtgcctcagtgaagagaaatgtagccaac tttctgaagaaggcaacgctgaagaacctgaggaagcagtacaggaaggtgaaaaagatg actgtgaaggagctggtgaaggtgttcttctctttcttctggatgttgtttgtggggcta ttccagttgttcttcaccatattgggaggaatctttcagatcctctggaacacggtgttt ggagggggcctagtggaaggggcaaagaacatcagagtgaccaagatcctgggtgacatg cctgaccctacccagtttggtatccatgacgatgctatggatgctgagcgggcagaggtg actgagccaggtattacaccggaactcatccacttcgtcaggggtgagagaggagatgca gatggtatgtcagatctctttggattccgctcaaagaaagaaggtggcttaaagcacggg cctgacgtgggtttgggtgacctttctgagattattggcaaggatgaaccacctacacta gagagtactgtacggaagaaaaggaaagcacaggcagcagagatgaaagctgtacatgaa gcagaaggaagaggggagcctgagaagacagacatggaagatggggagaaggaaggtatg gccaaagaggaagaccaagccgatgccctgtgggcagaagcgacaaagaagaggaagcgg cgacggggccagaaagtcgagaagcccgaagccttcatggctaatttcttcaaagggctg gaaatctatcagaccaagttactgcattacctagccaggaatttctacaacctgaggttc ctcgctctgttcgtagccttcgctatcaacttcatcctgctcttctacaaggtcactgaa gaacctttagaagaagagacagaggatgttgcaaacctgtggaattcctttaatgatgag gaagaggaagaagcgatggtgttctttgtcctacaggaaagcactgggtatatggcgcca gcactgcgggccttggccgtcatccacaccatcatctcattagtctgtgtggtgggctat tactgcctgaaggtccctttggtggtattcaaaagagaaaaagaaattgccaggaagctg gagttcgatggcctgtatatcactgaacagccatctgaagatgacatcaaggggcagtgg gaccgcttggtaatcaacacaccatcttttcctaataactactgggacaagtttgtaaag agaaaggtgatcaacaagtacggtgatctctatggagcggaacgcattgctgaactcctg ggattggacaaaaatgcccttgacttcagcccggtagaagaaagcaaagcagaggcagcc tctctggtgtcatggctgagttccatcgacatgaagtaccacatctggaagctgggagtt gtttttaccgataactcctttctctaccttgcctggtacacaaccatgtcaatcctgggc cactacaataacttcttctttgctgcccatctgctagacattgccatgggcttcaagacg ctgaggaccattctgtcatctgtaactcacaacggcaaacagctggttctgactgtgggt ctcctggccgtggtggtttacctctacaccgtggtggccttcaactttttccgcaagttc tacaacaaaagtgaagatgacgatgaacccgatatgaagtgtgatgacatgatgacgtgt tacctattccacatgtatgtgggagtgcgagcgggaggtggcattggagacgaaattgaa gaccctgctggtgatccctatgaaatgtaccgcattgtttttgacatcaccttcttcttc tttgtcattgtcatcttgctggccatcattcaaggtcttattattgatgcttttggagag ctaagagaccagcaggaacaggtgcgagaagatatggagactaaatgtttcatctgcgga attggcaatgactactttgacacgatccctcatggctttgaaacacacaccttacaagag cacaacttagccaactacttgttcttcctgatgtatctgattaacaaagatgaaacagaa cacacgggtcaggaatcttatgtctggaaaatgtaccaagaaaggtgctgggatttcttc ccggctggtgactgctttcggaaacaatatgaagatcagcttggataa

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