Hyaena hyaena (striped hyena): 120246717 Help Entry 120246717         CDS       T07257                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism hhv  Hyaena hyaena (striped hyena) Pathway hhv04020   Calcium signaling pathway hhv04024   cAMP signaling pathway hhv04260   Cardiac muscle contraction hhv04261   Adrenergic signaling in cardiomyocytes hhv04371   Apelin signaling pathway hhv04713   Circadian entrainment hhv04911   Insulin secretion hhv04921   Oxytocin signaling pathway hhv04972   Pancreatic secretion hhv05020   Prion disease hhv05022   Pathways of neurodegeneration - multiple diseases hhv05410   Hypertrophic cardiomyopathy hhv05412   Arrhythmogenic right ventricular cardiomyopathy hhv05414   Dilated cardiomyopathy hhv05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:hhv00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     120246717 (RYR2)    04020 Calcium signaling pathway     120246717 (RYR2)    04024 cAMP signaling pathway     120246717 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     120246717 (RYR2)    04921 Oxytocin signaling pathway     120246717 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     120246717 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     120246717 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     120246717 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     120246717 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     120246717 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     120246717 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     120246717 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     120246717 (RYR2)    05414 Dilated cardiomyopathy     120246717 (RYR2)    05415 Diabetic cardiomyopathy     120246717 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:hhv04040]     120246717 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:hhv04990]     120246717 (RYR2) Ion channels [BR:hhv04040]  Voltage-gated cation channels   Ryanodine receptor    120246717 (RYR2) Domain-containing proteins not elsewhere classified [BR:hhv04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    120246717 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  120246717 NCBI-ProteinID:  XP_039110283 LinkDB All DBs Position Unknown AA seq 4956 aa AA seqDB search MVMMMVMMMMMKTIMAAFPLSTQNVPPDLSICTFVLEQSLSVRALQEMLANTVEKSEGQV DVEKWKFMMKTAQGGGHRTLLYGHAILLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEET TGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWS VAPISSGSEAAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARS LWRLETLRVAWSGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRS SKEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHINTGLWLTYQSVDVKSVRMGSIQRKAIM HHEGHMDDGLSLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKVKASTVDLPIESVS LSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAH FADVAGREGGESWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILE VLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLIC DNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEATHL RVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDD VISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKF LPPPGYAPCYEAVLPKEKLKVEHSREYKQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIV LPPHLERIREKLAENIHELWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNL QMSLETLKTLLALGCHVGIADEHAEEKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQE AMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYALLDDRTKKSNKDSLREA VRTLLGYGYHLEAPDQDHAARAEVCSGTGERFRIFRAEKTYAVKAGRWYFEFEAVTAGDM RVGWSRPGCQPDQELGSDERAFAFDGFKAQRWHQGNEHYGRSWQAGDVVGCMVDMTEHTM MFTLNGEILLDDSGSELAFKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQ EGYEPFAVNTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQ NSTADIMFYRLSMPIECAEVFSKTVAGGLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGH LVPDRVDKDKEAAKPEFNNHKDYAQEKPSRLKQRFLLRRTKPDYSTSHSARLTEDVLADD RDDYDYLMQTSTYYYSVRIFPGQEPANVWVGWITSDFHQYDAGFDLDRVRTVTVTLGDEK GKVHESIKRSNCYMVCAGESMSPGQGRNNNGLEIGCVVDAASGLLTFTANGKELSTYYQV EPSTKLFPAAFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSH VLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRSVDILELTEQEELLKF HYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSS YATARLMMNSEFIVPMTEETKSITLFPDENKKHGLPGIGLSTSLRPRIQFSSPSFVSINN EGYQFSPEFPLDILKAKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGI FHNEDLKHILQLIEPSVFKEAATPNEETEALEKEPSIEDSKPDGAGEEEVKGAKRPKEGL LQMKLPEPVKLQMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNM SAALTARKTKEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIELDE DGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEKPVESDSKKSSTLQQLISETMVRWAQES VIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLLSVR MGKEEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMV ANCCRFLCYFCRISRQNQKAMFDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNEL ALALREPDLEKVVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESV EENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSPTSGSSKTLE TEEEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLV GVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQEFLLHLLEVGFL PDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVY RLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNH YERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVA GALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHSHDKWS MDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWRVERTR EGDSMALYNRSRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWA KKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFKDLELD TPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRSKAEHFPYEQEIKFFAKVVLPLIDQ YFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCL HILGQTLDARTVMKTGLESVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQI INYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYVERQRS ALGECLAAFAGAFPVAFLETHLNKHNIYSIYNTKSSRERAALNLPTNVEDVCPNIPSLEK LMEEIVELAESGIRYTQMPHVMEVILPMLCSYMSRWWEHGPESNPERAEMCCTALSSEHM NTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKKKAAMV VSEEDHLKAEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAE DLFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQERKKMK RKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSMKDTEDEVRDIIRSNI HLQGKLEDPAIRWQMALYKDLPNRTEDTSDPEKTVERVLDIANVLFHLEQKSTCMRRRYY SLGSTVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIE TEEHYFEDKLIEDLAKPGTDPPEEEEGTKRVDPLHQLILLFSRTALTEKCKLEEDFLYMA YADIMAKSCHDEEDDDGEEEVKSFEVTGSQRSKEKEMEKQKLLYQQARLHDRGAAEMVLQ TISASKGDTGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSV LDLNAFERQNKAEGLGMVTEEGSASHFESHRLQTGEKVLQDDEFTCDLFRFLQLLCEGHN SDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQ VAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKEL MDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDT FKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPA KDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFE ISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDL NERSVNKEESEKEKPEEQGPRMGFFSIVTVKSALFALRYNILTLMRMLSLKSLKKQMKKV KKMTMKDMVTAAFSSYWSIFMSLLHFVASVSRGFFRIICSLLLGGSLVEGAKKIRVAELL ANMPDPTQDEVRGDGEEGDRKPMEAALPSEDLTDLKELTEESDLLSDIFGLDLKREGGQY KLIPHNPNAGLSDLMSNPVPIPDVQEKFQEQKVKEEEKEEKEENKSEPEKAEGEDGEKEE KAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAF AINFILLFYKVSTSSVVEGKELPTRSSSGNAKVSSLDSGSPRIITVHYVLEESSGYMEPT LRILAILHTIISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWD RLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKD SSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFK TLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLT CYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFG ELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDET EHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14871 nt NT seq  +upstreamnt  +downstreamnt atggtgatgatgatggtgatgatgatgatgatgaagacgataatggcagctttccctctc tccacacagaatgttcccccagacctctccatctgcacttttgtgctggaacagtctctc tctgtccgggccctacaggagatgctggctaacacagtggagaagtcagaagggcaagtt gatgtggaaaaatggaaattcatgatgaagactgctcaaggtggtggtcaccgaacactc ctgtatggacacgccatattgctacgccattcctacagtggcatgtatctgtgctgtctg tccacctcccggtcttcaactgataaactagcctttgacgtcggcttgcaagaggagaca acaggtgaggcgtgttggtggactatccatcctgcctctaagcagaggtcagaaggagaa aaggtgcgcgttggagacgacctcatcttagttagtgtgtcctctgagaggtacctgcat ttgtcttatggcaatggcagcctacacgtggatgccgctttccagcaaactctctggagc gtggccccaatcagctcaggaagtgaagccgcccaagggtatctaattggtggtgacgtc ctcaggttgctgcacggacacatggatgaatgcctcactgtcccttcaggagaacatggg gaagagcagcggagaaccgttcactatgaaggtggtgctgtatctgtccatgcacgttcc ctgtggagactagagacactaagagttgcgtggagtggaagccacataaggtggggccag cctttccgactacgccatgtcacaacaggaaaatacttgagtctcatggaagacaaaaac cttctactcatggacaaagaaaaggctgatgtaaagtcaacagcatttaccttccgatct tccaaggaaaaattggatgtaggggtgagaaaagaagtcgatggcatgggaacttcagaa ataaaatatggagactcagtatgctatattcaacatataaatacaggcctgtggcttact tatcagtctgtggatgtgaaatcggtgagaatgggatccatacagcgtaaggctattatg catcatgaaggccacatggatgatggcttaagtttatctagatctcagcatgaagaatca cggaccgcacgagttatccggagcacagtcttccttttcaatagatttataaggggcctc gatgcgctcagcaaaaaagtgaaggcttccacagtagacctgcctatagagtctgtgagc ctgagtctgcaggacctgattggctacttccatccccccgatgagcatctggaacatgag gacaaacagaacaggttacgggctctaaagaaccggcagaatctcttccaggaagagggc atgatcaacctcgtgcttgagtgcattgacaggctacatgtgtacagcagtgcagcccac ttcgcggatgtggccgggagagaaggaggcgagtcgtggaagtcgattctgaattctctc tatgagttgctagcggctctaattagaggaaatcgtaaaaactgtgctcagttttctggc tccctggactggttgatcagccgattggaaagactggaagcttcttctggtatacttgaa gttttacactgtgtgttagtagaaagtccagaagctctaaatattattaaagaaggacat atcaaatctataatctcccttttagacaagcatggaagaaaccacaaggttctggacgtc ctgtgttctctgtgtgtctgccatggagtcgcagtccgttccaaccagcatctcatctgc gacaatcttctgccgggaagagacctcctcctgcagacgcgtcttgtaaaccacgtcagc agcatgaggcccaatatttttctgggcgtcagtgaagggtccgcccagtataagaagtgg tactatgagctgatggtggaccacacggagccattcgtcactgctgaagccactcacctg cgggtgggctgggcatccaccgaagggtactctccctaccccggaggcggagaggaatgg ggtggaaatggagttggagatgatctcttttcctacggatttgatggccttcacctctgg tcaggttgtattgcgcgtactgtaagctcaccaaaccaacatctgttgagaactgacgat gtcatcagttgctgtttagatctgagcgccccaagcatctcattccgaattaacgggcaa cctgttcaaggaatgtttgagaatttcaacatcgatggcctcttctttccagttgttagt ttctctgcaggaataaaggtacgctttctgcttggggggagacatggagaatttaaattc cttcctccacctgggtatgctccttgttatgaagctgtcctgccgaaagagaagttgaaa gtggagcacagcagagaatacaagcaagaaagaacttacacccgagacctgctgggcccc acagtttccctgacgcaggccgccttcacgccaatccctgtggataccagccagattgtg ttaccacctcacctggagagaataagagaaaaactggcagagaatatccatgaactctgg gttatgaataaaatcgaacttggctggcagtatggtccagttagagatgacaataagaga cagcacccgtgtctggtggagttctccaagctgcctgagcaggaacgcaattacaatttg cagatgtcgcttgagactctgaagactttgctggcattaggatgtcatgtgggaatagca gatgaacatgctgaagaaaaggtgaaaaaaatgaagctgcccaagaattaccagctgaca agtgggtataagcctgccccgatggatcttagctttattaaactcaccccgtctcaggaa gcgatggtggacaagttggcggagaatgctcacaacgtgtgggcccgagatcgaatccgg cagggctggacttacggcatccaacaggacgtaaagaacagaagaaaccctcgcctggtc ccctatgcccttctagatgaccgcaccaagaaatccaacaaggacagcctccgtgaggcc gtgcgcacactgctgggatatggctaccacctggaggcaccagatcaagatcatgctgcc cgagctgaagtgtgtagcggcaccggggagaggttccgaatcttccgtgctgagaaaacc tatgcagtcaaggcaggaaggtggtattttgaattcgaggctgtcactgctggagacatg agagttggatggagcaggccaggttgtcaaccggatcaagagctgggctcggacgaacgt gcctttgccttcgatggcttcaaggcccaacggtggcaccagggcaacgaacactatgga cgctcttggcaagcgggagatgttgtaggatgcatggtggacatgactgagcacaccatg atgttcacgctgaatggcgaaatccttcttgatgactcaggctccgaactggccttcaag gatttcgatgttggtgatggattcattcctgtctgtagcctcggagtggctcaagtgggc aggatgaactttggaaaggatgtcagcaccttgaaatattttaccatctgtggcttacaa gaaggctacgaaccatttgctgtgaacacaaacagggatattaccatgtggctaagcaag aggcttcctcagtttctccaggtcccttcaaaccatgagcatatcgaggtgaccagaata gacggcaccattgacagttctccgtgtttaaaggtcacccagaagtcctttggctctcag aacagcactgctgacatcatgttctatcgcctaagcatgccgattgagtgcgctgaggtt ttctccaagacagtggcaggcgggctcccaggcgctggtctctttgggcccaagaatgat ctggaagattatgatgcagattctgactttgaggttctaatgaagacagctcatggccat ctggtgccagaccgtgttgacaaagacaaggaagccgcaaaaccagagtttaataaccac aaagattatgctcaggaaaagccctctcgtctgaaacagagatttttgcttagaagaaca aagccagattatagcacgagccattctgcaagactcactgaggacgtccttgcagatgat cgggatgattatgattacttgatgcaaacgtccacgtactattactcagtgagaatcttt cctggccaagaacctgctaacgtctgggtaggctggattacatcagatttccatcagtat gatgcaggctttgacttggacagagttcgtacagtaaccgttactctaggagatgaaaag ggaaaagttcatgaaagcatcaaacgcagcaactgctatatggtgtgtgcgggtgagagc atgagccccgggcaaggacgcaacaataacggcctggagattgggtgcgtggtggatgcc gctagtgggcttctcacattcactgccaacggcaaggagctgagcacgtactaccaggtg gagccaagtacaaagttatttcctgcagcttttgcccaagctacaagtcccaatgttttc cagtttgagttgggaagaataaagaatgtgatgcctctctccgcgggattattcaagagc gagcacaaaaaccccgtgccgcagtgtcccccgcgtctccacgtgcagtttctgtcccac gtcctgtggagcagaatgcccaaccagttcctgaaggtagatgtgtctcgaataagtgag cgccaaggctggctggtgcagtgtttggatcctctgcagttcatgtctctccatatcccg gaggagaacagatctgtggacatactggaactgacagagcaggaagagctgctgaaattc cactaccacactctccggctttactctgccgtctgcgctcttggcaaccaccgagtagca catgcattgtgcagccacgtggatgagccccagctgctctatgccatcgagaacaagtac atgcctggtttgctgcgtgccggctactacgacctgctgattgacatccacctgagctcc tacgctactgccaggctcatgatgaacagtgagttcattgtgcccatgacggaggagacc aagagcatcaccctcttccctgatgagaataaaaagcatggcctccccgggatcggtctc agcacctccctcaggcctcggatccagttttcctcccctagttttgtgagcatcaataat gaaggttaccaattcagtccagagttcccgctggacatcctgaaggccaaaaccattcag atgctgacagaagctgtgaaggagggcagcctgcatgcccgggaccctgtggggggcacc actgaatttctgtttgtcccactcatcaagcttttctacactctgctcatcatggggatc ttccacaatgaggacttaaaacacatactgcagttgatagagcccagtgtgttcaaggag gctgccactcccaatgaagagacggaggcactggagaaggagccctccatagaagactcc aaaccagacggagctggagaagaagaagtgaaaggggctaagaggcccaaggaaggactg ctccagatgaaactgcctgaaccagttaaattgcagatgtgtctgctgctccagtacctc tgtgactgccaggtccgacaccggatagaagccattgtggccttttcagacgactttgta gccaagctccaagacaatcagcgcttccgatacaatgaagttatgcaagctttaaacatg tcagccgcactcactgccaggaagacaaaggaatttagatccccacctcaggaacagatc aatatgcttctcaattttaaggatgacaaaagtgaatgtccgtgtcctgaagaaatccga gaccaactcttagattttcacgaggatttgatgacacattgtggaattgagctggatgaa gatgggtctcttgatggaaacagtgacctaacaattagaggacgcctgctgtccttggta gaaaaggtgacatacctgaagaagaaacaagccgaaaagccagttgagagtgactccaag aagtcctccactcttcagcagttgatttctgagaccatggtccgatgggcgcaagagtct gtcattgaagaccctgaactggtgagggccatgtttgtgttgctccatcgacagtatgat ggcattgggggtctggtccgggctctgccaaagacctacactataaatggtgtctccgtg gaggataccatcaacctgctggcatctcttggtcagattcgttctctgctgagtgtaaga atgggcaaagaagaagagaagcttatgattcgtggattaggggacatcatgaataataag gtgttttaccagcaccctaatctcatgagggcacttgggatgcacgagacggtgatggag gtcatggtgaatgtccttggaggtggagagtccaaggaaatcacttttcccaagatggtg gccaactgttgccgttttctttgttacttctgtcgtataagtaggcagaatcaaaaagct atgtttgatcatctcagctatttattggagaacagcagtgttggtcttgcctcaccagct atgagaggttcaacaccactggatgtagcagctgcgtcagtgatggataataatgaactg gccttagctctgcgtgagccagatttggaaaaggtagttcgatatttggctgggtgtgga ctgcagagttgccagatgctagtgtctaaaggttacccagacattggctggaatccagtt gaaggagagagataccttgactttctcagatttgctgtattctgtaatggggagagtgtg gaagagaatgccaacgtcgtggtgaggttactcatccggaggcccgagtgctttggtcct gccctgagaggagaaggtgggaatggtcttctcgcagccatggaagaagccataaaaata gccgaggatccctctcgagatggcccctcaccaactagcggatccagtaaaacacttgag acagaagaggaggaagatgacactatccacatggggaatgccatcatgacgttttatgcg gctttgattgacctcttgggacgctgtgctcctgaaatgcatttgattcatgctggtaag ggggaagccatcagaatccggtcaattttgagatccctaattccactgggagatttggtg ggagtaatcagcattgcttttcagatgccaacaatagctaaagatgggaatgtggtggag cctgacatgtctgcggggttttgcccagatcacaaggcagccatggttttgttccttgac agggtctatggaattgaggttcaagagttcctcctccatcttctcgaggttggctttctg ccagatctccgggctgctgcttctttagatacggctgctttgagtgccacagacatggcc ctggccctcaatcggtacctttgcacagccgtgttgcctttgctaacaagatgtgcccct ctctttgcgggcacagaacaccacgcttctctcattgactcattactgcacactgtgtac agactttctaagggctgctcacttaccaaagctcagcgggattccatagaagtttgttta ctctctatttgtggccaattgagaccttctatgatgcagcacttgctccgaagattagta tttgatgtcccattattaaatgaacatgcaaagatgcctcttaagttgctgacaaatcat tatgaaagatgctggaaatattactgcctgcctggagggtggggaaacttcggagctgcc tcagaagaagaacttcatttatcaagaaagttattttggggcatttttgacgccctgtct caaaagaaatacgaacaagaacttttcaaactggcactgccttgcctgagtgccgttgcg ggagctttgcctccagactacatggagtcaaattatgtcagtatgatggaaaaacagtca tcaatggattctgaagggaactttaacccacaacctgttgatacctcaaacattacaatc cctgagaagttggaatacttcattaacaaatatgctgagcattctcatgacaaatggtca atggacaagttggcaaatggatggatttatggagaaatatattcagactcatctaaagtt caaccattaatgaagccatataaactattatctgaaaaggaaaaagaaatttatcgctgg ccaatcaaggaatctttgaaaaccatgctggcgtggggttggcgggttgagcgaacacgg gaaggagacagcatggccctttacaaccgttctcgtcgtatttcgcagacaagccaggtt tctgttgatgctgcgcatggttatagcccccgagccattgacatgagcaatgtcacactg tccagagacctgcatgctatggcagaaatgatggctgaaaactaccataatatatgggcg aagaaaaagaaaatggagctggaatccaaaggaggtggaaaccatcccctgctggtaccc tatgatacactgacagccaaagagaaagccaaggatagggaaaaagcacaggacatcctc aagttcttgcagatcaatggatatgctgtatccaggggattcaaggacctggaattggac acaccttccattgagaaacgatttgcctatagtttccttcagcaactcattcgctatgtg gatgaagcccatcagtatatcctggagttcgatggtggcagcagaagcaaagcagaacat ttcccttacgagcaagaaatcaagttctttgctaaagttgttcttcctttaattgatcag tatttcaaaaaccatcgtttatacttcttatctgcagcaagcagacctctctgctctgga ggacatgcatcaaacaaagagaaagaaatggtgacaagcctattctgcaaacttggagtt cttgtcaggcataggatttcactatttggaaatgatgccacatcaattgtcaactgtctt catattttgggtcaaactttggatgcaaggactgtcatgaagactggcctggagagtgtt aaaagtgcgctcagagcttttctggacaatgctgcagaagacctggagaaaacgatggag aatctcaagcaaggccagttcacccatacccgaaaccaacccaaaggtgttactcagatt atcaattataccacggtggctctgttgccgatgctgtcttcattatttgagcatattggc cagcatcagttcggagaagatctaatattggaagatgtacaggtgtcatgttatagaatt ctgactagcttatatgctttgggaaccagcaaaagtatttatgtggaaaggcagcgctct gcgttaggagaatgtcttgctgcttttgctggtgcctttcctgttgcattcttggaaact catctcaacaagcataacatctattctatctacaataccaagtcctcacgagaacgagca gctctcaatttgccaactaatgtggaggatgtttgcccgaacataccatctttggagaaa ctcatggaagaaatcgtggaattagccgagtccgggattcgctacacgcagatgccacat gtcatggaagtcatactgcccatgctttgcagctacatgtctcgttggtgggagcacgga cctgaaagtaatcccgagagggccgaaatgtgctgtacagccctgagctcagagcacatg aacacactcttggggaatatactgaagatcatatataataacctgggaattgatgaggga gcctggatgaagaggctggcagtattttcgcagcccattataaataaagtgaaacctcag ctcctgaaaactcatttcttgccattaatggagaaactcaagaaaaaggcagcaatggtg gtgtcggaggaggaccatctgaaagctgaggccaggggggatatgtccgaggcagaactt ctcattctcgacgagttcaccactctggccagagatctctatgccttctacccgctcttg attagatttgtggactataacagggcaaagtggctgaaagaacctaaccctgaagcagag gaccttttccgcatggtggctgaagtgtttatttactggtccaaatcccacaatttcaaa agagaggagcagaacttcgtggtacagaatgaaatcaacaatatgtctttccttattacc gacaccaagtcaaagatgtcaaaggccgctgtctctgatcaggaaaggaagaaaatgaag cgtaaaggagatcggtactccatgcagacctctctcattgtggcagctctgaagcgatta ctgcccattgggttgaacatctgtgcccctggggaccaggagctcattgctctggccaaa aaccggtttagtatgaaagacactgaggatgaagtacgagatataatccgcagtaatatt catttacaaggcaagttagaggatcctgctatcagatggcaaatggctctttacaaagac ttaccaaacaggactgaagatacatcggacccagagaagaccgtggagagagtattagat atagcaaatgtgcttttccatcttgagcagaaatctacatgtatgcgccggagatattac agtctgggaagtacagtggaacacccccagaggtcaaagaaagctgtgtggcacaaactt ctgtccaagcagaggaagagggctgtggtggcctgcttccgaatggctcctttatataac ctgccaaggcaccgggccgttaacctctttcttcagggatatgaaaagtcttggattgag acagaagaacactactttgaagataagctgatcgaggatttagcaaaacccggcacagac cctccagaggaagaggaaggcacgaagagagttgatcccctccatcagctcatccttctg tttagtcgaacagctttaacagagaaatgcaaactggaggaagattttttgtatatggct tatgcagatattatggcaaagagttgtcatgacgaggaagatgatgatggtgaagaagaa gtgaagagttttgaagtcacaggatcccaacgcagcaaggaaaaagaaatggaaaagcaa aagcttctataccagcaagccaggctccatgaccgcggggctgctgagatggtgctgcag accatcagcgccagcaaaggtgatactggaccaatggtagctgcgactttgaaactcgga attgcgatcttaaatggtgggaactctacagtgcagcagaaaatgcttgactacctcaag gagaaaaaggatgtgggtttctttcaaagccttgctggcctgatgcagtcatgcagtgtc ctcgacctaaatgcctttgagcggcagaacaaagctgaaggacttggaatggtcactgaa gaaggatcagcctctcactttgaaagtcacagactgcagactggggaaaaggttctccag gatgacgagtttacttgtgacctcttccgcttcctgcagctgctttgtgagggacacaac tcagattttcaaaattatctgagaactcagactggcaataacactactgtcaacatcatc atctctactgtagactacctcctgagagtccaggaatccattagcgatttctattggtat tactctgggaaagatgttattgatgaacaaggacagcggaatttctccaaagcaattcaa gtagcaaaacaggtctttaacacgctcacagagtatattcagggtccttgcaccgggaat cagcagagcttggctcacagcaggctgtgggatgcggttgtgggcttccttcacgtgttt gcccacatgcagatgaagctgtctcaggattccagtcaaattgagctactaaaagaatta atggatcttcagaaggatatggtggtcatgttgctgtccatgctagaaggtaatgttgtc aatggaaccattggcaaacagatggtcgatatgcttgtggagtcttccaacaacgtggag atgattctcaagttttttgacatgttcttaaaactgaaggatttgacctcttctgacaca tttaaagaatatgaccctgatggtaagggagtcatttccaagagggacttccataaagcg atggagagccataaacactacacgcagtcagaaaccgagtttcttctgtcctgtgcggag acggatgaaaacgaaaccctggactatgaagagtttgtcaaaaggtttcacgagcctgca aaggacattggcttcaatgtggccgttcttctgaccaatctttcagagcacatgcccaat gatacgcgcctgcagactttcctggagttggcagagagcgtgctgaattacttccagccc tttctgggccgcatcgagatcatgggaagtgccaaacgcattgagagggtgtattttgaa atcagtgagtccagccgaacccagtgggagaagccacaggtcaaggagtccaaaaggcag ttcatatttgacgtggtcaacgaagggggagaaaaggagaaaatggaactttttgtcaac ttctgcgaggacaccatatttgaaatgcagctggcggcacagatctccgagtcggatttg aacgagaggtcagtgaataaagaagaaagtgagaaggagaagccggaagagcaggggccc agaatgggtttcttttccatcgtgactgtcaagtcggccctgtttgctctcaggtataat atcttgaccctcatgcgaatgctcagcctgaagagcctgaagaaacagatgaaaaaagtg aagaagatgaccatgaaggatatggtcacggctgccttttcgtcctactggagtatcttc atgagcctcttgcactttgtggccagtgtttccagaggcttcttccgcatcatttgcagc ctgctgctgggaggaagccttgtagaaggagcgaaaaagatccgagttgcggagctcttg gccaacatgccagaccccactcaggatgaggtgagaggggatggagaggagggggacagg aagcccatggaagccgccctgccctcggaagacctgacagacctgaaggaactgacggag gaaagcgaccttctctcagacatatttggcttggatctgaagagagaaggaggacagtac aaacttatccctcataatccaaatgctggcctcagcgacttaatgagcaacccagtcccc atccctgacgtgcaggaaaaatttcaggaacagaaggtgaaagaggaagaaaaggaggag aaagaagaaaacaaatctgaacccgaaaaggccgagggagaagatggagaaaaagaagaa aaagccaaagaagacaagggtaaacagaagttgaggcagctccacacacacagatatgga gagccagaagttcccgagtcagcattctggaagaaaatcatcgcctatcaacagaaactt ctaaactattttgctcgcaacttttacaacatgagaatgttagccttatttgtcgcgttt gcaatcaatttcatcttgctcttttataaggtctccacttcttctgtggttgaaggaaag gagctacccactcgcagttcaagtggaaatgccaaagttagcagcctggacagtggctca cctagaatcatcacggttcactacgtcctggaggagagcagcggctacatggagcccacg ctgcggatcttagcaattcttcacaccatcatttctttcttctgcatcatcggctactac tgcttgaaagtcccattggttatttttaagcgagaaaaggaagtagctcgaaaattggaa tttgatgggctttatattacagaacagccttcagaagatgatattaaaggccagtgggat agactcgtaatcaacacacagtcatttcccaacaactactgggacaaatttgttaaaaga aaggttatggataaatatggggagttctatggccgggacagaatcagcgagctccttggt atggacaaagccgccctggacttcagcgatgcccgggaaaagaagaagccaaagaaggac agctccctgtcagccgtactgaactctatcgatgtgaagtatcagatgtggaaactagga gtcgtcttcacggacaactctttcctctacctggcctggtatatgactatgtctgttctg ggacattataacaactttttttttgctgctcatcttcttgacattgctatgggattcaag acactaagaaccatcttgtcatcggtaactcacaatggcaagcagcttgtattaaccgtt ggcttgttagctgttgttgtatacctgtatactgttgtggcattcaattttttccgaaaa ttctacaataaaagtgaagatggtgacacaccagatatgaaatgtgatgatatgctaacg tgctatatgttccacatgtatgtcggggtacgcgctggagggggaatcggcgatgaaatt gaagacccagcaggcgacgaatatgagatctatcggatcatctttgatatcaccttcttc ttcttcgtgattgtcattctcttggccataatacaaggtttaattattgatgcttttgga gagctaagagaccaacaagagcaagtcaaagaagacatggagaccaaatgtttcatctgt gggataggcaacgattacttcgacacagtgccacatggctttgaaacccacactttacag gaacacaacctggccaattacctgttttttctgatgtatctcatcaacaaagatgaaaca gagcacacaggacaggaatcttatgtctggaagatgtaccaagaaaggtgctgggaattc ttcccagcgggggactgcttccgaaaacagtatgaagaccagctaaattaa

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