KEGG   Hyaena hyaena (striped hyena): 120246696
Entry
120246696         CDS       T07257                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
hhv  Hyaena hyaena (striped hyena)
Pathway
hhv00562  Inositol phosphate metabolism
hhv01100  Metabolic pathways
hhv01521  EGFR tyrosine kinase inhibitor resistance
hhv01522  Endocrine resistance
hhv01524  Platinum drug resistance
hhv04012  ErbB signaling pathway
hhv04014  Ras signaling pathway
hhv04015  Rap1 signaling pathway
hhv04024  cAMP signaling pathway
hhv04062  Chemokine signaling pathway
hhv04066  HIF-1 signaling pathway
hhv04068  FoxO signaling pathway
hhv04070  Phosphatidylinositol signaling system
hhv04071  Sphingolipid signaling pathway
hhv04072  Phospholipase D signaling pathway
hhv04081  Hormone signaling
hhv04140  Autophagy - animal
hhv04150  mTOR signaling pathway
hhv04151  PI3K-Akt signaling pathway
hhv04152  AMPK signaling pathway
hhv04210  Apoptosis
hhv04211  Longevity regulating pathway
hhv04213  Longevity regulating pathway - multiple species
hhv04218  Cellular senescence
hhv04360  Axon guidance
hhv04370  VEGF signaling pathway
hhv04380  Osteoclast differentiation
hhv04510  Focal adhesion
hhv04550  Signaling pathways regulating pluripotency of stem cells
hhv04611  Platelet activation
hhv04613  Neutrophil extracellular trap formation
hhv04620  Toll-like receptor signaling pathway
hhv04625  C-type lectin receptor signaling pathway
hhv04630  JAK-STAT signaling pathway
hhv04650  Natural killer cell mediated cytotoxicity
hhv04660  T cell receptor signaling pathway
hhv04662  B cell receptor signaling pathway
hhv04664  Fc epsilon RI signaling pathway
hhv04666  Fc gamma R-mediated phagocytosis
hhv04668  TNF signaling pathway
hhv04670  Leukocyte transendothelial migration
hhv04722  Neurotrophin signaling pathway
hhv04725  Cholinergic synapse
hhv04750  Inflammatory mediator regulation of TRP channels
hhv04810  Regulation of actin cytoskeleton
hhv04910  Insulin signaling pathway
hhv04914  Progesterone-mediated oocyte maturation
hhv04915  Estrogen signaling pathway
hhv04917  Prolactin signaling pathway
hhv04919  Thyroid hormone signaling pathway
hhv04923  Regulation of lipolysis in adipocytes
hhv04926  Relaxin signaling pathway
hhv04929  GnRH secretion
hhv04930  Type II diabetes mellitus
hhv04931  Insulin resistance
hhv04932  Non-alcoholic fatty liver disease
hhv04933  AGE-RAGE signaling pathway in diabetic complications
hhv04935  Growth hormone synthesis, secretion and action
hhv04960  Aldosterone-regulated sodium reabsorption
hhv04973  Carbohydrate digestion and absorption
hhv05010  Alzheimer disease
hhv05017  Spinocerebellar ataxia
hhv05020  Prion disease
hhv05100  Bacterial invasion of epithelial cells
hhv05132  Salmonella infection
hhv05135  Yersinia infection
hhv05142  Chagas disease
hhv05146  Amoebiasis
hhv05160  Hepatitis C
hhv05161  Hepatitis B
hhv05162  Measles
hhv05163  Human cytomegalovirus infection
hhv05164  Influenza A
hhv05165  Human papillomavirus infection
hhv05166  Human T-cell leukemia virus 1 infection
hhv05167  Kaposi sarcoma-associated herpesvirus infection
hhv05168  Herpes simplex virus 1 infection
hhv05169  Epstein-Barr virus infection
hhv05170  Human immunodeficiency virus 1 infection
hhv05171  Coronavirus disease - COVID-19
hhv05200  Pathways in cancer
hhv05203  Viral carcinogenesis
hhv05205  Proteoglycans in cancer
hhv05206  MicroRNAs in cancer
hhv05207  Chemical carcinogenesis - receptor activation
hhv05208  Chemical carcinogenesis - reactive oxygen species
hhv05210  Colorectal cancer
hhv05211  Renal cell carcinoma
hhv05212  Pancreatic cancer
hhv05213  Endometrial cancer
hhv05214  Glioma
hhv05215  Prostate cancer
hhv05218  Melanoma
hhv05220  Chronic myeloid leukemia
hhv05221  Acute myeloid leukemia
hhv05222  Small cell lung cancer
hhv05223  Non-small cell lung cancer
hhv05224  Breast cancer
hhv05225  Hepatocellular carcinoma
hhv05226  Gastric cancer
hhv05230  Central carbon metabolism in cancer
hhv05231  Choline metabolism in cancer
hhv05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hhv05415  Diabetic cardiomyopathy
hhv05417  Lipid and atherosclerosis
hhv05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hhv00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    120246696 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    120246696 (PIK3CA)
   04014 Ras signaling pathway
    120246696 (PIK3CA)
   04015 Rap1 signaling pathway
    120246696 (PIK3CA)
   04370 VEGF signaling pathway
    120246696 (PIK3CA)
   04630 JAK-STAT signaling pathway
    120246696 (PIK3CA)
   04668 TNF signaling pathway
    120246696 (PIK3CA)
   04066 HIF-1 signaling pathway
    120246696 (PIK3CA)
   04068 FoxO signaling pathway
    120246696 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    120246696 (PIK3CA)
   04072 Phospholipase D signaling pathway
    120246696 (PIK3CA)
   04071 Sphingolipid signaling pathway
    120246696 (PIK3CA)
   04024 cAMP signaling pathway
    120246696 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    120246696 (PIK3CA)
   04152 AMPK signaling pathway
    120246696 (PIK3CA)
   04150 mTOR signaling pathway
    120246696 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    120246696 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    120246696 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    120246696 (PIK3CA)
   04218 Cellular senescence
    120246696 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    120246696 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    120246696 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    120246696 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    120246696 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    120246696 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    120246696 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    120246696 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    120246696 (PIK3CA)
   04660 T cell receptor signaling pathway
    120246696 (PIK3CA)
   04662 B cell receptor signaling pathway
    120246696 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    120246696 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    120246696 (PIK3CA)
   04670 Leukocyte transendothelial migration
    120246696 (PIK3CA)
   04062 Chemokine signaling pathway
    120246696 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    120246696 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    120246696 (PIK3CA)
   04929 GnRH secretion
    120246696 (PIK3CA)
   04915 Estrogen signaling pathway
    120246696 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    120246696 (PIK3CA)
   04917 Prolactin signaling pathway
    120246696 (PIK3CA)
   04926 Relaxin signaling pathway
    120246696 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    120246696 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    120246696 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    120246696 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    120246696 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    120246696 (PIK3CA)
   04722 Neurotrophin signaling pathway
    120246696 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    120246696 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    120246696 (PIK3CA)
   04380 Osteoclast differentiation
    120246696 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    120246696 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    120246696 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    120246696 (PIK3CA)
   05206 MicroRNAs in cancer
    120246696 (PIK3CA)
   05205 Proteoglycans in cancer
    120246696 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    120246696 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    120246696 (PIK3CA)
   05203 Viral carcinogenesis
    120246696 (PIK3CA)
   05230 Central carbon metabolism in cancer
    120246696 (PIK3CA)
   05231 Choline metabolism in cancer
    120246696 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    120246696 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    120246696 (PIK3CA)
   05212 Pancreatic cancer
    120246696 (PIK3CA)
   05225 Hepatocellular carcinoma
    120246696 (PIK3CA)
   05226 Gastric cancer
    120246696 (PIK3CA)
   05214 Glioma
    120246696 (PIK3CA)
   05221 Acute myeloid leukemia
    120246696 (PIK3CA)
   05220 Chronic myeloid leukemia
    120246696 (PIK3CA)
   05218 Melanoma
    120246696 (PIK3CA)
   05211 Renal cell carcinoma
    120246696 (PIK3CA)
   05215 Prostate cancer
    120246696 (PIK3CA)
   05213 Endometrial cancer
    120246696 (PIK3CA)
   05224 Breast cancer
    120246696 (PIK3CA)
   05222 Small cell lung cancer
    120246696 (PIK3CA)
   05223 Non-small cell lung cancer
    120246696 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    120246696 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    120246696 (PIK3CA)
   05161 Hepatitis B
    120246696 (PIK3CA)
   05160 Hepatitis C
    120246696 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    120246696 (PIK3CA)
   05164 Influenza A
    120246696 (PIK3CA)
   05162 Measles
    120246696 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    120246696 (PIK3CA)
   05163 Human cytomegalovirus infection
    120246696 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    120246696 (PIK3CA)
   05169 Epstein-Barr virus infection
    120246696 (PIK3CA)
   05165 Human papillomavirus infection
    120246696 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    120246696 (PIK3CA)
   05135 Yersinia infection
    120246696 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    120246696 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    120246696 (PIK3CA)
   05142 Chagas disease
    120246696 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    120246696 (PIK3CA)
   05017 Spinocerebellar ataxia
    120246696 (PIK3CA)
   05020 Prion disease
    120246696 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    120246696 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    120246696 (PIK3CA)
   05415 Diabetic cardiomyopathy
    120246696 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    120246696 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    120246696 (PIK3CA)
   04931 Insulin resistance
    120246696 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    120246696 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    120246696 (PIK3CA)
   01524 Platinum drug resistance
    120246696 (PIK3CA)
   01522 Endocrine resistance
    120246696 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hhv04131]
    120246696 (PIK3CA)
Enzymes [BR:hhv01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     120246696 (PIK3CA)
Membrane trafficking [BR:hhv04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    120246696 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 120246696
NCBI-ProteinID: XP_039110272
LinkDB
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacattagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaaatatcctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattctttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatatcctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccggaactgccaaagcac
atatataataaactagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttccttgaaaaatatcctctgagtcagtataagtacataagaagttgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactcccaactgccaatggac
tgtttcacgatgccatcttattccagacgcatctccacagctacaccgtatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaatcctttgt
gcaacatatgtgaatgtaaatattagagacatcgacaagatctatgttcgaacaggtatc
tatcatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctaaattacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaacccgattggt
gttactgggtcaaatccaaataaagaaaccccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcacgccaattggtctgtg
tctcgagaagcaggattcagttattctcatgcaggactgagtaacagactagctagagac
aatgaattaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctctc
tctgaaatcactgagcaagagaaagatttcctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtgaaagattggcccccaatcaaacctgaacaggcaatggag
cttctggattgtaactacccagatcctatggttcgaggttttgctgttcgatgcttggaa
aaatacttaacagatgacaagctttctcagtacttaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttctggagtcctattgtcgtgcatgtgggatgtatctgaag
cacctaaataggcaagttgaggctatggaaaagctcattaacttaactgacattctcaaa
caagagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgaacaaatgcgg
agaccagatttcatggatgctctgcagggttttctgtctcctctaaatcctgctcatcag
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacactgcagatcattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggctgtctgtca
atcggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcagatt
cagtgcaaaggcggcctgaaaggcgcactgcagttcaacagccacacgctacaccagtgg
cttaaagacaagaacaaaggagaaatatatgatgcagccattgacctgttcacacgctcg
tgtgccggatactgtgtcgctaccttcatactgggaattggagatcgtcacaatagtaac
atcatggttaaagatgatggacagctatttcatatagattttggacactttttggatcat
aagaagaaaaagtttggttataagcgggagcgtgtgccatttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgaaaggttt
caggagatgtgttacaaggcttacctagctattcggcagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactgcagtcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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