Haemophilus influenzae R2866 (nontypeable): R2866_0512
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Entry
R2866_0512 CDS
T01981
Symbol
thrA
Name
(GenBank) Aspartokinase I/homoserine dehydrogenase I
KO
K12524
bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:
2.7.2.4
1.1.1.3
]
Organism
hiz
Haemophilus influenzae R2866 (nontypeable)
Pathway
hiz00260
Glycine, serine and threonine metabolism
hiz00261
Monobactam biosynthesis
hiz00270
Cysteine and methionine metabolism
hiz00300
Lysine biosynthesis
hiz01100
Metabolic pathways
hiz01110
Biosynthesis of secondary metabolites
hiz01120
Microbial metabolism in diverse environments
hiz01230
Biosynthesis of amino acids
Module
hiz_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
hiz_M00018
Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:
hiz00001
]
09100 Metabolism
09105 Amino acid metabolism
00260 Glycine, serine and threonine metabolism
R2866_0512 (thrA)
00270 Cysteine and methionine metabolism
R2866_0512 (thrA)
00300 Lysine biosynthesis
R2866_0512 (thrA)
09110 Biosynthesis of other secondary metabolites
00261 Monobactam biosynthesis
R2866_0512 (thrA)
Enzymes [BR:
hiz01000
]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.3 homoserine dehydrogenase
R2866_0512 (thrA)
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.2 Phosphotransferases with a carboxy group as acceptor
2.7.2.4 aspartate kinase
R2866_0512 (thrA)
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Gene cluster
GFIT
Motif
Pfam:
Homoserine_dh
AA_kinase
ACT_9
NAD_binding_3
ACT_7
ACT
DUF3158
Motif
Other DBs
NCBI-ProteinID:
ADO80478
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All DBs
Position
518643..521090
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AA seq
815 aa
AA seq
DB search
MRVLKFGGTSLANPERFSQAAKLIEQAHLEEQAAGVLSAPAKITNHLVALSEKAALNQST
DTHFNEAIEIFYNIINGLHTENNQFDLNGTKALIDAEFAQIKGLLEEIRQAGKVEDAVKA
TIDCRGEKLSIAMMKAWFEARGYSIHIVDPVKQLLAKGGYLESSVEIEESTKRVDAANIA
KDKVVLMAGFTAGNEKGELVLLGRNGSDYSAACLAACLGASVCEIWTDVDGVYTCDPRLV
PDARLLPTLSYREAMELSYFGAKVIHPRTIGPLLPQNIPCVIKNTGNPSAPGSIIDGNVK
SESLQVKGITNLDNLAMFNVSGPGMQGMVGMASRVFSAMSGAGISVILITQSSSEYSISF
CVPVKSAEVAKTVLETEFANELNEHQLESIEVIKDLSIISVVGDGMKQAKGIAARFFSAL
AQANISIVAIAQGSSERSISAVVPQNKAIEAVKATHQALFNNKKVVDMFLVGVGGVGGEL
IEQVKRQKEYLAKKNVEIRVCAIANSNRMLLDENGLNLEDWKNDLENATQPSDFDVLLSF
IKLHHVVNPVFVDCTSAESVAGLYARALKEGFHVVTPNKKANTRELVYYNELRQNAQASQ
HKFLYETNVGAGLPVIENLQNLLAAGDELEYFEGILSGSLSFIFGKLEEGLSLSEVTALA
REKGFTEPDPRDDLSGQDVARKLLILAREAGIELELSDVEVEGVLPKGFSEGKSADEFMA
MLPQLDEEFKTRVATAKAEGKVLRYVGKISEGKCKVSIVAVDLNNPLYKVKDGENALAFY
TRYYQPIPLLLRGYGAGNAVTAAGIFADILRTLQH
NT seq
2448 nt
NT seq
+upstream
nt +downstream
nt
atgcgcgtacttaaatttggcggcacttcgcttgcaaatccggaacgtttttcccaagcg
gcgaaattgatcgaacaagctcatttagaagagcaggctgcaggtgttttatctgcacca
gccaaaataaccaaccatctcgtcgccctttctgaaaaagctgcattaaatcaatcaacc
gatacgcatttcaacgaagcaatcgaaattttctataacatcatcaacggcttacatacg
gaaaataatcaattcgacttaaatggtaccaaagcacttattgatgctgaatttgctcaa
atcaaaggattattagaagaaattcgtcaagcgggaaaagtagaagatgcagttaaagcg
accattgattgccgtggggaaaaactttctattgcaatgatgaaagcttggtttgaagcg
cgtggctatagcatacatattgtggatcctgtcaaacaattattggcaaaaggcggttat
cttgaatcttctgttgaaattgaagaatcaacaaaacgtgttgatgcagcaaatatcgca
aaagataaagtggtgctgatggcaggttttactgcgggtaatgaaaaaggcgagttggta
ttgctcggtcgtaatggctcagactattctgccgcctgtttagccgcttgtttaggcgca
agtgtatgcgaaatttggaccgatgtggacggcgtttatacttgcgatccgcgtttagtg
cctgatgcacgtttattaccaacgctttcttatcgtgaagcgatggaactctcttatttc
ggtgcgaaagtgattcatcctcgtacgattgggccattgttgccacaaaatattccttgt
gtcattaaaaatacaggaaatccttctgcgccaggttcgattattgatggcaatgtgaaa
tcagaaagtttgcaagttaaaggtatcactaacttagacaatttggcgatgtttaatgtg
tcaggccccggtatgcaaggtatggtaggcatggcatctcgcgtattttcagccatgtca
ggcgcaggcatttcagttattttaattactcagtcttcgtctgaatatagtattagtttc
tgtgtgcctgtgaaatctgcagaagtagcgaaaaccgtactagaaacggagtttgctaat
gaattaaatgaacatcaattagaatcaattgaagtgattaaagatttatccattatttct
gttgtgggcgatggaatgaagcaagcgaaaggcattgctgctcgtttcttctcggcatta
gcgcaggcaaacattagcattgtggcgattgcacaaggatctagcgaacgttcaatttct
gcggttgtgccgcaaaataaagccattgaagcggtgaaggccacccatcaggcgcttttc
aataataaaaaagtcgtggatatgtttttagtgggcgttggtggagtaggcggagaatta
atagagcaggtaaagcgtcaaaaggagtatctagcaaagaagaatgttgaaattcgagtt
tgtgctattgcgaattccaaccgtatgttgcttgatgaaaatggattaaatttagaggat
tggaaaaacgatttagaaaatgcgactcagccatcagattttgatgtattgctttctttc
attaaattacatcatgtggtgaatccagtatttgtagattgtacttcagccgaatctgta
gcagggctttatgctcgtgcgttaaaagaaggtttccatgtggttacgccaaacaaaaaa
gcgaatacacgagaattagtttattacaatgagttacgccaaaatgcccaagcaagccag
cataaatttttatatgaaaccaatgtaggtgcgggcttgccagttattgaaaatctccaa
aacttacttgcagcaggtgatgagcttgaatattttgaagggattttatctggctcgctt
tcctttatttttggtaagttggaagaaggactttctctttcagaagtaaccgcacttgcg
cgtgaaaaaggctttactgagccagatcctcgagatgatctttctggacaagatgtagcg
cgcaaattattaattcttgctcgtgaagcgggaattgaacttgaactttcagatgttgaa
gttgaaggtgtattgccgaaaggcttctctgaaggaaaatctgcagatgagtttatggca
atgttgccacagcttgacgaggagtttaaaactcgcgttgccacagctaaagcagaaggc
aaagtattgcgttatgttggaaaaattagtgaaggaaaatgcaaagtatccatcgttgcg
gtagatctgaataatccactttataaagtgaaagatggtgaaaatgccttggcattttat
actcgttattatcaaccgattccacttttattacgtggttatggcgcaggtaatgcagtt
actgcggcaggtatctttgcagatattttaagaacattacaacattaa
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